-
1
-
-
0012473279
-
The Nuclear Receptor Superfamily - The 2nd Decade
-
Mangelsdorf, D. J.; Thummel, C.; Beato, M.; Herrlich, P.; Schutz, G.; Umesono, K.; Blumberg, B.; Kastner, P.; Mark, M.; Chambon, P.; Evans, R. M. The Nuclear Receptor Superfamily - the 2nd Decade Cell 1995, 83, 835-839
-
(1995)
Cell
, vol.83
, pp. 835-839
-
-
Mangelsdorf, D.J.1
Thummel, C.2
Beato, M.3
Herrlich, P.4
Schutz, G.5
Umesono, K.6
Blumberg, B.7
Kastner, P.8
Mark, M.9
Chambon, P.10
Evans, R.M.11
-
2
-
-
0026342117
-
RXRβ: A Coregulator that Enhances Binding of Retinoic Acid, Thyroid Hormone, and Vitamin D Receptors to Their Cognate Response Elements
-
Yu, V. C.; Delsert, C.; Andersen, B.; Holloway, J. M.; Devary, O. V.; Naar, A. M.; Kim, S. Y.; Boutin, J. M.; Glass, C. K.; Rosenfeld, M. G. RXRβ: a Coregulator that Enhances Binding of Retinoic Acid, Thyroid Hormone, and Vitamin D Receptors to Their Cognate Response Elements Cell 1991, 67, 1251-1266
-
(1991)
Cell
, vol.67
, pp. 1251-1266
-
-
Yu, V.C.1
Delsert, C.2
Andersen, B.3
Holloway, J.M.4
Devary, O.V.5
Naar, A.M.6
Kim, S.Y.7
Boutin, J.M.8
Glass, C.K.9
Rosenfeld, M.G.10
-
3
-
-
70349645985
-
Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor (RXR) Selective Agonists: Novel Analogues of 4-[1-(3,5,5,8,8- Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene)
-
Wagner, C. E.; Jurutka, P. W.; Marshall, P. A.; Groy, T. L.; van der Vaart, A.; Ziller, J. W.; Furmick, J. K.; Graeber, M. E.; Matro, E.; Miguel, B. V.; Tran, I. T.; Kwon, J.; Tedeschi, J. N.; Moosavi, S.; Danishyar, A.; Philp, J. S.; Khamees, R. O.; Jackson, J. N.; Grupe, D. K.; Badshah, S. L.; Hart, J. W. Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor (RXR) Selective Agonists: Novel Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7, 8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) J. Med. Chem. 2009, 52, 5950-5966
-
(2009)
J. Med. Chem.
, vol.52
, pp. 5950-5966
-
-
Wagner, C.E.1
Jurutka, P.W.2
Marshall, P.A.3
Groy, T.L.4
Van Der Vaart, A.5
Ziller, J.W.6
Furmick, J.K.7
Graeber, M.E.8
Matro, E.9
Miguel, B.V.10
Tran, I.T.11
Kwon, J.12
Tedeschi, J.N.13
Moosavi, S.14
Danishyar, A.15
Philp, J.S.16
Khamees, R.O.17
Jackson, J.N.18
Grupe, D.K.19
Badshah, S.L.20
Hart, J.W.21
more..
-
4
-
-
0035253128
-
Retinoid X Receptor and Its Partners in the Nuclear Receptor Family
-
Rastinejad, F. Retinoid X Receptor and Its Partners in the Nuclear Receptor Family Curr. Opin. Struct. Biol. 2001, 11, 33-38
-
(2001)
Curr. Opin. Struct. Biol.
, vol.11
, pp. 33-38
-
-
Rastinejad, F.1
-
5
-
-
0029562554
-
The RXR Heterodimers and Orphan Receptors
-
Mangelsdorf, D. J.; Evans, R. M. The RXR Heterodimers and Orphan Receptors Cell 1995, 83, 841-850
-
(1995)
Cell
, vol.83
, pp. 841-850
-
-
Mangelsdorf, D.J.1
Evans, R.M.2
-
7
-
-
0035954826
-
Chemoprevention of NMU-Induced Rat Mammary Carcinoma with the Combination of Melatonin and 9- cis -Retinoic Acid
-
Teplitzky, S. R.; Kiefer, T. L.; Cheng, Q.; Dwivedi, P. D.; Moroz, K.; Myers, L.; Anderson, M. B.; Collins, A.; Dai, J.; Yuan, L.; Spriggs, L. L.; Blask, D. E.; Hill, S. M. Chemoprevention of NMU-Induced Rat Mammary Carcinoma with the Combination of Melatonin and 9- cis -Retinoic Acid Cancer Lett. 2001, 168, 155-163
-
(2001)
Cancer Lett.
