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Volumn 4, Issue 2, 2012, Pages 181-187

microRNA signature for human pancreatic cancer invasion and metastasis (review)

Author keywords

Metastasis; MicroRNAs; Pancreatic cancer

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; EPITHELIAL CELL ADHESION MOLECULE; GELATINASE A; GELATINASE B; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; JAGGED1; MICRORNA; MICRORNA 101; MICRORNA 126; MICRORNA 146A; MICRORNA 200; MICRORNA 200A; MICRORNA 200C; MICRORNA 20A; MICRORNA 21; MICRORNA 29A; MUCIN 4; NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH3 RECEPTOR; PROTEIN BCL 2; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN; VIMENTIN; VORINOSTAT;

EID: 84862689011     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2012.585     Document Type: Review
Times cited : (23)

References (87)
  • 2
    • 38049040752 scopus 로고    scopus 로고
    • Adjuvant therapy for pancreatic cancer: A review
    • Zuckerman DS and Ryan DP: Adjuvant therapy for pancreatic cancer: a review. Cancer 112: 243-249, 2008.
    • (2008) Cancer , vol.112 , pp. 243-249
    • Zuckerman, D.S.1    Ryan, D.P.2
  • 3
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - microRNAs with a role in cancer
    • Esquela-Kerscher A and Slack FJ: Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 6: 259-269, 2006.
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 5
    • 0027730383 scopus 로고
    • Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    • Wightman B, Ha I and Ruvkun G: Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75: 855-862, 1993.
    • (1993) Cell , vol.75 , pp. 855-862
    • Wightman, B.1    Ha, I.2    Ruvkun, G.3
  • 6
    • 0034708122 scopus 로고    scopus 로고
    • The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
    • Reinhart BJ, Slack FJ, Basson M, et al: The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403: 901-906, 2000.
    • (2000) Nature , vol.403 , pp. 901-906
    • Reinhart, B.J.1    Slack, F.J.2    Basson, M.3
  • 7
    • 18744396337 scopus 로고    scopus 로고
    • Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    • Calin GA, Dumitru CD, Shimizu M, et al: Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 99: 15524-15529, 2002.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15524-15529
    • Calin, G.A.1    Dumitru, C.D.2    Shimizu, M.3
  • 8
    • 34247862190 scopus 로고    scopus 로고
    • microRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis
    • Bloomston M, Frankel WL, Petrocca F, et al: microRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA 229: 1901-1908, 2007.
    • (2007) JAMA , vol.229 , pp. 1901-1908
    • Bloomston, M.1    Frankel, W.L.2    Petrocca, F.3
  • 9
    • 52049097315 scopus 로고    scopus 로고
    • Altered microRNA expression in cervical carcinomas
    • Lee JW, Choi CH, Choi JJ, et al: Altered microRNA expression in cervical carcinomas. Clin Cancer Res 14: 2535-2542, 2008.
    • (2008) Clin Cancer Res , vol.14 , pp. 2535-2542
    • Lee, J.W.1    Choi, C.H.2    Choi, J.J.3
  • 10
    • 23844555119 scopus 로고    scopus 로고
    • MicroRNA gene expression deregulation in human breast cancer
    • Iorio MV, Ferracin M, Liu CG, et al: MicroRNA gene expression deregulation in human breast cancer. Cancer Res 65: 7065-7070, 2005.
    • (2005) Cancer Res , vol.65 , pp. 7065-7070
    • Iorio, M.V.1    Ferracin, M.2    Liu, C.G.3
  • 11
    • 40949087185 scopus 로고    scopus 로고
    • Identification of metastasis-related microRNAs in hepatocellular carcinoma
    • Budhu A, Jia HL, Forgues M, et al: Identification of metastasis-related microRNAs in hepatocellular carcinoma. Hepatology 47: 897-907, 2008.
    • (2008) Hepatology , vol.47 , pp. 897-907
    • Budhu, A.1    Jia, H.L.2    Forgues, M.3
  • 12
    • 35148886434 scopus 로고    scopus 로고
    • Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    • Ma L, Teruya-Feldstein J and Weinberg RA: Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449: 682-688, 2007.
