V-ATPases in osteoclasts: Structure, function and potential inhibitors of bone resorption

International Journal of Biochemistry and Cell Biology

Volumn 44, Issue 9, 2012, Pages 1422-1435

  Qin, A ^a,b   Cheng, T S ^a   Pavlos, N J ^a   Lin, Z ^a,c   Dai, K R ^b,d   Zheng, M H ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^d SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Osteoclasts; V ATPase; V ATPase inhibitors

Indexed keywords

BAFILOMYCIN; CATHEPSIN K; COLONY STIMULATING FACTOR 1; CONCANAMYCIN A; DIPROPHYLLINE; ENOXACIN; F ACTIN; FR 167356; FR 177995; FR 202126; KM 91104; MYOCYTE ENHANCER FACTOR 2; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE INHIBITOR; SALICYLIHALAMIDE A; SB 242784; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; BINDING SITE; BONE DENSITY; CELL ACTIVATION; CELL MEMBRANE; CELL MEMBRANE DEPOLARIZATION; CONFORMATIONAL TRANSITION; CYTOSKELETON; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; EXOCYTOSIS; HUMAN; HYDROPHILICITY; HYDROPHOBICITY; IC 50; IN VITRO STUDY; IN VIVO STUDY; MISSENSE MUTATION; MOLECULAR DOCKING; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; PH; PROTEIN EXPRESSION; PROTEIN HYDROLYSIS; PROTON TRANSPORT; REVIEW; SIGNAL TRANSDUCTION; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BONE RESORPTION; ENZYME INHIBITORS; HUMANS; OSTEOCLASTS; SUBSTRATE SPECIFICITY; VACUOLAR PROTON-TRANSLOCATING ATPASES;

MUS;

EID: 84862755051     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2012.05.014     Document Type: Review

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