Characterizing the effects of Eugenol on neuronal ionic currents and hyperexcitability

Psychopharmacology

Volumn 221, Issue 4, 2012, Pages 575-587

  Huang, Chin Wei ^a   Chow, Julie Chi ^b   Tsai, Jing Jane ^a   Wu, Sheng Nan ^c  

^a NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^b CHI MEI MEDICAL CENTER   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Action potential; Ca 2+ current; Eugenol; K + current; Na + current; Neuron

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM ION; CYCLIC AMP; DELAYED RECTIFIER POTASSIUM CHANNEL; EUGENODILOL; EUGENOL; EUGENOLOL; PILOCARPINE; PLANT MEDICINAL PRODUCT; POTASSIUM ION; RILUZOLE; SODIUM CHANNEL BLOCKING AGENT; SODIUM ION; TEFLUTHRIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CURRENT; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG MECHANISM; GLIOMA CELL; GROWTH INHIBITION; IC 50; IN VIVO STUDY; ION CURRENT; LATENT PERIOD; MORTALITY; MOUSE; NERVE CELL DIFFERENTIATION; NERVE CELL HYPEREXCITABILITY; NERVE POTENTIAL; NERVOUS SYSTEM PARAMETERS; NEUROBLASTOMA CELL; NEUROMODULATION; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SIMULATION; SODIUM CURRENT; TEMPORAL LOBE EPILEPSY;

ACTION POTENTIALS; ANIMALS; CALCIUM CHANNELS, L-TYPE; CELL LINE, TUMOR; DELAYED RECTIFIER POTASSIUM CHANNELS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EUGENOL; GLIOMA; MALE; MICE; NEUROBLASTOMA; NEURONS; PATCH-CLAMP TECHNIQUES; PILOCARPINE; RATS; RATS, SPRAGUE-DAWLEY; RILUZOLE; SEIZURES; SEVERITY OF ILLNESS INDEX; SODIUM CHANNELS;

EID: 84862688950     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-011-2603-y     Document Type: Article

References (61)

