메뉴 건너뛰기




Volumn 39, Issue 7, 2008, Pages 572-591

Comparison of ambient and spray aerosol deposition in a standard induction port and more realistic mouth-throat geometry

Author keywords

Aerosol transport and deposition; Capillary aerosol generation; Mouth throat geometry; Respiratory aerosol dynamics; Respiratory drug delivery; Spray momentum effects; USP induction port

Indexed keywords

AEROSOLS; COMPUTATIONAL FLUID DYNAMICS; DEPOSITION; DRUG DELIVERY; GEOMETRY; MOMENTUM;

EID: 45049088663     PISSN: 00218502     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaerosci.2008.03.008     Document Type: Article
Times cited : (107)

References (53)
  • 2
    • 0031281841 scopus 로고    scopus 로고
    • Measurements of airway dimensions and calculation of mass transfer characteristics of the human oral passage
    • Cheng K.H., Cheng Y.S., Yeh H.C., and Swift D.L. Measurements of airway dimensions and calculation of mass transfer characteristics of the human oral passage. Journal of Biomechanical Engineering 119 (1997) 476-482
    • (1997) Journal of Biomechanical Engineering , vol.119 , pp. 476-482
    • Cheng, K.H.1    Cheng, Y.S.2    Yeh, H.C.3    Swift, D.L.4
  • 3
    • 0034885367 scopus 로고    scopus 로고
    • Respiratory deposition patterns of salbutamol pMDI with CFC and HFA-134a formulations in a human airway replica
    • Cheng Y.S., Fu C.S., Yazzie D., and Zhou Y. Respiratory deposition patterns of salbutamol pMDI with CFC and HFA-134a formulations in a human airway replica. Journal of Aerosol Medicine 14 2 (2001) 255-266
    • (2001) Journal of Aerosol Medicine , vol.14 , Issue.2 , pp. 255-266
    • Cheng, Y.S.1    Fu, C.S.2    Yazzie, D.3    Zhou, Y.4
  • 6
    • 0028386760 scopus 로고
    • The inertial lift on a rigid sphere in a linear shear flow field near a flat wall
    • Cherukat P., and McLaughlin J.B. The inertial lift on a rigid sphere in a linear shear flow field near a flat wall. Journal of Fluid Mechanics 263 (1994) 1-18
    • (1994) Journal of Fluid Mechanics , vol.263 , pp. 1-18
    • Cherukat, P.1    McLaughlin, J.B.2
  • 7
    • 25844483208 scopus 로고    scopus 로고
    • Revised internal volumes of cascade impactors for those provided by Mitchell and Nagel
    • Copley M., Smurthwaite M., Roberts D.L., and Mitchell J.P. Revised internal volumes of cascade impactors for those provided by Mitchell and Nagel. Journal of Aerosol Medicine 18 3 (2005) 364-366
    • (2005) Journal of Aerosol Medicine , vol.18 , Issue.3 , pp. 364-366
    • Copley, M.1    Smurthwaite, M.2    Roberts, D.L.3    Mitchell, J.P.4
  • 8
    • 1542291134 scopus 로고    scopus 로고
    • Predicting extrathoracic deposition from dry powder inhalers
    • DeHaan W.H., and Finlay W.H. Predicting extrathoracic deposition from dry powder inhalers. Journal of Aerosol Science 35 (2004) 309-331
    • (2004) Journal of Aerosol Science , vol.35 , pp. 309-331
    • DeHaan, W.H.1    Finlay, W.H.2
  • 9
    • 0031646978 scopus 로고    scopus 로고
    • Estimating the type of hygroscopic behavior exhibited by aqueous droplets
    • Finlay W.H. Estimating the type of hygroscopic behavior exhibited by aqueous droplets. Journal of Aerosol Medicine 11 4 (1998) 221-229
    • (1998) Journal of Aerosol Medicine , vol.11 , Issue.4 , pp. 221-229
    • Finlay, W.H.1
  • 10
    • 0020847040 scopus 로고
    • Aspects of computer simulation of liquid-fueled combustors
