In vitro myotoxicity of selected cationic macromolecules used in non- viral gene delivery

Pharmaceutical Research

Volumn 15, Issue 5, 1998, Pages 680-684

  Brazeau, Gayle A ^a   Attia, Steve ^a   Poxon, Scott ^a   Hughes, Jeffrey A ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

Dendrimers; Gene delivery; Liposomes; Myotoxicity; Plasmid DNA; Polylysine

Indexed keywords

CREATINE KINASE; DENDRIMER; DNA; LIPID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; DNA ADDUCT; GENE TARGETING; GENE THERAPY; GENE TRANSFER; MUSCLE TISSUE; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE CULTURE; TISSUE INJURY; TOXICITY TESTING;

ANIMALS; CATIONS; GENE TRANSFER TECHNIQUES; LIPOSOMES; MALE; MUSCLES; PLASMIDS; POLYLYSINE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0031750860     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011954516233     Document Type: Article

References (28)

1. W. F. Anderson. Gene therapy. Scien. Amer. 273:124-128 (1995).
2. E. C. Svensson, S. K. Tripathy, and J. M. Leiden. Muscle-based gene therapy: realistic possibilities for the future. Mol. Med. Today 2:166-172 (1996).
3. H. E. J. Hofland, D. Nagy, J-J. Liu, K. Spratt, Y.-L. Lee, O. Danos, and S. M. Sullivan. In vivo gene transfer by intravenous administration of stable cationic lipid/DNA complex. Pharm. Res. 14:742-749 (1997).
4. A. S. G. Curtis. The Cell Surface: Its Molecular Role in Morphogenesis. Academic, New York, 1967.
5. A. Katchalsky. Polyelectrolytes and their biological interactions. Biophys. J. 4:9-41 (1964).
6. E. Mayhew and S. J. Nordling. Electrophoretic mobility of mouse cells and homologous isolated nuclei. J. Cell Physiol. 68:75-80 (1966).
7. H. Fernandez-Moran, T. Oda, P. V. Blair, and D. E. Green. A macromolecular repeating unit of mitochondrial structure and function. J. Cell Biol. 22:63-100 (1964).
8. H. Moroson. Polycation-treated tumor cells in vivo. Cancer Res. 31:373-380 (1971).
9. G. A. Brazeau and H.-L. Fung. An in vitro model to evaluate muscle damage following intramuscular injections. Pharm. Res. 6:167-179 (1989).
10. G. A. Brazeau and H.-L. Fung. Use of an in vitro model for the assessment of muscle damage from intramuscular injections: in vitro-in vivo correlation and predictability with mixed solvent systems. Pharm. Res. 6:766-771 (1989).
11. R. R. R. C. New. Preparation of liposomes. In R. R. R. C. New (ed.), Liposomes: A Practical Approach, Oxford University Press, Oxford, 1990, pp. 33-103.
12. K. L. Manchester. Use of UV methods for measurement of protein and nucleic acid concentrations. Biotechniq. 20:968, 970-971 (1996).
13. R. J. Lee and L. Huang. Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer. J. Biol. Chem. 271:8481-8487 (1996).
14. C. J. Wheeler, P. L. Felgner, Y. J. Tsai, J. Marshall, L. Sukhu, S. G. Doh, J. Hartikka, J. Nietupski, M. Manthorpe, M. Nicholes, M. Plewe, X. Liang, J. Norman, A. Smith, and S. H. Cheng. A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung. Proc. Natl. Acad. Sci. USA. 93:11454-11459 (1996).
15. H. E. Hofland, L. Shephard, and S. M. Sullivan. Formation of stable cationic lipid/DNA complexes for gene transfer. Proc. Natl. Acad. Sci. USA. 93:7305-7309 (1996).
16. R. J. Lee and L. Huang. Lipidic vector systems for gene transfer. Crit. Rev. Ther. Drug Carr. Syst. 14:173-206 (1997).
17. G. A. Brazeau and H.-L. Fung. Mechanisms of creatine kinase release from isolated rat skeletal muscles damaged by propylene glycol and ethanol. J. Pharm. Sci. 79:393-397 (1990).
18. M. Tokui, I. Takei, F. Tashiro, A. Shimada, A. Kasuga, M. Ishii, T. Ishii, K. Takatsu, T. Saruta, and J. Miyazaki. Intramuscular injection of expression of plasmid DNA is an effective means of long-term systemic delivery of interleukin-5. Biochem. Biophys. Res. Comm. 233:527-531 (1997).
19. R. W. Herzog, J. N. Hagstrom, S. H., Kung, S. J. Tai, J. M. Wilson, K. J. Fisher, and K. A. High. Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus. Proc. Natl. acad. Sci. USA. 94:5804-5809 (1997).
20. G. J. Nabel, E. G. Nabel, Z. Y. Yang, B. A. Fox, G. E. Plautz, X. Gao, L. Hunag, S. Shu, D. Gordon, and A. E. Change. Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans. Proc. Natl. Acad. Sci. USA 90(23):11307-11311 (1993).
21. J. A. Wolff, R. W. Malone, P. Williams, W. Chong, G. Acsadi, A. Jani, and P. L. Felgner. Direct gene transfer into mouse muscle in vivo. Science 247:1465-1468 (1990).
22. S. A. Al-Suwayeh, I. R. Tebbett, D. Wielbo, and G. A. Brazeau. Invitro-in rivo myotoxicity of intramuscular liposomal formulations. Pharm. Res. 13:1384-1388 (1996).
23. M. Cotton, A. Baker, M. Saltik, E. Wagner, and M. Buschle. Lipopolysaccharide is a frequent contaminant of plasmid DNA preparations and can be toxic to primary human cells in the presence of adenovirus. Gene Ther. 1:239-246 (1994).
24. P. Wicks, M. L. Howell, T. Hancock, H. Kohsaka, T. Olee, and D. A. Carson. Bacterial lipopolysaccharide copurifies with plasmid DNA: implications for animal models and human gene therapy. Human Gene Ther. 6:317-323 (1995).
25. P. M. Montbriand and R. W. Malone. Improved method for the removal of endotoxin from DNA. J. Biotechnol. 44:43-46 (1996).
26. J. Liao and R. M. Ottenbrite. Biological effects of polymeric drugs. In K. Park (ed.) Controlled Drug Delivery Challenges and Strategies, American Chemical Society, Washington, 1997, pp. 455-467.
27. A. Fasbender, J. Zabner, M. Chillon, T. O. Moninger, A. P. Puga, B. L. Davidson, and M. J. Welsh. Complexes of adenovirus with polycationic polymers and cationic lipids increase the efficiency of gene transfer in vitro and in vivo J. Biol Chem. 277 (10):6479-6489.
28. H. Gershon, R. Ghirlando, S. B. Guttman, and A. Minsky. Mode of formation and structural features of DNA-cationic liposome complexes used for transfection. Biochemistry 32(28):7143-7151 (1993).