Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: Role of glutamate- and GABA-mediated neurotransmission and of ion channels

Neuroscience

Volumn 101, Issue 3, 2000, Pages 547-561

  Pea, F ^a   Tapia, R ^a  

^a INSTITUTO DE FISIOLOGÍA CELULAR   (Mexico)

Author keywords

Epilepsy; GABA transport; Glutamate release; Hippocampus; Riluzole; Tetrodotoxin

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOPYRIDINE; CARBAMAZEPINE; GLUTAMATE RECEPTOR; GLUTAMIC ACID; ION CHANNEL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; RILUZOLE; TETRODOTOXIN; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONTROLLED STUDY; EPILEPSY; GABAERGIC TRANSMISSION; HIPPOCAMPUS; LATENT PERIOD; MALE; MICRODIALYSIS; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; SEIZURE;

EID: 0034669136     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(00)00400-0     Document Type: Article

References (100)

1. Potassium channel activators abolish excitotoxicity in cultured hippocampal pyramidal neurons
2. Pharmacological evidence for two kinds of GABA receptor on rat hippocampal pyramidal cells studied in vitro
3. Neuronal damage and MAP2 changes induced by the glutamate transport inhibitor dihydrokainate and by kainate in rat hippocampus in vivo
4. Synchronous GABA-mediated potentials and epileptiform discharges in the rat limbic system in vitro
5. Immunohistochemical localization of calcium-binding protein in the cerebellum, hippocampal formation and olfactory bulb of the rat
6. Anticonvulsive effect of AMPA receptor antagonist GYKI 52466 on 4-aminopyridine-induced cortical activity in rat
7. The effect of sodium valproate on extracellular GABA and other amino acids in the rat ventral hippocampus: an in vivo microdialysis study
8. Suppression by GABA(B) receptors of 4-aminopyridine-induced hyperactivity in guinea-pig neurons
9. Glutamate, GABA and epilepsy
10. Effects of standard anticonvulsant drugs on different patterns of epileptiform discharges induced by 4-aminopyridine in combined entorhinal cortex-hippocampal slices
11. 2+) channel of intermediate conductance in bovine aortic endothelial cells
12. Electrophysiology of the neuroprotective agent riluzole on striatal spiny neurons
13. Suppression of 4-aminopyridine-induced epileptogenesis by the GABA(A) agonist muscimol
14. Glutamate neurotoxicity and diseases of the nervous system
15. Effects of GABA-uptake inhibitor tiagabine on electroencephalogram, spike-wave discharges and behaviour of rats
16. Protection against dendrotoxin-induced clonic seizures in mice by anticonvulsant drugs
17. Kainic acid and 4-aminopyridine seizure models in mice: evaluation of efficacy of antiepileptic agents and calcium antagonists
18. The effects of convulsant and anticonvulsant drugs on the release of radiolabeled GABA, glutamate, noradrenaline, serotonin and acetylcholine from rat cortical slices
19. The antibipolar drug valproate mimics lithium in stimulating glutamate release and inositol 1,4,5-trisphosphate accumulation in brain cortex slices but not accumulation of inositol monophosphates and bisphosphates
20. Effect of glutamate receptor antagonist (GYKI 52466) on 4-aminopyridine-induced seizure activity developed in rat cortical slices
21. GABA accelerates excitotoxic cell death in cortical cultures: protection by blockers of GABA-gated chloride channels
22. Patterns of excitatory and inhibitory synaptic transmission in the rat neostriatum as revealed by 4-AP
23. Seizures and wet-dog shakes induced by 4-aminopyridine, and their potentiation by nifedipine
24. NMDA receptor antagonists protect against seizures and wet-dog shakes induced by 4-aminopyridine
25. Effects of antiepileptic drugs on 4-aminopyridine-induced epileptiform activity in young and adult rat hippocampus
26. Extracellular magnesium and anticonvulsant effects of valproate in young rat hippocampus
27. + channel inhibitors
28. + channel blocker-induced seizures
29. Epileptiform activity induced by 4-aminopyridine in rat amygdala neurons: the involvement of N-methyl-D-aspartate receptors
30. Anticonvulsant activity of intracerebroventricularly administered glial GABA uptake inhibitors and other GABA mimetics in chemical seizure models
31. + channel openers protect hippocampal neurons against oxidative injury and amyloid β-peptide toxicity
32. Effects of channel modulators on cloned large-conductance calcium-activated potassium channels
33. Riluzole protects from motor deficits and striatal degeneration produced by systemic 3-nitropropionic acid intoxication in rats
34. On the origin of extracellular glutamate levels monitored in the basal ganglia of the rat by in vivo microdialysis
35. Effects of anticonvulsant lactams on in vitro seizures in the hippocampal slice preparation
36. Postischemic inhibition of GABA reuptake by tiagabine slows neuronal death in the gerbil hippocampus
37. The ontogeny of excitatory amino acid receptors in rat forebrain-I. N-Methyl-D-aspartate and quisqualate receptors
38. Activity-dependent enhancement of hyperpolarizing and depolarizing γ-aminobutyric acid (GABA) synaptic responses following inhibition of GABA uptake tiagabine
39. + currents: quantitative distinction from phenytoin and possible therapeutic implications
40. Evidence for neuronal origin and metabotropic receptor-mediated regulation of extracellular glutamate and aspartate in rat striatum in vivo following electrical stimulation of the prefrontal cortex
