Antioxidants Countermeasures against sulfur mustard

Mini-Reviews in Medicinal Chemistry

Volumn 12, Issue 8, 2012, Pages 742-748

  Pohanka, M ^a  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Apoptosis; DNA repair; Inflammation; Oxidative stress; Poly(ADP ribose) polymerase; Sulfur mustard

Indexed keywords

3 AMINOBENZAMIDE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CATALASE; DNA; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EPIGALLOCATECHIN GALLATE; ETHYL 2 CHLOROETHYL SULFIDE; FLAVONE; GLUTATHIONE; GOSSYPINE; HIPPOPHAE RHAMNOIDES EXTRACT; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 8; MALONALDEHYDE; MELATONIN; MUSTARD GAS; MUSTARD GAS DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; NUCLEOTIDE; REACTIVE OXYGEN METABOLITE; SARIN; STEROID; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; BRAIN; BRONCHUS MUCOSA; CELL DEATH; CHEMICAL STRUCTURE; CYCLOADDITION; CYTOKINE PRODUCTION; CYTOTOXICITY; DNA DAMAGE; DNA REPAIR; DRUG ABSORPTION; DRUG EFFICACY; DRUG FORMULATION; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; GAS POISONING; HUMAN; IMMUNE SYSTEM; INFLAMMATION; KERATINOCYTE; LD 50; LIVER; MOLECULAR WEIGHT; NEUTROPENIA; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; REVIEW; SKIN INJURY; SULFUR MUSTARD POISONING;

ANIMALS; ANTIOXIDANTS; CHEMICAL WARFARE AGENTS; DNA DAMAGE; HUMANS; INFLAMMATION; MUSTARD GAS; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES;

EID: 84862626030     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/138955712801264783     Document Type: Review

References (61)