    • (2007) Nature , vol.449 , pp. 682-688
    • Ma, L.1    Teruya-Feldstein, J.2    Weinberg, R.A.3
  • 13
    • 34547524771 scopus 로고    scopus 로고
    • MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    • Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST and Patel T: MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133: 647-658, 2007.
    • (2007) Gastroenterology , vol.133 , pp. 647-658
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3    Ghoshal, K.4    Jacob, S.T.5    Patel, T.6
  • 14
    • 41749113108 scopus 로고    scopus 로고
    • MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
    • Asangani IA, Rasheed SA, Nikolova DA, et al: MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 27: 2128-2136, 2008.
    • (2008) Oncogene , vol.27 , pp. 2128-2136
    • Asangani, I.A.1    Rasheed, S.A.2    Nikolova, D.A.3
  • 15
    • 40449131878 scopus 로고    scopus 로고
    • Loss of mir-146a function in hormone-refractory prostate cancer
    • Lin SL, Chiang A, Chang D and Ying SY: Loss of mir-146a function in hormone-refractory prostate cancer. RNA 14: 417-424, 2008.
    • (2008) RNA , vol.14 , pp. 417-424
    • Lin, S.L.1    Chiang, A.2    Chang, D.3    Ying, S.Y.4
  • 16
    • 48949115082 scopus 로고    scopus 로고
    • MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines
    • Crawford M, Brawner E, Batte K, et al: MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. Biochem Biophys Res Commun 373: 607-612, 2008.
    • (2008) Biochem Biophys Res Commun , vol.373 , pp. 607-612
    • Crawford, M.1    Brawner, E.2    Batte, K.3
  • 17
    • 38849107424 scopus 로고    scopus 로고
    • The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis
    • Huang Q, Gumireddy K, Schrier M, et al: The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. Nat Cell Biol 10: 202-210, 2008.
    • (2008) Nat Cell Biol , vol.10 , pp. 202-210
    • Huang, Q.1    Gumireddy, K.2    Schrier, M.3
  • 18
    • 77956296766 scopus 로고    scopus 로고
    • Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer
    • Hwang JH, Voortman J, Giovannetti E, et al: Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer. PloS One 5: e10630, 2010.
    • (2010) PloS One , vol.5 , pp. 10630
    • Hwang, J.H.1    Voortman, J.2    Giovannetti, E.3
  • 19
    • 77953169001 scopus 로고    scopus 로고
    • MicroRNA-21 in pancreatic cancer: Correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity
    • Giovannetti E, Funel N, Peters GJ, et al: MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity. Cancer Res 70: 4528-4538, 2010.
    • (2010) Cancer Res , vol.70 , pp. 4528-4538
    • Giovannetti, E.1    Funel, N.2    Peters, G.J.3
  • 20
    • 66849124564 scopus 로고    scopus 로고
    • MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance
    • Moriyama T, Ohuchida K, Mizumoto K, et al: MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance. Mol Cancer Ther 8: 1067-1074, 2009.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1067-1074
    • Moriyama, T.1    Ohuchida, K.2    Mizumoto, K.3
  • 21
    • 52149102044 scopus 로고    scopus 로고
    • Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells
    • Bhaumik D, Scott GK, Schokrpur S, Patil CK, Campisi J and Benz CC: Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells. Oncogene 27: 5643-5647, 2008.
    • (2008) Oncogene , vol.27 , pp. 5643-5647
    • Bhaumik, D.1    Scott, G.K.2    Schokrpur, S.3    Patil, C.K.4    Campisi, J.5    Benz, C.C.6
  • 22
    • 79960336510 scopus 로고    scopus 로고
    • Clinical significance of miR-146a in gastric cancer cases
    • Kogo R, Mimori K, Tanaka F, Komune S and Mori M: Clinical significance of miR-146a in gastric cancer cases. Clin Cancer Res 17: 4277-4284, 2011.
    • (2011) Clin Cancer Res , vol.17 , pp. 4277-4284
    • Kogo, R.1    Mimori, K.2    Tanaka, F.3    Komune, S.4    Mori, M.5
  • 23
    • 0037242595 scopus 로고    scopus 로고
    • Function of nuclear factor kappaB in pancreatic cancer metastasis
    • Fujioka S, Sclabas GM, Schmidt C, et al: Function of nuclear factor kappaB in pancreatic cancer metastasis. Clin Cancer Res 9: 346-354, 2003.
