Simulation of Particle Deposition in an Idealized Mouth with Different Small Diameter Inlets

Aerosol Science and Technology

Volumn 37, Issue 11, 2003, Pages 924-932

  Matida, E A ^a   DeHaan, W H ^b   Finlay, W H ^a   Lange, C F ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b ALKERMES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTER SIMULATION; DEPOSITION; NAVIER STOKES EQUATIONS; REYNOLDS NUMBER;

MONODISPERSE PARTICLES;

PARTICLES (PARTICULATE MATTER);

AEROSOL;

ANISOTROPY; ARTICLE; CALCULATION; DATA ANALYSIS; DISPERSION; EDDY INTERACTION MODEL; EXPERIMENT; FLOW RATE; GEOMETRY; HUMAN; INHALATION; MATHEMATICAL ANALYSIS; MEASUREMENT; MODEL; MOUTH; PARTICLE DEPOSITION; PARTICLE SIZE; PRIORITY JOURNAL; REYNOLDS AVERAGED NAVIER STOKES MODEL; SIMULATION; STATISTICAL ANALYSIS; STOCHASTIC MODEL; TURBULENT FLOW; VELOCITY;

EID: 0142011486     PISSN: 02786826     EISSN: None     Source Type: Journal    
DOI: 10.1080/02786820300932     Document Type: Article

References (36)

