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Volumn 45, Issue 12, 2010, Pages 5910-5918

Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone

(5) Familiar, Olga a Munier Lehmann, Hélne b,c Aínsa, José Antonio d Camarasa, María José a Pérez Pérez, María Jesús a

a INSTITUTO DE QUÍMICA MÉDICA (Spain)

b INSTITUT PASTEUR (France)

c CNRS (France)

d UNIVERSITY OF ZARAGOZA (Spain)

Author keywords

Bioisoster; Enzymatic inhibitors; Imidazoquinolinone; Kinase; M. tuberculosis; Thymine

Indexed keywords

1 [4 (THYMIN 1 YL)BUT 2 ENYL] 5,6 DIHYDRO 1H IMIDAZO[4,5,1 IJ]QUINOLIN 2(4H) ONE; 1 [[4 (5 BROMOURACIL 1 YL)BUT 2 ENYL]] 5,6 DIHYDRO 1H,4H 1,2,5 THIADIAZOLO[4,3,2 IJ]QUINOLIN 2,2 DIOXIDE; 1 [[4 (THYMIN 1 YL)BUT 2 ENYL]] 5,6 DIHYDRO 1H,4H 1,2,5 THIADIAZOLO[4,3,2 IJ]QUINOLIN 2,2 DIOXIDE; 5 ACETAMIDO 1 [4 (THYMIN 1 YL)BUT 2 ENYL] 5,6 DIHYDRO 1H IMIDAZO[4,5,1 IJ]QUINOLIN 2(4H) ONE; 5 AMINO 1 [4 (THYMIN 1 YL)BUT 2 ENYL] 5,6 DIHYDRO 1H IMIDAZO[4,5,1 IJ]QUINOLIN 2(4H) ONE; 8 ACETAMIDO 1 [4 (THYMIN 1 YL)BUT 2 ENYL] 5,6 DIHYDRO 1H IMIDAZO[4,5,1 IJ]QUINOLIN 2(4H) ONE; 8 AMINO 1 [4 (THYMIN 1 YL)BUT 2 ENYL] 5,6 DIHYDRO 1H IMIDAZO[4,5,1 IJ]QUINOLIN 2(4H) ONE; ACYCLIC NUCLEOSIDE; ANTIMYCOBACTERIAL AGENT; IMIDAZOQUINOLINE DERIVATIVE; IODOBENZENE; THYMIDINE PHOSPHATE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ACETYLATION; ANTIBACTERIAL ACTIVITY; ARTICLE; CATALYSIS; CYCLIZATION; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; MYCOBACTERIUM BOVIS; MYCOBACTERIUM SMEGMATIS; NONHUMAN; OXIDATION;

DRUG DESIGN; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; NUCLEOSIDE-PHOSPHATE KINASE; NUCLEOSIDES; QUINOLONES; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78649321987 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2010.09.056 Document Type: Article

Times cited : (35)

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