, vol.168
, pp. 155-163
-
-
Teplitzky, S.R.1
Kiefer, T.L.2
Cheng, Q.3
Dwivedi, P.D.4
Moroz, K.5
Myers, L.6
Anderson, M.B.7
Collins, A.8
Dai, J.9
Yuan, L.10
Spriggs, L.L.11
Blask, D.E.12
Hill, S.M.13
-
8
-
-
0033281964
-
Melatonin and 9- cis -Retinoic Acid in the Chemoprevention of NMU-Induced Rat Mammary Carcinoma
-
Teplitzky, S. R.; Blask, D. E.; Cheng, Q.; Myers, L.; Hill, S. M. Melatonin and 9- cis -Retinoic Acid in the Chemoprevention of NMU-Induced Rat Mammary Carcinoma Adv. Exp. Biol. Med. 1999, 460, 363-367
-
(1999)
Adv. Exp. Biol. Med.
, vol.460
, pp. 363-367
-
-
Teplitzky, S.R.1
Blask, D.E.2
Cheng, Q.3
Myers, L.4
Hill, S.M.5
-
9
-
-
33646010000
-
Clinical Trials with Retinoids for Breast Cancer Chemoprevention
-
Zanardi, S.; Serrano, D.; Argusti, A.; Barile, M.; Puntoni, M.; Decensi, A. Clinical Trials with Retinoids for Breast Cancer Chemoprevention Endocr.-Relat. Cancer 2006, 13, 51-68
-
(2006)
Endocr.-Relat. Cancer
, vol.13
, pp. 51-68
-
-
Zanardi, S.1
Serrano, D.2
Argusti, A.3
Barile, M.4
Puntoni, M.5
Decensi, A.6
-
10
-
-
22344432472
-
Effects of 9- cis -Retinoic Acid on the Insulin-like Growth Factor Axis in Former Smokers
-
Lee, H. Y.; Chang, Y. S.; Han, J. Y.; Liu, D. D.; Lee, J. J.; Lotan, R.; Spitz, M. R.; Hong, W. K. Effects of 9- cis -Retinoic Acid on the Insulin-like Growth Factor Axis in Former Smokers J. Clin. Oncol. 2005, 23, 4439-4449
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 4439-4449
-
-
Lee, H.Y.1
Chang, Y.S.2
Han, J.Y.3
Liu, D.D.4
Lee, J.J.5
Lotan, R.6
Spitz, M.R.7
Hong, W.K.8
-
11
-
-
0036897019
-
Selective Retinoids and Rexinoids in Cancer Therapy and Chemoprevention
-
Zusi, F. C.; Lorenzi, M. V.; Vivat-Hannah, V. Selective Retinoids and Rexinoids in Cancer Therapy and Chemoprevention Drug Discovery Today 2002, 7, 1165-1174
-
(2002)
Drug Discovery Today
, vol.7
, pp. 1165-1174
-
-
Zusi, F.C.1
Lorenzi, M.V.2
Vivat-Hannah, V.3
-
12
-
-
12244302882
-
The Efficacy of 9- cis -Retinoic Acid (Aliretinoin) As a Chemopreventive Agent for Cervical Dysplasia: Results of a Randomized Double-blind Clinical trial
-
Alvarez, R. D.; Conner, M. G.; Weiss, H.; Klug, P. M.; Niwas, S.; Manne, U.; Bacus, J.; Kagan, V.; Sexton, K. C.; Grubbs, C. J.; Eltoum, I. E.; Grizzle, W. E. The Efficacy of 9- cis -Retinoic Acid (Aliretinoin) As a Chemopreventive Agent for Cervical Dysplasia: Results of a Randomized Double-blind Clinical trial Cancer Epidemiol., Biomarkers Prev. 2003, 12, 114-119
-
(2003)
Cancer Epidemiol., Biomarkers Prev.
, vol.12
, pp. 114-119
-
-
Alvarez, R.D.1
Conner, M.G.2
Weiss, H.3
Klug, P.M.4
Niwas, S.5
Manne, U.6
Bacus, J.7
Kagan, V.8
Sexton, K.C.9
Grubbs, C.J.10
Eltoum, I.E.11
Grizzle, W.E.12
-
13
-
-
40949115877
-
Efficacy and Safety of Oral Alitretinoin (9- cis -Retinoic Acid) in Patients with Severe Chronic Hand Eczema Refractory to Topical Corticosteroids: Results of a Randomized, Double-Blind, Placebo-Controlled, Multicentre Trial
-
Ruzicka, T.; Lynde, C. W.; Jemec, G. B. E.; Diepgen, T.; Berth-Jones, J.; Coenraads, P. J.; Kaszuba, A.; Bissonnette, R.; Varjonen, E.; Hollo, P.; Cambazard, F.; Lahfa, M.; Elsner, P.; Nyberg, F.; Svensson, A.; Brown, T. C.; Harsch, M.; Maares, J. Efficacy and Safety of Oral Alitretinoin (9- cis -Retinoic Acid) in Patients with Severe Chronic Hand Eczema Refractory to Topical Corticosteroids: Results of a Randomized, Double-Blind, Placebo-Controlled, Multicentre Trial Br. J. Dermatol. 2008, 158, 808-817
-
(2008)
Br. J. Dermatol.
