Dexmedetomidine, an α2-adrenergic agonist, inhibits neuronal delayed-rectifier potassium current and sodium current

British Journal of Anaesthesia

Volumn 103, Issue 2, 2009, Pages 244-254

  Chen, B S ^a,b   Peng, H ^a   Wu, S N ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

Author keywords

Ions, ion channels, pharmacology; Ions, ion channels, voltage gated; Model, neuroblastoma cells; Pharmacology, dexmedetomidine

Indexed keywords

CALCIUM ION; DEXMEDETOMIDINE; EFAROXAN; POTASSIUM ION; SODIUM ION; YOHIMBINE; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; DELAYED RECTIFIER POTASSIUM CHANNEL; SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CHANNEL GATING; CONTROLLED STUDY; GRANULE CELL; IC 50; MOUSE; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE POTENTIAL; NEUROBLASTOMA CELL; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SODIUM CURRENT; WAVEFORM; ACTION POTENTIAL; ANIMAL; CELL DIFFERENTIATION; CEREBELLUM; DOSE RESPONSE; DRUG EFFECT; METABOLISM; NERVE CELL; PATCH CLAMP; TUMOR CELL CULTURE; WISTAR RAT;

ACTION POTENTIALS; ADRENERGIC ALPHA-AGONISTS; ANIMALS; CELL DIFFERENTIATION; CEREBELLUM; DELAYED RECTIFIER POTASSIUM CHANNELS; DEXMEDETOMIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ION CHANNEL GATING; MICE; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, WISTAR; SODIUM CHANNELS; TUMOR CELLS, CULTURED;

EID: 68049147560     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aep107     Document Type: Article

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