Shift of oxidants and antioxidants levels in rats as a reaction to exposure to sulfur mustard

Journal of Applied Toxicology

Volumn 29, Issue 8, 2009, Pages 643-647

  Pohanka, Miroslav ^a   Stetina, Rudolf ^b  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Antioxidants; Cyclic voltammetry; Inflammation; Oxidative stress; Sulfur mustard; Yperite

Indexed keywords

ANTIOXIDANT; MUSTARD GAS; OXIDIZING AGENT;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYCLIC POTENTIOMETRY; ELECTRODE; EXPERIMENTAL MODEL; FEMALE; IN VIVO STUDY; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TOXICITY TESTING;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIOXIDANTS; CHEMICAL WARFARE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCHEMICAL TECHNIQUES; FEMALE; MALE; MUSTARD GAS; OXIDANTS; RATS; RATS, WISTAR;

RATTUS;

EID: 70849085839     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1451     Document Type: Article

References (39)

1. Adam V, Mikelova R, Hubalek J, Hanustiak P, Beklova M, Hodek P, Horna A, Trnkova L, Stiborova M, Zeman L, Kizek R. 2007. Utilizing of square wave voltammetry to detect flavonoids in the presence of human urine. Sensors 7: 2402-2418.
2. Amir A, Chapman S, Kadar T, Gozes Y, Sahar R, Allon N. 2000. Sulfur mustard toxicity in macrophages: effect of dexamethasone. J. Appl. Toxicol. 20: 51-58.
3. Atkins KB, Lodhi IJ, Hurley LL, Hinshaw DB. 2000. N-acetylcysteine and endothelial cell injury by sulfur mustard. J. Appl. Toxicol. 20: 125-128.
4. Brokes P, Lawley PD. 1960. The reaction of mustard gas with nucleic acids in vitro and in vivo. Biochem. J. 77: 465-475.
5. Chen J, Gorton L, Akesson B. 2002. Electrochemical studies on antioxidants in bovine milk. Anal. Chim. Acta 474: 137-146.
6. Chevion S, Roberts MA, Chevion M. 2000. The use of cyclic voltammetry for the evaluation of antioxidant capacity. Free Radic. Biol. Med. 28: 860-870.
7. Dacre JC, Goldman M. 1996. Toxicology and pharmacology of the chemical warfare agent sulfur mustard. Pharmacol. Rev. 48: 289-326.
8. Debiak M, Kehe K, Burkle A. 2008. Role of poly(ADP-ribose) polymerase in sulfur mustard toxicity. Toxicology, in press. PMID: 18602966.
9. Diopan V, Babula P, Shestivska V, Adam V, Zamlicka M, Dvorska M, Hubalek J, Trnkova L, Havel L, Kizek R. 2008. Electrochemical and spectrometric study of antioxidant activity of pomiferin, isopomiferin, osajin and catalposide. J. Pharm. Biomed. Anal. 48: 127-133.
10. Evans O. 1999. On-line deoxygenation in reductive (and oxidative) amperometric detection: environmental applications in the liquid chromatography of organic peroxides. Analyst 124: 1811-1816.
11. Evison D, Hincley D, Rice P. 2002. Regular review: chemical weapons. Brit. Med. J. 324: 332-335.
12. Fox M, Scott D. 1980. The genetic toxicology of nitrogen and sulphur mustard. Mutat. Res. 75: 131-168.
13. Genovese T, Cuzzocrea S. 2008. Role of free radicals and poly(ADP-ribose) polymerase-1 in the development of spinal cord injury: new potential therapeutic targets. Curr. Med. Chem. 15: 477-487.
14. Goetz ME, Luch A. 2008. Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett. 266: 73-83.
15. Gould N, White CW, Day BJ. 2008. A role for mitochondrial oxidative stress in sulfur mustard analog CEES-induced lung cell injury and antioxidant protection. J. Pharmacol. Exp. Ther., in press. PMCID: PMC2682257.
16. Guengerich FP. 2003. Activations of dihaloalkanes by thiol-dependent mechanisms. J. Biochem. Mol. Biol. 36: 20-27.
17. Ishida H, Ray R, Ray P. 2008. Sulfur mustard downregulates iNOS expression to inhibit wound healing in a human keratinocyte model. J. Dermatol. Sci. 49: 207-216.
18. Kaetzel RS, Stapels MD, Barofsky DF, Reed DJ. 2004. Alkylation of protein disulfide isomerase by the episolfunium ion derived from the glutathhione conjugative of 1,2-dichloroethane and mass spectrometric characterization of the adducts. Arch. Biochem. Biophys. 423: 136-147.
19. Kehe K, Balszuweit F, Emmler J, Kreppel H, Jochum M, Thiermann H. 2008. Sulfur mustard research - strategies for the development of improved medical therapy. Eplasty 8: e32.
