You Wnt some, you lose some: Oncogenes in the Wnt signaling pathway

Current Opinion in Genetics and Development

Volumn 13, Issue 1, 2003, Pages 28-33

  Van Es, Johan H ^a   Barker, Nick ^a   Clevers, Hans ^a  

^a HUBRECHT INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; WNT PROTEIN;

CARCINOGENESIS; CELL FATE; CYTOPLASM; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; REVIEW;

EID: 0037309239     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(02)00012-6     Document Type: Review

References (50)

1. Peifer M., Polakis P. Wnt signalling in oncogenesis and embryogenesis - a look outside the nucleus. Science. 287:2000;1606-1609.
2. Kuhl M., Sheldahl L.C., Park M., Miller J.R., Moon R.T. The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet. 16:2000;279-283.
3. Peifer M., McEwen D.G. The ballet of morphogenesis: unveiling the hidden choreographers. Cell. 109:2002;271-274.
4. Capdevila J., Belmonte J.C.I. Extracellular modulation of the Hedgehog, Wnt and TGF-β signalling pathways during embryonic development. Curr. Opin. Genet. Dev. 9:1999;427-433.
5. Saneyoshi T., Kume S., Amasaki Y., Mikoshiba K. The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos. Nature. 417:2002;295-299.
6. Malbon C.C., Wang H., Moon R.T. Wnt signalling and hetertrimeric G-proteins: strange bedfellows or a classic romance? Biochem. Biophys. Res. Commun. 287:2001;589-593.
7. Kuhl M., Geis K., Sheldahl L.C., Pukrop T., Moon R.T., Wedlich D. Antagonistic regulation of convergent extension movements in Xenopus by Wnt/beta-catenin and Wnt/Ca2+ signalling. Mech. Dev. 106:2001;61-76.
8. Winklbauer R., Medina A., Swain R.K., Steinbeisser H. Frizzled-7 signaling controls tissue separation during Xenopus. Nature. 413:2001;856-860.
9. Sokol S. A role for Wnts in morphogenesis and tissue polarity. Nat. Cell. Biol. 2:2000;E124-E125.
10. Lu B., Roegiers F., Jan L.Y., Jan Y.N. Adherens junctions inhibit asymmetric division in the Drosophila epithelium. Nature. 409:2001;522-525.
11. Zeng W., Wharton K.A. Jr., Mack J.A., Wang K., Gadbaw M., Suyama K., Klein P.S., Scott M.P. Naked cuticle encodes an inducible antagonist of Wnt signaling. Nature. 403:2000;789-795.
12. Park M., Moon R.T. The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos. Nat. Cell. Biol. 4:2001;20-25.
13. Schwarz-Romond T., Asbrand C., Bakkers J., Kühl M., Schaeffer H.-J., Huelsken J., Behrens J., Hammerschmidt M., Birchmeier W. The ankyrin repeat protein Diversin recruits Casein kinase Iε to the β-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes Dev. 16:2002;2073-2084 The authors describe the identification and characterization of a novel member of the Wnt signaling cascade: Diversin. This molecule acts as a molecular switch between the canonical Wnt pathway and the PCP pathway. The Wnt signal mediated by the canonical pathway is suppressed and signaling via JNK is stimulated. This mode of action is achieved by Diversin's interaction with CK1e and Axin/Conductin.
14. Sun T.-Q., Lu B., Feng J.-J., Reinhard C., Jan Y.N., Fantl W.J., Williams L.T. PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. Nat. Cell. Biol. 3:2001;628-636.
15. Cheyette B.N.R., Waxman J.S., Miller J.R., Takemaru K.-I., Sheldahl L.C., Khlebtsova N., Fox E.P., Earnest T., Moon R.T. Dapper, a Dishevelled-associated antagonist of β-Catenin and JNK signaling, is required for notochord formation. Dev. Cell. 2:2002;449-461.
16. Behrens J., Jerchow B.A., Wurtele M., Grimm J., Asbrand C., Wirtz R., Kuhl M., Wedlich D., Birchmeier W. Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3. Science. 280:1998;596-599.
17. Jiang J., Struhl G. Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. Nature. 391:1998;493-496.
