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Volumn 50, Issue 9, 2005, Pages 1177-1188

Principles of metered-dose inhaler design

Author keywords

Aerosol; Asthma; Chronic obstructive pulmonary disease; Drug delivery; MDI; Metered dose inhaler; Spacer

Indexed keywords

ANTIASTHMATIC AGENT; BECLOMETASONE DIPROPIONATE; BUDESONIDE; CHLOROFLUOROCARBON; FLUTICASONE; FORMOTEROL; PIRBUTEROL; PROPELLANT; SALBUTAMOL;

EID: 33846636423     PISSN: 00201324     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (223)

References (67)
  • 1
    • 33846566169 scopus 로고    scopus 로고
    • Thiel CG. From Susie's question to CFC free: an inventor's perspective on forty years of MDI development and regulation. In: Dalby RN, Byron PR, Farr SJ, editors. Respiratory drug delivery V. Buffalo Grove: Interpharm Press; 1996:115-123
    • Thiel CG. From Susie's question to CFC free: an inventor's perspective on forty years of MDI development and regulation. In: Dalby RN, Byron PR, Farr SJ, editors. Respiratory drug delivery V. Buffalo Grove: Interpharm Press; 1996:115-123.
  • 2
    • 33846608103 scopus 로고    scopus 로고
    • Dispelling the myths of MDIs
    • Brown BAS. Dispelling the myths of MDIs. Drug Delivery Technology 2002;2(7):1-7.
    • (2002) Drug Delivery Technology , vol.2 , Issue.7 , pp. 1-7
    • Brown, B.A.S.1
  • 3
    • 33846588739 scopus 로고
    • The challenges in the development of metered-dose inhalation aerosols using ozone-friendly propellants
    • Dusseldorf;
    • Tansey IP. The challenges in the development of metered-dose inhalation aerosols using ozone-friendly propellants. Proceedings of the First European Pharm Tech Conference, Dusseldorf; 1993:182-187.
    • (1993) Proceedings of the First European Pharm Tech Conference , pp. 182-187
    • Tansey, I.P.1
  • 4
    • 0014500692 scopus 로고
    • Influence of formulation on aerosol particle size
    • Polli GP, Grim WM, Bacher FA, Yunker MH. Influence of formulation on aerosol particle size. J Pharm Sci 1969;58(4):484-486.
    • (1969) J Pharm Sci , vol.58 , Issue.4 , pp. 484-486
    • Polli, G.P.1    Grim, W.M.2    Bacher, F.A.3    Yunker, M.H.4
  • 5
    • 0038433196 scopus 로고    scopus 로고
    • The influence of formulation variables on the performance of alternative propellant-driven metered dose inhalers
    • Smyth HD. The influence of formulation variables on the performance of alternative propellant-driven metered dose inhalers. Adv Drug Deliv Revs 2003;55(7):807-828.
    • (2003) Adv Drug Deliv Revs , vol.55 , Issue.7 , pp. 807-828
    • Smyth, H.D.1
  • 6
    • 0036882590 scopus 로고    scopus 로고
    • Medical aerosol propellants
    • Noakes T. Medical aerosol propellants. J Fluorine Chem 2002;118(1-2):35-45.
    • (2002) J Fluorine Chem , vol.118 , Issue.1-2 , pp. 35-45
    • Noakes, T.1
  • 7
    • 0016322177 scopus 로고
    • Stratospheric sink for chlorofluoromethanes: Chlorine atomcatalysed destruction of ozone
    • Molina MJ, Rowlands FS. Stratospheric sink for chlorofluoromethanes: chlorine atomcatalysed destruction of ozone. Nature 1974;249: 1810-1812.
