Bacterial RNA mediates activation of caspase-1 and IL-1β release independently of TLRs 3, 7, 9 and TRIF but is dependent on UNC93B

Journal of Immunology

Volumn 189, Issue 1, 2012, Pages 328-336

  Eigenbrod, Tatjana ^a   Franchi, Luigi ^b   Muñoz Planillo, Raul ^b   Kirschning, Carsten J ^c   Freudenberg, Marina A ^d   Núñez, Gabriel ^b   Dalpke, Alexander ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

^d MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL RNA; CELL PROTEIN; ENDOPLASMIC RETICULUM PROTEIN UNC93B; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN PRECURSOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; ENDOSOME; ENZYME ACTIVATION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RNA ANALYSIS; TERMINAL SEQUENCE;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; CASPASE 1; CELL LINE; DENDRITIC CELLS; ENZYME ACTIVATION; INTERLEUKIN-1BETA; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; RNA, BACTERIAL; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 9;

EID: 84862906988     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1103258     Document Type: Article

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