1. Evison, D.; Hincley, D.; Rice, P. Regular review: chemical weapons, Brit. Med. J., 2002, 324, 332-335.
2. Guengerich, F.P. Activations of dihaloalkanes by thiol-dependent mechanisms. J. Biochem. Mol. Biol., 2003, 36, 20-27.
3. Paromov, V.; Suntres, Z.; Smith, M.; Stone, W.L. Sulfur mustard toxicity following dermal exposure: role of oxidative stress, and antioxidant therapy, J. Burns Wounds, 2007, 7, 60-85
4. Pohanka, M.; Musilek, K.; Kuca, K. Progress of biosensors based on cholinesterase inhibition. Curr. Med. Chem., 2009, 16, 1790-1798.
5. Lodhi, I.J.; Sweeney, J.F.; Clift, R.E.; Hinshaw, D.B. Nuclear dependence of sulfur mustard-mediated cell death. Toxicol. Appl. Pharmacol., 2001, 170, 69-77.
6. Laskin, J.D.; Black, A.T.; Jan, Y.H.; Sinko, P.J.; Heindel, N.D.; Sunil, V.; Heck, D.E.; Laskin, D.L. Oxidants and antioxidants in sulfur mustard-induced injury. Ann. N.Y. Acad. Sci., 2010, 1203, 92-100.
7. Lomash, V.; Deb, U.; Rai, R.; Jadhav, S.E.; Vijayaraghavan, R.; Pant, S.C. Designing of mouse model: a new approach for studying sulfur mustard-induced skin lesions. Burns, 2011, In press.
8. Sharma, D.R.; Sunkaria, A.; Bal, A.; Bhutia, Y.D.; Vijayaraghavan, R.; Flora, S.J.; Gill, K.D. Neurobehavioral impairments, generation of oxidative stress and release of pro-apoptotic factors after chronic exposure to sulfur mustard in mouse brain. Toxicol. Appl. Pharmacol., 2009, 240, 208-218.
9. Zojaji, R.; Balali-Mood, M.; Mirzadeh, M.; Saffari, A.; Maleki, M. Delayed head and neck complications of sulphur mustard poisoning in Iranian veterans. J. Laryngol. Otol., 2009, 123, 1150-1154.
10. Naderi, M.; Jadidi, K.; Falahati, F.; Alavi, S.A. The effect of sulfur mustard and nitrogen mustard on corneal collagen degradation induced by the enzyme collagenase. Cutan. Ocul. Toxicol., 2010, 29, 234-240.
11. Vijayaraghavan, R.; Kulkami, A.; Pant, S.C.; Kumar, P.; Rao, P.V.; Gupta, N.; Gutam, A.; Ganesan, K. Differential toxicity of sulfur mustard administered through percutaneous, subcutaneous, and oral routes. Toxicol. Appl. Pharmacol., 2005, 202, 180-188.
12. Clement, J.G. Toxicity of the combined nerve agents GB/GF in mice: efficacy of atropine and various oximes as antidotes. Arch. Toxicol., 1994, 68, 64-66.
13. Ghanei, M.; Harandi, A.A. Lung carcinogenicity of sulfur mustard. Clin. Lung Cancer., 2010, 11, 13-17
14. Rowell, M.; Kehe, K.; Balszuweit, F.; Thiermann, H. The chronic effects of sulfur mustard exposure. Toxicology, 2009, 263, 9-11.
15. Hefazi, M.; Maleki, M.; Mahmoudi, M.; Tabatabaee, A.; Balali-Mood, M. Delayed complication of sulfur mustard poisoning in the skin and the immune system of Iranian veterans 16-20 years after exposure. Int. J. Dermatol., 2006, 45, 1025-1031.
16. Kehe, K.; Balszuweit, F.; Steinritz, D.; Thiermann, H. Molecular toxicology of sulfur mustard-induced cutaneous inflammation and blistering. Toxicology, 2009, 263, 12-19.
17. Malaviya, R.; Sunil, V.R.; Cervelli, J.; Anderson, D.R.; Holmes, W.W.; Conti, M.L.; Gordon, R.E.; Laskin, J.D.; Laskin, D.L. Inflammatory effects of inhaled sulfur mustard in rat lung. Toxicol. Appl. Pharmacol., 2010, 248, 89-99.
18. Qui, M.; Paromov, V.M.; Yang, H.; Smith, M.; Stone, W.L. Inhibition of inducible nitric oxide synthase by a mustard gas analog in murine macrophages. BMC Cell Biol., 2006, 7, 39.
19. Wormser, U.; Brodsky, B.; Proscura, E.; Foley, J.F.; Jones, T.; Nyska, A. Involvement of tumor necrosis factor-alpha in sulfur mustard-induced skin lesion; effect of topical iodine. Arch. Toxicol., 2005, 79, 660-670.
20. Mishra, N.C.; Rir-sima-ah, J.; March, T.; Weber, W.; Benson, J.; Jaramillo, R.; Seagrave, J.C.; Schultz, G.; Grotendorst, G.; Sopori, M. Sulfur mustard induces immune sensitization in hairless guinea pigs. Int. Immunopharmacol., 2010, 10, 193-199.
21. Ekstrand-Hammarstrom, B.; Wigenstam, E.; Wigenstam, E.; Bucht, A. Inhalation of alkylating mustard causes long-term T celldependent inflammation in airways and growth of connective tissue. Toxicology, 2011, 280, 88-97.
22. Emmler, J.; Hermanns, M.I.; Steinritz, D.; Kreppel, H.; Kirkpatrick, C.J.; Bloch, W.; Szinicz, L.; Kehe, K. Assessment of alterations in barrier functionality and induction of proinflammatory and cytotoxic effects after sulfur mustard exposure of an in vitro coculture model of the human alveolocapillary barrier. Inhal. Toxicol., 2007, 19, 657-665.