, vol.158
, pp. 808-817
-
-
Ruzicka, T.1
Lynde, C.W.2
Jemec, G.B.E.3
Diepgen, T.4
Berth-Jones, J.5
Coenraads, P.J.6
Kaszuba, A.7
Bissonnette, R.8
Varjonen, E.9
Hollo, P.10
Cambazard, F.11
Lahfa, M.12
Elsner, P.13
Nyberg, F.14
Svensson, A.15
Brown, T.C.16
Harsch, M.17
Maares, J.18
-
14
-
-
0035555873
-
Bioavailability and Dose-Dependent Anti-Tumour Effects of 9- cis -Retinoic Acid on Human Neuroblastoma Xenografts in Rat
-
Ponthan, F.; Kogner, P.; Bjellerup, P.; Klevenvall, L.; Hassan, M. Bioavailability and Dose-Dependent Anti-Tumour Effects of 9- cis -Retinoic Acid on Human Neuroblastoma Xenografts in Rat Br. J. Cancer 2001, 85, 2004-2009
-
(2001)
Br. J. Cancer
, vol.85
, pp. 2004-2009
-
-
Ponthan, F.1
Kogner, P.2
Bjellerup, P.3
Klevenvall, L.4
Hassan, M.5
-
15
-
-
0029050432
-
9- cis -Retinoic Acid Induces Complete Remission but Does Not Reverse Clinically Acquired Retinoid Resistance in Acute Promyelocytic Leukemia
-
Miller, W. H.; Jakubowski, A.; Tong, W. P.; Miller, V. A.; Rigas, J. R.; Benedetti, F.; Gill, G. M.; Truglia, J. A.; Ulm, E.; Shirley, M.; Warrell, R. P. 9- cis -Retinoic Acid Induces Complete Remission but Does Not Reverse Clinically Acquired Retinoid Resistance in Acute Promyelocytic Leukemia Blood 1995, 85, 3021-3027
-
(1995)
Blood
, vol.85
, pp. 3021-3027
-
-
Miller, W.H.1
Jakubowski, A.2
Tong, W.P.3
Miller, V.A.4
Rigas, J.R.5
Benedetti, F.6
Gill, G.M.7
Truglia, J.A.8
Ulm, E.9
Shirley, M.10
Warrell, R.P.11
-
16
-
-
34848862778
-
Design of Selective Nuclear Receptor Modulators: RAR and RXR As a Case Study
-
de Lera, A. R.; Bourguet, W.; Altucci, L.; Gronemeyer, H. Design of Selective Nuclear Receptor Modulators: RAR and RXR As a Case Study Nature Rev. Drug Discovery 2007, 6, 811-820
-
(2007)
Nature Rev. Drug Discovery
, vol.6
, pp. 811-820
-
-
De Lera, A.R.1
Bourguet, W.2
Altucci, L.3
Gronemeyer, H.4
-
17
-
-
34848834842
-
RAR and RXR Modulation in Cancer and Metabolic Disease
-
Altucci, L.; Leibowitz, M. D.; Ogilvie, K. M.; de Lera, A. R.; Gronemeyer, H. RAR and RXR Modulation in Cancer and Metabolic Disease Nature Rev. Drug Discovery 2007, 6, 793-810
-
(2007)
Nature Rev. Drug Discovery
, vol.6
, pp. 793-810
-
-
Altucci, L.1
Leibowitz, M.D.2
Ogilvie, K.M.3
De Lera, A.R.4
Gronemeyer, H.5
-
18
-
-
0037445123
-
Multicenter Phase II Study of Oral Bexarotene for Patients with Metastatic Breast Cancer
-
Esteva, F. J.; Glaspy, J.; Baidas, S.; Laufman, L.; Hutchins, L.; Dickler, M.; Tripathy, D.; Cohen, R.; DeMichele, A.; Yocum, R. C.; Osborne, C. K.; Hayes, D. F.; Hortobagyi, G. N.; Winer, E.; Demetri, G. D. Multicenter Phase II Study of Oral Bexarotene for Patients with Metastatic Breast Cancer J. Clin. Oncol. 2003, 21, 999-1006
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 999-1006
-
-
Esteva, F.J.1
Glaspy, J.2
Baidas, S.3
Laufman, L.4
Hutchins, L.5
Dickler, M.6
Tripathy, D.7
Cohen, R.8
Demichele, A.9
Yocum, R.C.10
Osborne, C.K.11
Hayes, D.F.12
Hortobagyi, G.N.13
Winer, E.14
Demetri, G.D.15
-
19
-
-
0033535580
-
Central Hypothyroidism Associated with Retinoid X Receptor-Selective Ligands
-
Sherman, S. I.; Gopal, J.; Haugen, B. R.; Chiu, A. C.; Whaley, K.; Nowlakha, P.; Duvic, M. Central Hypothyroidism Associated with Retinoid X Receptor-Selective Ligands N. Engl. J. Med. 1999, 340, 1075-1079
-
(1999)