    • Gosman A.D., and Ioannides E. Aspects of computer simulation of liquid-fueled combustors. Journal of Energy 7 (1981) 482-490
    • (1981) Journal of Energy , vol.7 , pp. 482-490
    • Gosman, A.D.1    Ioannides, E.2
  • 12
    • 3242722612 scopus 로고    scopus 로고
    • In vitro intersubject and intrasubject deposition measurements in realistic mouth-throat geometries
    • Grgic B., Finlay W.H., Burnell P.K.P., and Heenan A.F. In vitro intersubject and intrasubject deposition measurements in realistic mouth-throat geometries. Journal of Aerosol Science 35 8 (2004) 1025-1040
    • (2004) Journal of Aerosol Science , vol.35 , Issue.8 , pp. 1025-1040
    • Grgic, B.1    Finlay, W.H.2    Burnell, P.K.P.3    Heenan, A.F.4
  • 13
    • 1842704857 scopus 로고    scopus 로고
    • Investigation of a novel condensation aerosol generator: solute and solvent effects
    • Gupta R., Hindle M., Byron P.R., Cox K.A., and McRae D.D. Investigation of a novel condensation aerosol generator: solute and solvent effects. Aerosol Science and Technology 37 8 (2003) 672-681
    • (2003) Aerosol Science and Technology , vol.37 , Issue.8 , pp. 672-681
    • Gupta, R.1    Hindle, M.2    Byron, P.R.3    Cox, K.A.4    McRae, D.D.5
  • 14
    • 3342886225 scopus 로고    scopus 로고
    • An investigation of the relationship between the flow field and regional deposition in realistic extra-thoracic airways
    • Heenan A.F., Finlay W.H., Grgic B., Pollard A., and Burnell P.K.P. An investigation of the relationship between the flow field and regional deposition in realistic extra-thoracic airways. Journal of Aerosol Science 35 8 (2004) 1013-1023
    • (2004) Journal of Aerosol Science , vol.35 , Issue.8 , pp. 1013-1023
    • Heenan, A.F.1    Finlay, W.H.2    Grgic, B.3    Pollard, A.4    Burnell, P.K.P.5
  • 15
    • 0041969929 scopus 로고    scopus 로고
    • Experimental measurements and computational modeling of the flow field in an idealized human oropharynx
    • Heenan A.F., Matida E., Pollard A., and Finlay W.H. Experimental measurements and computational modeling of the flow field in an idealized human oropharynx. Experiments in Fluids 35 1 (2003) 70-84
    • (2003) Experiments in Fluids , vol.35 , Issue.1 , pp. 70-84
    • Heenan, A.F.1    Matida, E.2    Pollard, A.3    Finlay, W.H.4
  • 16
    • 34249053835 scopus 로고    scopus 로고
    • Fluid flow and particle deposition analysis in a realistic extrathoracic airway model using unstructured grids
    • Jayaraju S.T., Bronus M., Verbanck S., and Lacor C. Fluid flow and particle deposition analysis in a realistic extrathoracic airway model using unstructured grids. Journal of Aerosol Science 38 (2007) 494-508
    • (2007) Journal of Aerosol Science , vol.38 , pp. 494-508
    • Jayaraju, S.T.1    Bronus, M.2    Verbanck, S.3    Lacor, C.4
  • 17
    • 0023155294 scopus 로고
    • Turbulence statistics in fully developed channel flow at low Reynolds number
    • Kim J., Moin P., and Moser R.D. Turbulence statistics in fully developed channel flow at low Reynolds number. Journal of Fluid Mechanics 177 (1987) 133-166
    • (1987) Journal of Fluid Mechanics , vol.177 , pp. 133-166
    • Kim, J.1    Moin, P.2    Moser, R.D.3
  • 18
    • 45049084754 scopus 로고    scopus 로고
    • Comparative in vitro performance of a BDP HFA solution MDI using USP and anatomical induction ports