23. Wormser, U.; Langenbach, R.; Peddada, S.; Sintov, A.; Brodsky, B.; Nyska, A. Reduced sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice. Toxicol. Appl. Pharmacol., 2004, 200, 40-47.
24. Amitai, G.; Adani, R.; Fishbein, E; Meshulam, H.; Laish, I.; Dachir, S. Bifunctional compounds eliciting anti-inflammatory and anti-cholinesterase activity as potential treatment of nerve and blister chemical agents poisoning. Chem. Biol. Interact., 2005, 157, 361-362.
25. Wormser, U.; Sintov, A.; Brodsky, B.; Casillas, R.P.; Nyska, A. Protective effect of topical iodine containing anti-inflammatory drugs against sulfur mustard-induced skin lesions. Arch. Toxicol., 2004, 78, 156-166.
26. Anderson, D.R.; Holmes, W.W.; Lee, R.B.; Dalal, S.J.; Hurst, C.G.; Maliner, B.I.; Newmark, J.; Smith, W.J. Sulfur mustardinduced neutropenia: treatment with granulocyte colonystimulating factor. Mil. Med., 2006, 171, 448-453.
27. Gao, X.; Ray, R.; Xiao, Y.; Barker, P.E.; Ray, P. Inhibition of sulfur mustard-induced cytotoxicity and inflammation by the macrolide antibiotic roxithromycin in human respiratory epithelial cells. BMC Cell Biol., 2007, 8, 17.
28. Gao, X.; Anderson, D.R.; Brown, A.W.; Lin, H.; Amnuaysirikul, J.; Chua, A.L.; Holmes, W.W.; Ray, P. Pathological studies on the protective effect of a macrolide antibiotic, roxithromycin, against sulfur mustard inhalation toxicity in a rat model. Toxicol. Pathol., 2011, 39, 1056-1064.
29. Hamza, A.; Broch, H.; Vasilescu, D. Quantum molecular study of S-methylated forms of sulfur mustard. Chem. Phys., 1996, 204, 373-389.
30. Ludlum, D.B.; Austin-Ritchie, P.; Hagopian, M.; Niu, T.Q.; Yu, D. Detection of sulfur mustard-induced DNA modifications. Chem. Biol. Interact., 1994, 91, 39-49.
31. Matijasevic, Z.; Stering, A.; Niu, T.Q.; Austin-Ritchie, P.; Ludlum, D.B. Release of sulfur mustard-modified DNA bases by Escherichia coli 3-methyladenine DNA glycosylase II. Carcinogenesis, 1996, 17, 2249-2252.
32. Broch, H.; Hamza, A.; Vasilescu, D. Ab initio modeling of the interaction between guanin-cytosine base pair and mustard alkylating agents. Int. J. Quant. Chem., 1996, 60, 1745-1764.
33. Jowsey, P.A.; Williams, F.M.; Blain, P.G. DNA damage, signaling and repair after exposure of cells to the sulphur mustard analogue 2-chloroethyl ethyl sulphide. Toxicology, 2009, 257, 105-112.
34. Jowsey, P.A.; Williams, F.M.; Blain, P.G. The role of homologous recombination in the cellular response to sulphur mustard. Toxicol. Lett., 2010, 197, 12-18.
35. Mol, M.A.; van der Schans, G.P.; Lohman, P.H. Quantification of sulfur mustard-induced DNA interstrand cross-links and singlestrand breaks in cultured human epidermal keratinocytes. Mutat. Res., 1993, 294, 235-245.
36. Hinshaw, D.B.; Lodhi, I.J.; Hurley, L.L.; Atkins, K.B.; Dabrowska, M.I. Activation of poly [ADP-ribose] polymerase in endothelial cells and keratinocytes: role in an in vitro model of sulfur mustardmediated vesication. Toxicol. Appl. Pharmacol., 1999, 156, 17-29.
37. Kehe, K.; Raithel, K.; Kreppel, H.; Jochum, M.; Worek, F.; Thiermann, H. Inhibition of poly(DP-ribose) polymerase (PARP) influences the mode of sulfur mustard (SM)-induced cell death in HaCaT cells. Arch. Toxicol., 2008, 82, 461-470.
38. Cole, K.K.; Perez-Polo, J.R. Poly(ADP-ribose) polymerase inhibition prevents both apoptotic-like delayed neuronal death and necrosis after H2O2 injury. J. Neurochem., 2002, 82, 19-29.
39. Juranek, I.; Bezek, S. Controversy of free radical hypothesis: reactive oxygen species cause or consequence of tissue injury? Gen. Physiol. Biophys., 2005, 24, 263-278.
40. Bezek, S.; Ujhazy, E.; Dubovicky, M.; Mach, M. Nongenomic memory of foetal history in chronic diseases development. Neuroendocrinol. Lett., 2008, 29, 620-626.
41. Pohanka, M.; Stetina, R. Shift of oxidants and antioxidants levels in rats as a reaction to exposure to sulfur mustard. J. Appl. Toxicol., 2009, 29, 643-647.
42. Bandouchova, H.; Pohanka, M.; Vlckova, K.; Damkova, V.; Peckova, L.; Sedlackova, J.; Treml, F.; Vitula, F.; Pikula, J. Biochemical responses and oxidative stress in Francisella tularensis infection: a European brown hare model. Acta Vet. Scand., 2011, 53, 2.
