SNP-induced apoptosis may be mediated with caspase inhibitor by JNK signaling pathways in rabbit articular chondrocytes

Journal of Toxicological Sciences

Volumn 37, Issue 1, 2012, Pages 157-167

  Chen, Qun ^a   Gao, Yan ^b   Kao, XiBin ^c   Chen, JingHong ^a   Xue, WanLi ^a   Xiong, YongMin ^a   Wang, ZhiLun ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^b Institute of Health Supervision   (China)

^c Institute of Industrial Hygiene of Ordnance Industry   (China)

Author keywords

Apoptosis; Caspase 3; Chondrocytes; JNK; NF B; p53; Sodium nitroprusside

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BETA ACTIN; CASPASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; NITRIC OXIDE; NITROPRUSSIDE SODIUM; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARTILAGE CELL; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE EXPRESSION; NICK END LABELING; NONHUMAN; PREMEDICATION; PROTEIN EXPRESSION; RABBIT; SIGNAL TRANSDUCTION;

ORYCTOLAGUS CUNICULUS;

EID: 84863130860     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.37.157     Document Type: Article

References (37)

1. Bennett, B.L., Sasaki, D.T., Murray, B.W., O'Leary, E.C., Sakata, S.T., Xu, W.M., Leisten, J.C., Motiwala, A., Pierce, S., Satoh, Y., Bhagwat, S.S., Manning, A.M. and Anderson, D.W. (2001): SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc. Natl. Acad. Sci. USA, 98, 13681-13686
2. Boronkai, A., Bellyei, S., Szigeti, A., Pozsgai, E., Bognar, Z., Sumegi, B. and Gallyas, F. (2009): Potentiation of paclitaxel-induced apoptosis by galectin-13 overexpression via activation of Ask-1-p38-MAP kinase and JNK/SAPK pathways and suppression of Akt and ERK1/2 activation in U-937 human macrophage cells. Eur. J. Cell. Biol., 88, 753-763
3. Caterson, B., Flannery, C.R., Hughes, G.E. and Little, C.B. (2000): Mechanisms involved in cartilage proteoglycan catabolism. Matrix Biol., 19, 333-344
4. Chang, Q.Z., Zhang, S.L. and Yin, J.B. (2010): Role of chloride channels in nitric oxide-induced rat hippocampal neuronal apoptosis in vitro. Neural. Regeneration. Research, 5, 690-694
5. Chen, M.H., Wang, J.L., Wong, C.Y., Yao, C.C., Chen, Y.J. and Jiang, C.C. (2005): Relationship of chondrocyte apoptosis to matrix degradation and swelling potential of osteoarthritic cartilage. J. Formos. Med. Assoc., 104, 264-272
6. Cherng, Y.G., Chang, H.C., Lin, Y.L., Kuo, M.L., Chiu, W.T. and Chen, R.M. (2008): Apoptotic insults to human chondrocytes induced by sodium nitroprusside are involved in sequential events, including cytoskeletal remodeling, phosphorylation of mitogen-activated protein kinase kinase kinase-1/c-Jun N-terminal kinase, and Bax-mitochondria-mediated caspase activation. J. Orthopedic. Res., 26, 1018-1026
7. Clancy, R.M., Abramson, S.B., Kohne, C. and Rediske, J. (1997): Nitric oxide attenuates cellular hexose monophosphate shunt response to oxidants in articular chondrocytes and acts to promote oxidant injury. J. Cell. Physiol., 172, 183-191
8. Clancy, R., Rediske, J., Koehne, C., Stoyanovsky, D., Amin, A., Attur, M., Iyama, K. and Abramson, S.B. (2001): Activation of stress-activated protein kinase in osteoarthritic cartilage: evidence for nitric oxide dependence. Osteoarthritis Cartilage, 9, 294-299
9. Dlima, D.D., Kuhn, K. and Lotz, M.K. (2004): Detection of apoptosis in cartilage in situ and in isolated chondrocytes. Methods Mol. Med., 100, 275-290
10. Ea, H.K., Uzan, B., Rey, C. and Liote, F. (2005): Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes. Arthritis. Res. Ther., 7, R915-R926.
11. Feelisch, M. (2008): The chemical biology of nitric oxide--an outsider's reflections about its role in osteoarthritis. Osteoarthritis Cartilage, 16, S3-S13.
12. Fleming, Y., Armstrong, C.G., Morrice, N., Paterson, A., Goedert, M. and Cohen, P. (2000): Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. Biochem. J., 352, 145-154
13. Fogarty, M.P., Downer, E.J. and Campbell, V. (2003): A role for c-Jun N-terminal kinase 1 (JNK1), but not JNK2, in the betaamyloidmediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neurons. Biochem. J., 371, 789-798
14. Gulmann, C., Sheehan, K.M., Conroy, R.M., Wulfkuhie, J.D., Espina, V., Mullarkey, M.J., Kay, E.W., Liotta, L.A. and Petricoin, E.F. (2009): Quantitative cell signalling analysis reveals down-regulation of MAPK pathway activation in colorectal cancer. J. Pathol., 218, 514-519
15. Heck, D.E., Kagan, V.E., Shvedova, A.A. and Laskin, J.D. (2005): An epigrammatic (abridged) recounting of the myriad tales of astonishing deeds and dire consequences pertaining to nitric oxide and reactive oxygen species in mitochondria with an ancillary missive concerning the origins of apoptosis. Toxicology, 208, 259-271
