Prophylactic effect of gossypin against percutaneously administered sulfur mustard

Biomedical and Environmental Sciences

Volumn 20, Issue 3, 2007, Pages 250-259

  Gautam, Anshoo ^a   Vijayaraghavan, R ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

Glutathione; Gossypin; Intraperitoneal; Oral; Oxidative stress; Sulfur mustard

Indexed keywords

CHEMICAL WARFARE AGENT; FLAVONOID; GOSSYPINE; HEMOGLOBIN; MUSTARD GAS;

ANIMAL; ARTICLE; BLOOD CELL COUNT; BODY WEIGHT; CYTOLOGY; DRUG EFFECT; FEMALE; INTRADERMAL DRUG ADMINISTRATION; LIVER; METABOLISM; MOUSE; OXIDATIVE STRESS; PATHOLOGY; TIME;

ADMINISTRATION, CUTANEOUS; ANIMALS; BLOOD CELL COUNT; BODY WEIGHT; CHEMICAL WARFARE AGENTS; FEMALE; FLAVONOIDS; HEMOGLOBINS; LIVER; MICE; MUSTARD GAS; OXIDATIVE STRESS; TIME FACTORS;

MUS;

EID: 34547906433     PISSN: 08953988     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Wormser U (1991). Toxicology of mustard gas. Trends Pharmacol Sci 12, 164-167.
2. Smith W J, Dunn M A (1991). Medical defence against blistering chemical warfare agents. Arch Dermatol 127, 1207-1213.
3. Eisenmenger W, Drasch G, Von Clarmann M, et al. (1991). Clinical and morphological findings on mustard gas [bis(2-chloro ethyl) sulphide] poisoning. J Forensic Sci 36, 1688-1698.
4. Momeni A Z, Enschaeih S, Meghdadi M (1992). Skin manifestations of mustard gas. A clinical study of 535 patients exposed to mustard gas. Arch Dermatol 128, 775-780.
5. Papirmeister B, Feister A J, Robinson S L, et al. (1991). Medical defense against mustard gas: toxic mechanisms and pharmacological implications, CRC press Boca, Raton, p. 359.
6. Somani S M, Babu S R (1989). Toxicodynamics of sulphur mustard. Int J Clin Pharmacol Ther Toxicol 27, 419-435.
7. Pechura C M, Rall D P (1993). Veterans at Risk: The health effect of mustard and Lewisite. National Academy Press, Washington, D.C., p. 428.
8. Vijayaraghavan R, Kumar P, Joshi U, et al. (2001). Prophylactic efficacy of amifostine and its analogue against sulphur mustard toxicity. Toxicology 163, 83-91.
9. Callaway S, Pearce K A (1958). Protection against systemic poisoning by mustard gas di(2-chloro ethyl) sulphide by sodium thiosulphate and thiocit in albino rat. Br J Pharmacol 13, 395-399.
10. Vojvodic V, Milosavljevic Z, Boskovic B, et al. (1985). The protective effect of different drugs in rats poisoned by sulphur and nitrogen mustards. Fundam Appl Toxicol 5, S160-S168.
11. Vijayaraghavan R, Sugendran K, Pant S C, et al. (1991). Dermal intoxication of mice with bis (2-chloroethyl) sulphide and the protective effect of flavonoids. Toxicology 69, 35-42.
12. Dacre J C, Goldman M (1996). Toxicology and Pharmacology of the chemical warfare agent sulphur Mustard. Pharmacol Rev 48, 290-326.
13. Sawyer T W, Lundy P M, Weiss M T (1996). Protective effects of an inhibitor of nitric oxide synthase on sulphur mustard toxicity in vitro. Toxicology 141, 138-144.
14. Om Kumar, Sugendran K, Vijayaraghavan R (2001). Protective effects of various antioxidants on the toxicity of sulphur mustard administered to mice by inhalation or percutaneous route. Chem Biol Interact 134, 1-12.
15. Vijayaraghavan R, Kulkarni A, Pant S C, et al. (2005). Differential toxicity of sulphur mustard administered through percutaneous, subcutaneous and oral routes. Toxicol Applied Pharmacol, 202, 180-188.
16. Vijayaraghavan R, Pravin Kumar, Dubey D K et al. (2001). Evaluation of CC2 as a decontaminant in various hydrophilic and lipophilic formulations against sulphur mustard. Biomed Environ Sci 15, 25-31.
17. Lakshamana Rao P V, Vijayaraghavan R, Bhaskar, A S B (1999). Sulphur mustard induced DNA damage in mice after dermal and inhalation exposure. Toxicology 139, 39-57.
18. Formica J V, Regelson W (1995). Review of the biology of quercetin and related bioflavonoids. Food Chem Toxicol 33, 1061-1080.
19. Molina M F, Sanchez-Reus I, Iglesias I, et al. (2003). Quercetin, a flavonoid antioxidant, prevents and protects against ethanol-induced oxidative stress in mouse liver. Biol Pharm Bull 26, 1398-1402.
20. Alarcon De La Lastra C, Martin M J Motilva V (1994). Antiulcer and gastroprotective effects of quercetin: a gross and histologic study. Pharmacology 48, 56-62.
21. Kuhlmann M K, Horsch E, Burkhardt G, et al. (1998). Reduction of cisplatin toxicity in cultured renal tubular cells by the bioflavonoid quercetin. Arch Toxicol 72, 536-540.
