Comparative analysis of the effects of a novel vacuolar adenosine 5′-triphosphatase inhibitor, FR202126, and doxycycline on bone loss caused by experimental periodontitis in rats

Journal of Periodontology

Volumn 77, Issue 7, 2006, Pages 1211-1216

  Niikura, Kazuaki ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Alveolar bone loss; Doxycycline; Matrix metalloproteinase; Osteoclast; Vacuolar ATPase

Indexed keywords

2,6 DICHLORO N [3 METHYL 4 (3 METHYL 2 OXO 1 IMIDAZOLIDINYL) 8 QUINOLINYL]BENZAMIDE; ADENOSINE TRIPHOSPHATASE INHIBITOR; CALCIUM; DOXYCYCLINE; FR 202126; INTERLEUKIN 1; INTERLEUKIN 6; MATRIX METALLOPROTEINASE; PARATHYROID HORMONE; UNCLASSIFIED DRUG; 2,6 DICHLORO N (3 METHYL 4 (3 METHYL 2 OXO 1 IMIDAZOLIDINYL) 8 QUINOLINYL)BENZAMIDE; 2,6-DICHLORO-N-(3-METHYL-4-(3-METHYL-2-OXO-1-IMIDAZOLIDINYL)-8-QUINOLINYL)BENZAMIDE; AMINOQUINOLINE DERIVATIVE; BENZAMIDE DERIVATIVE; ENZYME INHIBITOR; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ALVEOLAR BONE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE ATROPHY; CALCIUM TRANSPORT; CELL CULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; HISTOPATHOLOGY; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; OSTEOLYSIS; PERIODONTITIS; RAT; ANALYSIS OF VARIANCE; ANIMAL; DRUG ANTAGONISM; ENZYMOLOGY; LIGATION; MOUSE STRAIN; NONPARAMETRIC TEST; OSTEOCLAST; PH; WISTAR RAT;

ALVEOLAR BONE LOSS; AMINOQUINOLINES; ANALYSIS OF VARIANCE; ANIMALS; BENZAMIDES; DOXYCYCLINE; ENZYME INHIBITORS; HYDROGEN-ION CONCENTRATION; LIGATION; MALE; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED STRAINS; OSTEOCLASTS; PERIODONTITIS; RATS; RATS, WISTAR; STATISTICS, NONPARAMETRIC; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 33748522043     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2006.050344     Document Type: Article

References (26)

