Mutational Biosynthesis of Ansamitocin Antibiotics: A Diversity-Oriented Approach to Exploit Biosynthetic Flexibility

ChemBioChem

Volumn 12, Issue 4, 2011, Pages 540-547

  Knobloch, Tobias ^a   Harmrolfs, Kirsten ^a   Taft, Florian ^a   Thomaszewski, Binia ^a   Sasse, Florenz ^b   Kirschning, Andreas ^a  

^a LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

Ansamitocin; Antitumor agents; Mutasynthesis; Polyketide biosynthesis; Structure activity relationships

Indexed keywords

3 AMINIO 5 HYDROXYBENZOIC ACID; AMINOBENZOIC ACID; ANSAMITOCIN; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM CULTURE; BIOSYNTHESIS; CELL PROLIFERATION; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ACTINOMYCETALES; ANTI-BACTERIAL AGENTS; MAYTANSINE; MOLECULAR STRUCTURE; MUTAGENESIS; STRUCTURE-ACTIVITY RELATIONSHIP;

ACTINOSYNNEMA PRETIOSUM;

EID: 79952015068     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201000608     Document Type: Article

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