FR177995, a novel vacuolar ATPase inhibitor, exerts not only an inhibitory effect on bone destruction but also anti-immunoinflammatory effects in adjuvant-induced arthritic rats

Bone

Volumn 40, Issue 4, 2007, Pages 888-894

  Niikura, Kazuaki ^a   Nakajima, Satoko ^a   Takano, Mikiko ^a   Yamazaki, Harumi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Adjuvant induced arthritis; Anti immunoinflammatory effect; Bone destruction; Osteoclast; Vacuolar ATPase

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE INHIBITOR; FR 177995; GLYCOSAMINOGLYCAN; INTERLEUKIN 1; INTERLEUKIN 6; PARATHYROID HORMONE; RETINOIC ACID; SIALIC ACID; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DENSITY; BONE DESTRUCTION; CARTILAGE DEGENERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG INDICATION; ENZYME ACTIVITY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FEMUR CONDYLE; HYPERCALCEMIA; IN VITRO STUDY; INFLAMMATION; MALE; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OVARIECTOMY; PATHOGENESIS; PAW EDEMA; PROTEIN EXPRESSION; PROTON TRANSPORT; RAT; RHEUMATOID ARTHRITIS; THYROPARATHYROIDECTOMY; TREATMENT OUTCOME;

ANIMALS; ARTHRITIS, EXPERIMENTAL; AUTOIMMUNITY; BENZIMIDAZOLES; BONE DENSITY; BONE RESORPTION; ENZYME INHIBITORS; FEMALE; HYPERCALCEMIA; INFLAMMATION; MALE; MICE; MORPHOLINES; PREGNANCY; RABBITS; RATS; RATS, INBRED LEW; RATS, WISTAR; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 33847727477     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2006.10.015     Document Type: Article

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