    • Lewis D., Brambilla G., Church T., and Meakin B. Comparative in vitro performance of a BDP HFA solution MDI using USP and anatomical induction ports. Respiratory Drug Delivery 3 (2006) 943-946
    • (2006) Respiratory Drug Delivery , vol.3 , pp. 943-946
    • Lewis, D.1    Brambilla, G.2    Church, T.3    Meakin, B.4
  • 19
    • 0026864375 scopus 로고
    • Dispersion and deposition of spherical particles from point sources in a turbulent channel flow
    • Li A., and Ahmadi G. Dispersion and deposition of spherical particles from point sources in a turbulent channel flow. Aerosol Science and Technology 16 (1992) 209-226
    • (1992) Aerosol Science and Technology , vol.16 , pp. 209-226
    • Li, A.1    Ahmadi, G.2
  • 20
    • 34548582075 scopus 로고    scopus 로고
    • Numerical simulations of capillary aerosol generation: CFD model development and comparisons with experimental data
    • Longest P.W., Hindle M., Das Choudhuri S., and Byron P.R. Numerical simulations of capillary aerosol generation: CFD model development and comparisons with experimental data. Aerosol Science and Technology 41 (2007) 952-973
    • (2007) Aerosol Science and Technology , vol.41 , pp. 952-973
    • Longest, P.W.1    Hindle, M.2    Das Choudhuri, S.3    Byron, P.R.4
  • 21
    • 14044273704 scopus 로고    scopus 로고
    • Computational models for simulating multicomponent aerosol evaporation in the upper respiratory airways
    • Longest P.W., and Kleinstreuer C. Computational models for simulating multicomponent aerosol evaporation in the upper respiratory airways. Aerosol Science and Technology 39 (2005) 124-138
    • (2005) Aerosol Science and Technology , vol.39 , pp. 124-138
    • Longest, P.W.1    Kleinstreuer, C.2
  • 22
    • 0242286607 scopus 로고    scopus 로고
    • Efficient computation of micro-particle dynamics including wall effects
    • Longest P.W., Kleinstreuer C., and Buchanan J.R. Efficient computation of micro-particle dynamics including wall effects. Computers & Fluids 33 4 (2004) 577-601
    • (2004) Computers & Fluids , vol.33 , Issue.4 , pp. 577-601
    • Longest, P.W.1    Kleinstreuer, C.2    Buchanan, J.R.3
  • 23
    • 33845320525 scopus 로고    scopus 로고
    • Effects of mesh style and grid convergence on particle deposition in bifurcating airway models with comparisons to experimental data
    • Longest P.W., and Vinchurkar S. Effects of mesh style and grid convergence on particle deposition in bifurcating airway models with comparisons to experimental data. Medical Engineering and Physics 29 3 (2007) 350-366
    • (2007) Medical Engineering and Physics , vol.29 , Issue.3 , pp. 350-366
    • Longest, P.W.1    Vinchurkar, S.2
  • 24
    • 33845600916 scopus 로고    scopus 로고
    • Validating CFD predictions of respiratory aerosol deposition: effects of upstream transition and turbulence
    • Longest P.W., and Vinchurkar S. Validating CFD predictions of respiratory aerosol deposition: effects of upstream transition and turbulence. Journal of Biomechanics 40 (2007) 305-316
    • (2007) Journal of Biomechanics , vol.40 , pp. 305-316
    • Longest, P.W.1    Vinchurkar, S.2
  • 25
    • 33745227332 scopus 로고    scopus 로고
    • Transport and deposition of respiratory aerosols in models of childhood asthma
    • Longest P.W., Vinchurkar S., and Martonen T.B. Transport and deposition of respiratory aerosols in models of childhood asthma. Journal of Aerosol Science 37 (2006) 1234-1257
    • (2006) Journal of Aerosol Science , vol.37 , pp. 1234-1257