43. Korkmaz, A.; Yaren, H.; Kunak, Z.; Uysal, B.; Kurt, B.; Topal, T.; Kenar, L.; Ucar, E.; Oter, S. Epigenetic perturbations in the pathogenesis of mustard toxicity; hypothesis and preliminary results. Interdiscip. Toxicol., 2008, 1, 236-241.
44. Korkmaz, A.; Yaren, H.; Topal, T.; Oter, S. Molecular targets against mustard toxicity: implication of cell surface receptors, peroxynitrite production, and PARP activation. Arch. Toxicol., 2006, 80, 662-670.
45. Pal, A.; Tewari-Singh, N.; Gu, M.; Agarwal, C.; Huang, J.; Day, B.J.; White, C.W.; Agarwal, R. Sulfur mustard analog induces oxidative stress and activates signaling cascades in the skin of SKH-1 haireless mice. Free Radic. Biol. Med., 2009, 47, 1640-1651.
46. Steinritz, D.; Elischer, A.; Balszuweit, F.; Gonder, S.; Heinrich, A.; Bloch, W.; Thiermann, H.; Kehe, K. Sulphur mustard induces timeand concentration dependent regulation of NO-synthesizing enzymes. Toxciol. Lett., 2009, 188, 263-269.
47. Gould, N.S.; White, C.W.; Day, B.J. A role for mitochondrial oxidative stress in sulfur mustard analog 2-chloroethyl ethyl sulfide-induced lung cell injury and antioxidant protection. J. Pharmacol. Exp. Ther., 2009, 328, 732-739.
48. Pohanka, M.; Sobotka, J.; Jilkova, M.; Stetina, R. Oxidative stress after sulfur mustard intoxication and its reduction by melatonin: efficacy of antioxidant therapy during serious intoxication. Drug Chem. Toxicol., 2011, 34, 85-91.
49. Pohanka, M.; Sobotka, J.; Svobodova, H.; Stetina, R. Investigation of oxidative stress in blood, brain, kidney, and liver after oxidme antidote HI-6 application in a mouse experimental model. Drug Chem. Toxciol., 2011, 34, 255-260.
50. Korkamaz, A.; Kunak, Z.I.; Paredes, S.D.; Yaren, H.; Tan, D.X.; Reiter, R.J. The use of melatonin to combat mustard toxicity. Review. Neuroendocrinol. Lett., 2008, 29, 614-619.
51. Shohrati, M.; Ganei, M.; Shamspour, N.; Jafari, M. Activity and function in lung injuries due to sulphur mustard. Biomarkers, 2008, 13, 728-733.
52. Shohrati, M.; Ghanei, M.; Shamspour, N.; Babaei, F.; Abadi, M.N.; Jafari, M.; Harandi, A.A. Glutathione and malondialdehyde levels in late pulmonary complications of sulfur mustard intoxication. Lung, 2009, 188, 77-83.
53. Pohanka, M.; Sobotka, J.; Stetina, R. Sulfur mustard induced oxidative stress and its alteration by epigallocatechin gallate. Toxicol. Lett., 2011, 201, 105-109.
54. Jafari, M. Doseand timedependent effects of sulfur mustard on antioxidant system in liver and brain of rat. Toxicology, 2007, 231, 30-39.
55. Vijayaraghavan, R.; Gautam, A.; Kumar, O.; Pant, S.C.; Sharma, M.; Singh, S.; Kumar, H.T.; Singh, A.K.; Nivsarkar, M.; Kaushik, M.P.; Sawhney, R.C.; Chaurasia, O.P.; Prasad, G.B. Protetive effect of ethanolic and water extracts of sea buckthorn (Hippophae rhamnoides L.) against the toxic effects of mustard gas. Indian J. Exp. Biol., 2006, 44, 821-831.
56. Gautam, A.; Vijayaraghavan, R. Prophylactic effect of gossypin against percutaneously administered sulfur mustard. Biomed. Environ. Sci., 2007, 20, 250-259.
57. Pohanka, M. Alzehimeŕs disease and related neurodegenerative disorders: implication and counteracting of melatonin. J. Appl. Biomed., 2011, 196, 185-196.
58. Padayatty, S.J.; Katz, A.; Wang, Y.; Eck, P.; Kwon, O.; Lee, J.H.; Chen S.; Corpe, C.; Dutta, A.; Dutta, S.K.; Levine, M. Vitamin C as an antioxidant: Evaluation of its role in disease prevention. Am. J. Clin. Nutr., 2003, 22, 18-35.
59. Wiegenstam, E.; Rocksen, D.; Ekstrand-Hammarstrom, B.; Bucht, A. Tretment with dexamethasone or liposime-encapsulated vitamin E provides beneficial effect after chemical-induced lung injury. Inhal. Toxicol., 2009, 21, 958-964.
60. Tiwari, P.; Kumar, A.; Balakrishnan, S.; Kushwaha, H.S.; Mishra, K.P. Radiation-induced micronucleus formation and DNA damage in human lymphocytes and their prevention by antioxidant thiols. Mutat. Res., 2009, 676, 62-68.
61. Kumar, B.S.; Kunwar, A.; Ahmad, A.; Kumbhare, L.B.; Jain, V.K.; Privadarsini, K.I. In vitro radioprotection studies of organoselenium compounds: differences between monoand diselenides. Radiat. Environ. Biophys., 2009, 48, 379-384.