    • (1974) Nature , vol.249 , pp. 1810-1812
    • Molina, M.J.1    Rowlands, F.S.2
  • 8
    • 84926367529 scopus 로고    scopus 로고
    • Partridge MR, Woodcock AA. Propellants. In: Bisgaard H, O'Callaghan C, Smaldone GC, editors. Drug delivery to the lung. New York: Marcel Dekker; 2002:371-388.
    • Partridge MR, Woodcock AA. Propellants. In: Bisgaard H, O'Callaghan C, Smaldone GC, editors. Drug delivery to the lung. New York: Marcel Dekker; 2002:371-388.
  • 9
    • 0034658554 scopus 로고    scopus 로고
    • Transition to CFC-free metered dose inhalers: Into the new millenium
    • McDonald KJ, Martin GP. Transition to CFC-free metered dose inhalers: into the new millenium. Int J Pharm 2000;201(1):89-107.
    • (2000) Int J Pharm , vol.201 , Issue.1 , pp. 89-107
    • McDonald, K.J.1    Martin, G.P.2
  • 10
    • 0032790248 scopus 로고    scopus 로고
    • Drug-surfactant-propellant interactions in HFA-formulations
    • Vervaet C, Byron PR. Drug-surfactant-propellant interactions in HFA-formulations. Int J Pharm 1999;186(1):13-20.
    • (1999) Int J Pharm , vol.186 , Issue.1 , pp. 13-20
    • Vervaet, C.1    Byron, P.R.2
  • 11
    • 0029091264 scopus 로고
    • The challenge of reformulation
    • Smith IJ. The challenge of reformulation. J Aerosol Med 1995;8 Suppl 1:S19-S27.
    • (1995) J Aerosol Med , vol.8 , Issue.SUPPL. 1
    • Smith, I.J.1
  • 12
    • 33846642473 scopus 로고
    • Chlorofluorocarbon propellants in self-propelled containers; addition to list of essential uses
    • Food and Drug Administration
    • Food and Drug Administration. Chlorofluorocarbon propellants in self-propelled containers; addition to list of essential uses. Federal Register 1993;58:6086-6088.
    • (1993) Federal Register , vol.58 , pp. 6086-6088
  • 13
    • 0001923877 scopus 로고
    • The formulation and evaluation of pressurised metered dose inhalers
    • Ganderton D, Jones T, editors, Chichester, United Kingdom: Ellis Horwood;
    • Hallworth GW. The formulation and evaluation of pressurised metered dose inhalers. In: Ganderton D, Jones T, editors. Drug delivery to the respiratory tract. Chichester, United Kingdom: Ellis Horwood; 1987:87-118.
    • (1987) Drug delivery to the respiratory tract , pp. 87-118
    • Hallworth, G.W.1
  • 14
    • 33846564311 scopus 로고    scopus 로고
    • Lewis DA, Ganderton D, Meakin BJ, Brambilla G. Theory and practice with solution systems. In: Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ, editors. Respiratory drug delivery IX. River Grove, Illinois: Davis Healthcare International; 2004:109-115.
    • Lewis DA, Ganderton D, Meakin BJ, Brambilla G. Theory and practice with solution systems. In: Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ, editors. Respiratory drug delivery IX. River Grove, Illinois: Davis Healthcare International; 2004:109-115.
  • 15
    • 0033894918 scopus 로고    scopus 로고
    • Pharmaceutical transition to non-CFC pressurized metered dose inhalers
    • Cripps A, Riebe M, Schulze M, Woodhouse R. Pharmaceutical transition to non-CFC pressurized metered dose inhalers. Respir Med 2000;94 Suppl B:S3-S9.
    • (2000) Respir Med , vol.94 , Issue.SUPPL. B
    • Cripps, A.1    Riebe, M.2    Schulze, M.3    Woodhouse, R.4
  • 16
    • 0032438394 scopus 로고    scopus 로고
    • Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone
    • Leach CL, Davidson PJ, Boudreau RJ. Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone. Eur Respir J 1998;12(6):1346-1353.