    • Longest, P.W.1    Vinchurkar, S.2    Martonen, T.B.3
  • 26
    • 33847775957 scopus 로고    scopus 로고
    • Effectiveness of direct Lagrangian tracking models for simulating nanoparticle deposition in the upper airways
    • Longest P.W., and Xi J. Effectiveness of direct Lagrangian tracking models for simulating nanoparticle deposition in the upper airways. Aerosol Science and Technology 41 (2007) 380-397
    • (2007) Aerosol Science and Technology , vol.41 , pp. 380-397
    • Longest, P.W.1    Xi, J.2
  • 27
    • 0033744380 scopus 로고    scopus 로고
    • Numerical approaches for motion of dispersed particles droplets and bubbles
    • Loth E. Numerical approaches for motion of dispersed particles droplets and bubbles. Progress in Energy and Combustion Science 26 (2000) 161-223
    • (2000) Progress in Energy and Combustion Science , vol.26 , pp. 161-223
    • Loth, E.1
  • 28
    • 33750937946 scopus 로고    scopus 로고
    • Improving prediction of aerosol deposition in an idealized mouth using large-eddy simulation
    • Matida E.A., Finlay W.H., Breuer M., and Lange C.F. Improving prediction of aerosol deposition in an idealized mouth using large-eddy simulation. Journal of Aerosol Medicine 19 3 (2006) 290-300
    • (2006) Journal of Aerosol Medicine , vol.19 , Issue.3 , pp. 290-300
    • Matida, E.A.1    Finlay, W.H.2    Breuer, M.3    Lange, C.F.4
  • 29
    • 0345688026 scopus 로고    scopus 로고
    • Improved numerical simulation of aerosol deposition in an idealized mouth-throat
    • Matida E.A., Finlay W.H., and Grgic L.B. Improved numerical simulation of aerosol deposition in an idealized mouth-throat. Journal of Aerosol Science 35 (2004) 1-19
    • (2004) Journal of Aerosol Science , vol.35 , pp. 1-19
    • Matida, E.A.1    Finlay, W.H.2    Grgic, L.B.3
  • 30
    • 0034253316 scopus 로고    scopus 로고
    • Statistical simulation of particle deposition on the wall from turbulent dispersed pipe flow
    • Matida E.A., Nishino K., and Torii K. Statistical simulation of particle deposition on the wall from turbulent dispersed pipe flow. International Journal of Heat and Fluid Flow 21 (2000) 389-402
    • (2000) International Journal of Heat and Fluid Flow , vol.21 , pp. 389-402
    • Matida, E.A.1    Nishino, K.2    Torii, K.3
  • 31
    • 1642515060 scopus 로고    scopus 로고
    • Studies of the human oropharyngeal airspaces using magnetic resonance imaging. I. Validation of a three-dimesional MRI method for producing ex vivo virtual and physical casts of the oropharyngeal airways during inspiration
    • McRobbie D.W., Pritchard S.E., and Quest R.A. Studies of the human oropharyngeal airspaces using magnetic resonance imaging. I. Validation of a three-dimesional MRI method for producing ex vivo virtual and physical casts of the oropharyngeal airways during inspiration. Journal of Aerosol Medicine 16 4 (2003) 401-415
    • (2003) Journal of Aerosol Medicine , vol.16 , Issue.4 , pp. 401-415
    • McRobbie, D.W.1    Pritchard, S.E.2    Quest, R.A.3
  • 32
    • 84974142389 scopus 로고
    • An investigation of particle trajectories in two-phase flow systems
    • Morsi S.A., and Alexander A.J. An investigation of particle trajectories in two-phase flow systems. Journal of Fluid Mechanics 55 2 (1972) 193-208
    • (1972) Journal of Fluid Mechanics , vol.55 , Issue.2 , pp. 193-208
    • Morsi, S.A.1    Alexander, A.J.2
  • 33
    • 1842739201 scopus 로고    scopus 로고
