Labeling lysosomes and tracking lysosome-dependent apoptosis with a cell-permeable activity-based probe

Bioconjugate Chemistry

Volumn 23, Issue 6, 2012, Pages 1309-1317

  Fan, Fengkai ^a,b   Nie, Si ^a,b   Yang, Dongmei ^a,b   Luo, Meijie ^a,b   Shi, Hua ^a,b   Zhang, Yu Hui ^a,b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH;

ACTIVITY-BASED PROBE; CELL-PERMEABLE; CO-LOCALIZATION STUDIES; CONDITION; COVALENTLY BOUND; CYTOSOLS; LABELINGS; LIVE CELL; PERMEABILIZED CELLS;

PROBES;

AMMONIUM CHLORIDE; CATHEPSIN; CELL PROTEIN; FLUORESCENT DYE; PEPSTATIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL LABELING; CELL MEMBRANE PERMEABILITY; CELL PERMEABILIZATION; CELL PERMEABLE FLUORESCENT ACTIVITY BASED PROBE; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; HUMAN; HUMAN CELL; LYSOSOME; MOLECULAR PROBE; NONHUMAN; PEPTIDE SYNTHESIS; PROTEIN BINDING; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CATHEPSINS; CELL LINE; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOSOL; FLUORESCENT DYES; HUMANS; LYSOSOMES; MICE; MICROSCOPY, CONFOCAL; PERMEABILITY; STAINING AND LABELING;

EID: 84862650253     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc300143p     Document Type: Article

References (46)

