Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility

Journal of Biological Chemistry

Volumn 281, Issue 24, 2006, Pages 16681-16690

  Dixit, Vishwa Deep ^a   Weeraratna, Ashani T ^a   Yang, Hyunwon ^a   Bertak, Dorothy ^a   Cooper Jenkins, Anthony ^a   Riggins, Gregory J ^a   Eberhart, Charles G ^a   Taub, Dennis D ^a,b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b Intramural Research Program   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGICAL ORGANS; CELLS; HORMONES; NEUROLOGY; POLYMERIZATION; POLYPEPTIDES; RNA; TUMORS;

GHRELIN; GROWTH HORMONE SECRETAGOGUE RECEPTOR (GHS-R); GROWTH HORMONES; HUMAN ASTROCYTOMA CELL LINES;

MOLECULAR BIOLOGY;

ACTIN; GELATINASE A; GHRELIN; GROWTH HORMONE SECRETAGOGUE RECEPTOR; PROTEIN KINASE C; RAC1 PROTEIN;

ARTICLE; ASTROCYTE; ASTROCYTOMA; ASTROCYTOMA CELL; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL MEMBRANE; CELL MOTILITY; CENTRAL NERVOUS SYSTEM TUMOR; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIGATION; NUCLEOTIDE SEQUENCE; OLIGODENDROGLIOMA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN POLYMERIZATION; RNA INTERFERENCE; TISSUE MICROARRAY; TUMOR CELL;

ASTROCYTOMA; CALCIUM; CELL LINE, TUMOR; CELL MOVEMENT; CENTRAL NERVOUS SYSTEM; HUMANS; MODELS, BIOLOGICAL; PEPTIDE HORMONES; PEPTIDES; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; RNA INTERFERENCE;

EID: 33745210354     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M600223200     Document Type: Article

References (68)

1. Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., and Kangawa, K. (1999) Nature 402, 656-660
2. Smith, R. G., Betancourt, L., and Sun, Y. (2004) Endocr. Rev. 26, 203-250
3. Ukkola, O., Ravussin, E., Jacobson, P., Snyder, E. E., Chagnon, M., Sjostrom, L., and Bouchard, C. (2001) J. Clin. Endocrinol. Metab. 86, 3996-3999
4. Smith, R. G., Feighner, S., Prendergast, K., Guan, X., and Howard, A. (1999) Trends Endocrinol. Metab. 10, 128-135
5. Inui, A. (2001) Nat. Rev. Neurosci. 2, 551-560
6. Tschöp, M., Smiley, D. L., and Heiman, M. L. (2000) Nature 407, 908-913
7. Hosoda, H., Kojima, M., Mizushima, T., Shimizu, S., and Kangawa, K. (2003) J. Biol. Chem. 278, 64-70
8. Dixit, V. D., Schaffer, E. M., Pyle, R. S., Collins, G. D., Sakthivel, S. K., Palaniappan, R., Lillard, J. W., Jr., and Taub, D. D. (2004) J. Clin. Investig. 114, 57-66
9. Banks, W. A., Tschop, M., Robinson, S. M., and Heiman, M. L. (2002) J. Pharmacol. Exp. Ther. 302, 822-827
10. Ariyasu, H., Takaya, K., Iwakura, H., Hosoda, H., Akamizu, T., Arai, Y., Kangawa, K., and Nakao, K. (2004) Endocrinology 146, 355-364
11. Gnanapavan, S., Kola, B., Bustin, S. A., Morris, D. G., McGee, P., Fairclough, P., Bhattacharya, S., Carpenter, R., Grossman, A. B., and Korbonits, M. (2002) J. Clin. Endocrinol. Metab. 87, 2988-2991
12. Li, W. G., Gavrila, D., Liu, X., Wang, L., Gunnlaugsson, S., Stoll, L. L., McCormick, M. L., Sigmund, C. D., Tang, C., and Weintraub, N. L. (2004) Circulation 109, 2221-2226
13. Zhang, W., Lin, T. R., Hu, Y., Fan, Y., Zhao, L., Stuenkel, E. L., and Mulholland, M. W. (2004) J. Physiol. (Lond.) 559, 729-737
14. Carlini, V. P., Monzon, M. E., Varas, M. M., Cragnolini, A. B., Schioth, H. B., Scimonelli, T. N., and de Barioglio, S. R. (2002) Biochem. Biophys. Res. Commun. 299, 739-743
15. Kim, K., Arai, K., Sanno, N., Osamura, R. Y., Teramoto, A., and Shibasaki, T. (2001) Clin. Endocrinol. 54, 759-768
16. Baldanzi, G., Filigheddu, N., Cutrupi, S., Catapano, F., Bonissoni, S., Fubini, A., Malan, D., Baj, G., Granata, R., Broglio, F., Papotti, M., Surico, N., Bussolino, F., Isgaard, J., Deghenghi, R., Sinigaglia, F., Prat, M., Muccioli, G., Ghigo, E., and Graziani, A. (2002) J. Cell Biol. 159, 1029-1037
17. Nagaya, N., Moriya, J., Yasumura, Y., Uematsu, M., Ono, F., Shimizu, W., Ueno, K., Kitakaze, M., Miyatake, K., and Kangawa, K. (2004) Circulation 110, 3674-3679
18. Baessler, A., Hasinoff, M. J., Fischer, M., Reinhard, W., Sonnenberg, G. E., Olivier, M., Erdmann, J., Schunkert, H., Doering, A., Jacob, H. J., Comuzzie, A. G., Kissebah, A. H., and Kwitek, A. E. (2005) Diabetes 54, 259-267
19. Kissebah, A. H., Sonnenberg, G. E., Myklebust, J., Goldstein, M., Broman, K., James, R. G., Marks, J. A., Krakower, G. R., Jacob, H. J., Weber, J., Martin, L., Blangero, J., and Comuzzie, A. G. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 14478-14483
20. Calle, E. E., and Kaaks, R. (2004) Nat. Rev. Cancer 4, 579-591
21. Kari, F. W., Dunn, S. E., French, J. E., and Barrett, J. C. (1999) J. Nutr. Health Aging 3, 92-101
22. Dupont, J., Pierre, A., Froment, P., and Moreau, C. (2003) Horm. Metab. Res. 35, 740-750
23. LeRoith, D., and Helman, L. (2004) Cancer Cell 5, 201-202
24. Hirano, H., Lopes, M. B., Laws, E. R., Jr., Asakura, T., Goto, M., Carpenter, J. E., Karns, L. R., and VandenBerg, S. R. (1999) Neuro-Oncology 1, 109-119
25. Yu, H., and Rohan, T. (2000) J. Natl. Cancer Inst. 92, 1472-1489
26. Rininsland, F., Johnson, T. R., Chernicky, C. L., Schulze, E., Burfeind, P., and Ilan, J. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 5854-5859
27. Mukherjee, P., Abate, L. E., and Seyfried, T. N. (2004) Clin. Cancer Res. 10, 5622-5629
28. Kiaris, H., and Schally, A. V. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 226-231
29. Pola, S., Cattaneo, M. G., and Vicentini, L. M. (2003) J. Biol. Chem. 278, 40601-40606
30. Jeffery, P. L., Herington, A. C., and Chopin, L. K. (2002) Cytokine Growth Factor Rev. 14, 113-122
31. Barlier, A., Zamora, A. J., Grino, M., Gunz, G., Pellegrini-Bouiller, I., Morange-Ramos, I., Figarella-Branger, D., Dufour, H., Jaquet, P., and Enjalbert, A. (1999) J. Neuroendocrinol. 11, 491-502
32. Cassoni, P., Papotti, M., Ghe, C., Catapano, F., Sapino, A., Graziani, A., Deghenghi, R., Reissmann, T., Ghigo, E., and Muccioli, G. (2001) J. Clin. Endocrinol. Metab. 86, 1738-1745
33. Cassoni, P., Ghe, C., Marrocco, T., Tarabra, E., Allia, E., Catapano, F., Deghenghi, R., Ghigo, E., Papotti, M., and Muccioli, G. (2004) Eur. J. Endocrinol. 150, 173-184
