Evaluation of Enhanced Condensational Growth (ECG) for controlled respiratory drug delivery in a mouth-throat and upper tracheobronchial model

Pharmaceutical Research

Volumn 27, Issue 9, 2010, Pages 1800-1811

  Hindle, Michael ^a   Longest, P Worth ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b Virginia Commonwealth University   (United States)

Author keywords

computational fluid dynamics; condensational growth; in vitro aerosol deposition; nano aerosol drug delivery; respiratory drug delivery

Indexed keywords

SALBUTAMOL SULFATE;

AEROSOL; ARTICLE; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DEVICE; DRUG DELIVERY SYSTEM; ENHANCED CONDENSATION GROWTH; FLOW RATE; GAS FLOW; IN VITRO STUDY; NANOTECHNOLOGY; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROCESS DESIGN; SIMULATION; TRACHEOBRONCHIAL TREE;

ADMINISTRATION, INHALATION; AEROSOLS; ALBUTEROL; BRONCHI; COMPUTER SIMULATION; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; HUMANS; MODELS, ANATOMIC; MODELS, BIOLOGICAL; MOUTH; NANOPARTICLES; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; PHARYNX; PREDICTIVE VALUE OF TESTS; TRACHEA;

EID: 77955469508     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0165-z     Document Type: Article

References (49)