    • (2003) Clin Cancer Res , vol.9 , pp. 346-354
    • Fujioka, S.1    Sclabas, G.M.2    Schmidt, C.3
  • 24
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in cancer development and progression
    • Karin M: Nuclear factor-kappaB in cancer development and progression. Nature 441: 431-436, 2006.
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 25
    • 76749152907 scopus 로고    scopus 로고
    • MiR-146a suppresses invasion of pancreatic cancer cells
    • Li Y, Vandenboom TG II, Wang Z, et al: miR-146a suppresses invasion of pancreatic cancer cells. Cancer Res 70: 1486-1495, 2010.
    • (2010) Cancer Res , vol.70 , pp. 1486-1495
    • Li, Y.1    Vandenboom, T.G.I.I.2    Wang, Z.3
  • 26
    • 80455174863 scopus 로고    scopus 로고
    • Inhibitory effects of miR-146b-5p on cell migration and invasion of pancreatic cancer by targeting MMP16
    • Lin F, Wang X, Jie Z, et al: Inhibitory effects of miR-146b-5p on cell migration and invasion of pancreatic cancer by targeting MMP16. J Huazhong Univ Sci Technolog Med Sci 31: 509-514, 2011.
    • (2011) J Huazhong Univ Sci Technolog Med Sci , vol.31 , pp. 509-514
    • Lin, F.1    Wang, X.2    Jie, Z.3
  • 27
    • 77957948990 scopus 로고    scopus 로고
    • MiR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2
    • Ma Y, Yu S, Zhao W, Lu Z and Chen J: miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2. Cancer Lett 298: 150-158, 2010.
    • (2010) Cancer Lett , vol.298 , pp. 150-158
    • Ma, Y.1    Yu, S.2    Zhao, W.3    Lu, Z.4    Chen, J.5
  • 28
    • 77953950190 scopus 로고    scopus 로고
    • MicroRNA, hsa-miR-200c, is an independent prognostic factor in pancreatic cancer and its upregulation inhibits pancreatic cancer invasion but increases cell proliferation
    • Yu J, Ohuchida K, Mizumoto K, et al: MicroRNA, hsa-miR-200c, is an independent prognostic factor in pancreatic cancer and its upregulation inhibits pancreatic cancer invasion but increases cell proliferation. Mol Cancer 9: 169, 2010.
    • (2010) Mol Cancer , vol.9 , pp. 169
    • Yu, J.1    Ohuchida, K.2    Mizumoto, K.3
  • 29
    • 77955517749 scopus 로고    scopus 로고
    • hsa-miR-520h downregulates ABCG2 in pancreatic cancer cells to inhibit migration, invasion, and side populations
    • Wang F, Xue X, Wei J, et al: hsa-miR-520h downregulates ABCG2 in pancreatic cancer cells to inhibit migration, invasion, and side populations. Br J Cancer 103: 567-574, 2010.
    • (2010) Br J Cancer , vol.103 , pp. 567-574
    • Wang, F.1    Xue, X.2    Wei, J.3
  • 30
    • 80052445088 scopus 로고    scopus 로고
    • MicroRNA-10b expression correlates with response to neoadjuvant therapy and survival in pancreatic ductal adenocarcinoma
    • Preis M, Gardner TB, Gordon SR, et al: MicroRNA-10b expression correlates with response to neoadjuvant therapy and survival in pancreatic ductal adenocarcinoma. Clin Cancer Res 17: 5812-5821, 2011.
    • (2011) Clin Cancer Res , vol.17 , pp. 5812-5821
    • Preis, M.1    Gardner, T.B.2    Gordon, S.R.3
  • 31
    • 81855183857 scopus 로고    scopus 로고
    • MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells
    • Srivastava SK, Bhardwaj A, Singh S, et al: MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells. Carcinogenesis 32: 1832-1839, 2011.