    • (1998) Eur Respir J , vol.12 , Issue.6 , pp. 1346-1353
    • Leach, C.L.1    Davidson, P.J.2    Boudreau, R.J.3
  • 17
    • 0033431716 scopus 로고    scopus 로고
    • Efficacy response of inhaled beclomethasone dipropionate in asthma is proportional to dose and is improved by formulation with anew propellant
    • Busse WW, Brazinsky S, Jacobson K, Stricker W, Schmitt K, Vanden Burgt J, et al. Efficacy response of inhaled beclomethasone dipropionate in asthma is proportional to dose and is improved by formulation with anew propellant. J Allergy Clin Immunol 1999;104(6): 1215-1222.
    • (1999) J Allergy Clin Immunol , vol.104 , Issue.6 , pp. 1215-1222
    • Busse, W.W.1    Brazinsky, S.2    Jacobson, K.3    Stricker, W.4    Schmitt, K.5    Vanden Burgt, J.6
  • 18
    • 0032827577 scopus 로고    scopus 로고
    • Advances in metered dose inhaler technology with the development of a Chlorofluorocarbon-free drug delivery system
    • Ross DL, Gabrio BJ. Advances in metered dose inhaler technology with the development of a Chlorofluorocarbon-free drug delivery system. J Aerosol Med 1999;12(3):151-160.
    • (1999) J Aerosol Med , vol.12 , Issue.3 , pp. 151-160
    • Ross, D.L.1    Gabrio, B.J.2
  • 19
    • 0029144971 scopus 로고
    • In vitro properties of pressurised metered dose inhalers with and without spacer devices
    • Berg E. In vitro properties of pressurised metered dose inhalers with and without spacer devices. J Aerosol Med 1995;8 Suppl 3:S3-S11.
    • (1995) J Aerosol Med , vol.8 , Issue.SUPPL. 3
    • Berg, E.1
  • 20
    • 0036196011 scopus 로고    scopus 로고
    • In vivo lung deposition of hollow porous particles from a pressurized metered dose inhaler
    • Hirst PH, Pitcairn GR, Weers JG, Tarara TE, Clark AR, Dellamary LA, et al. In vivo lung deposition of hollow porous particles from a pressurized metered dose inhaler. Pharm Res 2002;19(3):258-264.
    • (2002) Pharm Res , vol.19 , Issue.3 , pp. 258-264
    • Hirst, P.H.1    Pitcairn, G.R.2    Weers, J.G.3    Tarara, T.E.4    Clark, A.R.5    Dellamary, L.A.6
  • 22
    • 33846579477 scopus 로고    scopus 로고
    • Stein SW, Forsyth BR, Stefely JS, Christensen JD, Alband TD, Jinks PA. Expanding the dosing range of metered dose inhalers through formulation and hardware optimisation. In: Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ, editors. Respiratory drug delivery IX. River Grove, Illinois: Davis Healthcare International; 2004:125-133.
    • Stein SW, Forsyth BR, Stefely JS, Christensen JD, Alband TD, Jinks PA. Expanding the dosing range of metered dose inhalers through formulation and hardware optimisation. In: Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ, editors. Respiratory drug delivery IX. River Grove, Illinois: Davis Healthcare International; 2004:125-133.
  • 23
    • 85010531118 scopus 로고    scopus 로고
    • The metered-dose inhaler
    • Bisgaard H, O'Callaghan C, Smaldone GC, editors, New York: Marcel Dekker;
    • O'Callaghan C, Wright P. The metered-dose inhaler. In: Bisgaard H, O'Callaghan C, Smaldone GC, editors. Drug delivery to the lung. New York: Marcel Dekker; 2002:337-370.
    • (2002) Drug delivery to the lung , pp. 337-370
    • O'Callaghan, C.1    Wright, P.2
  • 25
    • 0025890424 scopus 로고
    • Low first-spray drug content in albuterol metered dose inhalers
    • Cyr TD, Graham SJ, Lee KY, Lovering EG. Low first-spray drug content in albuterol metered dose inhalers. Pharm Res 1991;8(5): 658-660.
