Involvement of CD40 targeting miR-224 and miR-486 on the progression of pancreatic ductal adenocarcinomas

Annals of Surgical Oncology

Volumn 16, Issue 8, 2009, Pages 2339-2350

  Mees, Soeren Torge ^a   Mardin, Wolf Arif ^a   Sielker, Sonja ^b   Willscher, Edith ^c   Senninger, Norbert ^a   Schleicher, Christina ^a   Colombo Benkmann, Mario ^a   Haier, Joerg ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b Arrows Biomedical Deutschland GmbH   (Germany)

^c Integrated Functional Genomics ^*  (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 LIGAND; MESSENGER RNA; MICRORNA; MICRORNA 224; MICRORNA 486; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER INVASION; CONTROLLED STUDY; EPIGENETICS; FLOW CYTOMETRY; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENE TARGETING; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MALE; METASTASIS; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PANCREAS DUCT; QUANTITATIVE ANALYSIS;

ADENOCARCINOMA; ANIMALS; ANTIGENS, CD40; CARCINOMA, PANCREATIC DUCTAL; DISEASE PROGRESSION; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICE; MICE, NUDE; MICRORNAS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PANCREATIC NEOPLASMS; RNA, MESSENGER; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 67650999145     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-009-0531-4     Document Type: Article

References (44)