1. Ardjmand A, Fathollahi Y, Sayyah M, Kamalinejad M, Omrani A (2006) Eugenol depresses synaptic transmission but does not prevent the induction of long-term potentiation in the CA1 region of rat hippocampal slices. Phytomedicine 13:146-151
2. Benarroch EE (2010) Neuronal voltage-gated calcium channels: brief overview of their function and clinical implications in neurology. Neurology 74:1310-1315
3. Bender IB (2000) Pupal pain diagnosis-a review. J Endod 26:175-179
4. Black JA, Liu S, Tanaka M, Cummins TR, Waxman SG (2004) Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain. Pain 108:237-247
5. 2-agonist and calcium mobilization inhibition associated vasorelaxant activities. Drug Dev Res 40:239-250
6. 2- adrenergic agonist, inhibits neuronal delayed-rectifier potassium current and sodium current. Br J Anaesth 103:244-254
7. Chen S, Su H, Yue C, Remy S, Royeck M, Sochivco D, Opitz T, Beck H, Yaari Y (2011) An increase in persistent sodium current contributes to intrinsic neuronal bursting after status epilepticus. J Neurophysiol 105:117-129
8. +currents in rat dorsal root ganglion neurons. Brain Res 1243:53-62
9. Chung G, Rhee JN, Jung SJ, Kim JS, Oh SB (2008) Modulation of CaV2.3 calcium channel currents by eugenol. J Dent Res 87:137-141
10. Cifelli P, Grace AA (2011) Pilocarpine-induced temporal lobe epilepsy in the rat is associated with increased dopamine neuron activity. Int J Neuropsychopharmacol 12:1-8
11. +channels. Ann N Y Acad Sci 868:233-285
12. Dallmeier K, Carlini EA (1981) Anesthetic, hypothermic, myorelaxant and anticonvulsant effects of synthetic eugenol derivatives and natural analogues. Pharmacology 22:113-127
13. Dallmeier K, Zelger JL, Carlini EA (1983) New anticonvulsants derived from 4-allyl-2-methoxyphenol (Eugenol): comparison with common antiepileptics in mice. Pharmacology 27:40-49
14. Damiani CE, Rossoni LV, Vassallo DV (2003) Vasorelaxant effects of eugenol on rat thoracic aorta. Vascul Pharmacol 40:59-66
15. Damiani CE, Moreira CM, Zhang HT, Creazzo TL, Vassallo DV (2004) Effects of eugenol, an essential oil, on the mechanical and electrical activities of cardiac muscle. J Cardiovasc Pharmacol 44:688-695
16. +channel a subunit protein. J Physiol 546:565-576
17. Duarte FS, Gavioli EC, Duzzioni M, Hoeller AA, Canteras NS, De Lima TC (2010) Short- and long-term anxiogenic effects induced by a single injection of subconvulsant doses of pilocarpine in rats: investigation of the putative role of hippocampal pathways. Psychopharmacology (Berl) 212:653-661
18. Earl DE, Tietz EI (2011) Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors. J Pharmacol Exp Ther 337:301-311
19. Freire CM, Marques MO, Costa M (2006) Effects of seasonal variation on the central nervous system activity of Ocimum gratissimum L. essential oil. J Ethnopharmacol 105:161-166
20. He YL, Zhan XQ, Yang G, Sun J, Mei YA (2010) Amoxapine inhibits the delayed rectifier outward K+current in mouse cortical neurons via cAMP/protein kinase A pathways. J Pharmacol Exp Ther 332:437-445
21. 2-adrenoceptor agonist-associated vasorelaxant activities. J Cardiovasc Pharmacol 34:10-20
22. Huang CW, Huang CC, Lin MW, Tsai JJ,Wu SN (2008) The synergistic inhibitory actions of oxcarbazepine on voltage-gated sodium and potassium currents in differentiated NG108-15 neuronal cells and model neurons. Int J Neuropsychopharmacol 11:597-610
23. Huang CW, Cheng JT, Tsai JJ, Wu SN, Huang CC (2009) Diabetic hyperglycemia aggravates seizures and status epilepticus-induced hippocampal damage. Neurotox Res 15:71-81
24. Huang CW, Wu SN, Cheng JT, Tsai JJ, Huang CC (2010) Diazoxide reduces status epilepticus neuron damage in diabetes. Neurotox Res 17:305-316
25. Huang CW, Wu YJ, Wu SN (2011) Modification of activation kinetics of delayed rectifier K+currents and neuronal excitability by methyl-β- cyclodextrin. Neuroscience 176:431-441
26. Irie Y, Keung WM (2003) Rhizoma acori graminei and its active principles protect PC-12 cells from the toxic effect of amyloid-βpeptide. Brain Res 963:282-289
27. Kawaguchi A, Asano H, Matsushima K, Wada T, Yoshida S, Ichida S (2007) Enhancement of sodium current in NG108-15 cells during neural differentiation is mainly due to an increase in NaV1.7 expression. Neurochem Res 32:1469-1475
28. Köseoǧlu BG, Tanrikulu S, Sübay RK, Sencer S (2006) Anesthesia following overfilling of a root canal sealer into the mandibular canal: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:803-806
29. + current in pituitary GH3 cells. J Biol Chem 279:26885-26892
30. + current in differentiated NG108-15 neuronal cells. Neuropharmacology 54:912-923
31. Lionnet L, Beaudry F, Vachon P (2010) Intrathecal eugenol administration alleviates neuropathic pain in male Sprague-Dawley rats. Phytother Res 24:1645-1653
