Development of a stochastic individual path (SIP) model for predicting the tracheobronchial deposition of pharmaceutical aerosols: Effects of transient inhalation and sampling the airways

Journal of Aerosol Science

Volumn 42, Issue 11, 2011, Pages 781-799

  Tian, Geng ^a   Longest, P Worth ^a,b   Su, Guoguang ^a   Walenga, Ross L ^a   Hindle, Michael ^b  

^a Virginia Commonwealth University   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Aerosol deposition; Dry powder inhalers; Respiratory dosimetry; Respiratory drug delivery; Stochastic lung modeling; Transient inhalation waveforms

Indexed keywords

AEROSOLS; ATMOSPHERIC MOVEMENTS; ATOMIZERS; BIFURCATION (MATHEMATICS); BIOLOGICAL ORGANS; DEPOSITION; FORECASTING; GEOMETRY; STOCHASTIC MODELS; STOCHASTIC SYSTEMS;

AEROSOL DEPOSITION; DRY POWDER INHALER; LUNG MODEL; RESPIRATORY DRUG DELIVERIES; WAVE FORMS;

DRUG DELIVERY;

AEROSOL; AMBIENT AIR; DRUG; GEOMETRY; NUMERICAL MODEL; SAMPLING; STOCHASTICITY;

ACCURACY; AEROSOL; AEROSOL DEPOSITION; AIRWAY; ARTICLE; BRONCHUS; CONTROLLED STUDY; DRUG ACCUMULATION; GEOMETRY; IN VIVO STUDY; INHALATION; LUNG LOBE; MOUTH; POWDER INHALER; PRIORITY JOURNAL; STOCHASTIC MODEL; THROAT; TRACHEA;

EID: 80051622991     PISSN: 00218502     EISSN: 18791964     Source Type: Journal    
DOI: 10.1016/j.jaerosci.2011.07.005     Document Type: Article

References (82)

