The V-ATPase a3 subunit mutation R740S is dominant negative and results in osteopetrosis in mice

Journal of Bone and Mineral Research

Volumn 26, Issue 7, 2011, Pages 1484-1493

  Ochotny, Noelle ^a   Flenniken, Ann M ^b   Owen, Celeste ^b   Voronov, Irina ^a   Zirngibl, Ralph A ^c   Osborne, Lucy R ^b,c   Henderson, Janet E ^d   Adamson, S Lee ^b   Rossant, Janet ^b,c,e   Manolson, Morris F ^a   Aubin, Jane E ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d MCGILL UNIVERSITY   (Canada)

^e HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

Author keywords

Animal Model; Bone; Osteoclast; Osteopetrosis; Rodent

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CASPASE 3; ETHYLNITROSOUREA; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN BCL 2; PROTEIN SUBUNIT; PROTON PUMP;

ALBERS SCHOENBERG DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BONE DENSITY; CELL MEMBRANE; CELL VACUOLE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME SUBUNIT; FEMALE; GENE EXPRESSION; GENE MUTATION; GENETIC CODE; MALE; MISSENSE MUTATION; MORPHOMETRICS; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PROTON TRANSPORT; TRANSMISSION ELECTRON MICROSCOPY;

ADENOSINE TRIPHOSPHATE; AMINO ACID SUBSTITUTION; ANIMALS; APOPTOSIS; BASE SEQUENCE; BIOLOGICAL TRANSPORT; CELL COUNT; CELL SHAPE; DNA MUTATIONAL ANALYSIS; FEMALE; FEMUR; GENES, DOMINANT; HETEROZYGOTE; HYDROLYSIS; MALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; OSTEOBLASTS; OSTEOCLASTS; OSTEOPETROSIS; PROTEIN SUBUNITS; PROTONS; VACUOLAR PROTON-TRANSLOCATING ATPASES; X-RAY MICROTOMOGRAPHY;

EID: 79959497079     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.355     Document Type: Article

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