Ghrelin administration affects circulating pituitary and gastro-entero-pancreatic hormones in acromegaly

European Journal of Endocrinology

Volumn 150, Issue 1, 2004, Pages 27-32

  Arosio, Maura ^a,b,c   Ronchi, C L ^a   Gebbia, C ^a   Pizzinelli, S ^a   Conte, D ^a   Cappiello, V ^a   Epaminonda, P ^a,b   Cesana, B M ^a   Beck Peccoz, P ^a   Peracchi, M ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Operative Unit of Endocrinology   (Italy)

^c S Giuseppe Hospital   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; GASTROINTESTINAL HORMONE; GHRELIN; GLUCOSE; GROWTH HORMONE; HYDROCORTISONE; HYPOPHYSIS HORMONE; INSULIN; PANCREAS HORMONE; PANCREAS POLYPEPTIDE; PROLACTIN; SOMATOSTATIN;

ACROMEGALY; ADULT; AGED; ARTICLE; BOLUS INJECTION; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DOSE RESPONSE; DRUG MECHANISM; ENERGY BALANCE; FEMALE; HORMONE ACTION; HORMONE DETERMINATION; HUMAN; MALE; PRIORITY JOURNAL; TREATMENT OUTCOME;

ACROMEGALY; ADRENOCORTICOTROPIC HORMONE; ADULT; AGED; BLOOD GLUCOSE; FEMALE; HORMONES; HUMAN GROWTH HORMONE; HUMANS; HYDROCORTISONE; INSULIN; MALE; MIDDLE AGED; PANCREAS; PANCREATIC POLYPEPTIDE; PEPTIDE HORMONES; PITUITARY GLAND; PROLACTIN; SOMATOSTATIN;

EID: 10744231780     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1500027     Document Type: Article

