Inhibitors of mitogen-activated protein kinases downregulate COX-2 expression in human chondrocytes

Mediators of Inflammation

Volumn 2005, Issue 5, 2005, Pages 249-255

  Nieminen, Riina ^a   Leinonen, Sari ^a   Lahti, Aleksi ^a   Vuolteenaho, Katriina ^a   Jalonen, Ulla ^a   Kankaanranta, Hannu ^a   Goldring, Mary B ^b   Moilanen, Eeva ^a  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 ETHYL 2 (4 METHOXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CYCLOOXYGENASE 2; CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; N1 METHYL 1,9 PYRAZOLANTHRONE; PROSTAGLANDIN E2; PYRAZOLE DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INFLAMMATION; INHIBITION KINETICS; LIPOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION;

ANTHRACENES; CHONDROCYTES; CYCLOOXYGENASE 2; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME ACTIVATION; ENZYME INHIBITORS; FLAVONOIDS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; IMIDAZOLES; INTERLEUKIN-1; MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 27644524111     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/MI.2005.249     Document Type: Article

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