메뉴 건너뛰기




Volumn 8, Issue , 2012, Pages 861-869

Unprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations

Author keywords

Ansamitocins; Antibiotics; Antitumor agents; Mutasynthesis; Natural products

Indexed keywords


EID: 84862699472     PISSN: None     EISSN: 18605397     Source Type: Journal    
DOI: 10.3762/bjoc.8.96     Document Type: Article
Times cited : (11)

References (33)
  • 2
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • DOI 10.1021/np068054v
    • Newman, D. J.; Cragg, G. M. J. Nat. Prod. 2007, 70, 461-477. doi:10.1021/np068054v (Pubitemid 46595760)
    • (2007) Journal of Natural Products , vol.70 , Issue.3 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 4
    • 33746001269 scopus 로고    scopus 로고
    • doi:10.1002/anie.200600350
    • Angew. Chem. Int. Ed. 2006, 45, 5072-5129. doi:10.1002/anie.200600350.
    • (2006) Angew. Chem. Int. Ed. , vol.45 , pp. 5072-5129
  • 5
    • 84862701661 scopus 로고    scopus 로고
    • doi:10.1002/ange.201107386
    • Kirschning, A.; Hahn, F. Angew. Chem. 2012, 124, 4086-4096. doi:10.1002/ange.201107386
    • (2012) Angew. Chem. , vol.124 , pp. 4086-4096
    • Kirschning, A.1    Hahn, F.2
  • 6
    • 84859957277 scopus 로고    scopus 로고
    • doi:10.1002/anie.201107386
    • Angew. Chem. Int. Ed. 2012, 51, 4012-4022. doi:10.1002/anie.201107386.
    • (2012) Angew. Chem. Int. Ed. , vol.51 , pp. 4012-4022
  • 7
    • 23444460405 scopus 로고    scopus 로고
    • Mutational biosynthesis - A tool for the generation of structural diversity in the biosynthesis of antibiotics
    • DOI 10.1007/s00253-005-1891-8
    • Weist, S.; Süssmuth, R. D. Appl. Microbiol. Biotechnol. 2005, 68, 141-150. doi:10.1007/s00253-005-1891-8 (Pubitemid 41110935)
    • (2005) Applied Microbiology and Biotechnology , vol.68 , Issue.2 , pp. 141-150
    • Weist, S.1    Sussmuth, R.D.2
  • 8
    • 34948842023 scopus 로고    scopus 로고
    • Total synthesis approaches to natural product derivatives based on the combination of chemical synthesis and metabolic engineering
    • DOI 10.1039/b709549j
    • Kirschning, A.; Taft, F.; Knobloch, T. Org. Biomol. Chem. 2007, 5, 3245-3295. doi:10.1039/b709549j (Pubitemid 47519063)
    • (2007) Organic and Biomolecular Chemistry , vol.5 , Issue.20 , pp. 3245-3259
    • Kirschning, A.1    Taft, F.2    Knobloch, T.3
  • 9
    • 38849174356 scopus 로고    scopus 로고
    • Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: Combining synthetic chemistry and biosynthetic engineering for diversifying natural products
    • DOI 10.1039/b707678a
    • Kennedy, J. Nat. Prod. Rep. 2008, 25, 25-34. doi:10.1039/B707678A (Pubitemid 351207544)
    • (2008) Natural Product Reports , vol.25 , Issue.1 , pp. 25-34
    • Kennedy, J.1
  • 10
  • 11
    • 0027093080 scopus 로고
    • doi:10.1016/0163-7258 92 90028-X
    • Hamel, E. Pharmacol. Ther. 1992, 55, 31-51. doi:10.1016/0163-7258 (92) 90028-X
    • (1992) Pharmacol. Ther. , vol.55 , pp. 31-51
    • Hamel, E.1
  • 16
    • 33747203202 scopus 로고    scopus 로고
    • Determination of the cryptic stereochemistry of the first PKS chain-extension step in ansamitocin biosynthesis by Actinosynnema pretiosum
    • DOI 10.1002/cbic.200500506
    • Kubota, T.; Brünjes, M.; Frenzel, T.; Xu, J.; Kirschning, A.; Floss, H. G. ChemBioChem 2006, 7, 1221-1225. doi:10.1002/cbic.200500506 (Pubitemid 44230845)
    • (2006) ChemBioChem , vol.7 , Issue.8 , pp. 1221-1225
    • Kubota, T.1    Brunjes, M.2    Frenzel, T.3    Xu, J.4    Kirschning, A.5    Floss, H.G.6
  • 20
    • 84855809520 scopus 로고    scopus 로고
    • doi:10.1002/anie.201106249
    • Angew. Chem. Int. Ed. 2012, 51, 752-757. doi:10.1002/anie.201106249.
    • (2012) Angew. Chem. Int. Ed. , vol.51 , pp. 752-757
  • 29
    • 30944460157 scopus 로고    scopus 로고
    • Synthesis of the N-acetylcysteamine thioester of seco-proansamitocin
    • DOI 10.1021/ol052588q
    • Frenzel, T.; Brünjes, M.; Quitschalle, M.; Kirschning, A. Org. Lett. 2006, 8, 135-138. doi:10.1021/ol052588q (Pubitemid 43112856)
    • (2006) Organic Letters , vol.8 , Issue.1 , pp. 135-138
    • Frenzel, T.1    Brunjes, M.2    Quitschalle, M.3    Kirschning, A.4
  • 31
    • 0037067081 scopus 로고    scopus 로고
    • Identification of Asm19 as an acyltransferase attaching the biologically essential ester side chain of ansamitocins using N-desmethyl-4,5- desepoxymaytansinol, not maytansinol, as its substrate
    • DOI 10.1021/ja020214b
    • Moss, S. J.; Bai, L.; Toelzer, S.; Caroll, B. J.; Mahmud, T.; Yu, T.-W.; Floss, H. G. J. Am. Chem. Soc. 2002, 124, 6544-6545. doi:10.1021/ja020214b (Pubitemid 34602641)
    • (2002) Journal of the American Chemical Society , vol.124 , Issue.23 , pp. 6544-6545
    • Moss, S.J.1    Bai, L.2    Toelzer, S.3    Carroll, B.J.4    Mahmud, T.5    Yu, T.-W.6    Floss, H.G.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.