    • (2011) Carcinogenesis , vol.32 , pp. 1832-1839
    • Srivastava, S.K.1    Bhardwaj, A.2    Singh, S.3
  • 32
    • 78049265813 scopus 로고    scopus 로고
    • MicroRNA miR-17-5p is overexpressed in pancreatic cancer, associated with a poor prognosis, and involved in cancer cell proliferation and invasion
    • Yu J, Ohuchida K, Mizumoto K, Fujita H, Nakata K and Tanaka M: MicroRNA miR-17-5p is overexpressed in pancreatic cancer, associated with a poor prognosis, and involved in cancer cell proliferation and invasion. Cancer Biol Ther 10: 748-757, 2010.
    • (2010) Cancer Biol Ther , vol.10 , pp. 748-757
    • Yu, J.1    Ohuchida, K.2    Mizumoto, K.3    Fujita, H.4    Nakata, K.5    Tanaka, M.6
  • 33
    • 70350596499 scopus 로고    scopus 로고
    • MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines
    • Muniyappa MK, Dowling P, Henry M, et al: MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines. Eur J Cancer 45: 3104-3118, 2009.
    • (2009) Eur J Cancer , vol.45 , pp. 3104-3118
    • Muniyappa, M.K.1    Dowling, P.2    Henry, M.3
  • 34
    • 78650096337 scopus 로고    scopus 로고
    • MicroRNA-20a overexpression inhibited proliferation and metastasis of pancreatic carcinoma cells
    • Yan H, Wu J, Liu W, et al: MicroRNA-20a overexpression inhibited proliferation and metastasis of pancreatic carcinoma cells. Hum Gene Ther 21: 1723-1734, 2010.
    • (2010) Hum Gene Ther , vol.21 , pp. 1723-1734
    • Yan, H.1    Wu, J.2    Liu, W.3
  • 35
    • 84855992618 scopus 로고    scopus 로고
    • MiR-126 acts as a tumor suppressor in pancreatic cancer cells via the regulation of ADAM9
    • Hamada S, Satoh K, Fujibuchi W, et al: MiR-126 acts as a tumor suppressor in pancreatic cancer cells via the regulation of ADAM9. Mol Cancer Res 10: 3-10, 2012.
    • (2012) Mol Cancer Res , vol.10 , pp. 3-10
    • Hamada, S.1    Satoh, K.2    Fujibuchi, W.3
  • 36
    • 84862777219 scopus 로고    scopus 로고
    • Metformin alters the expression profiles of microRNAs in human pancreatic cancer cells
    • Li W, Yuan Y, Huang L, Qiao M and Zhang Y: Metformin alters the expression profiles of microRNAs in human pancreatic cancer cells. Diabetes Res Clin Pract 96: 187-195, 2012.
    • (2012) Diabetes Res Clin Pract , vol.96 , pp. 187-195
    • Li, W.1    Yuan, Y.2    Huang, L.3    Qiao, M.4    Zhang, Y.5
  • 37
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY and Nieto MA: Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890, 2009.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 38
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • Thiery JP and Sleeman JP: Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7: 131-142, 2006.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 39
    • 33749024777 scopus 로고    scopus 로고
    • Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis
    • Christiansen JJ and Rajasekaran AK: Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res 66: 8319-8326, 2006.
    • (2006) Cancer Res , vol.66 , pp. 8319-8326
    • Christiansen, J.J.1    Rajasekaran, A.K.2
  • 40
    • 84863115473 scopus 로고    scopus 로고
    • Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition
    • Xiong H, Hong J, Du W, et al: Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition. J Biol Chem 287: 5819-5832, 2012.
    • (2012) J Biol Chem , vol.287 , pp. 5819-5832
    • Xiong, H.1    Hong, J.2    Du, W.3
  • 41
    • 77954030498 scopus 로고    scopus 로고
    • NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells
    • Maier HJ, Schmidt-Strassburger U, Huber MA, Wiedemann EM, Beug H and Wirth T: NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells. Cancer Lett 295: 214-228, 2010.
    • (2010) Cancer Lett , vol.295 , pp. 214-228
    • Maier, H.J.1    Schmidt-Strassburger, U.2    Huber, M.A.3    Wiedemann, E.M.4    Beug, H.5    Wirth, T.6
  • 42
    • 39049160267 scopus 로고    scopus 로고
    • The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer
    • Spaderna S, Schmalhofer O, Wahlbuhl M, et al: The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer. Cancer Res 68: 537-544, 2008.