1. Sorsa T, Tjaderhane L, Salo T. Matrix metalloproteinases (MMPs) in oral diseases. Oral Dis 2004;10: 311-318.
2. Golub LM, Ramamurthy NS, McNamara TF, Greenwald RA, Rifkin BR. Tetracyclines inhibit connective tissue breakdown: New therapeutic implications for an old family of drugs. Crit Rev Oral Biol Med 1991;2:297-321.
3. Golub LM, Evans RT, McNamara TF, Lee HM, Ramamurthy NS. A non-antimicrobial tetracycline inhibits gingival matrix metalloproteinases and bone loss in Porphyromonas gingivalis-induced periodontitis in rats. Ann N Y Acad Sci 1994;732:96-111.
4. Karimbux NY, Ramamurthy NS, Golub LM, Nishimura I. The expression of collagen I and XII mRNAs in Porphyromonas gingivalis-induced periodontitis in rats: The effect of doxycycline and chemically modified tetracycline. J Periodontol 1998;69:34-40.
5. Caton JG. Evaluation of Periostat for patient management. Compend Contin Educ Dent 1999;20:451-462.
6. Zaidi M, Blair HC, Moonga BS, Abe E, Huang CL. Osteoclastogenesis, bone resorption, and osteoclast-based therapeutics. J Bone Miner Res 2003;18: 599-609.
7. Aibe K, Yazawa H, Abe K, et al. Substrate specificity of recombinant osteoclast-specific cathepsin K from rabbits. Biol Pharm Bull 1996;19:1026-1031.
8. Blair HC, Teitelbaum SL, Ghiselli R, Gluck S. Osteoclastic bone resorption by a polarized vacuolar proton pump. Science 1989;245:855-857.
9. Laitala T, Väänänen HK. Inhibition of bone resorption in vitro by antisense RNA and DNA molecules targeted against carbonic anhydrase II or two subunits of vacuolar H(+)-ATPase. J Clin Invest 1994;93:2311-2318.
10. Hu Y, Nyman J, Muhonen P, Väänänen HK, Laitala-Leinonen T. Inhibition of the osteoclast V-ATPase by small interfering RNAs. FEBS Lett 2005;579:4937-4942.
11. Li YP, Chen W, Liang Y, Li E, Stashenko P. Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification. Nat Genet 1999;23:447-451.
12. Niikura K, Takano M, Sawada M. A novel inhibitor of vacuolar ATPase, FR167356, which can discriminate between osteoclast vacuolar ATPase and lysosomal vacuolar ATPase. Br J Pharmacol 2004;142:558-566.
13. Niikura K, Takeshita N, Takano M. A vacuolar ATPase inhibitor, FR167356, prevents bone resorption in ovariectomized rats with high potency and specificity: Potential for clinical application. J Bone Miner Res 2005;20:1579-1588.
14. Niikura K, Takeshita N, Chida N. A novel inhibitor of vacuolar ATPase, FR202126, prevents alveolar bone destruction in experimental periodontitis in rats. J Toxicol Sci 2005;30:297-304.
15. Konishi H, Kawanami M, Kato H. Influence of bisphosphonate (incadronate) administration on bone resorption in experimental periodontitis in rats. Nihon Shishubyo Gakkaishi 2000;42:267-281.
16. Andersen TL, del Carmen Ovejero, M, Kirkegaard T, Lenhard T, Foged NT, Delaisse JM. A scrutiny of matrix metalloproteinases in osteoclasts: Evidence for heterogeneity and for the presence of MMPs synthesized by other cells. Bone 2004;35:1107-1119.
17. Johnson LL, Dyer R, Hupe DJ. Matrix metalloproteinases. Curr Opin Chem Biol 1998;2:466-471.
18. Oum'hamed Z, Garnotel R, Josset Y, Trenteseaux C, Laurent-Maquin D. Matrix metalloproteinases MMP-2, -9 and tissue inhibitors TIMPA, -2 expression and secretion by primary human osteoblast cells in response to titanium, zirconia, and alumina ceramics. J Biomed Mater Res A 2004;68:114-122.
19. Fratzl-Zelman N, Glantschnig H, Rumpler M, Nader A, Ellinger A, Varga F. The expression of matrix metalloproteinase-13 and osteocalcin in mouse osteoblasts is related to osteoblastic differentiation and is modulated by 1,25-dihydroxyvitamin D3 and thyroid hormones. Cell Biol Int 2003;27:459-468.
20. Gogly B, Hornebeck W, Groult N, Godeau G, Pellat B. Influence of heparin(s) on the interleukin-1 -beta-induced expression of collagenase, stromelysin-1, and tissue inhibitor of metalloproteinase-1 in human gingival fibroblasts. Biochem Pharmacol 1998;56:1447-1454.
21. Abe M, Kawamoto K, Okamoto H, Horiuchi N. Induction of collagenase-2 (matrix metalloproteinase-8) gene expression by interleukin-1 beta in human gingival fibroblasts. J Periodontal Res 2001;36:153-159.
22. Atley LM, Mort JS, Lalumiere M, Eyre DR. Proteolysis of human bone collagen by cathepsin K: Characterization of the cleavage sites generating by cross-linked N-telopeptide neoepitope. Bone 2000;26:241-247.
23. Chowdhury MH, Moak SA, Rifkin BR, Greenwald RA. Effect of tetracyclines which have metalloproteinase inhibitory capacity on basal and heparin-stimulated bone resorption by chick osteoclasts. Agents Actions 1993;40:124-128.
24. Reinhardt RA, Masada MP, Kaldahl WB, et al. Gingival fluid IL-1 and IL-6 levels in refractory periodontitis. J Clin Periodontol 1993;20:225-231.
25. Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 1999;20:345-357.
26. Liu Y, Ramamurthy N, Marecek J, et al. The lipophilicity, pharmacokinetics, and cellular uptake of different chemically-modified tetracyclines (CMTs). Curr Med Chem 2001;8:243-252.