PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer

Cancer Research

Volumn 62, Issue 19, 2002, Pages 5420-5424

  Pei, Lin ^a   Peng, Yue ^b   Yang, Ying ^b   Ling, Xuefeng Bruce ^a   Van Eyndhoven, Winfried G ^b   Nguyen, Ken C Q ^b   Rubin, Mark ^c   Hoey, Timothy ^a   Powers, Scott ^b   Li, Jing ^b  

^a AMGEN INC   (United States)

^b Tularik Inc   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GENE PRODUCT; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; RAB PROTEIN;

AMPLICON; ANIMAL CELL; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CHROMOSOME 17; CONTROLLED STUDY; GENE ACTIVITY; GENE AMPLIFICATION; GENE FUNCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE; POINT MUTATION; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE CANCER GENE 17; PROTEIN PROTEIN INTERACTION;

3T3 CELLS; AMINO ACID SEQUENCE; ANIMALS; CELL DIVISION; CHROMOSOMES, HUMAN, PAIR 17; ENZYME ACTIVATION; GENE AMPLIFICATION; GTPASE-ACTIVATING PROTEINS; HUMANS; MALE; MICE; MICE, NUDE; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ONCOGENE PROTEINS; PROSTATIC NEOPLASMS; RAB5 GTP-BINDING PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR CELLS, CULTURED;

EID: 0036791144     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Ozen, M., and Pathak, S. Genetic alterations in human prostate cancer: a review of current literature. Anticancer Res., 20: 1905-1912, 2000.
2. Ali, I. U., Schriml, L. M., and Dean, M. Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity. J. Natl. Cancer Inst. (Bethesda), 91: 1922-1932, 1999.
3. Peehl, D. M. Oncogenes in prostate cancer: an update. Cancer (Phila.), 71: 1159-1164, 1993.
4. Moul, J. W., Friedrichs, P. A., Lance, R. S., Theune, S. M., and Chang, E. H. Infrequent RAS oncogene mutations in human prostate cancer. Prostate, 20: 327-338, 1992.
5. McCann, A., Dervan, P. A., Johnston, P. A., Gullick, W. J., and Carney, D. N. C-erbB-2 oncoprotein expression in primary human tumors. Cancer (Phila.), 65: 88-92, 1990.
6. El Gedaily, A., Bubendorf, L., Willi, N., Fu, W., Richter, J., Moch, H., Mihatsch, M. J., Sauter, G., and Gasser, T. C. Discovery of new DNA amplification loci in prostate cancer by comparative genomic hybridization. Prostate, 46: 184-190, 2001.
7. Sattler, H. P., Rohde, V., Bonkhoff, H., Zwergel, T., and Wullich, B. Comparative genomic hybridization reveals DNA copy number gains to frequently occur in human prostate cancer. Prostate, 39: 79-86, 1999.
8. Lucito, R., West, J., Reiner, A., Alexander, J., Esposito, D., Mishra, B., Powers, S., Norton, L., and Wigler, M. Detecting gene copy number fluctuations in tumor cells by microarray analysis of genomic representations. Genome Res., 10: 1726-1736, 2000.
9. Snijders, A. M., Nowak, N., Segraves, R., Blackwood, S., Brown, N., Conroy, J., Hamilton, G., Hindle, A. K., Huey, B., Kimura, K., Law, S., Myambo, K., Palmer, J., Ylstra, B., Yue, J. P., Gray, J. W., Jain, A. N., Pinkel, D., and Albertson, D. G. Assembly of microarrays for genome-wide measurement of DNA copy number. Nat. Genet., 29: 263-264, 2001.
10. Pollack, J. R., Perou, C. M., Alizadeh, A. A., Eisen, M. B., Pergamenschikov, A., Williams, C. F., Jeffrey, S. S., Botstein, D., and Brown, P. O. Genome-wide analysis of DNA copy-number changes using cDNA microarrays. Nat. Genet., 23: 41-46, 1999.
11. Rubin, M. A., Putzi, M., Mucci, N., Smith, D. C., Wojno, K., Korenchuk, S., and Pienta, K. J. Rapid ("warm") autopsy study for procurement of metastatic prostate cancer. Clin. Cancer Res., 6: 1038-1045, 2000.
12. Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., and Lowe, S. W. Oncogenic Ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell, 88: 593-602, 1997.
13. Burge, C., and Karlin, S. Prediction of complete gene structures in human genomic DNA. J. Mol. Biol., 268: 78-94, 1997.
14. Matoskova, B., Wong, W. T., Seki, N., Nagase, T., Nomura, N., Robbins, K. C., and Di Fiore, P. P. RN-tre identifies a family of tre-related proteins displaying a novel potential protein binding domain. Oncogene, 12: 2563-2571, 1996.
15. Richardson, P. M., and Zon, L. I. Molecular cloning of a cDNA with a novel domain present in the tre-2 oncogene and the yeast cell cycle regulators BUB2 and cdc16. Oncogene, 11: 1139-1148, 1995.
16. Albert, S., Will, E., and Gallwitz, D. Identification of the catalytic domains and their functionally critical arginine residues of two yeast GTPase-activating proteins specific for Ypt/Rab transport GTPases. EMBO J., 18: 5216-5225, 1999.
17. Lanzetti, L., Rybin, V., Malabarba, M. G., Christoforidis, S., Scita, G., Zerial, M., and Di Fiore, P. P. The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5. Nature (Lond.), 408: 374-377, 2000.
18. Nakamura, T., Hillova, J., Mariage-Samson, R., Onno, M., Huebner, K., Cannizzaro, L. A., Boghosian-Sell, L., Croce, C. M., and Hill, M. A novel transcriptional unit of the tre oncogene widely expressed in human cancer cells. Oncogene, 7: 733-741, 1992.
19. Papa, F. R., and Hochstrasser, M. The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene. Nature (Lond.), 366: 313-319, 1993.
20. Gorvel, J. P., Chavrier, P., Zerial, M., and Gruenberg, J. Rab5 controls early endosome fusion in vitro. Cell, 64: 915-925, 1991.
21. Stenmark, H., Parton, R. G., Steele-Mortimer, O., Lutcke, A., Gruenberg, J., and Zerial, M. Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis. EMBO J., 13: 1287-1296, 1994.
22. Roberts, R. L., Barbieri, M. A., Pryse, K. M., Chua, M., Monsaki, J. H., and Stahl, P. D. Endosome fusion in living cells overexpressing GFP-Rab5. J. Cell Sci., 112: 3667-3675, 1999.
23. Barbieri, M. A., Roberts, R. L., Gumusboga, A., Highfield, H., Alvarez-Dominguez, C., Wells, A., and Stahl, P. D. Epidermal growth factor and membrane trafficking. EGF receptor activation of endocytosis requires Rab5a. J. Cell Biol., 151: 539-550, 2000.
24. Wienecke, R., Konig, A., and DeClue, J. E. Identification of tuberin, the tuberous sclerosis-2 product: tuberin possesses specific Rap1GAP activity. J. Biol. Chem., 270: 16409-16414, 1995.
25. Xiao, G. H., Shoarinejad, F., Jin, F., Golemis, E. A., and Yeung, R. S. The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis. J. Biol. Chem., 272: 6097-6100, 1997.