The use of combined single photon emission computed tomography and X-ray computed tomography to assess the fate of inhaled aerosol

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Volumn 24, Issue 1, 2011, Pages 49-60

  Fleming, John S ^a   Conway, Joy ^b   Majoral, Caroline ^c   Tossici Bolt, Livia ^a   Katz, Ira ^c,d   Caillibotte, Georges ^c   Perchet, Diane ^c   Pichelin, Marine ^c   Muellinger, Bernhard ^e   Martonen, Ted ^f,g   Kroneberg, Philipp ^e   Apiou Sbirlea, Gabriela ^h  

^a UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c AIR LIQUIDE   (France)

^d LAFAYETTE COLLEGE   (United States)

^e Activaero GmbH   (Germany)

^f CyberMedicine   (United States)

^g UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^h UNIVERSITÉ PARIS EST CRÉTEIL   (France)

Author keywords

aerosol deposition; SPECT CT imaging

Indexed keywords

HELIUM; OXYGEN;

ADULT; AEROSOL; AGED; AIR; ARTICLE; BODY POSITION; COMPUTER ASSISTED TOMOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; THREE DIMENSIONAL IMAGING; X RAY;

ADMINISTRATION, INHALATION; ADOLESCENT; ADULT; AEROSOLS; AGED; GAMMA CAMERAS; HUMANS; LUNG; MALE; MIDDLE AGED; NEBULIZERS AND VAPORIZERS; PILOT PROJECTS; TECHNETIUM TC 99M AGGREGATED ALBUMIN; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TOMOGRAPHY, X-RAY COMPUTED; YOUNG ADULT;

EID: 79551610650     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2010.0843     Document Type: Article

References (28)

1. Newman SP, Pitcairn G, and Hirst PH: A brief history of gamma scintigraphy J Aerosol Med. 2001;14:139-145.
2. Fleming JS, and Conway JH: Three-dimensional imaging of aerosol distribution. J Aerosol Med. 2001;14:147-153.
3. Perring S, Summers Q, Fleming JS, Nassim MA, and Holgate ST: A new method of quantification of the pulmonary regional distribution of aerosols using combined CT and SPECT and its application to nedocromil sodium administered by metered dose inhaler. Br J Radiol. 1994; 67:46-53.
4. Fleming JS, Halson P, Conway JH, Moore E, Nassim MA, Hashish AH, Bailey AG, Holgate ST, and Martonen TB: Three dimensional description of pulmonary deposition of inhaled aerosol using data from multimodality imaging. J Nucl Med. 1996;37:873-877.
5. Bocher M, Balan A, Krausz Y, Shrem Y, Lonn A, Wilk M, and Chisin R: Gamma camera-mounted anatomical X-ray tomography: technology, system characteristics and first images. Eur J Nucl Med. 2000;27:619-627.
6. Fleming JS, Britten AJ, Perring S, Keen AC, and Howlett PJ: A general software system for the handling of medical images. J Med Eng Technol. 1991;15:162-169.
7. Fleming JS, Conway JH, Bolt L, and Holgate ST: A comparison of planar scintigraphy and SPECT measurement of total lung deposition of inhaled aerosol. J Aerosol Med. 2003;16:9-19.
8. Fleming JS, Hashish AH, Conway JH, Hartley-Davies R, Nassim MA, Guy MJ, Coupe J, Holgate ST, Moore EA, Bailey AG, and Martonen TB: A technique for simulating radionuclide images from the aerosol deposition pattern in the airway tree. J Aerosol Med. 1997;10:199-212.
9. Fleming JS, Sauret V, Conway JH, Holgate ST, Bailey AG, and Martonen TB: Evaluation of the accuracy and precision of lung aerosol deposition measurements from SPECT using simulation. J Aerosol Med. 2000:13;187-198.
10. Dempster A, Laird N, and Rubin D: Maximum likelihood from incomplete data via the EM algorithm. J R Stat Soc. 1977;39:1-38.
11. Tossici Bolt L, Fleming JS, Conway JH, and Martonen TB: Analytical technique to recover the third dimension in planar imaging of inhaled aerosols: (1) impact on spatial quantification J Aerosol Med. 2000;19:565-579.
12. Fleming JS, Conway JH, Holgate ST, Moore EA, Hashish AH, Bailey AG, and Martonen TB: Evaluation of the accuracy and precision of lung aerosol deposition measurements from planar imaging using simulation. Phys Med Biol. 1998;43:2423-2429.
13. Fleming JS, Sauret V, Conway JH, Martonen TB: Validation of the conceptual anatomical model of the lung airway. J Aerosol Med. 2004;17:260-269.
14. ICRP Publication 66: Human Respiratory Tract Model for Radiological Protection. 1994 International Commission for Radiological Protection. Oxford: Pergamon Press; 1994.
15. Weibel ER: Morphometry of the Human Lung. Heidelberg: Springer Verlag; 1963.
16. Moller W, Felten K, Meyer G, Meyer P, Seitz J, and Kreyling WG: Corrections in dose assessment of Tc-99m radiolabeled aerosol particles targeted to central human airways using planar gamma camera imaging J Aerosol Med Pulmon Drug Del. 2009;22:45-54.
17. Lee Z, Berridge MS, Nelson AD, and Heald DL: The effect of scatter and attenuation on aerosol deposition as determined by gamma scintigraphy. J Aerosol Med. 2001;14:167-183.
18. Pitcairn GR, and Newman SP: Tissue attenuation corrections in gamma scintigraphy. J Aerosol Med. 1997;10:187-198.
19. Fleming JS Conway JH, and Tossici-Bolt L: Determining regional attenuation correction values for planar scintigraphy using CT images of the thorax. J Aerosol Med Pulmon Drug Del. 2009;22:182.
20. Fleming JS, Epps B, Conway JH, and Martonen TB: Comparison of SPECT aerosol deposition data with a human respiratory tract model. J Aerosol Med. 2006;19:268-278.
21. Fleming JS, Quint M, Bolt L, Martonen TB, and Conway JH: Comparison of SPECT aerosol deposition data with twentyfour hour clearance measurements. J Aerosol Med. 2006;19: 261-267.
22. Montesantos S, Fleming JS, and Tossici-Bolt L:Aspatial model of the human airway tree: Part 1. The Hybrid Conceptual Model. J Aerosol Med Pulmon Drug Del. 2010;23:59-68.
23. Schroeter JD, Fleming, JS Hwang D, and Martonen TB: A computer model of lung morphology to analyze SPECT images. Comput Med Imaging Graph 2002;26:237-246.
24. Kitaoka H, Takaki R, and Suki B: A three-dimensional model of the human airway tree. J Appl Physiol. 1999;87:2207-2217.
25. Tawhai MH, Pullan AJ, and Hunter PJ: Generation of an anatomically based 3D model of the conducting airways. Ann Biomed Eng. 2000;28:793-802.
26. Bennett WD, Brown JS, Zeman KL, Hu S-C, Scheuch G, and Sommerer K: Targeted delivery of aerosols to different lung regions. J Aerosol Med. 2002;15:179-188.
27. Moller W, Meyer G, Scheuch G, Kreyling WG, and Bennett WD: Left-to-right asymmetry of aerosol deposition after shallow bolus inhalation depends on lung ventilation. J Aerosol Med Pulmon Drug Del. 2009;22:333-339.
28. Phipps PR, Gonda I, Bailey DL, Borham P, Bautovich G, and Anderson SD: Comparison of planar and tomographic scintigraphy to measure the penetration index of inhaled aerosols. Am Rev Respir Dis. 1989;139:1516-1523.