Inhibition of proteasome activity by the dietary flavonoid apigenin is associated with growth inhibition in cultured breast cancer cells and xenografts

Breast Cancer Research

Volumn 9, Issue 6, 2007, Pages

  Chen, Di ^a   Landis Piwowar, Kristin R ^a   Chen, Marina S ^a   Dou, Q Ping ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APIGENIN; CASPASE 3; CASPASE 7; CHYMOTRYPSIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NUCLEOTIDYLTRANSFERASE; PROTEASOME; UBIQUITINATED PROTEIN; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER PREVENTION; CELL PROLIFERATION; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MDA-MB-231 CELL LINE; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION; TUMOR XENOGRAFT; TUNEL ASSAY; ANIMAL; BREAST TUMOR; CELL SURVIVAL; DIET THERAPY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM; NICK END LABELING; NUDE MOUSE; PATHOPHYSIOLOGY; RANDOMIZATION; TUMOR CELL LINE; WESTERN BLOTTING; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APIGENIN; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CASPASE 3; CASPASE 7; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; ENZYME INHIBITORS; FEMALE; HUMANS; IN SITU NICK-END LABELING; MICE; MICE, NUDE; PROTEASOME ENDOPEPTIDASE COMPLEX; RANDOM ALLOCATION; TRANSPLANTATION, HETEROLOGOUS;

EID: 40349111004     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr1797     Document Type: Article

References (32)