N. Engl. J. Med.
, vol.340
, pp. 1075-1079
-
-
Sherman, S.I.1
Gopal, J.2
Haugen, B.R.3
Chiu, A.C.4
Whaley, K.5
Nowlakha, P.6
Duvic, M.7
-
20
-
-
34547911767
-
The Optimal Use of Bexarotene in Cutaneous T-Cell Lymphoma
-
Gniadecki, R.; Assaf, C.; Bagot, M.; Dummer, R.; Duvic, M.; Knobler, R.; Ranki, A.; Schwandt, P.; Whittaker, S. The Optimal Use of Bexarotene in Cutaneous T-Cell Lymphoma Br. J. Dermatol. 2007, 157, 433-440
-
(2007)
Br. J. Dermatol.
, vol.157
, pp. 433-440
-
-
Gniadecki, R.1
Assaf, C.2
Bagot, M.3
Dummer, R.4
Duvic, M.5
Knobler, R.6
Ranki, A.7
Schwandt, P.8
Whittaker, S.9
-
21
-
-
0036637235
-
Chemoprevention: An Essential Approach to Controlling Cancer
-
Sporn, M. B.; Suh, N. Chemoprevention: An Essential Approach to Controlling Cancer Nature Rev. Cancer 2002, 2, 537-543
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 537-543
-
-
Sporn, M.B.1
Suh, N.2
-
22
-
-
71349084776
-
Bexarotene: A Promising Anticancer Agent
-
Qu, L.; Tang, X. Bexarotene: A Promising Anticancer Agent Cancer Chemother. Pharmacol. 2010, 65, 201-205
-
(2010)
Cancer Chemother. Pharmacol.
, vol.65
, pp. 201-205
-
-
Qu, L.1
Tang, X.2
-
23
-
-
79955833958
-
(WAF1/CIP1) by Indenoisoquinolines in MCF7 Cells
-
(WAF1/CIP1) by Indenoisoquinolines in MCF7 Cells Cancer Prev. Res. 2011, 4, 592-607
-
(2011)
Cancer Prev. Res.
, vol.4
, pp. 592-607
-
-
Park, E.J.1
Kondratyuk, T.P.2
Morrell, A.3
Kiselev, E.4
Conda-Sheridan, M.5
Cushman, M.6
Ahn, S.7
Choi, Y.8
White, J.J.9
Van Breemen, R.B.10
Pezzuto, J.M.11
-
24
-
-
77954093588
-
Toward the Elucidation of the Metabolism of 15- e (2)-Isoprostane: The Total Synthesis of the Methyl Ester of a Potential Central Metabolite
-
Jahn, U.; Dinca, E. Toward the Elucidation of the Metabolism of 15- E (2)-Isoprostane: The Total Synthesis of the Methyl Ester of a Potential Central Metabolite J. Org. Chem. 2010, 75, 4480-4491
-
(2010)
J. Org. Chem.
, vol.75
, pp. 4480-4491
-
-
Jahn, U.1
Dinca, E.2
-
25
-
-
68549135156
-
Synthesis and Evaluation of 3-Aroylindoles as Anticancer Agents: Metabolite Approach
-
Wu, Y. S.; Coumar, M. S.; Chang, J. Y.; Sun, H. Y.; Kuo, F. M.; Kuo, C. C.; Chen, Y. J.; Chang, C. Y.; Hsiao, C. L.; Liou, J. P.; Chen, C. P.; Yao, H. T.; Chiang, Y. K.; Tan, U. K.; Chen, C. T.; Chu, C. Y.; Wu, S. Y.; Yeh, T. K.; Lin, C. Y.; Hsieh, H. P. Synthesis and Evaluation of 3-Aroylindoles as Anticancer Agents: Metabolite Approach J. Med. Chem. 2009, 52, 4941-4945
-
(2009)
J. Med. Chem.
, vol.52
, pp. 4941-4945
-
-
Wu, Y.S.1
Coumar, M.S.2
Chang, J.Y.3
Sun, H.Y.4
Kuo, F.M.5
Kuo, C.C.6
Chen, Y.J.7
Chang, C.Y.8
Hsiao, C.L.9
Liou, J.P.10
Chen, C.P.11
Yao, H.T.12
Chiang, Y.K.13
Tan, U.K.14
Chen, C.T.15
Chu, C.Y.16
Wu, S.Y.17
Yeh, T.K.18
Lin, C.Y.19
Hsieh, H.P.20
more..
