TBC1D3, a hominoid-specific gene, delays IRS-1 degradation and promotes insulin signaling by modulating p70 S6 kinase activity

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Wainszelbaum, Marisa J ^a,b   Liu, Jialu ^a   Kong, Chen ^a   Srikanth, Priya ^a   Samovski, Dmitri ^a   Su, Xiong ^a   Stahl, Philip D ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MERRIMACK PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; S6 KINASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; INSULIN RECEPTOR SUBSTRATE; ONCOPROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2; PP2A B56ALPHA PROTEIN, HUMAN; PP2A-B56ALPHA PROTEIN, HUMAN; TBC1D3 PROTEIN, HUMAN;

ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; ENZYME SPECIFICITY; GENE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INDUCTION; GENE INTERACTION; GENE REPRESSION; HUMAN; HUMAN CELL; INSULIN RESPONSE; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TBC1D3 GENE; UBIQUITINATION; GENETICS; METABOLISM; PHOSPHORYLATION;

HOMINOIDEA;

GTPASE-ACTIVATING PROTEINS; HUMANS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION;

EID: 84863144480     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031225     Document Type: Article

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