The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin a in vivo

Infection and Immunity

Volumn 70, Issue 12, 2002, Pages 7136-7139

  Sarac, Miroslav S ^a   Cameron, Angus ^a,b   Lindberg, Iris ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; BACTERIAL TOXIN; CYTOKINE; ELONGATION FACTOR 2; ENZYME INHIBITOR; EXOTOXIN; FURIN; FURIN INHIBITOR; HEXA DEXTRO ARGININAMIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL MODEL; ARTICLE; BACTEREMIA; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; INTOXICATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SURVIVAL RATE; TOXIN ANALYSIS;

ADP RIBOSE TRANSFERASES; ANIMALS; BACTERIAL TOXINS; CHO CELLS; CRICETINAE; ENZYME INHIBITORS; EXOTOXINS; FURIN; MICE; PEPTIDES; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; SUBTILISINS; VIRULENCE FACTORS;

EID: 0036893450     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.12.7136-7139.2002     Document Type: Article

References (13)

1. Cameron, A., J. Appel, R. A. Houghten, and I. Lindberg. 2000. Polyarginines are potent furin inhibitors. J. Biol. Chem. 275:36741-36749.
2. Chiron, M., C. Fryling, and D. FitzGerald. 1997. Furin-mediated cleavage of Pseudomonas exotoxin-derived chimeric toxins. J. Biol. Chem. 272:31707-31711.
3. Friedman, T. C., V. M. Gordon, S. H. Leppla, K. R. Klimpel, N. P. Birch, and Y. P. Loh. 1995. In vitro processing of anthrax toxin protective antigen by recombinant PC1 (SPC3) and bovine intermediate lobe secretory vesicle membranes. Arch. Biochem. Biophys. 316:5-13.
4. Gordon, V. M., K. R. Klimpel, N. Arora, M. A. Henderson, and S. H. Leppla. 1995. Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases. Infect. Immun. 63:82-87.
5. Gordon, V. M., and S. H. Leppla. 1994. Proteolytic activation of bacterial toxins: Role of bacterial and host proteases. Infect. Immun. 62:333-340.
6. Gu, M., V. Gordon, D. Fitzgerald, and S. Leppla. 1996. Furin regulates both the activation of Pseudomonas exotoxin A and the quantity of the toxin receptor expressed on target cells. Infect. Immun. 64:524-527.
7. Inocencio, N. M., J. M. Moehring, and T. J. Moehring. 1994. Furin activates Pseudomonas exotoxin A by specific cleavage in vivo and in vitro. J. Biol. Chem. 269:31831-31835.
8. Jean, F., K. Stella, L. Thomas, G. Liu, Y. Xiang, A. J. Reason, and G. Thomas. 1998. α1-antitrypsin Portland, a bioengineered serpin highly selective for furin: Application as an antipathogenic agent. Proc. Natl. Acad. Sci. USA 95:7293-7298.
9. Matsumoto, T., K. Tateda, S. Miyazaki, N. Furuya, A. Ohno, Y. Ishii, Y. Hirakata, and K. Yamaguchi. 1999. Paradoxical synergistic effects of tumor necrosis factor and interleukin 1 in murine gut-derived sepsis with Pseudomonas aeruginosa. Cytokine 11:366-372.
10. Moehring, J. M., N. M. Inocencio, B. J. Robertson, and T. J. Moehring. 1993. Expression of mouse furin in a Chinese hamster cell resistant to Pseudomonas exotoxin A and viruses complements the genetic lesion. J. Biol. Chem. 268:2590-2594.
11. Molloy, S. S., E. D. Anderson, F. Jean, and G. Thomas. 1999. Bi-cycling the furin pathway: From TGN localization to pathogen activation and embryogenesis. Trends Cell Biol. 9:28-35.
12. Nakayama, K. 1997. Furin: A mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins. Biochem. J. 327:625-635.
13. Schumann, J., S. Angermuller, R. Bang, M. Lohoff, and G. Tiegs. 1998. Acute hepatotoxicity of Pseudomonas aeruginosa exotoxin A in mice depends on T cells and TNF. J. Immunol. 161:5745-5754.