Inhibition of microbial growth by ajoene, a sulfur-containing compound derived from garlic

Applied and Environmental Microbiology

Volumn 62, Issue 11, 1996, Pages 4238-4242

  Naganawa, Rie ^a   Iwata, Nami ^a   Ishikawa, Keiko ^a   Fukuda, Hiroyuki ^a   Fujino, Tsuchiyoshi ^a   Suzuki, Atsushi ^a  

^a Central Institute   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AJOENE; ALLICIN; ALLYL SULFIDE; AMPICILLIN; BACITRACIN; CEFALOTIN; CHLORAMPHENICOL; ERYTHROMYCIN; KANAMYCIN; SORBIC ACID; TETRACYCLINE;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS CEREUS; BACILLUS SUBTILIS; CONTROLLED STUDY; DISULFIDE BOND; ESCHERICHIA COLI; GARLIC; KLEBSIELLA PNEUMONIAE; LACTOBACILLUS PLANTARUM; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM SMEGMATIS; NONHUMAN; SACCHAROMYCES CEREVISIAE; STAPHYLOCOCCUS AUREUS; STENOTROPHOMONAS MALTOPHILIA; STREPTOMYCES GRISEUS;

ALLIUM SATIVUM; BACILLUS CEREUS; BACILLUS SUBTILIS; ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; LACTOBACILLUS PLANTARUM; MYCOBACTERIUM SMEGMATIS; NEGIBACTERIA; POSIBACTERIA; SACCHAROMYCES CEREVISIAE; STAPHYLOCOCCUS AUREUS; STENOTROPHOMONAS MALTOPHILIA; STREPTOMYCES GRISEUS; XANTHOMONAS; KLEBSIELLA PSEUMONIAE; LILIACEAE; XANTHOMONAS MALTOPHILIA;

AJOENE; BACTERIA; GARLIC; GROWTH INHIBITION; MICROBIAL GROWTH;

EID: 0029660277     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/aem.62.11.4238-4242.1996     Document Type: Article

References (17)

1. Amaha, M., Z. J. Ordal, and A. Touba. 1956. Sporulation requirements of Bacillus coagulans var. thermoacidurans in complex media. J. Bacteriol. 72: 34-41.
2. Apitz-Castro, R., S. Cabrera, M. R. Cruz, E. Ledezma, and M. K. Jain. 1983. Effect of garlic extract and of three pure components isolated from it on human platelet aggregation, arachidonate metabolism, release reaction and platelet ultrastructure. Thromb. Res. 32:155-169.
3. Apitz-Castro, R., M. K. Jain, F. Bartoli, E. Ledezma, M.-C. Ruiz, and R. Salas. 1991. Evidence for direct coupling of primary agonist-receptor interaction to the exposure of functional IIb-IIIa complexes in human blood platelets. Results from studies with the antiplatelet compound ajoene. Biochim. Biophys. Acta 1094:269-280.
4. Block, E., S. Ahamad, J. L. Catalfamo, M. K. Jain, and R. Apitz-Castro. 1986. Antithrombic organosulfur compounds from garlic: structural, mechanistic, and synthetic studies. J. Am. Chem. Soc. 108:7045-7055.
5. Block, E., S. Ahmad, M. K. Jain, R. W. Crecely, R. Apitz-Castro, and M. R. Cruz. 1984. (E,Z)-Ajoene: a potent antithrombotic agent from garlic. J. Am. Chem. Soc. 106:8295-8296.
6. Cavallito, C. J., J. S. Buck, and C. M. Suter. 1944. Allicin, the antibacterial principle of Allium sativum. I. Isolation, physical properties and antibacterial action. J. Am. Chem. Soc. 66:1950-1951.
7. Cavallito, C. J., J. S. Buck, and C. M. Suter. 1944. Allicin, the antibacterial principle of Allium sativum. II. Determination of the chemical structure. J. Am. Chem. Soc. 66:1952-1954.
8. DiPaolo, J. A., and C. Carruthers. 1960. The effect of allicin from garlic on tumor growth. Cancer Res. 20:431-434.
9. Lawson, L. D., Z.-Y. J. Wang, and B. G. Hughes. 1991. Identification and HPLC quantification of the sulfides and dialk(en)yl thiosulfinates in commercial garlic products. Planta Med. 57:363-370.
10. Perez, H. A., M. de la Rosa, and R. Apitz. 1994. In vivo activity of ajoene against rodent malaria. Antimicrob. Agents Chemother. 38:337-339.
11. San-Blas, G., L. Mariño, F. San-Blas, and R. Apitz-Castro. 1993. Effect of ajoene on dimorphism of Paracoccidioides brasiliensis. J. Med. Vet. Mycol. 31:133-141.
12. San-Blas, G., F. San-Blas, F. Gil, L. Mariño, and R. Apitz-Castro. 1989. Inhibition of growth of the dimorphic fungus Paracoccidioides brasiliensis by ajoene. Antimicrob. Agents Chemother. 33:1641-1644.
13. Tatarintsev, A. V., P. V. Vrizheshch, A. A. Schegolev, D. E. Yershov, A. S. Turgiev, S. D. Varfolomeyev, G. V. Kornilayeva, T. V. Makarova, and E. V. Karamov. 1992. Ajoene antagonizes integrin-dependent processes in HIV-infected T-lymphoblasts. AIDS 6:1215-1217.
14. Urbina, J. A., E. Marchan, K. Lazardi, G. Visbal, R. Apitz-Castro, F. Gil, T. Aguirre, and M. M. Piras. 1993. Inhibition of phosphatidylcholine biosynthesis and cell proliferation in Trypanosoma cruzi by ajoene, an antiplatelet compound isolated from garlic. Biochem. Pharmacol. 45:2381-2387.
15. Weber, N. D., D. O. Andersen, J. A. North, B. K. Murray, L. D. Lowson, and B. G. Hughes. 1992. In vitro virucidal effects of Allium sativum (garlic) extract and compounds. Planta Med. 58:417-423.
16. Weisberger, A. S., and J. Pensky. 1957. Tumor inhibiting effects derived from an active principle of garlic (Allium sativum). Science 126:1112-1114.
17. Yoshida, S., S. Kasuga, N. Hayashi, T. Ushiroguchi, H. Matsuura, and S. Nakagawa. 1987. Antifungal activity of ajoene derived from garlic. Appl. Environ. Microbiol. 53:615-617.