18. Roose J., Molenaar M., Peterson J., Hurenkamp J., Brantjes H., Moerer P., van de Wetering M., Destree O., Clevers H. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. Nature. 395:1998;608-612.
19. Brannon M., Brown J.D., Bates R., Kimelman D., Moon R.T. XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development. Development. 126:1999;3159-3170.
20. Ishitani T., Ninomiya-Tsuji J., Nagai S., Nishita M., Meneghini M., Barker N., Waterman M., Bowerman B., Clevers H., Shibuya H., Matsumoto K. The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF. Nature. 399:1999;798-802.
21. Bienz M., Clevers H. Linking colorectal cancer to Wnt signalling. Cell. 103:2000;311-320.
22. Li L., Yuan H., Weaver C.D., Mao J., Farr G.H. III, Sussman D.J., Jonkers J., Kimelman D., Wu D. axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J. 18:1999;4233-4240.
23. Seeling J.M., Miller J.R., Gil R., Moon R.T., White R., Virshup D.M. Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. Science. 283:1999;2089-2091.
24. Behrens J., von Kries J.P., Kuhl M., Bruhn L., Wedlich D., Grosschedl R., Birchmeier W. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature. 382:1996;638-642.
25. Molenaar M., van de Wetering M., Oosterwegel M., Peterson-Maduro J., Godsave S., Korinek V., Roose J., Destree O., Clevers H. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. Cell. 86:1996;391-399.
26. He T.C., Sparks A.B., Rago C., Hermeking H., Zawel L., da Costa L.T., Morin P.J., Vogelstein B., Kinzler K.W. Identification of c-MYC as a target of the APC pathway. Science. 281:1998;1509-1512.
27. Roose J., Huls G., van Beest M., Moerer P., van der Horn K., Goldschmeding R., Logtenberg T., Clevers H. Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. Science. 285:1999;1923-1926.
28. Tetsu O., McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature. 398:1999;422-426.
29. Bienz M. The subcellular destinations of APC proteins. Nat. Rev. Mol. Cell. Biol. 3:2002;328-338.
30. Nusse R., Varmus H.E. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region as the host genome. Cell. 31:1982;99-109.
31. Pinson K.I., Brennan J., Monkley S., Avery B.J., Skarnes W.C. An LDL-receptor-related protein mediates Wnt signalling in mice. Nature. 407:2000;535-538.
32. Wehrll M., Doughan S.T., Caldwell K., O'Keefe L., Schwartz S., Valzel-Ohayon D., Schejter E., Tomlinson A., Dinardo S. Arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature. 407:2000;527-530.
33. Tamal K., Semenov M., Kato Y., Spokony R., Liu C., Katsuyama Y., Hess F., Saint-Jeannet J.-P., He X. LDL-receptor-related proteins in Wnt signal transduction. Nature. 407:2000;530-535.
34. Mao B., Wu W., Li Y., Hoppe D., Stannek P., Glinka A., Niehrs C. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature. 411:2001;321-325 The authors show that LRP6 is a specific receptor for Dkk1 and Dkk2 and that the Dickkopf proteins inhibit the Wnt co-receptor function.
35. Bafico A., Liu G., Yaniv A., Gazit A., Aaronson S.A. Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat. Cell. Biol. 3:2001;683-686 The authors of this paper show that Dkk-1 specifically inhibits canonical Wnt signaling by binding to the LRP6 component of the receptor complex.
36. Semënov M.V., Tamai K., Brott B.K., Kühl M., Sokol S., He X. Head inducer Dickkopf-1 is a ligand for Wnt co-receptor LRP6. Curr. Biol. 11:2001;951-961 The results described in this paper demonstrate that Dkk-1 is an LRP6 ligand and inhibits Wnt signaling by blocking Wnt-induced Fz-LRP6 complex formation.