22. Satyanarayana P S, Singh D, Chopra K (2001). Quercetin a bioflavonoid, protects against oxidative stress-related renal dysfunction by cyclosporine in rats. Methods Find Exp Clin Pharmacol 23, 175-181.
23. Pavanato A, Tunon M J, Sanchez-Campos S, et al. (2003). Effects of quercetin on liver damage in rats with carbon tetrachloride-induced cirrhosis. Dig Dis Sci 48, 824-829.
24. Ferrandiz M L, Alcaraz M J (1991). Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids. Agents Actions 32, 283-288.
25. Viswanathan S, Thirugnanasambantham P, Reddy K, et al. (1984). Gossypin induced analgesia in mice. Eur J Pharmacol 98, 289-291.
26. Babu B H, Jayram H N, Nair M G, et al. (2003). Free radical scavenging, antitumor and anticarcinogenic activity of gossypin. J Exp Clin Cancer Res 22, 581-589.
27. Yoon I, Lee K H, Cho J (2004). Gossypin protects primary cultured rat cortical cell from oxidative stress-and beta amyloid-induced toxicity. Arch Pharm Res 27, 454-459.
28. Gad S C, Weil C S (1989). Statistics for toxicologists. In: Hayes, A.W. (Ed), Principles and Methods of Toxicology, second ed. Raven Press, New York, pp. 463-467.
29. Hisin P J, Hilf R (1976), A fluorometric method for for determination of oxidized and reduced glutathione in tissues. Anal Biochem 74, 214-226.
30. Buege J A, Aust S D (1978). Microsomal lipid peroxidation. Method Enzymol 52, 303-306.
31. Mc Manus F A, Mowry R W (1965). Staining methods: In histology and Histochemistry (Ed: P.B. Hoeber,) Harper and Brothers, New York, pp.73-90.
32. Gautam A, Vijayaraghavan R, Sharma M et al. (2006). Comparative toxicity studies of sulphur mustard (2,2'-dichloro diethyl sulphide) and monofunctional sulphur mustard (2-chloro ethyl ethyl sulphide), administered through various routes in mice. J Med Chem Biol Rad Def 4, 1-21.
33. Kumar O, Sugendran K, Vijayaraghavan R (2001). Protective effect of various antioxidants on the toxicity of sulphur mustard administered to mice by inhalation or percutaneous routes. Chem Biol Inter 134, 1-12.
34. Gabor M (1986). Anti-inflammatory and antiallergic properties of flavonoids. Prog Clin Biol Res 213, 471-480.
35. Ferrandiz M L, Nair A G, Alcaraz M J (1990). Inhibition of sheep platelet arachidonate metabolism by flavonoids from Spanish and Indian medicinal herbs. Pharmazie 45, 206-208.
36. 4-induced toxicity in isolated rat hepatocytes. Z Naturforsch 47, 275-279.
37. Santos N C, Figueira-Coelho J, Martin-Silva J, et al. (2003). Multidisciplinary utilization of dimethyl sulphoxide: pharmacological, cellular and molecular aspect. Biochem Pharmacol 65, 1035-1041.
38. Wakata N, Sugimoto H, Iguchi H, et al. (2001). Bupivacaine hydrochloride induces muscle fiber necrosis and hydroxyl radical formation-dimethyl sulphoxide reduces hydroxyl radical formation. Neurochem Res 26, 841-844.
39. Maddock C L, Green M N, Brown B L (1966). Topical administration of antitumour agents to locally implanted neoplasm. Cancer Res 7, 46-56.
40. Wormser U, Green B S, Arad-Yellin R, et al (1996). In vivo and in vitro toxicity of newly synthesized monofunctional sulfur mustard derivatives. Toxicology 108, 125-128.
41. Hollman P C, Katan M B (1997). Absorption, metabolism and health effects of dietary flavonoids in man. Biomed Pharmacother 51, 305-310.
42. Lefkowitz L J, Smith W J (2002). Sulfur mustard-induced arachidonic acid release is mediated by phospholipase D in human keratinocytes. Biochem Biophys Res Commun 295, 1062-1067.
43. Gentilhomme E, Neveux Y, Hua A, T et al. (1992). Action of bis (betachloroethyl) sulphide (BCES) on human epidermis reconstituted in culture: morphological alterations and biochemical depletion of Glutathione. Toxicol in vitro 6, 137-139.
44. Somani S M (1992). Chemical Warfare Agents. Academic press, London.
45. Sanchez-Perez Y, Carrasco-Legleu C, Garcia-Cuellar C, et al. (2005). Oxidative stress in carcinogenesis. Correlation between lipid peroxidation and induction of preneoplastic lesions in rat hepatocarcinogenesis. Cancer Lett 217, 25-32.
46. Ghanei M (2004). Delayed hematological complications of mustard gas. J Appl Toxicol 24, 493-495.
47. Mahmaudi M, Hefazi M, Rastin M, et al. (2005). Long-term hematological and immunological complications of sulphur mustard poisoning in Iranian veterans. Int Immunopharmacol 5, 1479-1485.
48. Cowan F M, Broomfield C A (1993). Putative roles of inflammation in the dermatopathology of sulphur mustard. Cell Biol Toxicol 9, 201-213.