    • (2008) Cancer Res , vol.68 , pp. 537-544
    • Spaderna, S.1    Schmalhofer, O.2    Wahlbuhl, M.3
  • 43
    • 47249091921 scopus 로고    scopus 로고
    • The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
    • Korpal M, Lee ES, Hu G and Kang Y: The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem 283: 14910-14914, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 14910-14914
    • Korpal, M.1    Lee, E.S.2    Hu, G.3    Kang, Y.4
  • 44
    • 44649163918 scopus 로고    scopus 로고
    • A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    • Burk U, Schubert J, Wellner U, et al: A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep 9: 582-589, 2008.
    • (2008) EMBO Rep , vol.9 , pp. 582-589
    • Burk, U.1    Schubert, J.2    Wellner, U.3
  • 45
    • 73049110243 scopus 로고    scopus 로고
    • The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
    • Wellner U, Schubert J, Burk UC, et al: The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol 11: 1487-1495, 2009.
    • (2009) Nat Cell Biol , vol.11 , pp. 1487-1495
    • Wellner, U.1    Schubert, J.2    Burk, U.C.3
  • 46
    • 68949213672 scopus 로고    scopus 로고
    • Let-7 microRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression
    • Torrisani J, Bournet B, du Rieu MC, et al: let-7 microRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression. Hum Gene Ther 20: 831-844, 2009.
    • (2009) Hum Gene Ther , vol.20 , pp. 831-844
    • Torrisani, J.1    Bournet, B.2    du Rieu, M.C.3
  • 47
    • 78650211014 scopus 로고    scopus 로고
    • Differentially expressed miRNAs in the plasma may provide a molecular signature for aggressive pancreatic cancer
    • Ali S, Almhanna K, Chen W, Philip PA and Sarkar FH: Differentially expressed miRNAs in the plasma may provide a molecular signature for aggressive pancreatic cancer. Am J Transl Res 3: 28-47, 2010.
    • (2010) Am J Transl Res , vol.3 , pp. 28-47
    • Ali, S.1    Almhanna, K.2    Chen, W.3    Philip, P.A.4    Sarkar, F.H.5
  • 48
    • 69249096109 scopus 로고    scopus 로고
    • Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells
    • Li Y, VandenBoom TG II, Kong D, et al: Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells. Cancer Res 69: 6704-6712, 2009.
    • (2009) Cancer Res , vol.69 , pp. 6704-6712
    • Li, Y.1    Vandenboom, T.G.I.I.2    Kong, D.3
  • 49
    • 33644560281 scopus 로고    scopus 로고
    • Cancer stem cells: An old idea - a paradigm shift
    • discussion 1895-1896
    • Wicha MS, Liu S and Dontu G: Cancer stem cells: an old idea - a paradigm shift. Cancer Res 66: 1883-1890; discussion 1895-1896, 2006.
    • (2006) Cancer Res , vol.66 , pp. 1883-1890
    • Wicha, M.S.1    Liu, S.2    Dontu, G.3
  • 50
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D and Dick JE: Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3: 730-737, 1997.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 51
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • Singh SK, Hawkins C, Clarke ID, et al: Identification of human brain tumour initiating cells. Nature 432: 396-401, 2004.
    • (2004) Nature , vol.432 , pp. 396-401
    • Singh, S.K.1    Hawkins, C.2    Clarke, I.D.3
  • 53
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • O'Brien CA, Pollett A, Gallinger S and Dick JE: A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445: 106-110, 2007.
    • (2007) Nature , vol.445 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 54
    • 33847052127 scopus 로고    scopus 로고
    • Identification of pancreatic cancer stem cells
    • Li C, Heidt DG, Dalerba P, et al: Identification of pancreatic cancer stem cells. Cancer Res 67: 1030-1037, 2007.
    • (2007) Cancer Res , vol.67 , pp. 1030-1037
    • Li, C.1    Heidt, D.G.2    Dalerba, P.3
  • 55
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • Hermann PC, Huber SL, Herrler T, et al: Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 1: 313-323, 2007.
