TNF-α/Fas-RIP-1-induced cell death signaling separates murine hematopoietic stem cells/progenitors into 2 distinct populations

Blood

Volumn 118, Issue 23, 2011, Pages 6057-6067

  Xiao, Yechen ^a   Li, Hongling ^a,c   Zhang, Jun ^a,d   Volk, Andrew ^a   Zhang, Shubin ^a   Wei, Wei ^a   Zhang, Shanshan ^a   Breslin, Peter ^a,b   Zhang, Jiwang ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

^c GANSU PROVINCIAL HOSPITAL   (China)

^d SHANGHAI NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; FAS ANTIGEN; NECROSTATIN 1; PROTEIN INHIBITOR; RECEPTOR INTERACTING PROTEIN 140; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BONE MARROW DEPRESSION; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DISEASE COURSE; ENZYME INHIBITION; GENE DELETION; HEMATOPOIETIC STEM CELL; KNOCKOUT MOUSE; MOUSE; NECROPTOSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

EID: 82955189314     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-06-359448     Document Type: Article

References (50)

1. Motoyama N, Wang F, Roth KA, et al. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science. 1995; 267(5203):1506-1510.
2. Opferman JT, Iwasaki H, Ong CC, et al. Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells. Science. 2005;307:1101- 1104.
3. Leung CG, Xu Y, Mularski B, Liu H, Gurbuxani S, Crispino JD. Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells. J Exp Med. 2007;204(7):1603-1611. (Pubitemid 47048027)
4. Domen J, Cheshier SH, Weissman IL. The role of apoptosis in the regulation of hematopoietic stem cells: overexpression of Bcl-2 increases both their number and repopulation potential. J Exp Med. 2000;191(2):253-264.
5. Baldridge MT, King KY, Goodell MA. Inflammatory signals regulate hematopoietic stem cells. Trends Immunol. 2010;32(2):57-65.
6. Karlsson R, Engstrom M, Jonsson M, et al. Phosphatidylinositol 3-kinase is essential for kit ligand-mediated survival, whereas interleukin-3 and flt3 ligand induce expression of antiapoptotic Bcl-2 family genes. J Leukoc Biol. 2003; 74(5):923-931. (Pubitemid 38040369)
7. Engstrom M, Karlsson R, Jonsson JI. Inactivation of the forkhead transcription factor FoxO3 is essential for PKB-mediated survival of hematopoietic progenitor cells by kit ligand. Exp Hematol. 2003;31(4):316-323. (Pubitemid 36407608)
8. Blume-Jensen P, Janknecht R, Hunter T. The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136. Curr Biol. 1998; 8(13):779-782. (Pubitemid 28301165)
9. Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB. NF-kappaB activation by tumour necrosis factor requires the Akt serinethreonine kinase. Nature. 1999;401(6748):82-85.
10. Dybedal I, Bryder D, Fossum A, Rusten LS, Jacobsen SE. Tumor necrosis factor (TNF)- mediated activation of the p55 TNF receptor negatively regulates maintenance of cycling reconstituting human hematopoietic stem cells. Blood. 2001;98(6):1782-1791.
11. Imamura M, Zhu X, Han M, et al. In vitro expansion of murine hematopoietic progenitor cells by leukemia inhibitory factor, SCF, and interleukin-1 beta. Exp Hematol. 1996;24(11):1280-1288. (Pubitemid 26348924)
12. Hara T, Ando K, Tsurumi H, Moriwaki H. Excessive production of tumor necrosis factor-alpha by bone marrow T lymphocytes is essential in causing bone marrow failure in patients with aplastic anemia. Eur J Haematol. 2004;73(1):10-16. (Pubitemid 38824184)
13. Sejas DP, Rani R, Qiu Y, et al. Inflammatory reactive oxygen species-mediated hemopoietic suppression in Fancc-deficient mice. J Immunol. 2007;178(8):5277-5287. (Pubitemid 46595313)