41. Ionic mechanisms of spontaneous GABAergic events in rat hippocampal slices exposed to 4-aminopyridine
42. The potassium channel opener (-)-cromakalim prevents glutamate-induced cell death in hippocampal neurons
43. Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action
44. Therapeutic advances in amyotrophic lateral sclerosis
45. Multiple calcium channel types control glutamatergic synaptic transmission in the hippocampus
46. GABA(A)-mediated toxicity of hippocampal neurons in vitro
47. GABA and neuroprotection
48. Accumulation of extracellular glutamate by inhibition of its uptake is not sufficient for inducing neuronal damage: an in vivo microdialysis study
49. Glutamate uptake impairment and neuronal damage in young and aged rats in vivo
50. Potassium channel activators counteract anoxic hyperexcitability but not 4-aminopyridine-induced epileptiform activity in the rat hippocampal slice
51. Excitotoxicity and epileptic brain damage
52. Neurotransmission in epilepsy
53. Excitatory synaptic responses mediated by GABA(A) receptors in the hippocampus
54. Preferential stimulation of glutamate release by 4-aminopyridine in rat striatum in vivo
55. Protection by NMDA receptor antagonists against seizures induced by intracerebral administration of 4-aminopyridine
56. Antiepileptic effects of tiagabine, a selective GABA uptake inhibitor, in the rat kindling model of temporal lobe epilepsy
57. GABA(B) receptor activation promotes seizure activity in the juvenile rat hippocampus
58. Picrotoxin- and 4-aminopyridine-induced activity in hilar neurons in the guinea pig hippocampal slice
59. Sodium and potassium channel modulators: their role in neuroprotection
60. Amyotrophic lateral sclerosis, excitotoxicity and riluzole
61. Altered glutamatergic transmission in neurological disorders: from high extracellular glutamate to excessive synaptic efficacy
62. + channel inhibitors in vitro and in global cerebral ischaemia in vivo
63. Relationships among seizures, extracellular amino acid changes, and neurodegeneration induced by 4-aminopyridine in rat hippocampus: a microdialysis and electroencephalographic study
64. Physiology and pharmacology of epileptiform activity induced by 4-aminopyridine in rat hippocampal slices
65. Effects of vigabatrin treatment on status epilepticus-induced neuronal damage and mossy fiber sprouting in the rat hippocampus
66. Sodium channel modulators prevent oxygen and glucose deprivation injury and glutamate release in rat neocortical cultures
67. Sodium channels as molecular targets for antiepileptic drugs
68. High extracellular GABA levels in hippocampus-as a mechanism of neuronal protection in cerebral ischemia in adrenalectomized gerbils
69. Differential effects of phenytoin and sodium valproate on seizure-induced changes in γ-aminobutyric acid and glutamate release in vivo
70. Decrease of glutamate decarboxylase after in vivo cortical infusion of γ-aminobutyric acid
71. Calcium-binding protein (calbindin-D28K) and parvalbumin immunocytochemistry in the normal and epileptic human hippocampus
72. The γ-aminobutyric acid uptake inhibitor, tiagabine, is anticonvulsant in two animal models of reflex epilepsy
73. Ionic mechanisms of neuronal excitation by inhibitory GABA(A) receptors
74. Differential inhibition by riluzole, lamotrigine, and phenytoin of sodium and calcium currents in cortical neurons: implications for neuroprotective strategies
75. Riluzole prevents hyperexcitability produced by the mast cell degranulating peptide and dendrotoxin I in the rat
76. Anticonvulsant profiles of the potent and orally active GABA uptake inhibitors SK&F 89976-A and SK&F 100300-A and four prototype antiepileptic drugs in mice and rats
77. Different types of calcium channels mediate central synaptic transmission
78. On the relationship between extracellular glutamate, hyperexcitation and neurodegeneration, in vivo
79. Effect of 4-aminopyridine on transmitter release in synaptosomes
80. Mechanism of the calcium-dependent stimulation of transmitter release by 4-aminopyridine in synaptosomes
81. Aminopyridines and synaptic transmission
82. 2+ and glutamate release
83. Brain microdialysis of GABA and glutamate: what does it signify?
84. 4-Aminopyridine differentially affects the spontaneous release of radiolabelled transmitters from rat brain slices in vitro
85. Effect of carbamazepine, oxcarbazepine and lamotrigine on the increase in extracellular glutamate elicited by veratridine in rat cortex and striatum
86. Effects of carbamazepine and baclofen on 4-aminopyridine-induced epileptic activity in rat hippocampal slices
87. Effects of anticonvulsant drugs on 4-aminopyridine-induced seizures in mice
88. The possible involvement of tetrodotoxin-sensitive ion channels in ischemic neuronal damage in the rat hippocampus
89. Pre-synaptic effect of ATP-sensitive potassium channel opener diazoxide on rat substantia nigra pars reticulata neurons
90. Enhanced GABAergic inhibition preserves hippocampal structure and function in a model of epilepsy
91. The effects of anticonvulsant agents on 4-aminopyridine induced epileptiform activity in rat hippocampus in vitro
92. Expression of heat shock protein-70 and limbic seizure-induced neuronal death in the rat brain
93. Effects induced by the antiepileptic drug valproic acid upon the ionic currents recorded in rat neocortical neurons in cell culture
94. Riluzole interacts with voltage-activated sodium and potassium currents in cultured rat cortical neurons