-
26
-
-
60849130137
-
Synthesis of Phenol and Quinone Metabolites of Benzo[ a ]pyrene, a Carcinogenic Component of Tobacco Smoke Implicated in Lung Cancer
-
Xu, D. W.; Penning, T. M.; Blair, I. A.; Harvey, R. G. Synthesis of Phenol and Quinone Metabolites of Benzo[ a ]pyrene, a Carcinogenic Component of Tobacco Smoke Implicated in Lung Cancer J. Org. Chem. 2009, 74, 597-604
-
(2009)
J. Org. Chem.
, vol.74
, pp. 597-604
-
-
Xu, D.W.1
Penning, T.M.2
Blair, I.A.3
Harvey, R.G.4
-
27
-
-
0037186491
-
Synthesis and Antitumor Activity of Several New Analogues of Penclomedine and Its Metabolites
-
Tiwari, A.; Riordan, J. M.; Waud, W. R.; Struck, R. F. Synthesis and Antitumor Activity of Several New Analogues of Penclomedine and Its Metabolites J. Med. Chem. 2002, 45, 1079-1085
-
(2002)
J. Med. Chem.
, vol.45
, pp. 1079-1085
-
-
Tiwari, A.1
Riordan, J.M.2
Waud, W.R.3
Struck, R.F.4
-
28
-
-
0036214244
-
Screening Drugs for Metabolic Stability Using Pulsed Ultrafiltration Mass Apectrometry
-
Shin, Y. G.; Bolton, J. L.; van Breemen, R. B. Screening Drugs for Metabolic Stability Using Pulsed Ultrafiltration Mass Apectrometry Comb. Chem. High Throughput Screening 2002, 5, 59-64
-
(2002)
Comb. Chem. High Throughput Screening
, vol.5
, pp. 59-64
-
-
Shin, Y.G.1
Bolton, J.L.2
Van Breemen, R.B.3
-
29
-
-
23944451585
-
A Unified Model for Predicting Human Hepatic, Metabolic Clearance from in Vitro Intrinsic Clearance Data in Hepatocytes and Microsomes
-
Riley, R. J.; McGinnity, D. F.; Austin, R. P. A Unified Model for Predicting Human Hepatic, Metabolic Clearance from In Vitro Intrinsic Clearance Data in Hepatocytes and Microsomes Drug Metab. Dispos. 2005, 33, 1304-1311
-
(2005)
Drug Metab. Dispos.
, vol.33
, pp. 1304-1311
-
-
Riley, R.J.1
McGinnity, D.F.2
Austin, R.P.3
-
30
-
-
0342592199
-
High-performance Liquid Chromatography Assay for the Separation and Characterization of Metabolites of the Potential Cytostatic Drug Oracine
-
Wsól, V.; Kvasnicková, E.; Szotáková, B.; Hais, I. M. High-performance Liquid Chromatography Assay for the Separation and Characterization of Metabolites of the Potential Cytostatic Drug Oracine J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. 1996, 681, 169-175
-
(1996)
J. Chromatogr., B: Anal. Technol. Biomed. Life Sci.
, vol.681
, pp. 169-175
-
-
Wsól, V.1
Kvasnicková, E.2
Szotáková, B.3
Hais, I.M.4
-
31
-
-
0032977774
-
Screening for Xenobiotic Electrophilic Metabolites Using Pulsed Ultrafiltration-Mass Spectrometry
-
Nikolic, D.; Fan, P. W.; Bolton, J. L.; van Breemen, R. B. Screening for Xenobiotic Electrophilic Metabolites Using Pulsed Ultrafiltration-Mass Spectrometry Comb. Chem. High Throughput Screening 1999, 2, 165-175
-
(1999)
Comb. Chem. High Throughput Screening
, vol.2
, pp. 165-175
-
-
Nikolic, D.1
Fan, P.W.2
Bolton, J.L.3
Van Breemen, R.B.4
-
32
-
-
34548504314
-
Optimization of the Indenone Ring of Indenoisoquinoline Topoisomerase i Inhibitors
-
Morrell, A.; Placzek, M.; Parmley, S.; Grella, B.; Antony, S.; Pommier, Y.; Cushman, M. Optimization of the Indenone Ring of Indenoisoquinoline Topoisomerase I Inhibitors J. Med. Chem. 2007, 50, 4388-4404
-
(2007)
J. Med. Chem.
, vol.50
, pp. 4388-4404
-
-
Morrell, A.1
Placzek, M.2
Parmley, S.3
Grella, B.4
Antony, S.5
Pommier, Y.6
Cushman, M.7
-
34
-
-
7044239576
-
Highly Efficient Stereoconservative Amidation and Deamidation of Alpha-Amino Acids
-
Shendage, D. M.; Frohlich, R.; Haufe, G. Highly Efficient Stereoconservative Amidation and Deamidation of Alpha-Amino Acids Org. Lett. 2004, 6, 3675-3678
-
(2004)
Org. Lett.