16. Hummon, A.B., Lim, S.R., Difilippantonio, M.J. and Ried, T. (2007): Isolation and solubilization of proteins after TRIzol((R)) extraction of RNA and DNA from patient material following prolonged storage. Biotechniques, 42, 467-470, 472.
17. Kim, J.Y., Yu, S.J., Oh, H.J., Lee, J.Y., Kim, Y. and Sohn, J. (2011): Panaxydol induces apoptosis through an increased intracellular calcium level, activation of JNK and p38 MAPK and NADPH oxidase-dependent generation of reactive oxygen species. Apoptosis, 16, 347-358
18. Kim, S.J., Ju, J.W., Oh, C.D., Yoon, Y.M., Song, W.K., Kim, J.H., Yoo, Y.J., Bang, O.S., Kang, S.S. and Chun, J.S. (2002a): ERK-1/2 and p38 Kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status. J. Biol. Chem., 277, 1332-1339
19. Kim, S.J., Hwang, S.G., Shin, D.Y., Kang, S.S. and Chun, J.S. (2002b): p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NF-κBdependent transcription and stabilization by serine 15 phosphorylation. J. Biol. Chem., 277, 33501-33508
20. Kraan, P.M. and Berg, W.B. (2000): Anabolic and destructive mediators in osteoarthritis. Curr. Opin. Clin. Nutr. Metab. Care, 3, 205-211
21. Levine, A.J. (1997): p53, the cellular gatekeeper for growth and division. Cell, 88, 323-331
22. Liu, H., Lo, C.R. and Czaja, M.J. (2002): NF-κB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun. Hepatology, 35, 772-778
23. Loeser, R.F. (2006): Molecular mechanisms of cartilage destruction: Mechanics, inflammatory mediators, and aging collide. Arthritis Rheum., 54, 1357-1360
24. Migita, K., Tanaka, F., Abiru, S., Ida, H., Izumi, Y., Kawakami, A., and Eguchi, K. (2003): The role of mitochondria in nitric oxidemediated thymocyte apoptosis. Immunol. Lett., 90, 87-91
25. Nakagawa, S., Arai, Y., Mazda, O., Kishida, T., Takahashi, K.A., Sakao, K., Saito, M., Honjo, K., Imanishi, J. and Kubo, T. (2010): N-Acetylcysteine prevents nitric oxide-induced chondrocyte apoptosis and cartilage degeneration in an experimental model of osteoarthritis. J. Orthopaedic. Res., 28, 156-163
26. Nieminen, R., Leinonen, S., Lahti, A., Vuolteenaho, K., Jalonen, U., Kankaanranta, H., Goldring, M.B. and Moilanen, E. (2005): Inhibitors of mitogen-activated protein kinases downregulate COX-2 expression in human chondrocytes. Mediat. Inflamm., 2005, 249-255
27. Nishikawa, Y., Kawase, O., Vielemeyer, O., Suzuki, H., Joiner, K.A., Xuan, X. and Nagasawa, H. (2007): Toxoplasma gondii infection induces apoptosis in noninfected macrophages: role of nitric oxide and other soluble factors. Parasite. Immunol., 29, 375-385
28. Rudolf, E., Rudolf, K. and Cervinka, M. (2008): Selenium activates p53 and p38 pathways and induces caspase-independent cell death in cervical cancer cells. Cell. Biol. Toxicol., 24, 123-141
29. Said, T.M., Paasch, U., Glander, H.J. and Agarwal, A. (2004): Role of caspases in male infertility. Hum. Reprod. Update, 10, 39-51
30. She, Q.B., Chen, N.Y. and Dong, Z.G. (2000): ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation. J. Biol. Chem., 275, 20444-20449
31. Siebenlist, U., Franzoso, G. and Brown, K. (1994): Structure, regulation and function of NF-Kappa-B. Annu. Rev. Cell. Biol., 10, 405-455
32. Tai, Y.T., Cherng, Y.G., Chang, C.C., Hwang, Y.P., Chen, J.T. and Chen, R.M. (2007): Pretreatment with low nitric oxide protects osteoblasts from high nitric oxide-induced apoptotic insults through regulation of c-Jun N-terminal kinase/c-Jun-mediated Bcl-2 gene expression and protein translocation. J. Orthop. Res., 25, 625-635
33. Wang, H.L., Wang, Z.L., Chen, J.H. and Wu, J. (2007): Apoptosis induced by NO via phosphorylation of p38 MAPK that stimulates NF-kappa B, p53 and caspase-3 activation in rabbit articularchondrocytes. Cell. Biol. Int., 31, 1027-1035
34. Wu, G.J., Chen, T.G., Chang, H.C., Chiu, W.T., Chang, C.C. and Chen, R.M. (2007): Nitric oxide from both exogenous and endogenous sources activates mitochondria-dependent events and induces insults to human chondrocytes. J. Cell. Biochem., 101, 1520-1531
35. Xu, Y.M., Zhu, F., Cho, Y.Y., Carper, A., Peng, C., Zheng, D., Yao, K., Lau, A.T.Y., Zykova, T.A., Kim, H.G., Bode, A.M. and Dong, Z.G. (2010): Extracellular signal-regulated kinase 8-mediated c-jun phosphorylation increases tumorigenesis of human colon cancer. Cancer Res., 70, 3218-3227
36. Zhang, L.H., Youn, H.D. and Liu, J.O. (2001): Inhibition of cell cycle progression by the novel cyclophilin ligand sanglifehrin A is mediated through the NF κB-dependent activation of p53. J. Biol. Chem., 276, 43534-43540
37. Zhang, S.Y., Lin, Z.N., Yang, C.F., Shi, X.L., Ong, C.N. and Shen, H.M. (2004): Suppressed NF-κB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNFalpha-induced apoptosis in human cancer cells. Carcinogenesis, 25, 2191-2199