14. Niho Y, Asano Y. Fas/Fas ligand and hematopoietic progenitor cells. Curr Opin Hematol. 1998; 5(3):163-165. (Pubitemid 28360539)
15. Bijangi-Vishehsaraei K, Saadatzadeh MR,Werne A, et al. Enhanced TNF-alpha-induced apoptosis in Fanconi anemia type C-deficient cells is dependent on apoptosis signal-regulating kinase 1. Blood. 2005; 106(13):4124-4130. (Pubitemid 41775917)
16. Pearl-Yafe M, Yolcu ES, Stein J, et al. Expression of Fas and Fas-ligand in donor hematopoietic stem and progenitor cells is dissociated from the sensitivity to apoptosis. Exp Hematol. 2007; 35(10):1601-1612. (Pubitemid 47419142)
17. Pearl-Yafe M, Stein J, Yolcu ES, et al. Fas transduces dual apoptotic and trophic signals in hematopoietic progenitors. Stem Cells. 2007;25(12): 3194-3203. (Pubitemid 350294445)
18. Rusten LS, Jacobsen FW, Lesslauer W, Loetscher H, Smeland EB, Jacobsen SE. Bifunctional effects of tumor necrosis factor alpha (TNF alpha) on the growth of mature and primitive human hematopoietic progenitor cells: involvement of p55 and p75 TNF receptors. Blood. 1994; 83(11):3152-3159. (Pubitemid 24158459)
19. Hangoc G, Williams DE, Falkenburg JH, Broxmeyer HE. Influence of IL-1 alpha and -1 beta on the survival of human bone marrow cells responding to hematopoietic colony-stimulating factors. J Immunol. 1989;142:4329-4334. (Pubitemid 19162321)
20. Schulze-Osthoff K, Ferrari D, Los M,Wesselborg S, Peter ME. Apoptosis signaling by death receptors. Eur J Biochem. 1998;254(3):439-459. (Pubitemid 28308094)
21. Baker SJ, Reddy EP. Modulation of life and death by the TNF receptor superfamily. Oncogene. 1998;17(25):3261-3270. (Pubitemid 29043978)
22. Sakurai H, Shigemori N, Hasegawa K, Sugita T. TGF-beta-activated kinase 1 stimulates NFkappa B activation by an NF-kappa B-inducing kinase-independent mechanism. Biochem Biophys Res Commun. 1998;243(2):545-549. (Pubitemid 28414061)
23. Sakurai H, Miyoshi H, Toriumi W, Sugita T. Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation. J Biol Chem. 1999;274(15):10641-10648.
24. Takaesu G, Surabhi RM, Park KJ, Ninomiya-Tsuji J, Matsumoto K, Gaynor RB. TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway. J Mol Biol. 2003;326(1):105-115. (Pubitemid 36279361)
25. Sakurai H, Suzuki S, Kawasaki N, et al. Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway. J Biol Chem. 2003;278(38):36916- 36923.
26. Dybedal I, Yang L, Bryder D, Aastrand-Grundstrom I, Leandersson K, Jacobsen SE. Human reconstituting hematopoietic stem cells up-regulate Fas expression upon active cell cycling but remain resistant to Fasinduced suppression. Blood. 2003;102(1):118-126. (Pubitemid 36759644)
27. Gunther C, Martini E, Wittkopf N, et al. Caspase-8 regulates TNF-alpha-induced epithelial necroptosis and terminal ileitis. Nature. 2011; 477(7364):335-339.
28. Christofferson DE, Yuan J. Necroptosis as an alternative form of programmed cell death. Curr Opin Cell Biol. 2010;22(2):263-268.
29. O'Donnell MA, Ting AT. RIP-1 comes back to life as a cell death regulator in TNFR1 signaling. FEBS J. 2011;278(6):877-887.
30. Tenev T, Bianchi K, Darding M, et al. The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol Cell. 2011;43(3):432-448.
31. Feoktistova M, Geserick P, Kellert B, et al. cIAPs block Ripoptosome formation, a RIP-1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell. 2011;43(3):449-463.
