Substrate cleavage analysis of furin and related proprotein convertases: A comparative study

Journal of Biological Chemistry

Volumn 283, Issue 30, 2008, Pages 20897-20906

  Remacle, Albert G ^a   Shiryaev, Sergey A ^a   Oh, Eok Soo ^a,d   Cieplak, Piotr ^a   Srinivasan, Anupama ^b   Wei, Ge ^a   Liddington, Robert C ^a   Ratnikov, Boris I ^a   Parent, Amelie ^c   Desjardins, Roxane ^c   Day, Robert ^c   Smith, Jeffrey W ^a   Lebl, Michal ^b   Strongin, Alex Y ^a  

^a BURNHAM INSTITUTE   (United States)

^b ILLUMINA INC   (United States)

^c UNIVERSITÉ DE SHERBROOKE   (Canada)

^d Ewha Womans University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; BACTERIOLOGY; PROTEINS;

AVIAN INFLUENZAS; BACTERIAL PATHOGENS; BIOLOGICALLY ACTIVE PROTEINS; BIRD FLUS; CLEAVAGE PREFERENCES; COMPARATIVE STUDIES; COMPUTER ANALYSES; CONVERTASES; DRUG TARGETS; HUMAN PROTEINS; INFECTIOUS DISEASES; INHIBITOR DESIGNS; PROTEIN TARGETS; RELATIVE EFFICIENCIES; RELATIVE IMPORTANCES; SPECIFIC INHIBITORS; VIRAL PROTEINS;

MICROCOMPUTERS;

BACTERIAL PROTEIN; FURIN; PROPROTEIN CONVERTASE 2; PROPROTEIN CONVERTASE 4; PROPROTEIN CONVERTASE 5; PROPROTEIN CONVERTASE 6; PROPROTEIN CONVERTASE 7; SERINE PROTEINASE; UNCLASSIFIED DRUG; VIRUS PROTEIN; PEPTIDE;

AMINO ACID SEQUENCE; ARTICLE; COMPARATIVE STUDY; COMPUTER ANALYSIS; CONTROLLED STUDY; ENZYME SUBSTRATE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN MOTIF; BIOLOGICAL MODEL; BIOLOGY; CHEMISTRY; ENZYME SPECIFICITY; HUMAN; MASS SPECTROMETRY; METHODOLOGY; MOLECULAR GENETICS; NUCLEIC ACID HYBRIDIZATION; PHYSIOLOGY; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN FOLDING;

AVES; BACTERIA (MICROORGANISMS);

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; COMPUTATIONAL BIOLOGY; FURIN; HUMANS; MASS SPECTROMETRY; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NUCLEIC ACID HYBRIDIZATION; PEPTIDES; PROPROTEIN CONVERTASES; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN FOLDING; SUBSTRATE SPECIFICITY;

EID: 51049092759     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M803762200     Document Type: Article

References (60)