1. Repnik, U., and Turk, B. (2010) Lysosomal-mitochondrial crosstalk during cell death. Mitochondrion 10, 662-669.
2. Reich, M., van Swieten, P. F., Sommandas, V., Kraus, M., Fischer, R., Weber, E., Kalbacher, H., Overkleeft, H. S., and Driessen, C. (2007) Endocytosis targets exogenous material selectively to cathepsin S in live human dendritic cells, while cell-penetrating peptides mediate nonselective transport to cysteine cathepsins. J. Leukocyte Biol. 81, 990-1001.
3. Guicciardi, M. E., Leist, M., and Gores, G. J. (2004) Lysosomes in cell death. Oncogene 23, 2881-2890.
4. Ghosh, M., Carlsson, F., Laskar, A., Yuan, X. M., and Li, W. (2011) Lysosomal membrane permeabilization causes oxidative stress and ferritin induction in macrophages. FEBS Lett. 585, 623-629.
5. Mizukami, H., Mi, Y., Wada, R., Kono, M., Yamashita, T., Liu, Y., Werth, N., Sandhoff, R., Sandhoff, K., and Proia, R. L. (2002) Systemic inflammation in glucocerebrosidase-deficient mice with minimal glucosylceramide storage. J. Clin. Invest. 109, 1215-1221.
6. Mohamed, M. M., and Sloane, B. F. (2006) Cysteine cathepsins: multifunctional enzymes in cancer. Nat. Rev. Cancer 6, 764-775.
7. Soreghan, B., Thomas, S. N., and Yang, A. J. (2003) Aberrant sphingomyelin/ceramide metabolic-induced neuronal endosomal/lysosomal dysfunction: potential pathological consequences in agerelated neurodegeneration. Adv. Drug Delivery Rev. 55, 1515-1524.
8. Berthiaume, E. P., Medina, C., and Swanson, J. A. (1995) Molecular size-fractionation during endocytosis in macrophages. J. Cell Biol. 129, 989-998.
9. Teter, K., Chandy, G., Quinones, B., Pereyra, K., Machen, T., and Moore, H. P. (1998) Cellubrevin-targeted fluorescence uncovers heterogeneity in the recycling endosomes. J. Biol. Chem. 273, 19625-19633.
10. Hu, Q., Bally, M. B., and Madden, T. D. (2002) Subcellular trafficking of antisense oligonucleotides and down-regulation of bcl-2 gene expression in human melanoma cells using a fusogenic liposome delivery system. Nucleic Acids Res. 30, 3632-3641.
11. Hanaki, K., Momo, A., Oku, T., Komoto, A., Maenosono, S., Yamaguchi, Y., and Yamamoto, K. (2003) Semiconductor quantum dot/albumin complex is a long-life and highly photostable endosome marker. Biochem. Biophys. Res. Commun. 302, 496-501.
12. Anderson, R. G., Falck, J. R., Goldstein, J. L., and Brown, M. S. (1984) Visualization of acidic organelles in intact cells by electron microscopy. Proc. Natl. Acad. Sci. U. S. A. 81, 4838-4842.
13. Svendsen, C., Spurgeon, D. J., Hankard, P. K., and Weeks, J. M. (2004) A review of lysosomal membrane stability measured by neutral red retention: is it a workable earthworm biomarker? Ecotoxicol. Environ. Saf. 57, 20-29.
14. Anderson, R. G., and Orci, L. (1988) A view of acidic intracellular compartments. J. Cell Biol. 106, 539-543.
15. Freundt, E. C., Czapiga, M., and Lenardo, M. J. (2007) Photoconversion of Lysotracker Red to a green fluorescent molecule. Cell Res. 17, 956-958.
16. Ohkuma, S., and Poole, B. (1978) Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. Proc. Natl. Acad. Sci. U. S. A. 75, 3327-3331.
17. Bidere, N., Lorenzo, H. K., Carmona, S., Laforge, M., Harper, F., Dumont, C., and Senik, A. (2003) Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis. J. Biol. Chem. 278, 31401-31411.
18. Xiao, Y., Forry, S. P., Gao, X., Holbrook, R. D., Telford, W. G., and Tona, A. (2010) Dynamics and mechanisms of quantum dot nanoparticle cellular uptake. J. Nanobiotechnol. 8, 13-22.
19. Shi, H., He, X., Yuan, Y., Wang, K., and Liu, D. (2010) Nanoparticle-based biocompatible and long-life marker for lysosome labeling and tracking. Anal. Chem. 82, 2213-2220.
20. Rejman, J., Oberle, V., Zuhorn, I. S., and Hoekstra, D. (2004) Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem. J. 377, 159-169.
21. Pryor, P. R., and Luzio, J. P. (2009) Delivery of endocytosed membrane proteins to the lysosome. Biochim. Biophys. Acta 1793, 615-624.
22. Cravatt, B. F., Wright, A. T., and Kozarich, J. W. (2008) Activity-based protein profiling: from enzyme chemistry to proteomic chemistry. Annu. Rev. Biochem. 77, 383-414.
23. Greenbaum, D., Medzihradszky, K. F., Burlingame, A., and Bogyo, M. (2000) Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools. Chem. Biol. 7, 569-581.