1. Aggarwal BB, Shishodia S: Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol. 2006, 71: 1397-1421 10.1016/j.bcp.2006.02.009.
2. Liu LZ, Fang J, Zhou Q, Hu X, Shi X, Jiang BH: Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer. Mol Pharmacol. 2005, 68: 635-643.
3. Birt DF, Mitchell D, Gold B, Pour P, Pinch HC: Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid. Anticancer Res. 1997, 17: 85-91.
4. Zheng PW, Chiang LC, Lin CC: Apigenin induced apoptosis through p53-dependent pathway in human cervical carcinoma cells. Life Sci. 2005, 76: 1367-1379 10.1016/j.lfs.2004.08.023.
5. Gupta S, Afaq F, Mukhtar H: Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells. Oncogene. 2002, 21: 3727-3738 10.1038/sj.onc.1205474.
6. Chen D, Daniel KG, Chen MS, Kuhn DJ, Landis-Piwowar KR, Dou QP: Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells. Biochem Pharmacol. 2005, 69: 1421-1432 10.1016/j.bcp.2005.02.022.
7. Choi JS, Choi YJ, Park SH, Kang JS, Kang YH: Flavones mitigate tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: role of nuclear factor-kappa B. J Nutr. 2004, 134: 1013-1019.
8. Sim GS, Lee BC, Cho HS, Lee JW, Kim JH, Lee DH, Pyo HB, Moon DC, Oh KW, Yun YP, et al: Structure activity relationship of antioxidative property of flavonoids and inhibitory effect on matrix metalloproteinase activity in UVA-irradiated human dermal fibroblast. Arch Pharm Res. 2007, 30: 290-298.
9. Chen D, Chen MS, Cui QC, Yang H, Dou QP: Structure-proteasome-inhibitory activity relationships of dietary flavonoids in human cancer cells. Front Biosci. 2007, 12: 1935-1945 10.2741/2199.
10. Groll M, Ditzel L, Lowe J, Stock D, Bochtler M, Bartunik HD, Huber R: Structure of 20S proteasome from yeast at 2.4 A resolution. Nature. 1997, 386: 463-471 10.1038/386463a0.
11. An B, Goldfarb RH, Siman R, Dou QP: Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts. Cell Death Differ. 1998, 5: 1062-1075 10.1038/sj.cdd.4400436.
12. Lopes UG, Erhardt P, Yao R, Cooper GM: p53-dependent induction of apoptosis by proteasome inhibitors. J Biol Chem. 1997, 272: 12893-12896 10.1074/jbc.272.20.12893.
13. Adams J: Potential for proteasome inhibition in the treatment of cancer. Drug Discov Today. 2003, 8: 307-315 10.1016/S1359-6446(03)02647-3.
14. Dou QP, Li B: Proteasome inhibitors as potential novel anticancer agents. Drug Resist Updat. 1999, 2: 215-223 10.1054/drup.1999.0095.
15. Almond JB, Cohen GM: The proteasome: a novel target for cancer chemotherapy. Leukemia. 2002, 16: 433-443 10.1038/sj.leu.2402417.
16. Goldberg AL: Functions of the proteasome: the lysis at the end of the tunnel. Science. 1995, 268: 522-523 10.1126/science.7725095.
17. Dou QP, Smith DM, Daniel KG, Kazi A: Interruption of tumor cell cycle progression through proteasome inhibition: implications for cancer therapy. Prog Cell Cycle Res. 2003, 5: 441-446.
18. Ma MH, Yang HH, Parker K, Manyak S, Friedman JM, Altamirano C, Wu ZQ, Borad MJ, Frantzen M, Roussos E, et al: The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents. Clin Cancer Res. 2003, 9: 1136-1144.
19. Frankel A, Man S, Elliott P, Adams J, Kerbel RS: Lack of multicellular drug resistance observed in human ovarian and prostate carcinoma treated with the proteasome inhibitor PS-341. Clin Cancer Res. 2000, 6: 3719-3728.
20. Adams J, Palombella VJ, Sausville EA, Johnson J, Destree A, Lazarus DD, Maas J, Pien CS, Prakash S, Elliott PJ: Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 1999, 59: 2615-2622.
21. Hideshima T, Richardson P, Chauhan D, Palombella VJ, Elliott PJ, Adams J, Anderson KC: The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res. 2001, 61: 3071-3076.
22. Crawford LJ, Walker B, Ovaa H, Chauhan D, Anderson KC, Morris TC, Irvine AE: Comparative selectivity and specificity of the proteasome inhibitors BzLLLCOCHO, PS-341, and MG-132. Cancer Res. 2006, 66: 6379-6386 10.1158/0008-5472.CAN-06-0605.
23. Patel D, Shukla S, Gupta S: Apigenin and cancer chemoprevention: progress, potential and promise [review]. Int J Oncol. 2007, 30: 233-245.
24. An B, Dou QP: Cleavage of retinoblastoma protein during apoptosis: an interleukin 1 beta-converting enzyme-like protease as candidate. Cancer Res. 1996, 56: 438-442.
25. Nam S, Smith DM, Dou QP: Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo. J Biol Chem. 2001, 276: 13322-13330 10.1074/jbc.M004209200.
26. Chen D, Peng F, Cui QC, Daniel KG, Orlu S, Liu J, Dou QP: Inhibition of prostate cancer cellular proteasome activity by a pyrrolidine dithiocarbamate-copper complex is associated with suppression of proliferation and induction of apoptosis. Front Biosci. 2005, 10: 2932-2939 10.2741/1749.
27. Chen D, Cui QC, Yang H, Dou QP: Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity. Cancer Res. 2006, 66: 10425-10433 10.1158/0008-5472.CAN-06-2126.
28. Jhanwar YS, Divgi C: Current status of therapy of solid tumors. J Nucl Med. 2005, 46 (Suppl 1): 141S-150S.
29. Landis-Piwowar KR, Milacic V, Chen D, Yang H, Zhao Y, Chan TH, Yan B, Dou QP: The proteasome as a potential target for novel anticancer drugs and chemosensitizers. Drug Resist Updat. 2006, 9: 263-273 10.1016/j.drup.2006.11.001.
30. Shukla S, Mishra A, Fu P, MacLennan GT, Resnick MI, Gupta S: Up-regulation of insulin-like growth factor binding protein-3 by apigenin leads to growth inhibition and apoptosis of 22Rv1 xenograft in athymic nude mice. FASEB J. 2005, 19: 2042-2044.
31. Shukla S, Gupta S: Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft. Mol Cancer Ther. 2006, 5: 843-852 10.1158/1535-7163.MCT-05-0370.
32. Horinaka M, Yoshida T, Shiraishi T, Nakata S, Wakada M, Sakai T: The dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligand. Mol Cancer Ther. 2006, 5: 945-951 10.1158/1535-7163.MCT-05-0431.