The Biosynthetic Incorporation of the Intact Leucine Skeleton into Sterol by the Trypanosomatid Leishmania mexicana

Journal of Biological Chemistry

Volumn 276, Issue 15, 2001, Pages 11674-11682

  Ginger, Michael L ^a,d   Chance, Michael L ^b   Sadler, Ian H ^c   Goad, L John ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; ENZYME INHIBITION; MASS SPECTROMETRY; MUSCULOSKELETAL SYSTEM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

CATABOLISM; PHOSPHORYLATION;

BIOCHEMISTRY;

12 HYDROXY 13 HYDROXYMETHYL 3,5,7 TRIMETHYLTETRADECA 2,4 DIENEDIOIC ACID 12,14 LACTONE; 14ALPHA METHYLERGOSTA 8,24(24) 3BETA OL; 3 HYDROXY 3 METHYLGLUTARYL COENZYME A; ACETIC ACID DERIVATIVE; ACETYL COENZYME A; CARBON 14; ISOPRENE; ISOPRENOID; KETOCONAZOLE; LEUCINE; MEVINOLIN; STEROL DERIVATIVE; UNCLASSIFIED DRUG; ANTIPROTOZOAL AGENT; CARBON; ENZYME INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; LACTONE; STEROL; UNSATURATED FATTY ACID;

AMINO ACID SEQUENCE; ARTICLE; BIOSYNTHESIS; CARBON NUCLEAR MAGNETIC RESONANCE; ENZYME INHIBITION; INCUBATION TIME; ISOTOPE LABELING; LEISHMANIA MEXICANA; NONHUMAN; PHOSPHORYLATION; PLANT; PRIORITY JOURNAL; PROMASTIGOTE; SKELETON; STRUCTURE ANALYSIS; TRYPANOSOMA; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANIMALIA; LEISHMANIA MEXICANA; PROTOZOA; TRYPANOSOMA; TRYPANOSOMATIDAE;

ANIMALS; ANTIPROTOZOAL AGENTS; CARBON ISOTOPES; ENZYME INHIBITORS; FATTY ACIDS, UNSATURATED; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; LACTONES; LEISHMANIA MEXICANA; LEUCINE; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; STEROLS;

EID: 0035853715     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M006850200     Document Type: Article

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