    • (1991) Pharm Res , vol.8 , Issue.5 , pp. 658-660
    • Cyr, T.D.1    Graham, S.J.2    Lee, K.Y.3    Lovering, E.G.4
  • 26
    • 0033436326 scopus 로고    scopus 로고
    • Pressurized metered dose inhalers: Chlorofluorocarbon to hydrofluorocarbon transition-valve performance
    • Cummings RH. Pressurized metered dose inhalers: chlorofluorocarbon to hydrofluorocarbon transition-valve performance. J Allergy Clin Immunol 1999;104(6):S230-S235.
    • (1999) J Allergy Clin Immunol , vol.104 , Issue.6
    • Cummings, R.H.1
  • 27
    • 0033407085 scopus 로고    scopus 로고
    • Deposition of fenoterol from pressurized metered dose inhalers containing hydrofluoroalkanes
    • Newman S, Pitcairn G, Steed K, Harrison A, Nagel J. Deposition of fenoterol from pressurized metered dose inhalers containing hydrofluoroalkanes. J Allergy Clin Immunol 1999;104(6):S253-S257.
    • (1999) J Allergy Clin Immunol , vol.104 , Issue.6
    • Newman, S.1    Pitcairn, G.2    Steed, K.3    Harrison, A.4    Nagel, J.5
  • 28
    • 0029052720 scopus 로고
    • Formulation of solution metered dose inhalers and comparison with aerosols emitted from conventional suspension systems
    • Warren SJ, Farr SJ. Formulation of solution metered dose inhalers and comparison with aerosols emitted from conventional suspension systems. Int J Pharm 1995;124(2):195-203.
    • (1995) Int J Pharm , vol.124 , Issue.2 , pp. 195-203
    • Warren, S.J.1    Farr, S.J.2
  • 29
    • 0029926013 scopus 로고    scopus 로고
    • Clark AR. MDIs: physics of aerosol formation. J Aerosol Med 1996; 9(Suppl 1):S19-S26.
    • Clark AR. MDIs: physics of aerosol formation. J Aerosol Med 1996; 9(Suppl 1):S19-S26.
  • 31
    • 0032764740 scopus 로고    scopus 로고
    • A new method to evaluate plume characteristics of hydrofluoroalkane and chlorofluorocarbon metered dose inhalers
    • Gabrio BJ, Stein SW, Velasquez DJ. A new method to evaluate plume characteristics of hydrofluoroalkane and chlorofluorocarbon metered dose inhalers. Int J Pharm 1999;186(1):3-12.
    • (1999) Int J Pharm , vol.186 , Issue.1 , pp. 3-12
    • Gabrio, B.J.1    Stein, S.W.2    Velasquez, D.J.3
  • 32
    • 0016331630 scopus 로고
    • Studies of the factors controlling the action of hair sprays
    • Rance RW. Studies of the factors controlling the action of hair sprays. J Soc Cosmet Chem 1974;25:545-561.
    • (1974) J Soc Cosmet Chem , vol.25 , pp. 545-561
    • Rance, R.W.1
  • 34
    • 4544242633 scopus 로고    scopus 로고
    • How do patients determine that their metered-dose inhaler is empty?
    • Rubin BK, Durotoye L. How do patients determine that their metered-dose inhaler is empty? Chest 2004;126(4):1134-1137.
    • (2004) Chest , vol.126 , Issue.4 , pp. 1134-1137
    • Rubin, B.K.1    Durotoye, L.2
  • 35
    • 33846582771 scopus 로고    scopus 로고
    • Food and Drug Administration, US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research CDER, Accessed June 21
    • Food and Drug Administration. Guidance for industry: integration of dose-counting mechanisms into MDI drug products: US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), 2001. http://www. fda.gov/cder/guidance/index.htm. Accessed June 21, 2005.