32. Lossin C, Wang DW, Rhodes TH, Vanoye CG, George AL (2002) Molecular basis of an inherited epilepsy. Neuron 34:877-884
33. Mathew SJ, Murrough JW, aan het Rot M, Collins KA, Reich DL, Charney DS (2010) Riluzole for relapse prevention following intravenous ketamine in treatment-resistant depression: a pilot randomized, placebo-controlled continuation trial. Int J Neuropsychopharmacol 13:71-82
34. Meves H, Schwarz JR,Wulfsen I (1999) Separation of M-like current and ERG current in NG108-15 cells. Br J Pharmacol 127:1213-1223
35. Müller M, Pape HC, Speckmann EJ, Gorji A (2006) Effect of eugenol on spreading depression and epileptiform discharges in rat neocortical and hippocampal tissues. Neuroscience 140:743-751
36. 2-adrenergic receptor stimulates γ-secretase activity and accelerates amyloid plaque formation. Nat Med 12:1390-1396
37. 2+-permeable currents in rat dorsal root ganglion cells. J Dent Res 76:1737-1744
38. Park CK, Kim K, Jung SJ, Kim MJ, Ahn DK, Hong SD, Kim JS, Oh SB (2009) Molecular mechanism for local anesthetic action of eugenol in the rat trigeminal system. Pain 144:84-94
39. Peña F, Tapia R (2000) Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels. Neuroscience 101:547-561
40. Pinsky PF, Rinzel J (1994) Intrinsic and network rhythmogenesis in a reduced Traub model for CA3 neurons. J Comput Neurosci 1:39-60
41. Pitkanen A, Schwartzkroin PA, Moshe SL (2006) Models of seizures and epilepsy. Elsevier Academic Press, Burlington
42. Pourgholami MH, Kamalinejad M, Javadi M, Majzoob S, Sayyah M (1999) Evaluation of the anticonvulsant activity of the essential oil of Eugenia caryophyllata in male mice. J Ethnopharmacol 64:167-171
43. Racine RJ, Burnham WM, Gartner JG, Levitan D (1973) Rates of motor seizure development in rats subjected to electrical brain stimulation: strain and inter-stimulation interval effects. Electroencephalogr Clin Neurophysiol 35:553-556
44. Sayyah M, Valizadeh J, Kamalinejad M (2002) Anticonvulsant activity of the leaf essential oi l of Laurus nobilis against pentylenetetrazole- and maximal electroshock-induced seizures. Phytomedicine 9:212-216
45. Segal MM (2002) Sodium channels and epilepsy electrophysiology. Novartis Found Symp 241:173-180
46. Segal MM, Douglas AF (1997) Late sodium channel openings underlying epileptiform activity are preferentially diminished by the anticonvulsant phenytoin. J Neurophysiol 77:3021-3034
47. Sensch O, Vierling W, Brandt W, Reiter M (2000) Effects of inhibition of calcium and potassium currents in guinea-pig cardiac contraction: comparison of β-caryophyllene oxide, eugenol, and nifedpine. Br J Pharmacol 131:1089-1096
48. Stafstrom CE (2007) Persistent sodium current and its role in epilepsy. Epilepsy Curr 7:15-22
49. Tsai TY, Tsai YC, Wu SN, Liu YC (2006) Tramadol-induced blockade of delayed rectifier potassium current in NG108-15 neuronal cells. Eur J Pain 10:597-601
50. Urbani A, Belluzzi O (2000) Riluzole inhibits the persistent sodium current in mammalian CNS neurons. Eur J Neurosci 12:3567-3574
51. Warren CA, Mok L, Gondon S, Fouad AF, Gold MS (2008) Quantification of neural protein in extirpated tooth pulp. J Endod 34:7-10
52. Wie MB, Won MH, Lee KH, Shin JH, Lee JC, Suh HW, Song DK, Kim YH (1997) Eugenol protects neuronal cells from excitotoxic and oxidative injury in primary cortical cultures. Neurosci Lett 225:93-96
53. Won MH, Lee JC, Kim YH, Song DK, Suh HW, Oh YS, Kim JH, Shin TK, Lee YJ, Wie MB (1998) Postischemic hypothermia induced by eugenol protects hippocampal neurons from global ischemia gerbils. Neurosci Lett 254:101-104
54. 2+ current. Brain Res 812:133-141
55. Wu BN, Shen KP, Lin RJ, Huang YC, Chiang LC, Lo YC, Lin CY, Chen IJ (2000) Lipid solubility of vasodilatory vanilloid-type β-blockers on the functional and binding activities of β- adrenoceptor subtypes. Gen Pharmacol 34:321-328
56. + current in NG108-15 neuronal cells. Neuropharmacology 41:834-843
57. Wu SN, Chen BS, Hsu TI, Peng H, Wu YH, Lo YC (2009a) Analytical studies of rapidly inactivating and noninactivating sodium currents in differentiated NG108-15 neuronal cells. J Theor Biol 259:828-836
58. Wu SN, Chen BS, Wu YH, Peng H, Chen LT (2009b) The mechanism of the actions of oxaliplatin on ion currents and action potentials in differentiatedNG108-15 neuronal cells.Neurotoxicology 30:677-685
59. 3) cells and GnRH-secreting (GT1-7) neurons. Toxicology 258:70-77
60. Yang BH, Piao ZG, Kim YB, Lee CH, Lee JK, Park K, Kim JS, Oh SB (2003) Activation of vanilloid receptor 1 (VR1) by eugenol. J Dent Res 82:781-785
61. Zgrajka W, Nieoczym D, Czuczwar M, Kiś J, Brzana W, Wlaź P, Turski WA (2010) Evidences for pharmacokinetic interaction of riluzole and topiramate with pilocarpine in pilocarpine-induced seizures in rats. Epilepsy Res 88:269-274