    • (2007) Cell Stem Cell , vol.1 , pp. 313-323
    • Hermann, P.C.1    Huber, S.L.2    Herrler, T.3
  • 56
    • 77954921889 scopus 로고    scopus 로고
    • Enhanced cell migration and invasion of CD133+ pancreatic cancer cells cocultured with pancreatic stromal cells
    • Moriyama T, Ohuchida K, Mizumoto K, et al: Enhanced cell migration and invasion of CD133+ pancreatic cancer cells cocultured with pancreatic stromal cells. Cancer 116: 3357-3368, 2010.
    • (2010) Cancer , vol.116 , pp. 3357-3368
    • Moriyama, T.1    Ohuchida, K.2    Mizumoto, K.3
  • 57
    • 77955599004 scopus 로고    scopus 로고
    • Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas
    • May R, Sureban SM, Lightfoot SA, et al: Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas. Am J Physiol Gastrointest Liver Physiol 299: G303-310, 2010.
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.299 , pp. 303-310
    • May, R.1    Sureban, S.M.2    Lightfoot, S.A.3
  • 58
    • 79952748822 scopus 로고    scopus 로고
    • DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism
    • Sureban SM, May R, Lightfoot SA, et al: DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism. Cancer Res 71: 2328-2338, 2011.
    • (2011) Cancer Res , vol.71 , pp. 2328-2338
    • Sureban, S.M.1    May, R.2    Lightfoot, S.A.3
  • 59
    • 34250868124 scopus 로고    scopus 로고
    • Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: MiR-34a is a p53 target that induces apoptosis and G1-arrest
    • Tarasov V, Jung P, Verdoodt B, et al: Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. Cell Cycle 6: 1586-1593, 2007.
    • (2007) Cell Cycle , vol.6 , pp. 1586-1593
    • Tarasov, V.1    Jung, P.2    Verdoodt, B.3
  • 60
    • 34547458550 scopus 로고    scopus 로고
    • P53-mediated activation of miRNA34 candidate tumor-suppressor genes
    • Bommer GT, Gerin I, Feng Y, et al: p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol 17: 1298-1307, 2007.
    • (2007) Curr Biol , vol.17 , pp. 1298-1307
    • Bommer, G.T.1    Gerin, I.2    Feng, Y.3
  • 61
    • 69949087531 scopus 로고    scopus 로고
    • MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells
    • Ji Q, Hao X, Zhang M, et al: MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PloS One 4: e6816, 2009.
    • (2009) PloS One , vol.4 , pp. 6816
    • Ji, Q.1    Hao, X.2    Zhang, M.3
  • 62
    • 53949090314 scopus 로고    scopus 로고
    • Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres
    • Ji Q, Hao X, Meng Y, et al: Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. BMC Cancer 8: 266, 2008.
    • (2008) BMC Cancer , vol.8 , pp. 266
    • Ji, Q.1    Hao, X.2    Meng, Y.3
  • 63
    • 84855405573 scopus 로고    scopus 로고
    • Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression
    • Bao B, Ali S, Banerjee S, et al: Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression. Cancer Res 72: 335-345, 2012.
    • (2012) Cancer Res , vol.72 , pp. 335-345
    • Bao, B.1    Ali, S.2    Banerjee, S.3
  • 64
    • 67349193226 scopus 로고    scopus 로고
    • Emerging role of Notch in stem cells and cancer
    • Wang Z, Li Y, Banerjee S and Sarkar FH: Emerging role of Notch in stem cells and cancer. Cancer Lett 279: 8-12, 2009.
    • (2009) Cancer Lett , vol.279 , pp. 8-12
    • Wang, Z.1    Li, Y.2    Banerjee, S.3    Sarkar, F.H.4
  • 66
    • 50849104230 scopus 로고    scopus 로고
    • Notch tumor suppressor function
    • Dotto GP: Notch tumor suppressor function. Oncogene 27: 5115-5123, 2008.
    • (2008) Oncogene , vol.27 , pp. 5115-5123
    • Dotto, G.P.1
  • 67
    • 33645049305 scopus 로고    scopus 로고
    • Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells
    • Wang Z, Banerjee S, Li Y, Rahman KM, Zhang Y and Sarkar FH: Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. Cancer Res 66: 2778-2784, 2006.