    • Effect of energy on propylene glycol aerosols using the capillary aerosol generator
    • Shen X., Hindle M., and Byron P.R. Effect of energy on propylene glycol aerosols using the capillary aerosol generator. International Journal of Pharmaceutics 275 1-2 (2004) 249-258
    • (2004) International Journal of Pharmaceutics , vol.275 , Issue.1-2 , pp. 249-258
    • Shen, X.1    Hindle, M.2    Byron, P.R.3
  • 34
    • 85010181389 scopus 로고
    • Intercomparison of experimental regional aerosol deposition data
    • Stahlhofen W., Rudolf G., and James A.C. Intercomparison of experimental regional aerosol deposition data. Journal of Aerosol Medicine 2 3 (1989) 285-308
    • (1989) Journal of Aerosol Medicine , vol.2 , Issue.3 , pp. 285-308
    • Stahlhofen, W.1    Rudolf, G.2    James, A.C.3
  • 35
    • 1242349621 scopus 로고    scopus 로고
    • Understanding throat deposition during cascade impactor testing
    • Stein S.W., and Gabrio B.J. Understanding throat deposition during cascade impactor testing. Respiratory Drug Delivery VII (2000) 287-290
    • (2000) Respiratory Drug Delivery VII , pp. 287-290
    • Stein, S.W.1    Gabrio, B.J.2
  • 36
    • 0000696217 scopus 로고
    • The oral airway-A conduit or collector for pharmaceutical aerosols
    • Swift D.L. The oral airway-A conduit or collector for pharmaceutical aerosols. Respiratory Drug Delivery IV (1994) 187-195
    • (1994) Respiratory Drug Delivery IV , pp. 187-195
    • Swift, D.L.1
  • 37
    • 34247149413 scopus 로고    scopus 로고
    • Particle deposition in turbulent duct flows-Comparisons of different model predictions
    • Tian L., and Ahmadi G. Particle deposition in turbulent duct flows-Comparisons of different model predictions. Journal of Aerosol Science 38 (2007) 377-397
    • (2007) Journal of Aerosol Science , vol.38 , pp. 377-397
    • Tian, L.1    Ahmadi, G.2
  • 38
    • 45049086064 scopus 로고    scopus 로고
    • USP (2005). Physical tests and determinations: Aerosols, nasal sprays, metered-dose inhalers, and dry powder inhalers. United States pharmacopeia first supplement, 28-NF, general chapter (601) (3298-3316). Rockville, MD: United States Pharmacopeial Convention.
    • USP (2005). Physical tests and determinations: Aerosols, nasal sprays, metered-dose inhalers, and dry powder inhalers. United States pharmacopeia first supplement, 28-NF, general chapter (601) (3298-3316). Rockville, MD: United States Pharmacopeial Convention.
  • 42
    • 0033117339 scopus 로고    scopus 로고
    • On the effect of anisotropy on the turbulent dispersion and deposition of small particles
    • Wang Y., and James P.W. On the effect of anisotropy on the turbulent dispersion and deposition of small particles. International Journal of Multiphase Flow 22 (1999) 551-558
    • (1999) International Journal of Multiphase Flow , vol.22 , pp. 551-558
    • Wang, Y.1    James, P.W.2
  • 44
    • 40449085356 scopus 로고    scopus 로고
    • Xi, J., Longest, P. W. (2007a). Effects of improved near-wall modeling on micro-particle deposition in oral airway geometries. In: Proceedings of the 2007 ASME summer bioengineering conference, Keystone, CO., Paper No. SBC2007-176227.
    • Xi, J., Longest, P. W. (2007a). Effects of improved near-wall modeling on micro-particle deposition in oral airway geometries. In: Proceedings of the 2007 ASME summer bioengineering conference, Keystone, CO., Paper No. SBC2007-176227.