    • (2001) Guidance for industry: Integration of dose-counting mechanisms into MDI drug products
  • 37
    • 0020322578 scopus 로고
    • Problems patients have using pressurised aerosol inhalers
    • Crompton GK. Problems patients have using pressurised aerosol inhalers. Eur J Respir Dis 1982;63(Supplement 119):57-65.
    • (1982) Eur J Respir Dis , vol.63 , Issue.SUPPL.EMENT 119 , pp. 57-65
    • Crompton, G.K.1
  • 38
    • 0025951893 scopus 로고
    • Improvement of drug delivery with a breath actuated pressurised aerosol for patients with poor inhaler technique
    • Newman SP, Weisz AW, Talaee N, Clarke SW. Improvement of drug delivery with a breath actuated pressurised aerosol for patients with poor inhaler technique. Thorax 1991;46(10):712-716.
    • (1991) Thorax , vol.46 , Issue.10 , pp. 712-716
    • Newman, S.P.1    Weisz, A.W.2    Talaee, N.3    Clarke, S.W.4
  • 39
    • 0036178365 scopus 로고    scopus 로고
    • Misuse of corticosteroid metered-dose inhaler is associated with decreased asthma stability
    • Giraud V, Roche N. Misuse of corticosteroid metered-dose inhaler is associated with decreased asthma stability. Eur Respir J 2002;19(2): 246-251.
    • (2002) Eur Respir J , vol.19 , Issue.2 , pp. 246-251
    • Giraud, V.1    Roche, N.2
  • 40
    • 0034129205 scopus 로고    scopus 로고
    • Inappropriate inhaler use: Assessment of use and patient preference of seven inhalation devices
    • Lenney J, Innes JA, Crompton GK. Inappropriate inhaler use: assessment of use and patient preference of seven inhalation devices. Respir Med 2000;94(5):496-500.
    • (2000) Respir Med , vol.94 , Issue.5 , pp. 496-500
    • Lenney, J.1    Innes, J.A.2    Crompton, G.K.3
  • 41
    • 84965272382 scopus 로고
    • Breath-activated aerosol
    • Crompton GK. Breath-activated aerosol. Br Med J 1971;2(762):652-653.
    • (1971) Br Med J , vol.2 , Issue.762 , pp. 652-653
    • Crompton, G.K.1
  • 42
    • 33846633128 scopus 로고    scopus 로고
    • A new breath operated actuator
    • Dalby RN, Byron PR, Peart J, Farr SF, editors, Raleigh: Davis Horwood;
    • Bacon RJ, McDermott I, Bell J. A new breath operated actuator. In: Dalby RN, Byron PR, Peart J, Farr SF, editors. Respiratory drug delivery VIII. Raleigh: Davis Horwood; 2002:403-406.
    • (2002) Respiratory drug delivery VIII , pp. 403-406
    • Bacon, R.J.1    McDermott, I.2    Bell, J.3
  • 43
    • 0029059091 scopus 로고
    • Aerosol deposition in the human lung following administration from a microprocessor controlled metered dose inhaler
    • Farr SJ, Rowe AM, Rubsamen R, Taylor G. Aerosol deposition in the human lung following administration from a microprocessor controlled metered dose inhaler. Thorax 1995;50(6):639-644.
    • (1995) Thorax , vol.50 , Issue.6 , pp. 639-644
    • Farr, S.J.1    Rowe, A.M.2    Rubsamen, R.3    Taylor, G.4
  • 44
    • 34248630555 scopus 로고    scopus 로고
    • Devices to assist patient co-ordination with pMDIs: A review
    • The Aerosol Society;
    • Howlett D. Devices to assist patient co-ordination with pMDIs: a review. Proceedings of Drug Delivery to the Lungs IX. Portishead: The Aerosol Society; 1998:184-187.