1. Borgström, L. (2001). On the Use of Dry Powder Inhalers in Situations Perceived as Constrained, J. Aerosol Med. 14(3):281-287.
2. Bredberg, J., Peng, S.-H., and Davidson, L. (2002). An Improved k - ω Turbulence Model Applied to Recirculating Flows, Int. J. Heat Fluid Flow 23(6):731-743.
3. Cooper, D., Jackson, D. C., Launder, B. E., and Liao, G. X. (1993). Impinging Jet Studies for Turbulence Model Assessment-I. Flow-field Experiments, Int. J. Heat Mass Transfer 36(10):2675-2684.
4. DeHaan, W. H. (2002). Mouth-throat deposition with non-ballistic pharmaceutical aerosol inhalation devices, PhD diss., University of Alberta, Edmonton, Alberta, Canada.
5. DeHaan, W. H., and Finlay, W. H. (2001). In vitro Monodisperse Aerosol Deposition in a Mouth and Throat with Six Different Inhalation Devices, J. Aerosol Med. 14(3):361-367.
6. DeHaan, W. H., and Finlay, W. H. (2003). Predicting Extrathoracic Deposition from Dry Powder Inhalers, To appear in the J. Aerosol Sci.
7. Elgobashi, S. (1994). On Predicting Particle-Laden Turbulent Flows, Applied Scientific Research 52:309-329.
8. Finlay, W. H. (2001). The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction. Academic Press, London.
9. Gosman, A. D., and Ioannides, E. (1981). Aspects of Computer Simulation of Liquid-fueled Combustors, AIAA 9th Aerospace Sci. Meeting, pages 81-0323.
10. Graham, D. I., and James, P. W. (1996). Turbulent Dispersion of Particles Using Eddy Interaction Models, Int. J. Multiphase Flow 22(1):157-175.
11. Grgic, B., Finlay, W. H., and Heenan, A. F. (2003). Regional Aerosol Deposition and Flow Measurements in an Idealized Mouth and Throat, To appear in the J. Aerosol Sci.
12. Grotjans, H., and Menter, F. R. (1998). Wall Functions for General Application CFD Codes. ECCOMAS 98 Proc. 4th European CFD Conf. edited by K. D. Papailiou et al. John Wiley & Sons, Chichester, pp. 1112-1117.
13. Hennick, E. A., and Lightstone, M. F. (2000). A Comparison of Stochastic Separated Flow Models for Particle Dispersion in Turbulent Flows, Energy & Fuels 14:95-103.
14. Kato, M., and Launder, B. E. (1993). The Modeling of Turbulent Flow Around Stationary and Vibrating Square Cylinders, Proc. 9th Symp. Turb. Shear Flows, Kyoto, Japan, August, pp. 10-4-1-10-4-6.
15. Kim, I., Elgobashi, S., and Sirignano, W. A. (1998). On the Equation for Spherical-Particle Motion: Effect of Reynolds and Acceleration Numbers, J. Fluid Mech. 367:221-253.
16. Kim, J., Moin, P., and Moser, R. D. (1987). Turbulence Statistics in Fully Developed Channel Flow at Low Reynolds Number, J. Fluid Mech. 177:133-166.
17. Li, W.-I., Perzl, M., Heyder, J., Langer, R., Brain, J. D., Englmeier, K. H., Niven, R. W., and Edwards, D. A. (1996). Aerodynamic and Aerosol Particle Deagglomeration Phenomena in Model Oral-Pharyngeal Cavities, J. Aerosol Sci. 27(8):1269-1286.
18. Lin, T.-C., Breysse, P. N., Laube, B. L., and Swift, D. L. (2001). Mouthpiece Diameter Affects Deposition Efficiency in Cast Models of the Human Oral Airways, J. Aerosol Med. 14(3):335-341.
19. MacInnes, J. M., and Bracco, F. V. (1992). Stochastic Particle Dispersion Modeling and the Tracer-particle Limit, Phys. Fluids A 4(12):2809-2824.
20. Matida, E. A., Nishino, K., and Torii, K. (2000). Statistical Simulation of Particle Deposition on the Wall from Turbulent Dispersed Pipe Flow, Int. J. Heat Fluid Flow 21:389-402.
21. Matida, E. A., Finlay, W. H., Lange, C. F., and Grgic, B. (2003). Improved Numerical Simulation of Aerosol Deposition in an Idealized Mouth-throat, To appear in the J. Aerosol Sci.
22. Maxey, M. R., and Riley, J. J. (1983). Equation of Motion for a Small Rigid Sphere in a Nonuniform Flow, Phys. Fluids 26(4):883-889.
23. Mei, R. (1994). Velocity Fidelity of Flow Tracer Particles, Exp. Fluids 22:1-13.
24. Menter, F. R. (1994). Two-equation Eddy-viscosity Turbulence Models for Engineering Applications, AIAA J. 32(8):1598-1605.
25. Nishino, K., Samada, M., and K. Kasuya, K. T. (1996). Turbulence Statistics in the Stagnation Region of an Axisymmetric Impinging Jet Flow, Int. J. Heat Fluid Flow 17:193-201.
26. Peng, S.-H., Davidson, L., and Holmberg, S. (1997). A Modified Low-Reynolds-Number k - ω model for Recirculating Flows, ASME: J. Fluids Eng. 119:867-875.
27. Sarangapani, R., and Wexler, A. S. (2000). Modeling Particle Deposition in Extrathoracic Airways, Aerosol Sci. and Technol. 32:72-89.
28. Schuen, J. S., Chen, L. D., and Faeth, G. M. (1983). Evaluation of a Stochastic Model of Particle Dispersion in a Turbulent Round Jet, AIChE J. 29(1):167-170.
29. Stapleton, K. W., Guentsch, E., Hoskinson, M. K., and Finlay, W. H. (2000). On the Suitability of k - ω Turbulence Modeling for Aerosol Deposition in the Mouth and Throat: A Comparison with Experiment, J. Aerosol Sci. 31(6):739-749.
30. Wang, L.-P., and Stock, D. E. (1992). Stochastic Trajectory Models for Turbulent Diffusion: Monte Carlo Process Versus Markov Chains, Atmosphere Envir. 26A:1599-1607.
31. Wang, Y., and James, P. W. (1999). On the Effect of Anisotropy on the Turbulent Dispersion and Deposition of Small Particles, Int. J. Multiphase Flow 25:551-558.
32. Wilcox, D. C. (1988). Reassessment of the Scale Determining Equation for Advanced Turbulence Models, AIAA J. 26(11):1299-1310.
33. Wilcox, D. C. (1998a). Two-equation Models. In Turbulence modeling for CFD, DCW Industries, Inc., La Canãda, Chap. 4, pp. 121-122.
34. Wilcox, D. C. (1998b). Two-equation Models. In Turbulence modeling for CFD, DCW Industries, Inc., La Canãda, Chap. 4, pp. 193-201.
35. Yu, G., Zhang, Z., and Lessman, R. (1998). Fluid Flow and Particle Diffusion in the Human Upper Respiratory System, Aerosol Sci. and Technol. 28:146-158.
36. Zhou, Q., and Leschziner, M. A. (1991). A Time Correlated Stochastic Model for Particle Dispersion in Anisotropic Turbulence, Proc. 8th Symp. Turb. Shear Flows, Munich, Germany, September.