, vol.6
, pp. 3675-3678
-
-
Shendage, D.M.1
Frohlich, R.2
Haufe, G.3
-
35
-
-
33144472888
-
Synthesis of Benz[ d ]indeno[1,2- b ]pyran-5,11-diones: Versatile Intermediates for the Design and Synthesis of Topoisomerase i Inhibitors
-
Morrell, A.; Antony, S.; Kohlhagen, G.; Pommier, Y.; Cushman, M. Synthesis of Benz[ d ]indeno[1,2- b ]pyran-5,11-diones: Versatile Intermediates for the Design and Synthesis of Topoisomerase I Inhibitors Bioorg. Med. Chem. Lett. 2006, 16, 1846-1849
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 1846-1849
-
-
Morrell, A.1
Antony, S.2
Kohlhagen, G.3
Pommier, Y.4
Cushman, M.5
-
36
-
-
34548510839
-
Nitrated Indenoisoquinolines as Topoisomerase i Inhibitors: A Systematic Study and Optimization
-
Morrell, A.; Placzek, M.; Parmley, S.; Antony, S.; Dexheimer, T. S.; Pommier, Y.; Cushman, M. Nitrated Indenoisoquinolines as Topoisomerase I Inhibitors: A Systematic Study and Optimization J. Med. Chem. 2007, 50, 4419-4430
-
(2007)
J. Med. Chem.
, vol.50
, pp. 4419-4430
-
-
Morrell, A.1
Placzek, M.2
Parmley, S.3
Antony, S.4
Dexheimer, T.S.5
Pommier, Y.6
Cushman, M.7
-
37
-
-
67650091783
-
Synthesis of Uracil Nucleotide Analogs with a Modified, Acyclic Ribose Moiety as P2Y(2) Receptor Antagonists
-
Sauer, R.; El-Tayeb, A.; Kaulich, M.; Muller, C. E. Synthesis of Uracil Nucleotide Analogs with a Modified, Acyclic Ribose Moiety as P2Y(2) Receptor Antagonists Bioorg. Med. Chem. 2009, 17, 5071-5079
-
(2009)
Bioorg. Med. Chem.
, vol.17
, pp. 5071-5079
-
-
Sauer, R.1
El-Tayeb, A.2
Kaulich, M.3
Muller, C.E.4
-
38
-
-
33845763974
-
Scope and Mechanistic Insights into the Use of Tetradecyl(trihexyl) phosphonium Bistriflimide: A Remarkably Selective Ionic Liquid Solvent for Substitution Reactions
-
McNulty, J.; Nair, J. J.; Cheekoori, S.; Larichev, V.; Capretta, A.; Robertson, A. J. Scope and Mechanistic Insights into the Use of Tetradecyl(trihexyl)phosphonium Bistriflimide: A Remarkably Selective Ionic Liquid Solvent for Substitution Reactions Chem.-Eur. J. 2006, 12, 9314-9322
-
(2006)
Chem.-Eur. J.
, vol.12
, pp. 9314-9322
-
-
McNulty, J.1
Nair, J.J.2
Cheekoori, S.3
Larichev, V.4
Capretta, A.5
Robertson, A.J.6
-
39
-
-
0025072938
-
A Convenient Synthesis of Hindered Amines and Alpha-Trifluoromethylamines from Ketones
-
Barney, C. L.; Huber, E. W.; McCarthy, J. R. A Convenient Synthesis of Hindered Amines and Alpha-Trifluoromethylamines from Ketones Tetrahedron Lett. 1990, 31, 5547-5550
-
(1990)
Tetrahedron Lett.
, vol.31
, pp. 5547-5550
-
-
Barney, C.L.1
Huber, E.W.2
McCarthy, J.R.3
-
40
-
-
0030071518
-
Activation of Retinoid Receptors RAR Alpha and RXR Alpha Induces Differentiation and Apoptosis, Respectively, in HL-60 Cells
-
Mehta, K.; McQueen, T.; Neamati, N.; Collins, S.; Andreeff, M. Activation of Retinoid Receptors RAR Alpha and RXR Alpha Induces Differentiation and Apoptosis, Respectively, in HL-60 Cells Cell Growth Differ. 1996, 7, 179-186
-
(1996)
Cell Growth Differ.
, vol.7
, pp. 179-186
-
-
Mehta, K.1
McQueen, T.2
Neamati, N.3
Collins, S.4
Andreeff, M.5
-
41
-
-
33847064207
-
Use of New T-Cell-based Cell Lines Expressing Two Luciferase Reporters for Accurately Evaluating Susceptibility to Anti-human Immunodeficiency Virus Type 1 Drugs
-
Chiba-Mizutani, T.; Miura, H.; Matsuda, M.; Matsuda, Z.; Yokomaku, Y.; Miyauchi, K.; Nishizawa, M.; Yamamoto, N.; Sugiura, W. Use of New T-Cell-based Cell Lines Expressing Two Luciferase Reporters for Accurately Evaluating Susceptibility to Anti-human Immunodeficiency Virus Type 1 Drugs J. Clin. Microbiol. 2007, 45, 477-487
-
(2007)