    • (2006) Cancer Res , vol.66 , pp. 2778-2784
    • Wang, Z.1    Banerjee, S.2    Li, Y.3    Rahman, K.M.4    Zhang, Y.5    Sarkar, F.H.6
  • 68
    • 70349751655 scopus 로고    scopus 로고
    • Development and cancer: At the crossroads of Nodal and Notch signaling
    • Strizzi L, Hardy KM, Seftor EA, et al: Development and cancer: at the crossroads of Nodal and Notch signaling. Cancer Res 69: 7131-7134, 2009.
    • (2009) Cancer Res , vol.69 , pp. 7131-7134
    • Strizzi, L.1    Hardy, K.M.2    Seftor, E.A.3
  • 69
    • 77951096677 scopus 로고    scopus 로고
    • Targeting Notch signaling in pancreatic cancer
    • Ristorcelli E and Lombardo D: Targeting Notch signaling in pancreatic cancer. Expert Opin Ther Targets 14: 541-552, 2010.
    • (2010) Expert Opin Ther Targets , vol.14 , pp. 541-552
    • Ristorcelli, E.1    Lombardo, D.2
  • 70
    • 80052316514 scopus 로고    scopus 로고
    • Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells
    • Nalls D, Tang SN, Rodova M, Srivastava RK and Shankar S: Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells. PloS One 6: e24099, 2011.
    • (2011) PloS One , vol.6 , pp. 24099
    • Nalls, D.1    Tang, S.N.2    Rodova, M.3    Srivastava, R.K.4    Shankar, S.5
  • 71
    • 79957487931 scopus 로고    scopus 로고
    • Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells
    • Bao B, Wang Z, Ali S, et al: Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells. Cancer Lett 307: 26-36, 2011.
    • (2011) Cancer Lett , vol.307 , pp. 26-36
    • Bao, B.1    Wang, Z.2    Ali, S.3
  • 73
    • 33947254016 scopus 로고    scopus 로고
    • Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers
    • Feldmann G, Dhara S, Fendrich V, et al: Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res 67: 2187-2196, 2007.
    • (2007) Cancer Res , vol.67 , pp. 2187-2196
    • Feldmann, G.1    Dhara, S.2    Fendrich, V.3
  • 74
    • 53549129980 scopus 로고    scopus 로고
    • Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells
    • Ferretti E, De Smaele E, Miele E, et al: Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells. EMBO J 27: 2616-2627, 2008.
    • (2008) EMBO J , vol.27 , pp. 2616-2627
    • Ferretti, E.1    de Smaele, E.2    Miele, E.3
  • 75
    • 65249186793 scopus 로고    scopus 로고
    • The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors
    • Northcott PA, Fernandez LA, Hagan JP, et al: The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors. Cancer Res 69: 3249-3255, 2009.
    • (2009) Cancer Res , vol.69 , pp. 3249-3255
    • Northcott, P.A.1    Fernandez, L.A.2    Hagan, J.P.3
  • 76
    • 48849104705 scopus 로고    scopus 로고
    • Control of antagonistic components of the hedgehog signaling pathway by microRNAs in Drosophila
    • Friggi-Grelin F, Lavenant-Staccini L and Therond P: Control of antagonistic components of the hedgehog signaling pathway by microRNAs in Drosophila. Genetics 179: 429-439, 2008.
    • (2008) Genetics , vol.179 , pp. 429-439
    • Friggi-Grelin, F.1    Lavenant-Staccini, L.2    Therond, P.3
  • 77
    • 33751264968 scopus 로고    scopus 로고
    • Synthetic microRNA designed to target glioma-associated antigen 1 transcription factor inhibits division and induces late apoptosis in pancreatic tumor cells
    • Tsuda N, Ishiyama S, Li Y, Ioannides CG, Abbruzzese JL and Chang DZ: Synthetic microRNA designed to target glioma-associated antigen 1 transcription factor inhibits division and induces late apoptosis in pancreatic tumor cells. Clin Cancer Res 12: 6557-6564, 2006.