    • (1998) Proceedings of Drug Delivery to the Lungs IX. Portishead , pp. 184-187
    • Howlett, D.1
  • 45
    • 33846583467 scopus 로고    scopus 로고
    • The breath coordinated inhaler (BCI): A new pulmonary drug delivery device for pressurized metered dose inhalers
    • Dalby RN, Byron PR, Farr SJ, Peart J, editors, Raleigh: Serentec Press;
    • Zhang FL, Genova PA, Tanguay JF, Cronin J, Sexton F, Cutie AJ, Jewett W, Adjei AL. The breath coordinated inhaler (BCI): a new pulmonary drug delivery device for pressurized metered dose inhalers. In: Dalby RN, Byron PR, Farr SJ, Peart J, editors. Respiratory drug delivery VII. Raleigh: Serentec Press; 2000:323-326.
    • (2000) Respiratory drug delivery VII , pp. 323-326
    • Zhang, F.L.1    Genova, P.A.2    Tanguay, J.F.3    Cronin, J.4    Sexton, F.5    Cutie, A.J.6    Jewett, W.7    Adjei, A.L.8
  • 46
    • 0024636265 scopus 로고
    • Optimized inhalation aerosols. I. The effects of spherical baffle size and position upon the output characteristics of several pressurized non-aqueous suspension formulations
    • Byron PR, Dalby RN, Hickey AJ. Optimized inhalation aerosols. I. The effects of spherical baffle size and position upon the output characteristics of several pressurized non-aqueous suspension formulations. Pharm Res 1989;6(3):225-229.
    • (1989) Pharm Res , vol.6 , Issue.3 , pp. 225-229
    • Byron, P.R.1    Dalby, R.N.2    Hickey, A.J.3
  • 47
    • 0033060047 scopus 로고    scopus 로고
    • Improved targeting of beclomethasone dipropionate (250 micrograms metered dose inhaler) to the lungs of asthmatics with the Spacehaler
    • Newman SP, Steed KP, Hooper G, Jones JI, Upchurch FC. Improved targeting of beclomethasone dipropionate (250 micrograms metered dose inhaler) to the lungs of asthmatics with the Spacehaler. Respir Med 1999;93(6):424-431.
    • (1999) Respir Med , vol.93 , Issue.6 , pp. 424-431
    • Newman, S.P.1    Steed, K.P.2    Hooper, G.3    Jones, J.I.4    Upchurch, F.C.5
  • 48
    • 0141712206 scopus 로고    scopus 로고
    • pMDI aerosol momentum manipulation and biotargeted delivery
    • Dalby RN, Byron PR, Peart J, Farr SF, editors, Raleigh: Davis Horwood;
    • Mohsen N. pMDI aerosol momentum manipulation and biotargeted delivery. In: Dalby RN, Byron PR, Peart J, Farr SF, editors. Respiratory drug delivery VIII. Raleigh: Davis Horwood; 2002:593-597.
    • (2002) Respiratory drug delivery VIII , pp. 593-597
    • Mohsen, N.1
  • 49
    • 0031763594 scopus 로고    scopus 로고
    • Metered dose inhaler add-on devices: An in vitro evaluation of the BronchoAir inhaler and several spacer devices
    • Steckel H, Müller BW. Metered dose inhaler add-on devices: an in vitro evaluation of the BronchoAir inhaler and several spacer devices. J Aerosol Med 1998;11(3):133-142.
    • (1998) J Aerosol Med , vol.11 , Issue.3 , pp. 133-142
    • Steckel, H.1    Müller, B.W.2
  • 50
    • 0029875614 scopus 로고    scopus 로고
    • Effect of add-on devices for aerosol drug delivery: Deposition studies and clinical aspects
    • Newman SP, Newhouse MT. Effect of add-on devices for aerosol drug delivery: deposition studies and clinical aspects. J Aerosol Med 1996;9(1):55-70.