J. Clin. Microbiol.
, vol.45
, pp. 477-487
-
-
Chiba-Mizutani, T.1
Miura, H.2
Matsuda, M.3
Matsuda, Z.4
Yokomaku, Y.5
Miyauchi, K.6
Nishizawa, M.7
Yamamoto, N.8
Sugiura, W.9
-
42
-
-
0033596124
-
Aberrant rel/nfkb Genes and Activity in Human Cancer
-
Rayet, B.; Gelinas, C. Aberrant rel/nfkb Genes and Activity in Human Cancer Oncogene 1999, 18, 6938-6947
-
(1999)
Oncogene
, vol.18
, pp. 6938-6947
-
-
Rayet, B.1
Gelinas, C.2
-
43
-
-
33750448661
-
Transcriptional Regulation Via the NF-kappa B Signaling Module
-
Hoffmann, A.; Natoli, G.; Ghosh, G. Transcriptional Regulation Via the NF-kappa B Signaling Module Oncogene 2006, 25, 6706-6716
-
(2006)
Oncogene
, vol.25
, pp. 6706-6716
-
-
Hoffmann, A.1
Natoli, G.2
Ghosh, G.3
-
44
-
-
4444376712
-
Signaling to NF-kappa B
-
Hayden, M. S.; Ghosh, S. Signaling to NF-kappa B Genes Dev. 2004, 18, 2195-2224
-
(2004)
Genes Dev.
, vol.18
, pp. 2195-2224
-
-
Hayden, M.S.1
Ghosh, S.2
-
45
-
-
33750466230
-
Introduction to NF-kappa B: Players, Pathways, Perspectives
-
Gilmore, T. D. Introduction to NF-kappa B: Players, Pathways, Perspectives Oncogene 2006, 25, 6680-6684
-
(2006)
Oncogene
, vol.25
, pp. 6680-6684
-
-
Gilmore, T.D.1
-
46
-
-
34250698168
-
NF-kappa B, Inflammation and Pancreatic Carcinogenesis: NF-kappa B As a Chemoprevention Target (Review)
-
Zhang, Z. Q.; Rigas, B. NF-kappa B, Inflammation and Pancreatic Carcinogenesis: NF-kappa B As a Chemoprevention Target (Review) Int. J. Oncol. 2006, 29, 185-192
-
(2006)
Int. J. Oncol.
, vol.29
, pp. 185-192
-
-
Zhang, Z.Q.1
Rigas, B.2
-
47
-
-
5644283296
-
Role of Chemopreventive Agents in Cancer Therapy
-
Dorai, T.; Aggarwal, B. B. Role of Chemopreventive Agents in Cancer Therapy Cancer Lett. 2004, 215, 129-140
-
(2004)
Cancer Lett.
, vol.215
, pp. 129-140
-
-
Dorai, T.1
Aggarwal, B.B.2
-
48
-
-
26044459061
-
Transcription Factors in the Cellular Signaling Network as Prime Targets of Chempreventive Phytochemicals
-
Surh, Y. J. Transcription Factors in the Cellular Signaling Network as Prime Targets of Chempreventive Phytochemicals Cancer Res. Treat. 2004, 36, 275-286
-
(2004)
Cancer Res. Treat.
, vol.36
, pp. 275-286
-
-
Surh, Y.J.1
-
49
-
-
1642564339
-
Novel Agents for the Prevention of Breast Cancer: Targeting Transcription Factors and Signal Transduction Pathways
-
Shen, Q.; Brown, P. H. Novel Agents for the Prevention of Breast Cancer: Targeting Transcription Factors and Signal Transduction Pathways J. Mammary Gland Biol. Neoplasia 2003, 8, 45-73
-
(2003)
J. Mammary Gland Biol. Neoplasia
, vol.8
, pp. 45-73
-
-
Shen, Q.1
Brown, P.H.2
-
50
-
-
77954520406
-
NF kappa B: A Promising Target for Natural Products in Cancer Chemoprevention
-
Luqman, S.; Pezzuto, J. M. NF kappa B: A Promising Target for Natural Products in Cancer Chemoprevention Phytother. Res. 2010, 24, 949-963
-
(2010)
Phytother. Res.
, vol.24
, pp. 949-963
-
-
Luqman, S.1
Pezzuto, J.M.2
-
51
-
-
0347756655
-
Commensal Anaerobic Gut Bacteria Attenuate Inflammation by Regulating Nuclear-Cytoplasmic Shuttling of PPAR-Gamma and RelA
-
Kelly, D.; Campbell, J. I.; King, T. P.; Grant, G.; Jansson, E. A.; Coutts, A. G. P.; Pettersson, S.; Conway, S. Commensal Anaerobic Gut Bacteria Attenuate Inflammation by Regulating Nuclear-Cytoplasmic Shuttling of PPAR-Gamma and RelA Nature Immunol. 2004, 5, 104-112
-
(2004)
Nature Immunol.