1. Asgharian B., Hofmann W., Bergmann R. Particle deposition in a multiple-path model of the human lung. Aerosol Science and Technology 2001, 34:332-339.
2. Asgharian B., Price O.T. Airflow distribution in the human lung and its influence on particle deposition. Inhalation Toxicology 2006, 18:795-801.
3. Asgharian B., Price O.T., Hofmann W. Prediction of particle deposition in the human lung using realistic models of lung ventilation. Aerosol Science 2006, 37:1209-1221.
4. Balashazy I., Hofmann W., Heistracher T. Computation of local enhancement factors for the quantification of particle deposition patterns in airway bifurcations. Journal of Aerosol Science 1999, 30:185-203.
5. Bisgaard H., Klug B., Sumby B.S., Burnell P.K.P. Fine particle mass from the Diskus inhaler and Turbuhaler inhaler in children with asthma. European Respiratory Journal 1998, 11(5):1111-1115.
6. Broeders M.E.A.C., Molema J., Hop W.C.J., Folgering H.T.M. Inhalation profiles in asthmatics and COPD patients: Reproducibility and effect of instruction. Journal of Aerosol Medicine 2003, 16(2):131-141.
7. Byron P.R., Delvadia R.R., Longest P.W., Hindle M. Stepping into the trachea with realistic physical models: Uncertainties in regional drug deposition from powder inhalers. Respiratory Drug Delivery 2010, 2010(1):215-224.
8. Cheng K.H., Cheng Y.S., Yeh H.C., Swift D.L. Measurements of airway dimensions and calculation of mass transfer characteristics of the human oral passage. Journal of Biomechanical Engineering 1997, 119:476-482.
9. Cheng Y.S., Fu C.S., Yazzie D., Zhou Y. Respiratory deposition patterns of salbutamol pMDI with CFC and HFA-134a formulations in a human airway replica. Journal of Aerosol Medicine 2001, 14(2):255-266.
10. Clark A.R., Hollingworth A.M. The relationship between powder inhaler resistance and peak inspiratory conditions in healthy volunteers-Implications for in vitro testing. Journal of Aerosol Medicine 1993, 6:99-110.
11. Delvadia R.R., Byron P.R., Longest P.W., Hindle M. In vitro prediction of regional drug deposition from dry powder inhalers. Respiratory Drug Delivery 2010, 2010:907-911.
12. Finlay W.H. The Mechanics of Inhaled Pharmaceutical Aerosols 2001, Academic Press, San Diego.
13. Finlay W.H., Gehmlich M.G. Inertial sizing of aerosol inhaled from two dry powder inhalers with realistic breath patterns versus constant flow rates. International Journal of Pharmaceutics 2000, 210:83-95.
14. Finlay W.H., Martin A.R. Modeling of aerosol deposition within interface devices. Journal of Aerosol Medicine 2007, 20(S1):S19-S28.
15. Finlay W.H., Martin A.R. Recent advances in predictive understanding of respiratory tract deposition. Journal of Aerosol Medicine and Pulmonary Drug Delivery 2008, 21(2):189-205.
16. Gemci T., Ponyavin V., Chen Y., Chen H., Collins R. Computational model of airflow in upper 17 generations of human respiratory tract. Journal of Biomechanics 2008, 41(9):2047-2054.
17. Grgic B., Martin A.R., Finlay W.H. The effect of unsteady flow rate increase on in vitro mouth-throat deposition of inhaled boluses. Aerosol Science 2006, 37:1222-1233.
18. Hammersley J.R., Olson D.E. Physical models of the smaller pulmonary airways. Journal of Applied Physiology 1992, 72:2402-2414.
19. Heistracher T., Hofmann W. Physiologically realistic models of bronchial airway bifurcations. Journal of Aerosol Science 1995, 26(3):497-509.
20. Hindle M., Longest P.W. Evaluation of enhanced condensational growth (ECG) for controlled respiratory drug delivery in a mouth-throat and upper tracheobronchial model. Pharmaceutical Research 2010, 27:1800-1811.
21. Hofmann W., Asgharian B., Winkler-Heil R. Modeling intersubject variability of particle deposition in human lungs. Aerosol Science 2002, 33:219-235.
22. Horsfield K., Dart G., Olson D.E., Cumming G. Models of the human bronchial tree. Journal of Applied Physiology 1971, 31:207-217.
23. Horsfield K., Dart G., Olson D.E., Filley G.F., Cumming G. Models of the human bronchial tree. Journal of Applied Physiology 1971, 31:207-217.
24. ICRP. (1994). Human Respiratory Tract Model for Radiological Protection. Elsevier Science Ltd.: New York.
25. Inthavong K., Choi L.-T., Tu J., Diang S., Thien F. Micron particle deposition in a tracheobronchial airway model under different breathing conditions. Medical Engineering and Physics 2010, 32:1198-1212.
26. Jin H.H., Fan J.R., Zeng M.J., Cen K.F. Large eddy simulation of inhaled particle deposition within the human upper respiratory tract. Aerosol Science 2007, 38:257-268.
27. Kamada A.K., Szefler S.J., Martin R.J., Boushey H.A., Chinchilli V.M., Drazen J.M., Fish J.E., Israel E., Lazarus S.C., Lemanske R.F., Cherniak R.M., Hurd S.S., Peters S.P., Sorkness C., Szefler S.J., Zwillich C.W. Issues in the use of inhaled glucocorticoids. American Journal of Respiratory and Critical Care Medicine 1996, 153(6):1739-1748.
28. Kim C.S. Deposition of aerosol particles in human lungs: In vivo measurement and modeling. Biomarkers 2009, 14(S1):54-58.
29. Kleinstreuer C., Shi H., Zhang Z. Computational analyses of a pressurized metered dose inhaler and an new drug-aerosol targeting methodology. Journal of Aerosol Medicine 2007, 20(3):294-309.