    • (1996) J Aerosol Med , vol.9 , Issue.1 , pp. 55-70
    • Newman, S.P.1    Newhouse, M.T.2
  • 51
    • 2342667615 scopus 로고    scopus 로고
    • Spacer devices for metered dose inhalers
    • Newman SP. Spacer devices for metered dose inhalers. Clin Pharmacokinetics 2004;43(6):349-360.
    • (2004) Clin Pharmacokinetics , vol.43 , Issue.6 , pp. 349-360
    • Newman, S.P.1
  • 53
    • 0030603993 scopus 로고    scopus 로고
    • A small volume spacer for use with a breath-operated pressurised metered dose inhaler
    • Hardy J, Jasuja A, Frier M, Perkins A. A small volume spacer for use with a breath-operated pressurised metered dose inhaler. Int J Pharm 1996;142(2):129-133.
    • (1996) Int J Pharm , vol.142 , Issue.2 , pp. 129-133
    • Hardy, J.1    Jasuja, A.2    Frier, M.3    Perkins, A.4
  • 54
    • 0024433602 scopus 로고
    • Pressurised aerosol deposition in the human lung with and without an "open" spacer
    • Newman SP, Clark AR, Talaee N, Clarke SW. Pressurised aerosol deposition in the human lung with and without an "open" spacer. Thorax 1989;44(9):706-710.
    • (1989) Thorax , vol.44 , Issue.9 , pp. 706-710
    • Newman, S.P.1    Clark, A.R.2    Talaee, N.3    Clarke, S.W.4
  • 55
    • 13544253826 scopus 로고    scopus 로고
    • Device selection and outcomes of aerosol therapy: Evidence-based guidelines
    • Dolovich MB, Ahrens RC, Hess DR, Anderson P, Dhand R, Rau JL, et al. Device selection and outcomes of aerosol therapy: evidence-based guidelines. Chest 2005;127(1):335-371.
    • (2005) Chest , vol.127 , Issue.1 , pp. 335-371
    • Dolovich, M.B.1    Ahrens, R.C.2    Hess, D.R.3    Anderson, P.4    Dhand, R.5    Rau, J.L.6
  • 56
    • 84964219078 scopus 로고    scopus 로고
    • Spacer devices
    • Bisgaard H, O'Callaghan C, Smaldone GC, editors, New York: Marcel Dekker;
    • Bisgaard H, Anhoj J, Wildhaber JH. Spacer devices. In: Bisgaard H, O'Callaghan C, Smaldone GC, editors. Drug delivery to the lung. New York: Marcel Dekker; 2002:389-420.
    • (2002) Drug delivery to the lung , pp. 389-420
    • Bisgaard, H.1    Anhoj, J.2    Wildhaber, J.H.3
  • 57
    • 0031901296 scopus 로고    scopus 로고
    • The effects of static charge in spacer devices on glucocorticosteroid aerosol deposition in asthmatic patients
    • Kenyon CJ, Thorsson L, Borgström L, Newman SP. The effects of static charge in spacer devices on glucocorticosteroid aerosol deposition in asthmatic patients. Eur Respir J 1998;11(3):606-610.
    • (1998) Eur Respir J , vol.11 , Issue.3 , pp. 606-610
    • Kenyon, C.J.1    Thorsson, L.2    Borgström, L.3    Newman, S.P.4
  • 58
    • 0029804408 scopus 로고    scopus 로고
    • Effect of electrostatic charge, flow, delay and multiple actuations on the in vitro delivery of salbutamol from different small volume spacers for infants
    • Wildhaber JH, Devadason SG, Eber E, Hayden MJ, Everard ML, Summers QA, Le Souëf PN. Effect of electrostatic charge, flow, delay and multiple actuations on the in vitro delivery of salbutamol from different small volume spacers for infants. Thorax 1996;51(10): 985-988.
