CD44 enhances the epithelial-mesenchymal transition in association with colon cancer invasion

International Journal of Oncology

Volumn 41, Issue 1, 2012, Pages 211-218

  Cho, Sang Hyuk ^a   Park, Yeon Sun ^a   Kim, Hun Jin ^a   Kim, Chang Hyun ^a   Lim, Sang Woo ^a   Huh, Jung Wook ^a   Lee, Jae Hyuk ^a   Kim, Hyeong Rok ^a  

^a Chonnam National University Medical School   (South Korea)

Author keywords

CD44; Colon cancer; Epithelial mesenchymal transition; Invasion

Indexed keywords

ACTIN; BETA CATENIN; BIOLOGICAL MARKER; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBRONECTIN; GAMMA TUBULIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOGEN SYNTHASE KINASE 3BETA; HERMES ANTIGEN; HYALURONIC ACID; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; NERVE CELL ADHESION MOLECULE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; SHORT HAIRPIN RNA; UVOMORULIN; VIMENTIN;

ANTIGEN EXPRESSION; ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; COLON CANCER; COMPLEX FORMATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; METASTASIS; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANTIGENS, CD44; ANTIGENS, DIFFERENTIATION; BETA CATENIN; CADHERINS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL MOVEMENT; CELL SHAPE; COLONIC NEOPLASMS; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MATRIX METALLOPROTEINASE 14; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; UP-REGULATION; VIMENTIN;

EID: 84862849738     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1453     Document Type: Article

References (48)

