Comparing MDI and DPI aerosol deposition using in vitro experiments and a new stochastic individual path (SIP) model of the conducting airways

Pharmaceutical Research

Volumn 29, Issue 6, 2012, Pages 1670-1688

  Longest, P Worth ^a,b   Tian, Geng ^a   Walenga, Ross L ^a   Hindle, Michael ^b  

^a Virginia Commonwealth University   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

aerosol deposition; bioequivalence testing of inhalers; inhaler performance; respiratory drug delivery; stochastic lung modeling

Indexed keywords

FLUTICASONE PROPIONATE; LACTOSE;

AIRWAY CONDUCTANCE; ARTICLE; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG TRANSPORT; EFFECT SIZE; ERROR; GEOMETRY; IN VITRO STUDY; INTERMETHOD COMPARISON; LUNG; LUNG VENTILATION; METERED DOSE INHALER; MOUTH; POWDER INHALER; PRIORITY JOURNAL; SINGLE DRUG DOSE; STOCHASTIC MODEL; THROAT;

ADMINISTRATION, INHALATION; AEROSOLS; ANDROSTADIENES; BRONCHODILATOR AGENTS; CHEMISTRY, PHARMACEUTICAL; COMPUTER SIMULATION; DRY POWDER INHALERS; METERED DOSE INHALERS; MODELS, ANATOMIC; NUMERICAL ANALYSIS, COMPUTER-ASSISTED; PARTICLE SIZE; POWDERS; REPRODUCIBILITY OF RESULTS; RESPIRATORY SYSTEM; RHEOLOGY; STOCHASTIC PROCESSES; TECHNOLOGY, PHARMACEUTICAL; THERAPEUTIC EQUIVALENCY; TISSUE DISTRIBUTION;

EID: 84862649849     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0691-y     Document Type: Article

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