Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by actinosynnema pretiosum as biocatalyst

ChemBioChem

Volumn 11, Issue 18, 2010, Pages 2517-2520

  Harmrolfs, Kirsten ^a   Brünjes, Marco ^a   Dräger, Gerald ^a   Floss, Heinz G ^b   Sasse, Florenz ^c   Taft, Florian ^a   Kirschning, Andreas ^a  

^a LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^b UNIVERSITY OF WASHINGTON   (United States)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

Amide synthase; Ansamitocin; Mutabiosynthesis; SNAC esters; Total synthesis

Indexed keywords

AMIDE SYNTHASE; ANSAMITOCIN P 3; ANTINEOPLASTIC AGENT; DESCHLORODESMETHOXYANSAMITOCIN P 3; ESTER; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG;

ACTINOBACTERIA; ACTINOSYNNEMA PRETIOSUM; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOCATALYST; CANCER CELL; CYCLIZATION; DRUG SYNTHESIS; ENZYME SPECIFICITY; IC 50; NONHUMAN; PRIORITY JOURNAL;

ACTINOMYCETALES; AMIDE SYNTHASES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIZATION; CYSTEAMINE; HUMANS; MAYTANSINE; MUTATION;

ACTINOSYNNEMA PRETIOSUM;

EID: 78650025431     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201000422     Document Type: Article

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