    • (1996) Thorax , vol.51 , Issue.10 , pp. 985-988
    • Wildhaber, J.H.1    Devadason, S.G.2    Eber, E.3    Hayden, M.J.4    Everard, M.L.5    Summers, Q.A.6    Le Souëf, P.N.7
  • 59
    • 33846584439 scopus 로고    scopus 로고
    • Mitchell J, Morton R, Schmidt J, Snyder S, Doyle C, Nagel M. Overcoming electrostatic charge retention in a new valved holding chamber (VHC): in vitro performance comparison with current devices. In: Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ, editors, Respiratory drug delivery IX. River Grove, Illinois: Davis Healthcare International, 2004, 705-707.
    • Mitchell J, Morton R, Schmidt J, Snyder S, Doyle C, Nagel M. Overcoming electrostatic charge retention in a new valved holding chamber (VHC): in vitro performance comparison with current devices. In: Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ, editors, Respiratory drug delivery IX. River Grove, Illinois: Davis Healthcare International, 2004, 705-707.
  • 61
    • 0022636609 scopus 로고
    • Effect of InspirEase on the deposition of metered dose aerosols in the human respiratory tract
    • Newman SP, Woodman G, Clarke SW, Sackner MA. Effect of InspirEase on the deposition of metered dose aerosols in the human respiratory tract. Chest 1986;89(4):551-556.
    • (1986) Chest , vol.89 , Issue.4 , pp. 551-556
    • Newman, S.P.1    Woodman, G.2    Clarke, S.W.3    Sackner, M.A.4
  • 62
    • 0029865528 scopus 로고    scopus 로고
    • In vitro measurements of delivery of medications from MDIs and spacer devices
    • Dolovich MB. In vitro measurements of delivery of medications from MDIs and spacer devices. J Aerosol Med 1996;9 Supplement 1:S49-S58.
    • (1996) J Aerosol Med , vol.9 , Issue.SUPPL.EMENT 1
    • Dolovich, M.B.1
  • 63
    • 0029119923 scopus 로고
    • The optimum size and shape of spacer devices for inhalational therapy
    • Barry PW, O'Callaghan C. The optimum size and shape of spacer devices for inhalational therapy. J Aerosol Med 1995;8:303-305.
    • (1995) J Aerosol Med , vol.8 , pp. 303-305
    • Barry, P.W.1    O'Callaghan, C.2
  • 64
  • 65
    • 0029787537 scopus 로고    scopus 로고
    • Inhalational drug delivery from seven different spacer devices
    • Barry PW, O'Callaghan C. Inhalational drug delivery from seven different spacer devices. Thorax 1996;51(8):835-840.
    • (1996) Thorax , vol.51 , Issue.8 , pp. 835-840
    • Barry, P.W.1    O'Callaghan, C.2
  • 66
    • 6544232840 scopus 로고    scopus 로고
    • Performance of large-volume versus small volume holding chambers with chlorofluorocarbon-albuterol and hydrofluoroalkane-albuterol sulphate
    • Mitchell JP, Nagel MW, Rau JL. Performance of large-volume versus small volume holding chambers with chlorofluorocarbon-albuterol and hydrofluoroalkane-albuterol sulphate. Respir Care 1999; 44(1):38-44.
    • (1999) Respir Care , vol.44 , Issue.1 , pp. 38-44
    • Mitchell, J.P.1    Nagel, M.W.2    Rau, J.L.3
  • 67
    • 17644363741 scopus 로고    scopus 로고
    • Aerosol profile extracted from spacers as a determinant of actual dose
    • Verbanck S, Vervaet C, Schuermans D, Vincken W. Aerosol profile extracted from spacers as a determinant of actual dose. Pharm Res 2004;21:2213-2218.
    • (2004) Pharm Res , vol.21 , pp. 2213-2218
    • Verbanck, S.1    Vervaet, C.2    Schuermans, D.3    Vincken, W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.