30. Kleinstreuer C., Zhang Z. An adjustable triple-bifurcation unit model for air-particle flow simulations in human tracheobronchial airways. Journal of Biomechanical Engineering 2009, 131:021007.
31. Kleinstreuer C., Zhang Z., Li Z. Modeling airflow and particle transport/deposition in pulmonary airways. Respiratory Physiology and Neurobiology 2008, 163:128-138.
32. Koblinger L., Hofmann W. Analysis of human lung morphometric data for stochastic aerosol deposition calculations. Physics in Medicine and Biology 1985, 30:541-556.
33. Koblinger L., Hofmann W. Monte Carlo modeling of aerosol deposition in human lungs. Part I: Simulation of particle transport in a stochastic lung structure. Journal of Aerosol Science 1990, 21(5):661-674.
34. Lambert A.R., O'Shaughnessy P.T., Tawhai M.H., Hoffman E.A., Lin C.-L. Regional deposition of particles in an image-based airway model: Large-eddy simulation and left-right lung ventilation asymmetry. Aerosol Science and Technology 2011, 45:11-25.
35. Leach C.L., Davidson P.J., Bouhuys A. Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone. European Respiratory Journal 1998, 12:1346-1353.
36. Li Z., Kleinstreuer C., Zhang Z. Particle deposition in the human tracheobronchial airways due to transient inspiratory flow patterns. Aerosol Science 2007, 38:625-644.
37. Lin C.-L., Tawhai M.H., McLennan G., Hoffman E.A. Characteristics of the turbulent laryngeal jet and its effect on airflow in the human intra-thoracic airways. Respiratory Physiology and Neurobiology 2007, 157:295-309.
38. Lin C.-L., Tawhai M.H., McLennan G., Hoffman E.A. Multiscale simulation of gas flow in subject-specific models of the human lung. IEEE Engineering in Medicine and Biology 2009, 28:25-33.
39. Longest P.W., Hindle M. Evaluation of the Respimat Soft Mist inhaler using a concurrent CFD and in vitro approach. Journal of Aerosol Medicine and Pulmonary Drug Delivery 2009, 22(2):99-112.
40. Longest P.W., Hindle M. Quantitative analysis and design of a spray aerosol inhaler. Part 1: Effects of dilution air inlets and flow paths. Journal of Aerosol Medicine and Pulmonary Drug Delivery 2009, 22(3):271-283.
41. Longest P.W., Hindle M., Das Choudhuri S. Effects of generation time on spray aerosol transport and deposition in models of the mouth-throat geometry. Journal of Aerosol Medicine and Pulmonary Drug Delivery 2009, 22(3):67-84.
42. Longest P.W., Hindle M., Das Choudhuri S., Byron P.R. Numerical simulations of capillary aerosol generation: CFD model development and comparisons with experimental data. Aerosol Science and Technology 2007, 41:952-973.
43. Longest P.W., Hindle M., Das Choudhuri S., Byron P.R. Developing a better understanding of spray system design using a combination of CFD modeling and experiment. Proceedings of Respiratory Drug Delivery 2008 2008, 151-163. Davis Healthcare International Publishing, Illinois. R.N. Dalby, P.R. Byron, J. Peart, J.D. Suman, S.J. Farr, P.M. Young (Eds.).
44. Longest P.W., Hindle M., Das Choudhuri S., Xi J. Comparison of ambient and spray aerosol deposition in a standard induction port and more realistic mouth-throat geometry. Journal of Aerosol Science 2008, 39:572-591.
45. Longest P.W., Oldham M.J. Mutual enhancements of CFD modeling and experimental data: A case study of one micrometer particle deposition in a branching airway model. Inhalation Toxicology 2006, 18(10):761-772.
46. Longest P.W., Tian G., Hindle M. Improving the lung delivery of nasally administered aerosols during noninvasive ventilation-an application of enhanced condensational growth (ECG). Journal of Aerosol Medicine and Pulmonary Drug Delivery 2011, 24(2):103-118. 10.1089/jamp.2010.0849.
47. Longest P.W., Vinchurkar S. Effects of mesh style and grid convergence on particle deposition in bifurcating airway models with comparisons to experimental data. Medical Engineering and Physics 2007, 29(3):350-366.
48. Longest P.W., Vinchurkar S. Validating CFD predictions of respiratory aerosol deposition: Effects of upstream transition and turbulence. Journal of Biomechanics 2007, 40:305-316.
49. Longest P.W., Xi J. Effectiveness of direct Lagrangian tracking models for simulating nanoparticle deposition in the upper airways. Aerosol Science and Technology 2007, 41:380-397.
50. Longest P.W., Xi J. Condensational growth may contribute to the enhanced deposition of cigarette smoke particles in the upper respiratory tract. Aerosol Science and Technology 2008, 42:579-602.
51. Lumb A.B. Nunn's Applied Respiratory Physiology 2000, Butterworth Heinemann, Oxford.
52. Ma B., Lutchen K.R. CFD simulations of aeroosl depostion in an anatomically based human large-medium airway model. Annals of Biomedical Engineering 2009, 37(2):271-285.
53. Martin A.R., Finlay W.H. A general, algebraic equation for predicting total respiratory tract deposition of micrometer-sized aerosol particles in humans. Journal of Aerosol Science 2007, 38(2):246-253.
54. Matida E.A., DeHaan W.H., Finlay W.H., Lange C.F. Simulation of particle deposition in an idealized mouth with different small diameter inlets. Aerosol Science and Technology 2003, 37:924-932.