24. Hillaert, U., Verdoes, M., Florea, B. I., Saragliadis, A., Habets, K. L., Kuiper, J., Van Calenbergh, S., Ossendorp, F., van der Marel, G. A., Driessen, C., and Overkleeft, H. S. (2009) Receptor-mediated targeting of cathepsins in professional antigen presenting cells. Angew. Chem., Int. Ed. Engl. 48, 1629-1632.
25. Kaschani, F., Verhelst, S. H., van Swieten, P. F., Verdoes, M., Wong, C. S., Wang, Z., Kaiser, M., Overkleeft, H. S., Bogyo, M., and van der Hoorn, R. A. (2009) Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using 'click chemistry'. Plant J. 57, 373-385.
26. Mizuno, T., Miyashita, M., and Miyagawa, H. (2009) Cellular internalization of arginine-rich peptides into tobacco suspension cells: a structure-activity relationship study. J. Pept. Sci. 15, 259-263.
27. Bolte, S., and Cordelieres, F. P. (2006) A guided tour into subcellular colocalization analysis in light microscopy. J. Microsc. 224, 213-232.
28. Chu, J., Zhang, Z., Zheng, Y., Yang, J., Qin, L., Lu, J., Huang, Z. L., Zeng, S., and Luo, Q. (2009) A novel far-red bimolecular fluorescence complementation system that allows for efficient visualization of protein interactions under physiological conditions. Biosens. Bioelectron. 25, 234-239.
29. Kato, D., Verhelst, S. H., Sexton, K. B., and Bogyo, M. (2005) A general solid phase method for the preparation of diverse azapeptide probes directed against cysteine proteases. Org. Lett. 7, 5649-5652.
30. Verhelst, S. H., and Bogyo, M. (2005) Solid-phase synthesis of double-headed epoxysuccinyl activity-based probes for selective targeting of papain family cysteine proteases. ChemBioChem 6, 824-827.
31. Greenbaum, D., Baruch, A., Hayrapetian, L., Darula, Z., Burlingame, A., Medzihradszky, K. F., and Bogyo, M. (2002) Chemical approaches for functionally probing the proteome. Mol. Cell Proteomics 1, 60-68.
32. Berlier, J. E., Rothe, A., Buller, G., Bradford, J., Gray, D. R., Filanoski, B. J., Telford, W. G., Yue, S., Liu, J., Cheung, C. Y., Chang, W., Hirsch, J. D., Beechem, J. M., Haugland, R. P., and Haugland, R. P. (2003) Quantitative comparison of long-wavelength Alexa Fluor dyes to Cy dyes: fluorescence of the dyes and their bioconjugates. J. Histochem. Cytochem. 51, 1699-1712.
33. Barrett, A. J., Kembhavi, A. A., Brown, M. A., Kirschke, H., Knight, C. G., Tamai, M., and Hanada, K. (1982) L-trans-Epoxysuccinyl-leucylamido(4- guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. Biochem. J. 201, 189-198.
34. Fonovic, M., Verhelst, S. H., Sorum, M. T., and Bogyo, M. (2007) Proteomics evaluation of chemically cleavable activity-based probes. Mol. Cell Proteomics 6, 1761-1770.
35. Ramos-Vara, J. A. (2011) Principles and methods of immunohistochemistry. Methods Mol. Biol. 691, 83-96.
36. Yang, Q., She, H., Gearing, M., Colla, E., Lee, M., Shacka, J. J., and Mao, Z. (2009) Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy. Science 323, 124-127.
37. Koh, Y. H., von Arnim, C. A., Hyman, B. T., Tanzi, R. E., and Tesco, G. (2005) BACE is degraded via the lysosomal pathway. J. Biol. Chem. 280, 32499-32504.
38. Vaux, D. L., and Flavell, R. A. (2000) Apoptosis genes and autoimmunity. Curr. Opin. Immunol. 12, 719-724.
39. Yuan, J., and Yankner, B. A. (2000) Apoptosis in the nervous system. Nature 407, 802-809.
40. Boya, P., and Kroemer, G. (2008) Lysosomal membrane permeabilization in cell death. Oncogene 27, 6434-6451.
41. Yin, L., Stearns, R., and Gonzalez-Flecha, B. (2005) Lysosomal and mitochondrial pathways in H2O2-induced apoptosis of alveolar type II cells. J. Cell Biochem. 94, 433-445.
42. Lamparska-Przybysz, M., Gajkowska, B., and Motyl, T. (2005) Cathepsins and BID are involved in the molecular switch between apoptosis and autophagy in breast cancer MCF-7 cells exposed to camptothecin. J. Physiol. Pharmacol. 56 (Suppl3), 159-179.
43. Werneburg, N. W., Guicciardi, M. E., Bronk, S. F., and Gores, G. J. (2002) Tumor necrosis factor-alpha-associated lysosomal permeabilization is cathepsin B dependent. Am. J. Physiol. Gastrointest. Liver Physiol. 283, G947-G956.
44. Jiang, B., Liang, P., Deng, G., Tu, Z., Liu, M., and Xiao, X. (2011) Increased stability of Bcl-2 in HSP70-mediated protection against apoptosis induced by oxidative stress. Cell Stress Chaperones 16, 143-152.
45. Edgington, L. E., Berger, A. B., Blum, G., Albrow, V. E., Paulick, M. G., Lineberry, N., and Bogyo, M. (2009) Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes. Nat. Med. 15, 967-973.
46. Lee, J., and Bogyo, M. (2010) Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain. ACS Chem. Biol. 5, 233-543.