  • 45
    • 33847771467 scopus 로고    scopus 로고
    • Transport and deposition of micro-aerosols in realistic and simplified models of the oral airway
    • Xi J., and Longest P.W. Transport and deposition of micro-aerosols in realistic and simplified models of the oral airway. Annals of Biomedical Engineering 35 4 (2007) 560-581
    • (2007) Annals of Biomedical Engineering , vol.35 , Issue.4 , pp. 560-581
    • Xi, J.1    Longest, P.W.2
  • 46
    • 47149100319 scopus 로고    scopus 로고
    • Effects of oral airway geometry characteristics on the diffusional deposition of inhaled nanoparticles
    • Xi J., and Longest P.W. Effects of oral airway geometry characteristics on the diffusional deposition of inhaled nanoparticles. ASME Journal of Biomechanical Engineering 130 (2008) 011008
    • (2008) ASME Journal of Biomechanical Engineering , vol.130 , pp. 011008
    • Xi, J.1    Longest, P.W.2
  • 47
    • 34247611172 scopus 로고    scopus 로고
    • Experimental measurement and numerical study of particle deposition in highly idealized mouth-throat models
    • Zhang Y., Chia T.L., and Finlay W.H. Experimental measurement and numerical study of particle deposition in highly idealized mouth-throat models. Aerosol Science and Technology 40 (2006) 361-372
    • (2006) Aerosol Science and Technology , vol.40 , pp. 361-372
    • Zhang, Y.1    Chia, T.L.2    Finlay, W.H.3
  • 48
    • 3242684091 scopus 로고    scopus 로고
    • Particle deposition measurements and numerical simulations in a highly idealized mouth-throat
    • Zhang Y., Finlay W.H., and Matida E.A. Particle deposition measurements and numerical simulations in a highly idealized mouth-throat. Journal of Aerosol Science 35 (2004) 789-803
    • (2004) Journal of Aerosol Science , vol.35 , pp. 789-803
    • Zhang, Y.1    Finlay, W.H.2    Matida, E.A.3
  • 49
    • 34648816355 scopus 로고    scopus 로고
    • In vivo-in vitro comparison of deposition in three mouth-throat models with Qvar and Turbuhaler inhalers
    • Zhang Y., Gilbertson K., and Finlay W.H. In vivo-in vitro comparison of deposition in three mouth-throat models with Qvar and Turbuhaler inhalers. Journal of Aerosol Medicine 20 3 (2007) 227-235
    • (2007) Journal of Aerosol Medicine , vol.20 , Issue.3 , pp. 227-235
    • Zhang, Y.1    Gilbertson, K.2    Finlay, W.H.3
  • 50
    • 3042736833 scopus 로고    scopus 로고
    • Airflow structures and nano-particle deposition in a human upper airway model
    • Zhang Z., and Kleinstreuer C. Airflow structures and nano-particle deposition in a human upper airway model. Journal of Computational Physics 198 1 (2004) 178-210
    • (2004) Journal of Computational Physics , vol.198 , Issue.1 , pp. 178-210
    • Zhang, Z.1    Kleinstreuer, C.2
  • 51
    • 12344301305 scopus 로고    scopus 로고
    • Comparison of micro- and nano-size particle depositions in a human upper airway model
    • Zhang Z., Kleinstreuer C., Donohue J.F., and Kim C.S. Comparison of micro- and nano-size particle depositions in a human upper airway model. Journal of Aerosol Science 36 2 (2005) 211-233
    • (2005) Journal of Aerosol Science , vol.36 , Issue.2 , pp. 211-233
    • Zhang, Z.1    Kleinstreuer, C.2    Donohue, J.F.3    Kim, C.S.4
  • 52
    • 0036852833 scopus 로고    scopus 로고
    • Micro-particle transport and deposition in a human oral airway model
    • Zhang Z., Kleinstreuer C., and Kim C.S. Micro-particle transport and deposition in a human oral airway model. Journal of Aerosol Science 33 12 (2002) 1635-1652
    • (2002) Journal of Aerosol Science , vol.33 , Issue.12 , pp. 1635-1652
    • Zhang, Z.1    Kleinstreuer, C.2    Kim, C.S.3
  • 53
    • 33745620202 scopus 로고    scopus 로고
    • Isotonic and hypertonic saline droplet deposition in a human upper airway model
    • Zhang Z., Kleinstreuer C., and Kim C.S. Isotonic and hypertonic saline droplet deposition in a human upper airway model. Journal of Aerosol Medicine 19 2 (2006) 184-198
    • (2006) Journal of Aerosol Medicine , vol.19 , Issue.2 , pp. 184-198
    • Zhang, Z.1    Kleinstreuer, C.2    Kim, C.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.