References (31)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H & Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999 402 656-660.
2. Peino R, Baldelli R, Rodriguez-Garcia J, Rodriguez-Segade S, Kojima M, Kangawa K et al. Ghrelin-induced growth hormone secretion in humans. European Journal of Endocrinology 2000 143 R11-R14.
3. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG et al. Ghrelin enhances appetite and increases food intake in humans. Journal of Clinical Endocrinology and Metabolism 2001 86 5992-5997.
4. Shuto Y, Shibasaki T, Otagiri A, Kuriyama H, Ohata H, Tamura H et al. Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity. Journal of Clinical Investigation 2002 109 1429-1436.
5. Muccioli G, Tschöp M, Papotti M, Deghenghi R, Heiman M & Ghigo E. Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity. European Journal of Pharmacology 2002 440 235-254.
6. Ghigo E, Arvat E, Giordano R, Broglio F, Gianotti L, Maccario M et al. Biologic activities of growth hormone secretagogues in humans. Endocrine 2001 14 87-93.
7. Masuda Y, Tanaka T, Inomata N, Ohnuma N, Tanaka S, Itoh Z et al. Ghrelin stimulates gastric acid secretion and motility in rats. Biochemical and Biophysical Research Communications 2000 276 905-908.
8. Date Y, Nakazato M, Muratami N, Kojima M, Kangawa K & Matsukura S. Ghrelin acts in the central nervous system to stimulate gastric acid secretion. Biochemical and Biophysical Research Communications 2001 280 904-907.
9. Lee H-M, Wang G, Englander EW, Kojima M & Greeley GH. Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations. Endocrinology 2002 143 185-190.
10. Broglio F, Arvat E, Benso A, Gottero C, Muccioli G, Papotti M et al. Ghrelin, a natural secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans. Journal of Clinical Endocrinology and Metabolism 2001 86 5083-5086.
11. Arosio M, Ronchi CL, Gebbia C, Cappiello V, Beck-Peccoz P & Peracchi M. Stimulatory effects of ghrelin on circulating somatostatin and pancreatic polypeptide levels. Journal of Clinical Endocrinology and Metabolism 2003 8 701-704.
12. Peracchi M, Porretti S, Gebbia C, Pagliari C, Bucciarelli P, Epaminonda P et al. Increased glucose-dependent insulinotropic polypeptide (GIP) secretion in acromegaly European Journal of Endocrinology 2001 145 R1-R4.
13. Arosio M, Porretti S, Epaminonda P, Giavoli C, Gebbia C, Penati C et al. Elevated circulating somatostatin levels in acromegaly. Journal of Endocrinological Investigation 2003 26 499-502.
14. Cappiello V, Ronchi C, Morpurgo PS, Epaminonda P, Arosio M, Beck-Peccoz P et al. Circulating ghrelin levels in basal conditions and during glucose tolerance test in acromegalic patients. European Journal of Endocrinology 2002 147 189-194.
15. Freda PU, Reyes CM, Conwell IM, Sundeen RE & Wardlaw SL. Serum ghrelin levels in acromegaly: effects of surgical and long-acting octreotide therapy. Journal of Clinical Endocrinology and Metabolism 2003 88 2037-2044.
16. Korbonits M, Bustin SA, Kojima M, Jordan S, Adams EF, Lowe DG et al. The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors. Journal of Clinical Endocrinology and Metabolism 2001 86 881-887.
17. Arosio M, Biella O, Casati G, Guglielmino L, Palmieri E & Faglia G. Effects of hexarelin (EP23905-MF6003) on circulating GH levels in acromegalic patients. In Frontiers in Endocrinology, vol 9, pp 151-154. Eds M Andreoli & M Shields. Rome: Ares Serono Symposia Publications, 1994.
18. Ciccarelli E, Grottoli S, Razzore P, Gianotti L, Arvat E, Deghenghi R et al. Hexarelin, a synthetic growth hormone releasing peptide, stimulates prolactin secretion in acromegalic but not in hyperprolactinaemic patients. Clinical Endocrinology 1996 44 67-71.
19. Korbonits M, Kaltsas G, Perry LA, Grossman AB, Monson JP, Besser GM et al. Hexarelin as a test of pituitary reserve in patients with pituitary disease. Clinical Endocrinology 1999 51 369-375.
20. Popovic V, Miljic D, Micic D, Damjanovic S, Arvat E, Ghigo E et al. Ghrelin main action on the regulation of growth hormone release is exerted at hypothalamic level. Journal of Clinical Endocrinology and Metabolism 2003 88 3450-3453.
21. Trainer PJ, Drake WM, Perry LA, Taylor NF, Besser GM & Monson JP. Modulation of cortisol metabolism by the growth hormone receptor antagonist pegvisomant in patients with acromegaly. Journal of Clinical Endocrinology and Metabolism 2001 86 2989-2992.
22. Stewart PM, Toogood AA & Tomlinson JW. Growth hormone, insulin-like growth factor-I and the cortisol-cortisone shuttle. Hormone Research 2001 56 (Suppl 1) 1-6.
23. Svensson J, Lonn L, Jansson JO, Murphy G, Wyss D, Krupa D et al. Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure. Journal of Clinical Endocrinology and Metabolism 1998 83 362-369.
24. Murata M, Okimura Y, Iida K, Matsumoto M, Sowa H, Kaji H et al. Ghrelin modulates the downstream molecules of insulin signaling in hepatoma cells. Journal of Biological Chemistry 2002 277 5667-5674.
25. Papotti M, Ghè C, Cassoni P, Catapano F, Deghenghi R, Ghigo E et al. Growth hormone secretagogue binding sites in peripheral human tissues. Journal of Clinical Endocrinology and Metabolism 2000 85 3803-3807.
26. Nagaya N, Kojima M, Uematsu M, Yamagishi M, Hosoda H, Oya H et al. Hemodinamic and hormonal effects of human ghrelin in healthy volunteers. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2001 280 R1483-R1487.
27. Schwartz TW. Pancreatic polypeptide: a hormone under vagal control. Gastroenterology 1983 85 1411-1425.
28. Chung SA, Greenbeg GR & Diamant NE. Vagal control of fasting somatostatin levels. Neurogastroenterology and Motility 1995 7 73-78.
29. Nerrelund H, Hansen TK, Ørskov H, Hosodata H, Kojima M, Kangawa K et al. Ghrelin immunoreactivity in human plasma is suppressed by somatostatin. Clinical Endocrinology 2002 57 539-546.
30. Barkan AL, Dimiraki EV, Jessup SK, Symons KV, Ermolenko M & Jaffe CA. Ghrelin secretion in humans is sexually dimorphic, suppressed by somatostatin, and not affected by the ambient growth hormone levels. Journal of Clinical Endocrinology and Metabolism 2003 88 2180-2184.
31. Asakawa A, Inui A, Yuzuriha H, Ueno N, Katsuura G, Fujimiya M et al. Characterization of the effects of pancreatic polypeptide in the regulation of energy balance. Gastroenterology 2003 124 1325-1336.