Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1

Analytical Biochemistry

Volumn 427, Issue 2, 2012, Pages 164-174

  Maki, Jenny L ^a   Smith, Elizabeth E ^a   Teng, Xin ^b   Ray, Soumya S ^b   Cuny, Gregory D ^b,c   Degterev, Alexei ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF HOUSTON   (United States)

Author keywords

Competition assays; Fluorescence polarization (FP); High throughput screening (HTS); Kinase; Ligand docking; Necrostatin (Nec); Receptor interaction protein 1 (RIP1)

Indexed keywords

AMINO ACIDS; BINDING SITES; CELL DEATH; DIAGNOSIS; DIMETHYL SULFOXIDE; FLUORESCENCE; LIGANDS; ORGANIC SOLVENTS; POLARIZATION;

COMPETITION ASSAYS; FLUORESCENCE POLARIZATION; HIGH-THROUGHPUT SCREENING; KINASE; LIGAND DOCKING; NECROSTATIN (NEC); RECEPTOR INTERACTION;

ENZYMES;

DIMETHYL SULFOXIDE; FLUORESCEIN DERIVATIVE; NECROSTATIN 1; NECROSTATIN 3; NECROSTATIN 4; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE INHIBITOR; RECEPTOR INTERACTING PROTEIN 1; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING COMPETITION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SYNTHESIS; FLUORESCENCE POLARIZATION; HIGH THROUGHPUT SCREENING; LIGAND BINDING; MOLECULAR DOCKING; NECROPTOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

EID: 84862749109     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2012.05.019     Document Type: Article

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