    • (2006) Clin Cancer Res , vol.12 , pp. 6557-6564
    • Tsuda, N.1    Ishiyama, S.2    Li, Y.3    Ioannides, C.G.4    Abbruzzese, J.L.5    Chang, D.Z.6
  • 78
    • 77955033963 scopus 로고    scopus 로고
    • MiRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancer
    • Yu S, Lu Z, Liu C, et al: miRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancer. Cancer Res 70: 6015-6025, 2010.
    • (2010) Cancer Res , vol.70 , pp. 6015-6025
    • Yu, S.1    Lu, Z.2    Liu, C.3
  • 79
    • 79954455860 scopus 로고    scopus 로고
    • Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas
    • Vogt M, Munding J, Gruner M, et al: Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas. Virchows Arch 458: 313-322, 2011.
    • (2011) Virchows Arch , vol.458 , pp. 313-322
    • Vogt, M.1    Munding, J.2    Gruner, M.3
  • 80
    • 34147096292 scopus 로고    scopus 로고
    • Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression
    • Tashiro E, Tsuchiya A and Imoto M: Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression. Cancer Sci 98: 629-635, 2007.
    • (2007) Cancer Sci , vol.98 , pp. 629-635
    • Tashiro, E.1    Tsuchiya, A.2    Imoto, M.3
  • 81
    • 65449166892 scopus 로고    scopus 로고
    • Epigenetic silencing of MicroRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancer
    • Lee KH, Lotterman C, Karikari C, et al: Epigenetic silencing of MicroRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancer. Pancreatology 9: 293-301, 2009.
    • (2009) Pancreatology , vol.9 , pp. 293-301
    • Lee, K.H.1    Lotterman, C.2    Karikari, C.3
  • 82
    • 0031944607 scopus 로고    scopus 로고
    • CD40 and CD154 in cell-mediated immunity
    • Grewal IS and Flavell RA: CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol 16: 111-135, 1998.
    • (1998) Annu Rev Immunol , vol.16 , pp. 111-135
    • Grewal, I.S.1    Flavell, R.A.2
  • 83
    • 0032704976 scopus 로고    scopus 로고
    • What is the real role of CD40 in cancer immunotherapy?
    • Costello RT, Gastaut JA and Olive D: What is the real role of CD40 in cancer immunotherapy? Immunology Today 20: 488-493, 1999.
    • (1999) Immunology Today , vol.20 , pp. 488-493
    • Costello, R.T.1    Gastaut, J.A.2    Olive, D.3
  • 84
    • 67650999145 scopus 로고    scopus 로고
    • Involvement of CD40 targeting miR-224 and miR-486 on the progression of pancreatic ductal adenocarcinomas
    • Mees ST, Mardin WA, Sielker S, et al: Involvement of CD40 targeting miR-224 and miR-486 on the progression of pancreatic ductal adenocarcinomas. Ann Surg Oncol 16: 2339-2350, 2009.
    • (2009) Ann Surg Oncol , vol.16 , pp. 2339-2350
    • Mees, S.T.1    Mardin, W.A.2    Sielker, S.3
  • 85
    • 0033000990 scopus 로고    scopus 로고
    • Histone acetylases and deacetylases in cell proliferation
    • Kouzarides T: Histone acetylases and deacetylases in cell proliferation. Curr Opin Genet Dev 9: 40-48, 1999.
    • (1999) Curr Opin Genet Dev , vol.9 , pp. 40-48
    • Kouzarides, T.1
  • 86
    • 0031439397 scopus 로고    scopus 로고
    • Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13)
    • Ida K, Kitabayashi I, Taki T, et al: Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13). Blood 90: 4699-4704, 1997.
    • (1997) Blood , vol.90 , pp. 4699-4704
    • Ida, K.1    Kitabayashi, I.2    Taki, T.3
  • 87
    • 73449085536 scopus 로고    scopus 로고
    • EP300 - a miRNA-regulated metastasis suppressor gene in ductal adenocarcinomas of the pancreas
    • Mees ST, Mardin WA, Wendel C, et al: EP300 - a miRNA-regulated metastasis suppressor gene in ductal adenocarcinomas of the pancreas. Int J Cancer 126: 114-124, 2010.
    • (2010) Int J Cancer , vol.126 , pp. 114-124
    • Mees, S.T.1    Mardin, W.A.2    Wendel, C.3


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