Quantitative analysis and design of a spray aerosol inhaler. Part 1: Effects of dilution air inlets and flow paths

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Volumn 22, Issue 3, 2009, Pages 271-283

  Longest, P Worth ^a,b   Hindle, Michael ^b  

^a Virginia Commonwealth University   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Computational fluid dynamics (CFD); Effective mouthpiece diameter; Inhaler design; Quality by design (QbD); Turbulence intensity

Indexed keywords

AEROSOL INHALER; ARTICLE; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG TRANSPORT; HUMAN; IN VITRO STUDY; INHALER; QUANTITATIVE ANALYSIS;

AEROSOLS; EQUIPMENT DESIGN; NEBULIZERS AND VAPORIZERS;

EID: 70349286796     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2008.0739     Document Type: Article

References (35)

1. Lewis DA, Ganderton D, Meakin BJ, and Brambilla G: Theory and practice with solution systems. Respir Drug Deliv IX. 2004:109-116.
2. Stein SW and Myrdal PB: The relative influence of atomization and evaporation on metered dose inhaler drug delivery efficiency. Aerosol Sci Technol. 2006;40:335-347.
3. Kleinstreuer C, Shi H, and Zhang Z: Computational analyses of a pressurized metered dose inhaler and an new drug-aerosol targeting methodology. J Aerosol Med. 2007;20:294-309.
4. Longest PW, Hindle M, Das Choudhuri S, and Byron PR: Developing a better understanding of spray system design using a combination of CFD modeling and experiment. In: Dalby RN, Byron PR, Peart J, et al. (eds). Proceedings of Respiratory Drug Delivery 2008, Davis Healthcare International Publishing, Illinois, pp. 151-163, 2008.
5. Longest PW, Hindle M, Das Choudhuri S, and Xi J: Comparison of ambient and spray aerosol deposition in a standard induction port and more realistic mouth-throat geometry. J Aerosol Sci. 2008;39:572-591.
6. Shi H, and Kleinstreuer C: Simulation and analysis of high-speed droplet spray dynamics. J Fluids Eng. 2007;129:621-633.
7. DeHaan WH, and Finlay WH: Predicting extrathoracic deposition from dry powder inhalers. J Aerosol Sci. 2004;35: 309-331.
8. Matida EA, DeHaan WH, Finlay WH, and Lange CF: Simulation of particle deposition in an idealized mouth with different small diameter inlets. Aerosol Sci Technol. 2003;37: 924-932.
9. Coates MS, Chan H-K, Fletcher DF, and Chiou H: Influence of mouthpiece geometry on the aerosol delivery performance of a dry powder inhalation. Pharmaceut Res. 2007; 24:1450-1456. (Pubitemid 46988211)
10. Coates MS, Chan H-K, Fletcher DF, and Raper JA: Influence of air flow on the performance of a dry powder inhaler using computational and experimental analyses. Pharmaceut Res. 2005;22:1445-1453.
11. Coates MS, Chan H-K, Fletcher DF, and Raper JA: Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 2: Air inlet size. J Phar-maceut Sci. 2006;95(6):1382-1392.
12. Coates MS, Fletcher DF, Chan H-K, and Raper JA: Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 1: Grid structure and mouthpiece length. J Pharmaceut Sci. 2004;93:2863-2876.
13. Newman SP: Aerosol deposition considerations in inhalation therapy. Chest. 1985;88:152S-160S.
14. Longest PW, and Kleinstreuer C: Computational models for simulating multicomponent aerosol evaporation in the upper respiratory airways. Aerosol Sci Technol. 2005;39:124-138.
15. Versteeg HK, Hargrave G, Harrington L, Shrubb I, and Hod-son D: The use of computational fluid dynamics (CFD) to predict pMDI air flows and aerosol plume formation. Respir Drug Deliv VII. 2000:257-264.
16. Dunbar CA, Watkins AP, and Miller JF: Theoretical investigation of the spray from a pressurized metered-dose inhaler. Atomizat Sprays. 1997;7:417-436.
17. Longest PW, Hindle M, Das Choudhuri S, and Byron PR: Numerical simulations of capillary aerosol generation: CFD model development and comparisons with experimental data. Aerosol Sci Technol. 2007;41:952-973.
18. Fadl A, Wang J, Zhang Z, and Cheng YS: Effects of MDI spray angle on aerosol penetration efficiency through an oral airway cast. J Aerosol Sci. 2007;38:853-864.
19. Shrewsbury SB, Armer TA, Newman SP, and Pitcairn G: Breath-synchronized plume-control inhaler for pulmonary delivery of fluticosone propionate. Int J Pharmaceut. 2008; 356:137-143.
20. Clark AR, and Hollingworth AM: The relationship between powder inhaler resistance and peak inspiratory conditions in healthy volunteers-implications for in vitro testing. J Aerosol Med. 1993;3:99-110.
21. Wilcox DC: Turbulence Modeling for CFD, 2nd ed. DCW Industries, Inc., La Cacada, CA, 1998.
22. Longest PW, Hindle M, and Das Choudhuri S: Effects of generation time on spray aerosol transport and deposition in models of the mouth-throat geometry. J Aerosol Med Pulmonary Drug Deliv. 2009;22. DOI:10.1089/jamp.2008.0692.
23. Bird RB, Steward WE, and Lightfoot EN: Transport Phenomena. John Wiley & Sons, New York, 1960.
24. Morsi SA, and Alexander AJ: An investigation of particle trajectories in two-phase flow systems. J Fluid Mech. 1972;55:193-208.
25. Longest PW, and Xi J: Effectiveness of direct Lagrangian tracking models for simulating nanoparticle deposition in the upper airways. Aerosol Sci Technol. 2007;41:380-397.
26. Matida EA, Finlay WH, and Grgic LB: Improved numerical simulation of aerosol deposition in an idealized mouth-throat. J Aerosol Sci. 2004;35:1-19.
27. Wang Y, and James PW: On the effect of anisotropy on the turbulent dispersion and deposition of small particles. Int J Multiphase Flow. 1999;22:551-558.
28. Clift R, Grace JR, and Weber ME: Bubbles, Drops, and Particles. Academic Press, New York, 1978.
29. Longest PW, and Vinchurkar S: Effects of mesh style and grid convergence on particle deposition in bifurcating airway models with comparisons to experimental data. Med Eng Phys. 2007;29:350-366.
30. Vinchurkar S, and Longest PW: Evaluation of hexahedral, prismatic and hybrid mesh styles for simulating respiratory aerosol dynamics. Comput Fluids. 2008;37:317-331.
31. Drossinos Y, and Housiadas C: Aerosol Flows. In: Crowe CT (ed.). Multiphase Flow Handbook, CRC Taylor Francis, Boca Raton, FL, 2006.
32. Friedlander SK, and Johnstone HF: Deposition of suspended particles from turbulent gas streams. Indus Eng Chem. 1957; 49:1151.
33. Liu BYH, and Agarwal JK: Experimental observation of aerosol deposition in turbulent flow. J Aerosol Sci. 1974; 5:145.
34. Matida EA, Finlay WH, Breuer M, and Lange CF: Improving prediction of aerosol deposition in an idealized mouth using large-eddy simulation. J Aerosol Med. 2006;19:290-300.
35. Grgic B, Martin AR, and Finlay WH: The effect of unsteady flow rate increase on in vitro mouth-throat deposition of inhaled boluses. Aerosol Sci. 2006;37:1222-1233.