32. Kaiser WJ, Upton JW, Long AB, et al. RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature. 2011;471(7338):368-372.
33. Adhikari A, Xu M, Chen ZJ. Ubiquitin-mediated activation of TAK1 and IKK. Oncogene. 2007; 26(22):3214-3226. (Pubitemid 46763016)
34. Omori E, Morioka S, Matsumoto K, Ninomiya-Tsuji J. TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity. J Biol Chem. 2008;283(38):26161-26168.
35. Wan YY, Chi H, Xie M, Schneider MD, Flavell RA. The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat Immunol. 2006;7(8):851-858. (Pubitemid 44084092)
36. Kajino-Sakamoto R, Omori E, Nighot PK, Blikslager AT, Matsumoto K, Ninomiya-Tsuji J. TGF-β-activated kinase 1 signaling maintains intestinal integrity by preventing accumulation of reactive oxygen species in the intestinal epithelium. J Immunol. 2010;185(8):4729-4737.
37. Sato S, Sanjo H, Takeda K, et al. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol. 2005;6(11): 1087-1095. (Pubitemid 41541786)
38. Tang M, Wei X, Guo Y, et al. TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice. J Exp Med. 2008;205(7):1611- 1619.
39. Ishitani T, Kishida S, Hyodo-Miura J, et al. The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol. 2003;23(1):131-139. (Pubitemid 36008507)
40. Pellegrini M, Bath S, Marsden VS, et al. FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells. Blood. 2005;106(5):1581-1589. (Pubitemid 41208569)
41. Jacobsen SE, Jacobsen FW, Fahlman C, Rusten LS. TNF-alpha, the great imitator: role of p55 and p75 TNF receptors in hematopoiesis. Stem Cells. 1994;12(suppl 1):111-126; discussion 126-118.
42. Rebel VI, Hartnett S, Hill GR, Lazo-Kallanian SB, Ferrara JL, Sieff CA. Essential role for the p55 tumor necrosis factor receptor in regulating hematopoiesis at a stem cell level. J Exp Med. 1999;190(10):1493-1504.
43. Zhang Y, Harada A, Bluethmann H, et al. Tumor necrosis factor (TNF) is a physiologic regulator of hematopoietic progenitor cells: increase of early hematopoietic progenitor cells in TNF receptor p55-deficient mice in vivo and potent inhibition of progenitor cell proliferation by TNF alpha in vitro. Blood. 1995;86(8):2930-2937.
44. Bryder D, Ramsfjell V, Dybedal I, et al. Selfrenewal of multipotent long-term repopulating hematopoietic stem cells is negatively regulated by Fas and tumor necrosis factor receptor activation. J Exp Med. 2001;194(7):941-952. (Pubitemid 32953263)
45. Jost PJ, Grabow S, Gray D, et al. XIAP discriminates between type I and type II FAS-induced apoptosis. Nature. 2009;460(7258):1035-1039.
46. Tateda K, Matsumoto T, Miyazaki S, Yamaguchi K. Lipopolysaccharide- induced lethality and cytokine production in aged mice. Infect Immun. 1996;64(3): 769-774. (Pubitemid 26065547)
47. Rezzoug F, Huang Y, Tanner MK, et al. TNF-alpha is critical to facilitate hemopoietic stem cell engraftment and function. J Immunol. 2008;180(1):49-57.
48. Jacobsen FW, Veiby OP, Stokke T, Jacobsen SE. TNF-alpha bidirectionally modulates the viability of primitive murine hematopoietic progenitor cells in vitro. J Immunol. 1996;157(3):1193-1199.
49. Muller-Sieburg CE, Cho RH, Karlsson L, Huang JF, Sieburg HB. Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished lymphoid progeny with impaired IL-7 responsiveness. Blood. 2004;103(11):4111-4118. (Pubitemid 38685351)
50. Challen GA, Boles NC, Chambers SM, Goodell MA. Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1. Cell Stem Cell. 2010;6(3):265-278.