55. Matida E.A., Finlay W.H., Breuer M., Lange C.F. Improving prediction of aerosol deposition in an idealized mouth using large-eddy simulation. Journal of Aerosol Medicine 2006, 19(3):290-300.
56. Matida E.A., Finlay W.H., Grgic L.B. Improved numerical simulation of aerosol deposition in an idealized mouth-throat. Journal of Aerosol Science 2004, 35:1-19.
57. Newman S.P., Busse W.W. Evolution of dry powder inhaler design, formulation, and performance. Respiratory Medicine 2002, 96:293-304.
58. Olsson B., Berg E., Svensson M. Comparing aerosol size distributions that penetrate mouth-throat models under realistic inhalation conditions. Respiratory Drug Delivery 2010, 2010:225-234.
59. Patton J.S., Byron P.R. Inhaling medicines: Delivering drugs to the body through the lungs. Nature Reviews Drug Discovery 2007, 6:67-74.
60. Pedley T.J. Viscous boundary layers in reversing flow. Journal of Fluid Mechanics 1976, 74:59-79.
61. Phalen R.F., Yeh H.C., Schum G.M., Raabe O.G. Application of an idealized model to morphometry of the mammalian tracheobronchial tree. Anat. Rec. 1978, 190:167-176.
62. Russo J., Robinson R., Oldham M.J. Effects of cartilage rings on airflow and particle deposition in the trachea and main bronchi. Medical Engineering and Physics 2008, 30:581-589.
63. Sosnowski T.R., Moskal A., Gradon L. Mechanisms of aerosol particle deposition in the oro-pharynx under non-steady airflow. Annals of Occupational Hygiene 2007, 51(1):19-25.
64. Sznitman J., Heimshch T., Wildhaber J.H., Tsuda A., Rosgen T. Respiratory flow phenomena and gravitational deposition in a three-dimensional space-filling model of the pulmonary acinar tree. Journal of Biomechanical Engineering 2009, 131:31010-31031.
65. Tarsin W.Y., Pearson S.B., Assi K.H., Chrystyn H. Emitted dose estimates from Seretide (R) Diskus (R) and Symbicort (R) Turbuhaler (R) following inhalation by severe asthmatics. International Journal of Pharmaceutics 2006, 316(1-2):131-137.
66. Tian G., Longest P.W., Su G., Hindle M. Characterization of respiratory drug delivery with enhanced condensational growth (ECG) using an individual path model of the entire tracheobronchial airways. Annals of Biomedical Engineering 2011, 39(3):1136-1153.
67. van der Palen J. Peak inspiratory flow through Diskus and Turbuhaler, measured by means of a peak inspiratory flow meter (In-Check Dial). Respiratory Medicine 2003, 97:285-298.
68. Vinchurkar S., Longest P.W. Evaluation of hexahedral, prismatic and hybrid mesh styles for simulating respiratory aerosol dynamics. Computers and Fluids 2008, 37:317-331.
69. Walters D.K., Luke W.H. Computational fluid dynamics simulations of particle deposition in large-scale multigenerational lung models. Journal of Biomechanical Engineering 2011, 133:011003.
70. Weers J.G., Bell J., Chan H.K., Cipolla D., Dunbar C., Hickey A.J., Smith I.J. Pulmonary formulations: What remains to be done?. Journal of Aerosol Medicine and Pulmonary Drug Delivery 2010, 23:S5-S23.
71. Xi J., Longest P.W. Transport and deposition of micro-aerosols in realistic and simplified models of the oral airway. Annals of Biomedical Engineering 2007, 35(4):560-581.
72. Xi J., Longest P.W. Effects of oral airway geometry characteristics on the diffusional deposition of inhaled nanoparticles. ASME Journal of Biomechanical Engineering 2008, 130:011008.
73. Xi J., Longest P.W., Martonen T.B. Effects of the laryngeal jet on nano- and microparticle transport and deposition in an approximate model of the upper tracheobronchial airways. Journal of Applied Physiology 2008, 104:1761-1777.
74. Yeh H.C., Schum G.M. Models of human lung airways and their application to inhaled particle deposition. Bulletin of Mathematical Biology 1980, 42:461-480.
75. Yin Y., Choi J., Hoffman E.A., Tawhai M.H., Lin C.-L. Simulation of pulmonary air flow with a subject-specific boundary condition. Journal of Biomechanics 2010, 43:2159-2163.
76. Zhang Z., Kleinstreuer C. Computational analysis of airflow and nanoparticle deposition in a combined nasal-oral-tracheobronchial airway model. Journal of Aerosol Science 2011, 42:174-194.
77. Zhang Z., Kleinstreuer C., Donohue J.F., Kim C.S. Comparison of micro- and nano-size particle depositions in a human upper airway model. Journal of Aerosol Science 2005, 36(2):211-233.
78. Zhang Z., Kleinstreuer C., Kim C.S. Cyclic micron-size particle inhalation and deposition in a triple bifurcation lung airway model. Journal of Aerosol Science 2002, 33(2):257-281.
79. Zhang Z., Kleinstreuer C., Kim C.S. Micro-particle transport and deposition in a human oral airway model. Journal of Aerosol Science 2002, 33(12):1635-1652.
80. Zhang Z., Kleinstreuer C., Kim C.S. Airflow and nanoparticle deposition in a 16-generation tracheobronchial airway model. Annals of Biomedical Engineering 2008, 36(12):2095-2110.
81. Zhang Z., Kleinstreuer C., Kim C.S. Comparison of analytical and CFD models with regard to micron particle deposition in a human 16-generation tracheobronchial airway model. Aerosol Science 2009, 40:16-28.
82. Zhou Y., Cheng Y.S. Particle deposition in a cast of human tracheobrochial airways. Aerosol Science and Technology 2005, 39:492-500.