1. De Wever O, Pauwels P, De Craene B, Sabbah M, Emami S, Redeuilh G, Gespach C, Bracke M and Berx G: Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion front. Histochem Cell Biol 130: 481-494, 2008.
2. Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454, 2002.
3. Lionel L and Alfonso B: Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3′ kinase/AKT pathways. Oncogene 24: 7443-7454, 2005.
4. Huber MA, Kraut N and Beug H: Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol 17: 548-558, 2005. (Pubitemid 41267170)
5. Hajra KM and Fearon ER: Cadherin and catenin alterations in human cancer. Genes Chromosomes Cancer 34: 255-268, 2002. (Pubitemid 34553304)
6. Brabletz T, Hlubek F, Spaderna S, Schmalhofer O, Hiendlmeyer E, Jung A and Kirchner T: Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and β-catenin. Cells Tissues Organs 179: 56-65, 2005. (Pubitemid 40976289)
7. Thiery JP and Sleeman JP: Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7: 131-142, 2006. (Pubitemid 43278296)
8. Gruenert S, Jechlinger M and Beug H: Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Nat Rev Mol Cell Biol 4: 657-665, 2003. (Pubitemid 36934968)
9. Kalluri R and Neilson EG: Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 112: 1776-1784, 2003. (Pubitemid 38063698)
10. Rodgers, LS, Lalani S, Hardy KM, Xiang X, Broka D, Antin PB and Camenisch TD: Depolymerized hyaluronan induces vascular endothelial growth factor, a negative regulator of developmental epithelial-to-mesenchymal transformation. Circ Res 99: 583-589, 2006. (Pubitemid 44401449)
11. Ponta H, Sherman L and Herrlich PA: CD44: from adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol 4: 33-45, 2003. (Pubitemid 36077255)
12. Nagano O and Saya H: Mechanism and biological significance of CD44 cleavage. Cancer Sci 95: 930935, 2004.
13. Haynes BF, Hale LP, Patton KL, Martin ME and McCallum RM: Measurement of an adhesion molecule as an indicator of inflammatory disease activity. Up-regulation of the receptor for hyaluronate (CD44) in rheumatoid arthritis. Arthritis Rheum 34: 1434-1443, 1991.
14. Kuppner MC, Liversidge J, McKillop-Smith S, Lumsden L and Forrester JV: Adhesion molecule expression in acute and fibrotic sympathetic ophthalmia. Curr Eye Res 12: 923-934, 1993. (Pubitemid 23343641)
15. Florquin S, Nunziata R, Claessen N, van den Berg FM, Pals ST and Weening JJ: CD44 expression in IgA nephropathy. Am J Kidney Dis 39: 407-414, 2002. (Pubitemid 34174266)
16. Svee K, White J, Vaillant P, Jessurun J, Roongta U, Krumwiede M, Johnson D and Henke C: Acute lung injury fibroblast migration and invasion of a fibrin matrix is mediated by CD44. J Clin Invest 98: 1713-1727, 1996. (Pubitemid 26359187)
17. Teder P, Vandivier RW, Jiang D, Liang J, Cohn L, Pure E, Henson PM and Noble PW: Resolution of lung inflammation by CD44. Science 296: 155-158, 2002. (Pubitemid 34280077)
18. Rouschop KM, Sewnath ME, Claessen N, Roelofs JJ, Hoedemaeker I, van der Neut R, Aten J, Pals ST, Weening JJ and Florquin S: CD44 deficiency increases tubular damage but reduces renal fibrosis in obstructive nephropathy. J Am Soc Nephrol 15: 674-686, 2004. (Pubitemid 38294797)
19. Noble PW and Jiang D: Matrix regulation of lung injury, inflammation, and repair: the role of innate immunity. Proc Am Thorac Soc 3: 401-404, 2006. (Pubitemid 44033352)
20. Holgate ST: Asthma: a dynamic disease of inflammation and repair. Ciba Found Symp 206: 106-110, 1997.
21. Jain M, He Q, Lee WS, Kashiki S, Foster LC, Tsai JC, Lee ME and Haber E: Role of CD44 in the reaction of vascular smooth muscle cells to arterial wall injury. J Clin Invest 98: 877, 1996.
22. Mikecz K, Brennan FR, Kim JH and Glant TT: Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis. Nat Med 1: 558-563, 1995.
23. Pure E and Cuff CA: A crucial role for CD44 in inflammation. Trends Mol Med 7: 213-221, 2001. (Pubitemid 32822893)
24. Grandis JR and Sok JC: Signaling through the epidermal growth factor receptor during the development of malignancy. Pharmacol Ther 102: 37-46, 2004. (Pubitemid 38429984)
25. Dancey JE: Predictive factors for epidermal growth factor receptor inhibitors - the bull's eye hits the arrow. Cancer Cell 5: 411-415, 2004.
26. Nagane M, Lin H, Cavenee WK and Huang HJ: Aberrant receptor signaling in human malignant gliomas: mechanisms and therapeutic implications. Cancer Lett 162 (Suppl): S17-21, 2001.
27. Fuster LM and Sandler AB: Select clinical trials of erlotinib (OSI-774) in non-small-cell lung cancer with emphasis on phase III outcomes. Clin Lung Cancer (Suppl) 1: S24-29, 2004.
28. Rosivatz E, Becker I, Specht K, Fricke E, Luber B, Busch R, Höfler H and Becker KF: Differential expression of the epithelial-mesenchymal transition regulators Snail, SIP1, and Twist in gastric cancer. Am J Pathol 61: 1881-1891, 2002. (Pubitemid 35265545)
29. Elloul S, Elstrand MB, Nesland JM, Tropé CG, Kvalheim G, Goldberg I, Reich R and Davidson B: Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma. Cancer 103: 1631-1643, 2005. (Pubitemid 40490024)
30. Kwok WK, Ling MT, Lee TW, et al: Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target. Cancer Res 65: 5153-5162, 2005. (Pubitemid 40827324)
31. Uchikado Y, Natsugoe S, Okumura H, Setoyama T, Matsumoto M, Ishigami S and Aikou T: Slug epression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal squamous cell carcinoma. Clin Cancer Res 11: 1174-1180, 2005. (Pubitemid 40175768)
32. Woodhouse EC, Chuaqui RF and Liotta LA: General mechanisms of metastasis. Cancer 80: 1529-1537, 1997. (Pubitemid 27444024)
33. Kirchner T and Brabletz T: Patterning and nuclear beta-catenin expression in the colonic adenoma-carcinoma sequence: Analogies with embryonic gastrulation. Am J Pathol 157: 1113-1121, 2000.
34. Lim SC and Lee MS: Significance of E-cadherin/beta-catenin complex and cyclin D1 in breast cancer. Oncol Rep 9: 915-928, 2002.
35. van Es JH, Barker N and Clevers H: You Wnt some, you lose some: oncogenes in the Wnt signaling pathway. Curr Opin Genet Dev 13: 28-33, 2003. (Pubitemid 36143924)
36. Brabletz T, Jung A, Spaderna S, Hlubek F and Kirchner T: Migrating cancer stem cells - an integrated concept of malignant tumor progression. Nat Rev Cancer 5: 744-749, 2005. (Pubitemid 41486367)
37. Yang L, Lin C and Liu ZR: P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin. Cell 127: 139-155, 2006. (Pubitemid 44466634)
38. Schmalhofer O, Brabletz S and Brabletz T: E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer. Cancer Metastasis Rev 28: 151-166, 2009.
39. Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, et al: The epithelial-messenchymal transition generates cells with properties of stem cells. Cell 133: 704-715, 2008. (Pubitemid 351636299)
40. Hill A, McFarlane S, Mulligan K, Gillespie H, Draffin JE, Trimble A, et al: Cortactin underpins CD44-promoted invasion and adhesion of breast cancer cells to bone marrow endothelial cells. Oncogene 25: 6079-6091, 2006. (Pubitemid 44562406)
41. Schabath H, Runz S, Joumaa S and Altevogt P: CD24 affects CXCR4 function in pre-B lymphocytes and breast carcinoma cells. J Cell Sci 119: 314-325, 2006. (Pubitemid 43210700)
42. Müller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, et al: Involvement of chemokine receptors in breast cancer metastasis. Nature 410: 50-56, 2001. (Pubitemid 32225831)
43. Hamada J, Sawamura Y and Van Meir EG: CD44 expression and growth factors. Front Biosci 3: d657-d664, 1998.
44. Wielenga VJ, Smits R, Korinek V, Smit L, Kielman M, Fodde R, Clevers H and Pals ST: Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. Am J Pathol 154: 515-523, 1999. (Pubitemid 29094101)
45. Zeilstra J, Joosten SP, Dokter M, Verwiel E, Spaargaren M and Pals ST: Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis. Cancer Res 68: 3655-3661, 2008.
46. Deckers M, van Dinther M, Buijs J, Que I, Ladwik C, van der Pluijm G and ten Dijke P: The tumor suppressor SMAD4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells. Cancer Res 66: 2202-2209, 2006.
47. Piek E, Moustakas A, Kurisaki A, Heldin CH and ten Dijke P: TGF-β type I receptor/ALK-5 and SMAD proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J Cell Sci 112: 4557-4568, 1999. (Pubitemid 30034805)
48. Valcourt U, Kowanetz M, Niimi H, Heldin CH and Moustakas A: TGF-beta and the SMAD signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Mol Biol Cell 16: 1987-2002, 2005. (Pubitemid 40471965)