1. MG Raraty CJ Magee P Ghaneh 2002 New techniques and agents in the adjuvant therapy of pancreatic cancer Acta Oncol 41 582 595
2. G Schneider JT Siveke F Eckel 2005 Pancreatic cancer: basic and clinical aspects Gastroenterology 128 1606 1625
3. AF Hezel AC Kimmelman BZ Stanger 2006 Genetics and biology of pancreatic ductal adenocarcinoma Genes Dev 20 1218 1249
4. EM Jaffee RH Hruban M Canto 2002 Focus on pancreas cancer Cancer Cell 2 25 28
5. A Esquela-Kerscher FJ Slack 2006 Oncomirs-micro-RNAs with a role in cancer Nat Rev Cancer 6 259 269
6. C Sevignani GA Calin LD Siracusa 2006 Mammalian microRNAs: a small world for fine-tuning gene expression Mamm Genome 17 189 202
7. DP Bartel 2004 MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 281 297
8. MA Valencia-Sanchez J Liu GJ Hannon 2006 Control of translation and mRNA degradation by miRNAs and siRNAs Genes Dev 20 515 524
9. E Hornstein JH Mansfield S Yekta 2006 The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development Nature 438 671 674
10. J Takamizawa H Konishi K Yanagisawa 2004 Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival Cancer Res 64 3753 3756
11. GA Calin C Sevignani CD Dumitru 2004 Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers Proc Natl Acad Sci USA 01 2999 3004
12. J Lu G Getz EA Miska 2005 MicroRNA expression profiles classify human cancers Nature 435 834 838
13. SP Thayer MP di Magliano PW Heiser 2003 Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis Nature 425 851 856
14. Y Miyamoto A Maitra B Ghosh 2003 Notch mediates TGF a-induced changes in epithelial differentiation during pancreatic tumorigenesis Cancer Cell 3 565 576
15. HG Hotz HA Reber B Hotz 2003 An orthotopic nude mouse model for evaluating pathophysiology and therapy of pancreatic cancer Pancreas 26 89 98
16. S Griffiths-Jones HK Saini S van Dongen 2008 miRBase: tools for microRNA genomics Nucleic Acids Res 36 154 158
17. Y Hochberg Y Benjamini 1990 More powerful procedures for multiple significance testing Stat Med 9 811 818
18. KJ Livak TD Schmittgen 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 402 408
19. M Megraw P Sethupathy B Corda 2006 miRGen: a database for the study of animal microRNA genomic organization and function Nucleic Acids Res 35 149 155
20. AB Alexandroff AM Jackson T Paterson 2000 Role for CD40-CD40 ligand interactions in the immune response to solid tumours Mol Immunol 37 515 526
21. MN Nikiforova GC Tseng D Steward 2008 MicroRNA expression profiling of thyroid tumors: biological significance and diagnostic utility J Clin Endocrinol Metab 93 1600 1608
22. Y Wang AT Lee JZ Ma 2008 Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target J Biol Chem 283 13205 13215
23. Y Ladeiro G Couchy C Balabaud 2008 MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations Hepatology 47 1955 1963
24. RL Prueitt M Yi RS Hudson 2008 Expression of microRNAs and protein-coding genes associated with perineural invasion in prostate cancer Prostate 68 1152 1164
25. Z Li J Lu M Sun 2008 Distinct microRNA expression profiles in acute myeloid leukemia with common translocations Proc Natl Acad Sci USA 105 15535 15540
26. GJ Hannon 2002 RNA interference Nature 418 244 251
27. S Yekta IH Shih DP Bartel 2004 MicroRNA-directed cleavage of HOXB8 mRNA Science 304 594 596
28. RS Pillai SN Bhattacharyya CG Artus 2005 Inhibition of translational initiation by let-7 microRNA in human cells Science 309 1573 1576
29. BJ Reinhart FJ Slack M Basson 2000 The 21 nucleotide let-7 RNA regulates C elegans developmental timing Nature 403 901 906
30. M Dillhoff J Liu W Frankel 2008 MicroRNA-21 is overexpressed in pancreatic cancer and a potential predictor of survival J Gastrointest Surg 12 2171 2176
31. C Roldo E Missiaglia JP Hagan 2006 MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior J Clin Oncol 24 4677 4684
32. M Bloomston WL Frankel F Petrocca 2007 MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis JAMA 297 1901 1908
33. H Gal G Pandi AA Kanner 2008 MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells Biochem Biophys Res Commun 376 86 90
34. S Qian JY Ding R Xie 2008 MicroRNA expression profile of bronchioalveolar stem cells from mouse lung Biochem Biophys Res Commun 377 668 673
35. IS Grewal RA Flavell 1998 CD40 and CD154 in cell-mediated immunity Annu Rev Immunol 16 111 135
36. RT Costello JA Gastaut D Olive 1999 What is the real role of CD40 in cancer immunotherapy? Immunol Today 20 488 493
37. A Nakajima T Kodama S Morimoto 1998 Antitumour effect of CD40 ligand: elicitation of local and systemic antitumour responses by IL-12 and B7 J Immunol 161 1901 1907
38. S Paulie B Ehlin-Henriksson H Mellstedt 1985 A p50 surface antigen restricted to human urinary bladder carcinomas and B lymphocytes Cancer Immunol Immunother 20 23 28
39. J Hamzah D Nelson G Moldenhauer 2008 Vascular targeting of anti-CD40 antibodies and IL-2 into autochthonous tumors enhances immunotherapy in mice J Clin Invest 118 1691 1699
40. SR Walker RE Redlinger Jr EM Barksdale Jr 2005 Neuroblastoma-induced inhibition of dendritic cell IL-12 production via abrogation of CD40 expression J Pediatr Surg 40 244 249
41. LE French B Huard M Wysocka 2005 Impaired CD40L signaling is a cause of defective IL-12 and TNF-alpha production in Sezary syndrome: circumvention by hexameric soluble CD40L Blood 105 219 225
42. MR Shurin ZR Yurkovetsky IL Tourkova 2002 Inhibition of CD40 expression and CD40-mediated dendritic cell function by tumour-derived IL-10 Int J Cancer 101 61 68
43. E Ryschich A Märten E Schmidt 2006 Activating anti-CD40 antibodies induce tumour invasion by cytotoxic T-lymphocytes and inhibition of tumour growth in experimental liver cancer Eur J Cancer 42 981 987
44. S Serba J Schmidt N Wentzensen 2008 Transfection with CD40L induces tumour suppression by dendritic cell activation in an orthotopic mouse model of pancreatic adenocarcinoma Gut 57 344 351