1. Seidah, N. G., Day, R., and Chretien, M. (1993) Biochem. Soc. Trans. 21, 685-691
2. Steiner, D. F. (1998) Curr. Opin. Chem. Biol. 2, 31-39
3. Thomas, G. (2002) Nat. Rev. Mol. Cell. Biol. 3, 753-766
4. Fugere, M., Limperis, P. C., Beaulieu-Audy, V., Gagnon, F., Lavigne, P., Klarskov, K., Leduc, R., and Day, R. (2002) J. Biol. Chem. 277, 7648-7656
5. Taylor, N. A., Van De Ven, W. J., and Creemers, J. W. (2003) FASEB J. 17, 1215-1227
6. Nakayama, K. (1997) Biochem. J. 327, 625-635
7. Scamuffa, N., Calvo, F., Chretien, M., Seidah, N. G., and Khatib, A. M. (2006) FASEB J. 20, 1954-1963
8. Collier, R. J., and Young, J. A. (2003) Annu. Rev. Cell Dev. Biol. 19, 45-70
9. Feldmann, H., Volchkov, V. E., Volchkova, V. A., and Klenk, H. D. (1999) Arch. Virol. 15, 159-169
10. Garten, W., Hallenberger, S., Ortmann, D., Schafer, W., Vey, M., Angliker, H., Shaw, E., and Klenk, H. D. (1994) Biochimie (Paris) 76, 217-225
11. Gordon, V. M., and Leppla, S. H. (1994) Infect. Immun. 62, 333-340
12. Moulard, M., and Decroly, E. (2000) Biochim. Biophys. Acta 1469, 121-132
13. Rockwell, N. C., Krysan, D. J., Komiyama, T., and Fuller, R. S. (2002) Chem. Rev. 102, 4525-4548
14. Rott, R., Klenk, H. D., Nagai, Y., and Tashiro, M. (1995) Am. J. Respir. Crit. Care Med. 152, 16-19
15. Stadler, K., Allison, S. L., Schalich, J., and Heinz, F. X. (1997) J. Virol. 71, 8475-8481
16. Decha, P., Rungrotmongkol, T., Intharathep, P., Malaisree, M., Aruksakunwong, O., Laohpongspaisan, C., Parasuk, V., Sompornpisut, P., Pianwanit, S., Kokpol, S., and Hannongbua, S. (2008) Biophys. J. 95, 128-134
17. Zambon, M. C. (2001) Rev. Med. Virol. 11, 227-241
18. Chiron, M. F., Fryling, C. M., and FitzGerald, D. (1997) J. Biol. Chem. 272, 31707-31711
19. Basak, A., Zhong, M., Munzer, J. S., Chretien, M., and Seidah, N. G. (2001) Biochem. J. 353, 537-545
20. Chen, J., Lee, K. H., Steinhauer, D. A., Stevens, D. J., Skehel, J. J., and Wiley, D. C. (1998) Cell 95, 409-417
21. Sarac, M. S., Cameron, A., and Lindberg, I. (2002) Infect. Immun. 70, 7136-7139
22. Shiryaev, S. A., Remacle, A. G., Ratnikov, B. I., Nelson, N. A., Savinov, A. Y., Wei, G., Bottini, M., Rega, M. F., Parent, A., Desjardins, R., Fugere, M., Day, R., Sabet, M., Pellecchia, M., Liddington, R. C., Smith, J. W., Mustelin, T., Guiney, D. G., Lebl, M., and Strongin, A. Y. (2007) J. Biol. Chem. 282, 20847-20853
23. Jiao, G. S., Cregar, L., Wang, J., Millis, S. Z., Tang, C., O'Malley, S., Johnson, A. T., Sareth, S., Larson, J., and Thomas, G. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 19707-19712
24. Denault, J. B., Lazure, C., Day, R., and Leduc, R. (2000) Protein Expr. Purif. 19, 113-124
25. Kozlov, I. A., Melnyk, P. C., Hachmann, J. P., Srinivasan, A., Shults, M., Zhao, C., Musmacker, J., Nelson, N., Barker, D. L., and Lebl, M. (2008) Comb. Chem. High Throughput. Screen. 11, 24-35
26. Lebl, M. (1999) Bioorg. Med. Chem. Lett. 9, 1305-1310
27. Lebl, M. (2003) J. Assoc. Lab. Autom. 8, 30-35
28. Hachmann, J., and Lebl, M. (2006) J. Comb. Chem. 8, 149
29. Hachmann, J., and Lebl, M. (2006) Biopolymers 84, 340-347
30. King, D. S., Fields, C. G., and Fields, G. B. (1990) Int. J. Pept. Protein Res. 36, 255-266
31. Lebl, M., Burger, C., Ellman, B., Heiner, D., Ibrahim, G., Jones, A., Nibbe, M., Thompson, J., Mudra, P., Pokorný, V., Poncar, P., and Ženíšek, K. (2001) Collect. Czech. Chem. Commun. 66, 1299-1314
32. Gunderson, K. L., Kruglyak, S., Graige, M. S., Garcia, F., Kermani, B. G., Zhao, C., Che, D., Dickinson, T., Wickham, E., Bierle, J., Doucet, D., Milewski, M., Yang, R., Siegmund, C., Haas, J., Zhou, L., Oliphant, A., Fan, J. B., Barnard, S., and Chee, M. S. (2004) Genome Res. 14, 870-877