1. L Borgstrom B Olsson L Thorsson 2006 Degree of throat deposition can explain the variability in lung deposition of inhaled drugs J Aerosol Med 19 473 483 10.1089/jam.2006.19.473 17196076 (Pubitemid 46067766)
2. SP Newman 1995 A comparison of lung deposition patterns between different asthma inhalers J Aerosol Med 8 Suppl 3 S21 26 10157895 discussion S27
3. CL Leach PJ Davidson A Bouhuys 1998 Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone Eur Respir J 12 1346 1353 10.1183/09031936.98.12061346 1:CAS:528:DyaK1MXlt1Wqsw%3D%3D 9877489 (Pubitemid 29011427)
4. GC Smaldone 2006 Advances in aerosols: adult respiratory disease J Aerosol Med 19 36 46 10.1089/jam.2006.19.36 1:CAS:528:DC%2BD28Xis1Gksb8%3D 16551213
5. PR Byron 2004 Drug delivery devices: issues in drug development Proc Am Thorac Soc 1 321 328 10.1513/pats.200403-023MS 1:CAS:528:DC%2BD28XhsFGjsL8%3D 16113453
6. Longest PW, Hindle M, Das Choudhuri S, Byron PR. Developing a better understanding of spray system design using a combination of CFD modeling and experiment. In: Dalby RN et al., editors. Proceedings of Respiratory Drug Delivery 2008. Illinois: Davis Healthcare International; 2008. p. 151-63.
7. Hindle, M. Soft mist inhalers: a review of current technology. The Drug Delivery Companies Report Autumn/Winter. 2004;31-4.
8. YS Cheng CS Fu D Yazzie Y Zhou 2001 Respiratory deposition patterns of salbutamol pMDI with CFC and HFA-134a formulations in a human airway replica J Aerosol Med 14 255 266 10.1089/08942680152484180 1:CAS:528:DC%2BD3MXmsVyitbk%3D 11681657
9. PW Longest M Hindle S Das Choudhuri J Xi 2008 Comparison of ambient and spray aerosol deposition in a standard induction port and more realistic mouth-throat geometry J Aerosol Sci 39 572 591 10.1016/j.jaerosci.2008.03.008 1:CAS:528:DC%2BD1cXns1Chur8%3D
10. Y Zhang K Gilbertson WH Finlay 2007 In vivo-in vitro comparison of deposition in three mouth-throat models with Qvar and Turbuhaler inhalers J Aerosol Med 20 227 235 10.1089/jam.2007.0584 1:CAS:528:DC%2BD2sXhtVyjtrfK 17894531 (Pubitemid 47463180)
11. J Xi PW Longest 2008 Effects of oral airway geometry characteristics on the diffusional deposition of inhaled nanoparticles ASME J Biomech Eng 130 011008 10.1115/1.2838039 (Pubitemid 351974962)
12. YS Cheng 2003 Aerosol deposition in the extrathoracic region Aerosol Sci Tech 37 659 671 10.1080/02786820300906 1:CAS:528:DC%2BD3sXlsVaks70%3D (Pubitemid 39280174)
13. JW Card DC Zeldin JC Bonner ER Nestmann 2008 Pulmonary applications and toxicity of engineered nanoparticles Am J Physiol Lung Cell Mol Physiol 295 L400 411 10.1152/ajplung.00041.2008 1:CAS:528:DC%2BD1cXhtFCgt7vJ 18641236
14. JC Sung BL Pulliam DA Edwards 2007 Nanoparticles for drug delivery to the lungs Trends Biotechnol 25 563 570 10.1016/j.tibtech.2007.09.005 1:CAS:528:DC%2BD2sXhtlCru7nK 17997181 (Pubitemid 350138179)
15. BS Cohen RG Sussman M Lippmann 1990 Ultrafine particle deposition in a human tracheobronchial cast Aerosol Sci Tech 12 1082 1093 10.1080/ 02786829008959418
16. PA Jaques CS Kim 2000 Measurement of total lung deposition of inhaled ultrafine particles in healthy men and women Inhal Toxicol 12 715 731 10.1080/08958370050085156 1:CAS:528:DC%2BD3cXmsFKjs7c%3D 10880153
17. L Morawska W Hofmann J Hitchins-Loveday C Swanson K Mengersen 2005 Experimental study of the deposition of combustion aerosols in the human respiratory tract J Aerosol Sci 36 939 957 10.1016/j.jaerosci.2005.03.015 1:CAS:528:DC%2BD2MXmt1WisL0%3D (Pubitemid 40968172)
18. W Stahlhofen G Rudolf AC James 1989 Intercomparison of experimental regional aerosol deposition data J Aerosol Med 2 285 308 10.1089/jam.1989.2.285
19. R Pandey, et al. 2003 Poly (DL-lactide-co-glycolide) nanoparticle-based inhalable sustained drug delivery system for experimental tuberculosis J Antimicrob Chemother 52 981 986 10.1093/jac/dkg477 1:CAS:528: DC%2BD3sXpvVels7g%3D 14613962 (Pubitemid 38008419)
20. PA Dickinson SW Howells IW Kellaway 2001 Novel nanoparticles for pulmonary drug administration J Drug Target 9 295 302 10.3109/10611860108997937 1:CAS:528:DC%2BD3MXmt1Sls7c%3D 11697032
21. S Azarmi WH Roa R Lobenberg 2008 Targeted delivery of nanoparticles for the treatment of lung diseases Adv Drug Deliv Rev 60 863 875 10.1016/j.addr.2007.11.006 1:CAS:528:DC%2BD1cXlslagu70%3D 18308418
22. BK Nyambura IW Kellaway KMG Taylor 2009 Insulin nanoparticles: stability and aerosolization from pressurized metered dose inhalers Int J Pharm 375 114 122 10.1016/j.ijpharm.2009.03.031 1:CAS:528:DC%2BD1MXmsFKnsLk%3D 19481697
23. GA Ferron 1977 The size of soluable aerosol particles as a function of the humidity of the air: application to the human respiratory tract J Aerosol Sci 3 251 267 10.1016/0021-8502(77)90045-3
24. GA Ferron G Oberdorster R Hennenberg 1989 Estimation of the deposition of aerosolised drugs in the human respiratory tract due to hygroscopic growth J Aerosol Med 2 271 10.1089/jam.1989.2.271
25. WH Finlay 1998 Estimating the type of hygroscopic behavior exhibited by aqueous droplets J Aerosol Med 11 221 229 10.1089/jam.1998.11.221 1:STN:280:DyaK1M7nvFGjtw%3D%3D 10346665