37. Mao J., Wang J., Liu B., Pan W., Farr G.H., Flynn C., Yuan H., Takada S., Kimelman D., Li L., Wu D. Low-density receptor related protein 5 binds to axin and regulates the canonical Wnt signalling pathway. Mol. Cell. 7:2001;801-809 The authors show in this paper that axin, a scaffold protein in the Wnt signaling cascade, is able to interact directly with the intracellular domain of the membrane receptor LRP5. The addition of Wnt causes the translocation of axin to the membrane and enhances the interaction between axin and LRP5. The binding of axin to LRP5 induces the degradation of axin, which leads to LEF-1 mediated transcriptional activation.
38. Mao B., Wu W., Davidson G., Marhold J., Li M., Mechler B.M., Delius H., Hoppe D., Stannek P., Walter C.et al. Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling. Nature. 417:2002;664-667.
39. Frame S., Cohen P., Biondi R.M. A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation. Mol. Cell. 7:2001;1321-1327.
40. Liu C., Li Y., Semenov M., Han C., Baeg G.-H., Tan Y., Zhang Z., Lin X., He X. Control of β-Catenin phosphorylation/degradation by a dual-kinase mechanism. Cell. 108:2002;837-847 This excellent paper describes the role of CK1 in β-catenin regulation. In the absence of Wnt, β-catenin is phosphorylated at residue Ser45 by CK1, which subsequently serves as the priming site for phosphorylation by GSK3β. This leads to degradation of β-catenin.
41. Amit S., Hatzzubai A., Birman Y., Andersen J.S., Ben-Shushan E., Mann M., Ben-Neriah Y., Alkalay I. axin mediated CK1 phosphorylation of β-catenin a molecular switch. Genes Dev. 16:2002;1066-1076 The authors show that a complex of axin and CKI induces β-catenin phosphorylation at residue Ser45. This CKI phosphorylation of β-catenin creates a priming site for GSK-3β and is both necessary and sufficient to initiate the degradation cascade of β-catenin.
42. Yanagawa S., Matsuda Y., Lee J., Matsubayashi H., Sese S., Kadowaki T., Ishimoto A. Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila. EMBO J. 21:2002;1733-1742 This paper describes how in Drosophila CKI functions as a negative regulator of Wnt signaling pathway by phosphorylating Zeste-white 3.
43. Ding Y., Dale T. Wnt signal transduction: kinase cogs in a nano-machine? Trends Biochem. Sci. 27:2002;327-329.
44. Kang D.E., Soriano S., Xia X., Eberhart C.G., De Strooper B., Zheng H., Koo E.H. Presenilin couples the paired phosphorylation of β-catenin independent of axin: implications for β-catenin activation in tumorigenesis. Cell. 110:2002;751-762.
45. Hurlstone A., Clevers H. T-cell factors: turn-ons and turn-offs. EMBO J. 21:2002;2303-2311.
46. Kramps T., Peter O., Brunner E., Nellen D., Froesch B., Chatterjee S., Murone M., Züllig S., Basler K. Wnt/Wingless signaling requires BCL9/Legless-mediated recruitment of Pygopus to the nuclear β-catenin-TCF complex. Cell. 109:2002;47-60 Using strong genetic studies in Drosophila, this paper reports the identification of two novel components of the Wnt signaling cascade, legless and pygopus, which are both necessary for Wnt signal transduction at the level of nuclear β-catenin. In addition, they provide genetic and molecular evidence that these proteins exert their function by physically linking Pygo via Legless to β-catenin.
47. •].
48. •].
49. Parker D.S., Jemison J., Cadigan K.M. Pygopus, a nuclear PHD-finger protein required for Wingless signalling in Drosophila. Development. 129:2002;2565-2576 The authors of these papers show on the basis of genetic and molecular evidence the presence of a novel and essential component of the Wnt signaling cascade, Pygo.
50. CIP1/WAF1. Cell. 111:2002;241-250 This paper describes the elucidation of the downstream genetic program activated by the β-catenin/TCF complex in colon carcinoma cells.