Membrane components separate early-onset Alzheimer's disease from senile dementia of the Alzheimer type

International Psychogeriatrics

Volumn 8, Issue 3, 1996, Pages 365-372

  Gottfries, Carl Gerhard ^a   Karlsson, Ingvar ^a   Svennerholm, Lars ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CEREBROSIDE; CHOLESTEROL; GANGLIOSIDE; MEMBRANE LIPID; PHOSPHOLIPID; SULFATIDE;

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN TISSUE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; GRAY MATTER; HUMAN; MEMBRANE COMPONENT; NORMAL HUMAN; SENILE DEMENTIA; SYNAPSE; WHITE MATTER;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BRAIN; CEREBROSIDES; CHOLESTEROL; FEMALE; FRONTAL LOBE; GANGLIOSIDES; HUMANS; MALE; MEMBRANE LIPIDS; PHOSPHOLIPIDS; REFERENCE VALUES; SULFOGLYCOSPHINGOLIPIDS; SYNAPTIC MEMBRANES;

EID: 0030478489     PISSN: 10416102     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1041610296002736     Document Type: Article

References (11)

1. 3H)GBR-12935 in Alzheimer's disease. European Neurology, 30, 181-185.
2. Blennow, K. (1990). Heterogeneity of Alzheimer's disease. Doctoral thesis. Medical Faculty of the University of Göteborg, Göteborg, Sweden.
3. Blennow, K., Davidsson, P., Wallin, A., Fredman, P., Gottfries, C. G., et al. (1991a). Gangliosides in cerebrospinal fluid in 'probable Alzheimer's disease.' Archives of Neurology, 48, 1032-1035.
4. Blennow, K., Davidsson, P., Wallin, A., Fredman, P., Gottfries, C. G., et al. (1992). Differences in cerebrospinal fluid gangliosides between "probable Alzheimer's disease" and normal aging. Aging, 4, 301-306.
5. Blennow, K., Wallin, A., & Gottfries, C. G. (1991b). Presence of parieto-temporal symptomatology distinguishes early- and late-onset Alzheimer's disease. International Journal of Geriatric Psychiatry, 6, 147-154.
6. Davies, C. A., Mann, D. M., Sumpter, P. Q., & Yates, P. O. (1987). A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease. Journal of Neurological Science, 78, 151-164.
7. Hamos, J. E., De Gennaro, L. J., & Drachman, D. A. (1989). Synaptic loss in Alzlieimer's disease and other dementias. Neurology, 39, 355-361.
8. 3H)imipramine binding of protein nature in the human brain. II. Effect of normal aging and dementia disorders. Brain Research, 425, 137-145.
9. Svennerholm, L. (1991). Biological markers in Alzheimer's disease. International Psychogeriatrics, 3(Suppl.), 29-41.
10. Svennerholm, L., & Gottfries, C. G. (1994). Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II). Journal of Neurochemistry, 62, 1039-1047.
11. Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., De Teresa, R., et al. (1991). Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment. Annals of Neurology, 30, 572-580.