26. Martonen TB, Bell KA, Phalen RF, Wilson AF, Ho A. Growth rate measurements and deposition modeling of hygroscopic aerosols in human tracheobronchial models. In: Walton WH, editor. Inhaled particles V. Oxford: Pergamon; 1982. p. 93-107.
27. PW Longest JT McLeskey M Hindle 2010 Characterization of nanoaerosol size change during enhanced condensational growth Aerosol Sci Tech. 44 473 483 10.1080/02786821003749525 1:CAS:528:DC%2BC3cXmt1Kqsro%3D
28. Longest PW, Hindle M, Xi J. Effective delivery of nanoparticles and micrometer-sized pharmaceutical aerosols to the lung through enhanced condensational growth. International Patent Application PCT/US2009/034360: 2009.
29. Hinds WC. Aerosol technology: properties, behavior, and measurement of airborne particles. New York: Wiley; 1999.
30. SK Friedlander RS Windeler AP Weber 1994 Ultrafine particle formation by aerosol processes in turbulent jets: mechanisms and scale-up NanoStruct Mat 4 521 528 10.1016/0965-9773(94)90059-0 1:CAS:528:DyaK2cXmsFyqsL8%3D
31. Longest PW, Hindle M. CFD simulations of enhanced condensational growth (ECG) applied to respiratory drug delivery with comparisons to in vitro data. J Aerosol Sci. 2010. doi: 10.1016/j.jaerosci.2010.04.006.
32. J Xi PW Longest 2007 Transport and deposition of micro-aerosols in realistic and simplified models of the oral airway Ann Biomed Eng 35 560 581 10.1007/s10439-006-9245-y 17237991 (Pubitemid 46448162)
33. T Heistracher W Hofmann 1995 Physiologically realistic models of bronchial airway bifurcations J Aerosol Sci 26 497 509 10.1016/0021-8502(94) 00113-D 1:CAS:528:DyaK2MXltFaku7c%3D
34. HC Yeh GM Schum 1980 Models of human lung airways and their application to inhaled particle deposition Bull Math Biol 42 461 480 1:STN:280: DyaL3c7pvVyruw%3D%3D 7378614
35. K Horsfield G Dart DE Olson G Cumming 1971 Models of the human bronchial tree J Appl Physiol 31 207 217 1:STN:280:DyaE3M3lt1aqtg%3D%3D 5558242
36. PW Longest M Hindle 2009 Evaluation of the respimat soft mist inhaler using a concurrent CFD and in vitro approach J Aerosol Med 22 99 112
37. PW Longest M Hindle S Das Choudhuri 2009 Effects of generation time on spray aerosol transport and deposition in models of the mouth-throat geometry J Aerosol Med 22 67 84
38. PW Longest J Xi 2008 Condensational growth may contribute to the enhanced deposition of cigarette smoke particles in the upper respiratory tract Aerosol Sci Tech. 42 579 602 10.1080/02786820802232964 1:CAS:528:DC%2BD1cXosVGjtLk%3D (Pubitemid 351990145)
39. PW Longest M Hindle S Das Choudhuri PR Byron 2007 Numerical simulations of capillary aerosol generation: CFD model development and comparisons with experimental data Aerosol Sci Tech 41 952 973 10.1080/02786820701607027 1:CAS:528:DC%2BD2sXhtVWiur%2FE (Pubitemid 47394484)
40. EA Matida WH Finlay LB Grgic 2004 Improved numerical simulation of aerosol deposition in an idealized mouth-throat J Aerosol Sci 35 1 19 10.1016/S0021-8502(03)00381-1 1:CAS:528:DC%2BD3sXpt1ensbg%3D (Pubitemid 37476251)
41. J Xi PW Longest TB Martonen 2008 Effects of the laryngeal jet on nano- and microparticle transport and deposition in an approximate model of the upper tracheobronchial airways J Appl Physiol 104 1761 1777 10.1152/japplphysiol. 01233.2007 18388247
42. PW Longest S Vinchurkar 2007 Effects of mesh style and grid convergence on particle deposition in bifurcating airway models with comparisons to experimental data Med Eng Phys 29 350 366 10.1016/j.medengphy.2006.05.012 16814588 (Pubitemid 44880187)
43. S Vinchurkar PW Longest 2008 Evaluation of hexahedral, prismatic and hybrid mesh styles for simulating respiratory aerosol dynamics Comput Fluids 37 317 331 10.1016/j.compfluid.2007.05.001 (Pubitemid 350286469)
44. Byron PR, Delvadia RR, Longest PW, Hindle M. Stepping into the Trachea with Realistic Physical Models: Uncertainties in Regional Drug Deposition from Powder Inhalers. In: Dalby, RN et al.,editors. Respiratory Drug Delivery 2010. Illinois: Davis Healthcare International Publishing; 2010. (in press).
45. D Kohler 2004 The Novolizer: overcoming inherent problems of dry powder inhalers Respir Med 98 Suppl A S17 21 10.1016/j.rmed.2004.02.005 15139564 (Pubitemid 38578717)
46. GA Ferron WG Kreyling B Haider 1988 Inhalation of salt aerosol particles - II. Growth and deposition in the human respiratory tract J Aerosol Sci 19 611 631 10.1016/0021-8502(88)90213-3 1:CAS:528:DyaL1MXntVOjsw%3D%3D
47. R Robinson CP Yu 1998 Theoretical analysis of hygroscopic growth rate of mainstream and sidestream cigarette smoke particles in the human respiratory tract Aerosol Sci Tech 28 21 32 10.1080/02786829808965509 1:CAS:528: DyaK1cXjsVSmsg%3D%3D
48. WH Finlay KW Stapleton 1995 The effect on regional lung deposition of coupled heat and mass-transfer between hygroscopic droplets and their surrounding phase J Aerosol Sci 26 655 670 10.1016/0021-8502(94)00132-I 1:CAS:528:DyaK2MXmtFCqtbY%3D
49. Z Zhang C Kleinstreuer CS Kim 2006 Isotonic and hypertonic saline droplet deposition in a human upper airway model J Aerosol Med 19 184 198 10.1089/jam.2006.19.184 1:CAS:528:DC%2BD28XmtFCnu7c%3D 16796543 (Pubitemid 43993385)