, vol.5
, pp. 104-112
-
-
Kelly, D.1
Campbell, J.I.2
King, T.P.3
Grant, G.4
Jansson, E.A.5
Coutts, A.G.P.6
Pettersson, S.7
Conway, S.8
-
52
-
-
0040958788
-
Retinoids Inhibit Interleukin-12 Production in Macrophages Through Physical Associations of Retinoid X Receptor and NF kappa B
-
Na, S. Y.; Kang, B. Y.; Chung, S. W.; Han, S. J.; Ma, X. J.; Trinchieri, G.; Im, S. Y.; Lee, J. W.; Kim, T. S. Retinoids Inhibit Interleukin-12 Production in Macrophages Through Physical Associations of Retinoid X Receptor and NF kappa B J. Biol. Chem. 1999, 274, 7674-7680
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 7674-7680
-
-
Na, S.Y.1
Kang, B.Y.2
Chung, S.W.3
Han, S.J.4
Ma, X.J.5
Trinchieri, G.6
Im, S.Y.7
Lee, J.W.8
Kim, T.S.9
-
53
-
-
34247526984
-
Triterpenoids and Rexinoids as Multifunctional Agents for the Prevention and Treatment of Cancer
-
Liby, K. T.; Yore, M. M.; Sporn, M. B. Triterpenoids and Rexinoids as Multifunctional Agents for the Prevention and Treatment of Cancer Nature Rev. Cancer 2007, 7, 357-369
-
(2007)
Nature Rev. Cancer
, vol.7
, pp. 357-369
-
-
Liby, K.T.1
Yore, M.M.2
Sporn, M.B.3
-
54
-
-
79952198976
-
Berberine, an Isoquinoline Alkaloid, Inhibits Melanoma Cancer Cell Migration by Reducing the Expressions of Cyclooxygenase-2, Prostaglandin E(2) and Prostaglandin E(2) Receptors
-
Singh, T.; Vaid, M.; Katiyar, N.; Sharma, S.; Katiyar, S. K. Berberine, an Isoquinoline Alkaloid, Inhibits Melanoma Cancer Cell Migration by Reducing the Expressions of Cyclooxygenase-2, Prostaglandin E(2) and Prostaglandin E(2) Receptors Carcinogenesis 2011, 32, 86-92
-
(2011)
Carcinogenesis
, vol.32
, pp. 86-92
-
-
Singh, T.1
Vaid, M.2
Katiyar, N.3
Sharma, S.4
Katiyar, S.K.5
-
55
-
-
0141676361
-
A Highly Selective Inhibitor of i kappa B Kinase, BMS-345541, Blocks Both Joint Inflammation and Destruction in Collagen-Induced Arthritis in Mice
-
McIntyre, K. W.; Shuster, D. J.; Gillooly, K. M.; Dambach, D. M.; Pattoli, M. A.; Lu, P.; Zhou, X. D.; Qiu, Y. P.; Zusi, F. C.; Burke, J. R. A Highly Selective Inhibitor of I kappa B Kinase, BMS-345541, Blocks Both Joint Inflammation and Destruction in Collagen-Induced Arthritis in Mice Semin. Arthritis Rheum. 2003, 48, 2652-2659
-
(2003)
Semin. Arthritis Rheum.
, vol.48
, pp. 2652-2659
-
-
McIntyre, K.W.1
Shuster, D.J.2
Gillooly, K.M.3
Dambach, D.M.4
Pattoli, M.A.5
Lu, P.6
Zhou, X.D.7
Qiu, Y.P.8
Zusi, F.C.9
Burke, J.R.10
-
56
-
-
0030937636
-
Prediction of in Vivo Drug Metabolism in the Human Liver from in Vitro Metabolism Sata
-
Iwatsubo, T.; Hirota, N.; Ooie, T.; Suzuki, H.; Shimada, N.; Chiba, K.; Ishizaki, T.; Green, C. E.; Tyson, C. A.; Sugiyama, Y. Prediction of In Vivo Drug Metabolism in the Human Liver from In Vitro Metabolism Sata Pharmacol. Ther. 1997, 73, 147-171
-
(1997)
Pharmacol. Ther.
, vol.73
, pp. 147-171
-
-
Iwatsubo, T.1
Hirota, N.2
Ooie, T.3
Suzuki, H.4
Shimada, N.5
Chiba, K.6
Ishizaki, T.7
Green, C.E.8
Tyson, C.A.9
Sugiyama, Y.10
-
57
-
-
77954331919
-
Selective Synthesis and Biological Evaluation of Sulfate-Conjugated Resveratrol Metabolites
-
Hoshino, J.; Park, E. J.; Kondratyuk, T. P.; Marler, L.; Pezzuto, J. M.; van Breemen, R. B.; Mo, S. Y.; Li, Y. C.; Cushman, M. Selective Synthesis and Biological Evaluation of Sulfate-Conjugated Resveratrol Metabolites J. Med. Chem. 2010, 53, 5033-5043
-
(2010)
J. Med. Chem.
, vol.53
, pp. 5033-5043
-
-
Hoshino, J.1
Park, E.J.2
Kondratyuk, T.P.3
Marler, L.4
Pezzuto, J.M.5
Van Breemen, R.B.6
Mo, S.Y.7
Li, Y.C.8
Cushman, M.9
|