Application of process quality engineering techniques to improve the understanding of the in vitro processing of stem cells for therapeutic use

Journal of Biotechnology

Volumn 136, Issue 3-4, 2008, Pages 148-155

  Thomas, R J ^a   Hourd, P C ^a   Williams, D J ^a  

^a LOUGHBOROUGH UNIVERSITY   (United Kingdom)

Author keywords

Automation; Cell based therapy; Mesenchymal stem cell; Quality engineering

Indexed keywords

ANIMAL CELL CULTURE; BIOTECHNOLOGY; CELLS; CONCENTRATION (PROCESS); CYTOLOGY; INDUSTRIAL ENGINEERING; POPULATION STATISTICS; PROCESS ENGINEERING; PRODUCTION ENGINEERING; SPECIFICATIONS; TECHNOLOGY; TISSUE ENGINEERING; WORK SIMPLIFICATION;

ALKALINE PHOSPHATASE; AUTOMATED CELL; AUTOMATION; BONE MARROW; CELL NUMBERS; CELL THERAPIES; CELL-BASED; CELL-BASED THERAPY; CURRENT GOOD MANUFACTURING PRACTICES; EXPANSION PROCESS; HUMAN MESENCHYMAL STEM CELLS; IN-VITRO; INCUBATION TIME; MANUFACTURING PROCESSES; MESENCHYMAL STEM CELL; PROCESS INPUTS; PROCESS OPTIMISATION; PROCESS QUALITY; QUALITY ENGINEERING; SCALEABLE; SEEDING DENSITIES; SERUM CONCENTRATIONS; SIX-SIGMA; SOURCES OF VARIATION; STEM CELLS; SYSTEMATIC QUALITY;

CELL CULTURE;

ALKALINE PHOSPHATASE; CD71 ANTIGEN; ENDOGLIN; STRO 1 PROTEIN;

ARTICLE; BIOENGINEERING; BLOOD LEVEL; CELL COUNT; CELL CULTURE; CELL EXPANSION; CELL THERAPY; CULTURE MEDIUM; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; INCUBATION TIME; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUALITY CONTROL; SCREENING;

AUTOMATION; BIOMEDICAL ENGINEERING; BONE MARROW CELLS; CELL COUNT; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; FLOW CYTOMETRY; HUMANS; MESENCHYMAL STEM CELLS; QUALITY CONTROL; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS;

EID: 49949108324     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2008.06.009     Document Type: Article

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