20. Kohen R, Vellaichamy E, Hrbac J, Gati I, Tirosh O. 2000. Quantification of the overall reactive oxygen species scavenging capacity of biological fluids and tissues. Free Radic. Biol. Med. 28: 871-879.
21. Korkmaz A, Kunak ZI, Paredes SD, Yaren H, Tan DX, Reiter RJ. 2008. The use of melatonin to combat mustard toxicity. Review. Neuroendocrinol. Lett. 29: 614-619.
22. Langenberg JP, van der Schans GP, Spruit HE, Kuijpers WC, Mars-Groenendijk RH, van Dijk-Knijnenburg HC, Trap HC, van Helden HP, Benschop HP. 1998. Toxicokinetics of sulfur mustard and its DNA-adducts in the hairless guinea pig. Drug Chem. Toxicol. 1: 131-147.
23. Lawley PD, Phillips DH. 1996. DNA adducts from chemotherapeutic agents. Mutat. Res. 355: 13-40.
24. McClintock SD, Till GO, Smith MG, Ward PA. 2002. Protection from halfmustard gas induced acute lung injury in the rat. J. Appl. Toxicol. 22:257-262.
25. Mittal A, Flint RJ, Fanous M, Delahumnt B, Kilmartin PA, Cooper GJS, Windsor JA, Phillips ARJ. 2008. Redox status of acute pancreatitis as measured by cyclic voltammetry: initial rodent studies to assess disease severity. Crit. Care Med. 36: 866-872.
26. Mousavi B, Soroush MR, Montazeri A. 2009. Quality of life in chemical warfare survivors with ophtalmologic injuries: the first results from Iran chemical warfare victims health assessment study. Health Qual. Life Outcomes 7, in press. PMID: 19152700.
27. Naghii MR. 2002. Sulfur mustard intoxication, oxidative stress, and antioxidants. Mil. Med. 167: 573-575.
28. Papirmeister B, Gross CL, Meier HL, Petrali JP, Johnson JB. 1985. Molecular basis for mustard induced vesication. Fundam. Appl. Toxicol. 5: 134-149.
29. Paromov V, Suntres Z, Smith M, Stone WL. 2007. Sulfur mustard toxicity following dermal exposure: role of oxidative stress, and antioxidant therapy. J. Burns. Wounds 7: e7.
30. Pohanka M, Zdarova-Karasova J, Musilek K, Kuca K, Kassa J. 2009. Effect of five acetylcholinesterase reactivators on tabun intoxicated rats: induction of oxidative stress versus reactivation efficacy. J. Appl. Toxicol., in press. DOI: 10.1002/jat.1432.
31. Psotova J, Zahalkova J, Hrbac J, Simanek V, Bartek J. 2001. Determination of total antioxidant capacity in plasma by cyclic voltammetry. Two case reports. Biomed. Papers 145: 81-83.
32. Stanic Z, Voulgaropoulos A, Girousi S. 2008. Electroanalytical study of the antioxidant and antitumor agent curcumin. Electroanalysis 20: 1263-1266.
33. Supalkova V, Huska D, Diopan V, Hanustiak P, Zitka O, Stejskal K, Baloun J, Pikula J, Havel L, Zehnalek J, Adam V, Trnkova L, Beklova M, Kizek R. 2007. Electroanalysis of plant thiols. Sensors 7: 932-959.
34. Thomas C, Will Y, Schoenberg SL, Sanderlin D, Reed DJ. 2001. Conjugative metabolism of 1,2-dibromoethane in mitochondria: disruption of oxidative phosphorylation and alkylation of mitochondrial DNA. Biochem. Pharmacol. 61: 595-603.
35. Vijayaraghavan R, Kulkami A, Pant SC, Kumar P, Rao PVL, Gupta N, Gautam A, Ganesan K. 2005. Differential toxicity of sulfur mustard administered through percutaneous, subcutaneous, and oral routes. Toxicol. Appl. Pharmacol. 202: 180-188.
36. Vogt RF, Dannenberg AM, Schofield BH, Hynes NA, Papimeister B. 1984. Pathogenesis of skin lessons caused by sulphur mustard. Fundam. Appl. Toxicol. 4: 71-83.
37. Vojvodic V, Milosavljevic Z, Boskovic B, Bojanic N. 1985. The protective effect of different drugs in rats poisoned by sulfur and nitrogen mustards. Fundam. Appl. Toxicol. 5: 160-168.
38. Zielinska D, Szawara-Nowak D, Zielinski H. 2007. Comparison of spectrophotometric and electrochemical methods for the evaluation of the antioxidant capacity of buckwheat products after hydrothermal treatment. J. Agric. Food Chem. 55: 6124-6131.
39. Zielinska D, Frias J, Piskula MK, Kozlowska H, Zielinsky H. 2008. Evaluation of the antioxidant capacity of lupin sprouts germinated in the presence of selenium. Eur. Food Res. Technol. 227: 17111-17120.