34. Ghe, C., Cassoni, P., Catapano, F., Marrocco, T., Deghenghi, R., Ghigo, E., Muccioli, G., and Papotti, M. (2002) Endocrinology 143, 484-491
35. Murata, M., Okimura, Y., Iida, K., Matsumoto, M., Sowa, H., Kaji, H., Kojima, M., Kangawa, K., and Chihara, K. (2002) J. Biol. Chem. 277, 5667-5674
36. Kanamoto, N., Akamizu, T., Hosoda, H., Hataya, Y., Ariyasu, H., Takaya, K., Hosoda, K., Saijo, M., Moriyama, K., Shimatsu, A., Kojima, M., Kangawa, K., and Nakao, K. (2001) J. Clin. Endocrinol. Metab. 86, 4984-4990
37. Gaytan, F., Morales, C., Barreiro, M. L., Jeffery, P., Chopin, L. K., Herington, A. C., Casanueva, F. F., Aguilar, E., Dieguez, C., and Tena-Sempere, M. (2004) J. Clin. Endocrinol. Metab. 90, 1798-1804
38. Corbetta, S., Peracchi, M., Cappiello, V., Lania, A., Lauri, E., Vago, L., Beck-Peccoz, P., and Spada, A. (2003) J. Clin. Endocrinol. Metab. 88, 3117-3120
39. Maher, E. A., Furnari, F. B., Bachoo, R. M., Rowitch, D. H., Louis, D. N., Cavenee, W. K., and DePinho, R. A. (2001) Genes. Dev. 15, 1311-1333
40. Burton, E. C., and Prados, M. D. (2000) Curr. Treat. Options Oncol. 1, 459-468
41. Weeraratna, A. T., Jiang, Y., Hostetter, G., Rosenblatt, K., Duray, P., Bittner, M., and Trent, J. M. (2002) Cancer Cell 1, 279-288
42. Boon K., Edwards, J. B., Eberhart, C. G., and Riggins, G. J. (2004) BMC Cancer 4, 39
43. Pollard, T. D., and Borisy, G. G. (2003) Cell 112, 453-465
44. Sanchez-Madrid, F., and del Pozo, M. A. (1999) EMBO J. 18, 501-511
45. da Rocha, A. B., Mans, D. R., Regner, A., and Schwartsmann, G. (2002) The Oncologist 7, 17-33
46. Zhang, J., Anastasiadis, P. Z., Liu, Y., Thompson, E. A., and Fields, A. P. (2004) J. Biol. Chem. 279, 22118-22123
47. Sliva, D., English, D., Lyons, D., and Lloyd, F. P., Jr. (2002). Biochem. Biophys. Res. Commun. 290, 552-557
48. De Vriese, C., Gregoire, F., De Neef, P., Robberecht, P., and Delporte, C. (2004) Endocrinology 146, 1514-1522
49. Caron, E. (2003) Nat. Cell Biol. 5, 185-187
50. Kraynov, V. S., Chamberlain, C., Bokoch, G. M., Schwartz, M. A., Slabaugh, S., and Hahn, K. M. (2000) Science 290, 333-337
51. Albini, A. (1998) Pathol. Oncol. Res. 4, 230-241
52. Westermarck, J., and Kahari, V. M. (1999) FASEB J. 13, 781-792
53. Strickler, R., and Phillips, M. L. (2000) Clin. J. Oncol. Nurs. 4, 153-158
54. Ware, M. L., Berger, M. S., and Binder, D. K. (2003) Histol. Histopathol. 18, 207-216
55. Zhou, Y., Larsen, P. H., Hao, C., and Yong, V. W. (2002) J. Biol. Chem. 277, 49481-49487
56. Rubin, J. B., Kung, A. L., Klein, R. S., Chan, J. A., Sun, Y., Schmidt, K., Kieran, M. W., Luster, A. D., and Segal, R. A. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 13513-13518
57. Skinner, M. M., Nass, R., Lopes, B., Laws, E. R., and Thorner, M. O. (1998) J. Clin. Endocrinol. Metab. 83, 4314-4320
58. Sun, Y., Wang, P., Zheng, H., and Smith, R. G. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 4679-4684
59. Volante, M., Allia, E., Fulcheri, E., Cassoni, P., Ghigo, E., Muccioli, G., and Papotti, M. (2003) Am. J. Pathol. 162, 645-654
60. Chen, C. Y., Inui, A., Asakawa, A., Fujino, K., Kato, I., Chen, C. C., Ueno, N., and Fujimiya, M. (2005) Gastroenterology 129, 8-25
61. Mellado, M., Rodriguez-Frade, J. M., Manes, S., and Martinez, A. C. (2001) Annu. Rev. Immunol. 19, 397-421
62. Shimonaka, M., Katagiri, K., Nakayama, T., Fujita, N., Tsuruo, T., Yoshie, O., and Kinashi, T. (2003) J. Cell Biol. 161, 417-427
63. Jaffe, A. B., and Hall, A. (2003) Science 302, 1690-1691
64. Duxbury, M. S., Waseem, T., Ito, H., Robinson, M. K., Zinner, M. J., Ashley, S. W., and Whang, E. E. (2003) Biochem. Biophys. Res. Commun. 309, 464-468
65. Gaytan, F., Barreiro, M. L., Caminos, J. E., Chopin, L. K., Herington, A. C., Morales, C., Pinilla, L., Paniagua, R., Nistal, M., Casanueva, F. F., Aguilar, E., Dieguez, C., and Tena-Sempere, M. (2004) J. Clin. Endocrinol. Metab. 89, 400-409
66. Tsolakis, A. V., Portela-Gomes, G. M., Stridsberg, M., Grimelius, L., Sundin, A., Eriksson, B. K., Oberg, K. E., and Janson, E. T. (2004) J. Clin. Endocrinol. Metab. 89, 3739-3744
67. Granado, M., Priego, T., Martin, A. I., Villanua, M. A., and Lopez-Calderon, A. (2004) Am. J. Physiol. 288, E486-E492
68. Garcia, J. M., Garcia-Touza, M., Hijazi, R. A., Taffet, G., Epner, D., Mann, D., Smith, R. G., Cunningham, G. R., and Marcelli, M. (2005) J. Clin. Endocrinol. Metab. 90, 2920-2926