Synthesis and antitumor activity of several new analogues of penclomedine and its metabolites

Journal of Medicinal Chemistry

Volumn 45, Issue 5, 2002, Pages 1079-1085

  Tiwari, Anita ^a   Riordan, James M ^a   Waud, William R ^a   Struck, Robert F ^a  

^a SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,5 DICHLORO 4 BUTOXY 6 METHOXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 4 ETHOXY 6 METHOXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 4 HYDROXY 6 METHOXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 4 HYDROXY 6 TRIFLUOROETHOXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 4 ISOPROPOXY 6 METHOXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 4 METHOXY 2,6 BIS(TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 4 METHOXY 6 PHENOXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 4 METHOXY 6 TRIFLUOROETHOXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 4 PROPOXY 6 METHOXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 4,6 DIACETOXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 4,6 DIBUTOXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 4,6 DIETHOXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 4,6 DIHYDROXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 4,6 DIISOPROPOXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 4,6 DIPHENOXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 4,6 DITRIFLUOROETHOXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 6 BUTOXY 4 HYDROXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 6 BUTOXY 4 METHOXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 6 ETHOXY 4 ACETOXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 6 ETHOXY 4 HYDROXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 6 ETHOXY 4 METHOXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 6 ETHOXY 4 METHOXYACETOXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 6 HYDROXY 4 METHOXY 2 (TRICHLOROMETHYL)PYRIDINE; 3,5 DICHLORO 6 METHOXY 4 ACETOXY 2 (TRICHLOROMETHYL)PYRIDINE; 4 HYDROXY 3,5,6 TRICHLORO 2 (TRICHLOROMETHYL)PYRIDINE; ANTINEOPLASTIC AGENT; DRUG METABOLITE; PENCLOMEDINE; PENCLOMEDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST TUMOR; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; HUMANS; MICE; MICE, NUDE; PICOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDINE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0037186491     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010334e     Document Type: Article

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