33. Crooks, G. E., Hon, G., Chandonia, J. M., and Brenner, S. E. (2004) Genome Res. 14, 1188-1190
34. Schneider, T. D., and Stephens, R. M. (1990) Nucleic Acids Res. 18, 6097-6100
35. Kozlov, I. A., Melnyk, P. C., Zhao, C., Hachmann, J. P., Shevchenko, V., Srinivasan, A., Barker, D. L., and Lebl, M. (2006) Comb. Chem. High Throughput Screen. 9, 481-487
36. Shiryaev, S. A., Kozlov, I. A., Ratnikov, B. I., Smith, J. W., Lebl, M., and Strongin, A. Y. (2007) Biochem. J. 401, 743-752
37. Shiryaev, S. A., Ratnikov, B. I., Aleshin, A. E., Kozlov, I. A., Nelson, N. A., Lebl, M., Smith, J. W., Liddington, R. C., and Strongin, A. Y. (2007) J. Virol. 81, 4501-4509
38. Mains, R. E. (2004) in Handbook of Proteolytic Enzymes (Barrett, A. J., Rawlings, N. D. & Woessner, J. F., eds), 2nd Ed., pp. 1871-1874, Elsevier, London
39. Seidah, N. G., and Chretien, M. (2004) in Handbook of Proteolytic Enzymes (Barrett, A. J., Rawlings, N. D. & Woessner, J. F., eds) 2nd Ed., pp. 1861-1864, Elsevier, London
40. Seidah, N. G., and Chretien, M. (2004) in Handbook of Proteolytic Enzymes (Barrett, A. J., Rawlings, N. D. & Woessner, J. F., eds), 2nd Ed., pp. 1865-1868, Elsevier, London
41. Seidah, N. G., and Chretien, M. (2004) in Handbook of Proteolytic Enzymes (Barrett, A. J., Rawlings, N. D. & Woessner, J. F., eds), 2nd Ed., pp. 1868-1870, Elsevier, London
42. Seidah, N. G., and Chretien, M. (2004) in Handbook of Proteolytic Enzymes (Barrett, A. J., Rawlings, N. D. & Woessner, J. F., eds), 2nd Ed., pp. 1874-1877, Elsevier, London
43. Seidah, N. G., and Chretien, M. (2004) in Handbook of Proteolytic Enzymes (Barrett, A. J., Rawlings, N. D. & Woessner, J. F., eds), 2nd Ed., pp. 1877-1880, Elsevier, London
44. Seidah, N. G., Mayer, G., Zaid, A., Rousselet, E., Nassoury, N., Poirier, S., Essalmani, R., and Prat, A. (2008) Int. J. Biochem. Cell Biol. 40, 1111-1125
45. Basak, A., Toure, B. B., Lazure, C., Mbikay, M., Chretien, M., and Seidah, N. G. (1999) Biochem. J. 343, 29-37
46. Bassi, D. E., Fu, J., Lopez de Cicco, R., and Klein-Szanto, A. J. (2005) Mol. Carcinog. 44, 151-161
47. Beinfeld, M. C. (1998) Endocrine 8, 1-5
48. Creemers, J. W., Jackson, R. S., and Hutton, J. C. (1998) Semin. Cell Dev. Biol. 9, 3-10
49. Decroly, E., Benjannet, S., Savaria, D., and Seidah, N. G. (1997) FEBS Lett. 405, 68-72
50. Dey, A., Norrbom, C., Zhu, X., Stein, J., Zhang, C., Ueda, K., and Steiner, D. F. (2004) Endocrinology 145, 1961-1971
51. Gensberg, K., Jan, S., and Matthews, G. M. (1998) Semin. Cell Dev. Biol. 9, 11-17
52. Golubkov, V. S., Chekanov, A. V., Shiryaev, S. A., Aleshin, A. E., Ratnikov, B. I., Gawlik, K., Radichev, I., Motamedchaboki, K., Smith, J. W., and Strongin, A. Y. (2007) J. Biol. Chem. 282, 36283-36291
53. Lissitzky, J. C., Luis, J., Munzer, J. S., Benjannet, S., Parat, F., Chretien, M., Marvaldi, J., and Seidah, N. G. (2000) Biochem. J. 346, 133-138
54. Munzer, J. S., Basak, A., Zhong, M., Mamarbachi, A., Hamelin, J., Savaria, D., Lazure, C., Hendy, G. N., Benjannet, S., Chretien, M., and Seidah, N. G. (1997) J. Biol. Chem. 272, 19672-19681
55. Paquet, L., Zhou, A., Chang, E. Y., and Mains, R. E. (1996) Mol. Cell. Endocrinol. 120, 161-168
56. Patel, Y. C., and Galanopoulou, A. (1995) Ciba Found. Symp. 190, 26-40
57. Pei, D., and Weiss, S. J. (1995) Nature 375, 244-247
58. Peinado, J. R., Li, H., Johanning, K., and Lindberg, I. (2003) J. Neurochem. 87, 868-878
59. Stawowy, P., and Fleck, E. (2005) J. Mol. Med. 83, 865-875
60. Wang, P., Tortorella, M., England, K., Malfait, A. M., Thomas, G., Arner, E. C., and Pei, D. (2004) J. Biol. Chem. 279, 15434-15440