Broad substrate specificity of the amide synthase in S. hygroscopicus -new 20-membered macrolactones derived from geldanamycin

Journal of the American Chemical Society

Volumn 134, Issue 3, 2012, Pages 1673-1679

  Eichner, Simone ^a   Eichner, Timo ^b   Floss, Heinz G ^c   Fohrer, Jörg ^a   Hofer, Edgar ^a   Sasse, Florenz ^d   Zeilinger, Carsten ^a   Kirschning, Andreas ^a  

^a LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c UNIVERSITY OF WASHINGTON   (United States)

^d HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPROLIFERATIVE ACTIVITIES; CHEMO-SELECTIVITY; CYTOTOXIC; GELDANAMYCIN; MACRO-CYCLIZATION; MACROCYCLES; MACROLACTONES; MODE OF ACTION; MOLECULAR MODELING STUDIES; NATURAL PRODUCTS; PHENOLIC HYDROXYL GROUP; POLYKETIDE SYNTHASES; STREPTOMYCES HYGROSCOPICUS; SUBSTRATE SPECIFICITY; SYNTHASES;

BIOCHEMISTRY; DRIERS (MATERIALS); KETONES; METHANOL; PHENOLS; STARTERS;

AMIDES;

3 AMINO 5 HYDROXYBENZOIC ACID; AMIDE SYNTHASE; ANSAMITOCIN; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HYDROXYL GROUP; MACROCYCLIC LACTAM; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG;

ACTINOSYNNEMA PRETIOSUM; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM; BACTERIUM TRANSFORMATION; BIOSYNTHESIS; ENZYME SPECIFICITY; MACROLACTONIZATION; MOLECULAR MODEL; NONHUMAN; STREPTOMYCES HYGROSCOPICUS;

AMIDE SYNTHASES; AMINO ACID SEQUENCE; BENZOQUINONES; LACTAMS, MACROCYCLIC; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; STREPTOMYCES; SUBSTRATE SPECIFICITY;

EID: 84856272105     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja2087147     Document Type: Article

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