Involvement of tumor necrosis factor-α in sulfur mustard-induced skin lesion; effect of topical iodine

Archives of Toxicology

Volumn 79, Issue 11, 2005, Pages 660-670

  Wormser, Uri ^a   Brodsky, Berta ^a   Proscura, Elena ^a   Foley, Julie F ^b   Jones, Tinette ^b   Nyska, Abraham ^b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Iodine; Mouse ear model; Neutrophils; Sulfur mustard; Tumor necrosis factor

Indexed keywords

GLUCOSE OXIDASE; HYDROXYL RADICAL; IODINE; MUSTARD GAS; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING; BLISTER; COMPARATIVE STUDY; CONTROLLED STUDY; EAR; EDEMA; HISTOLOGY; INFLAMMATION; MALE; MOUSE; NECROSIS; NEUTROPHIL; NEUTROPHILIA; NONHUMAN; OTITIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RESPIRATORY BURST; SKIN INJURY; SKIN TOXICITY; SKIN ULCER;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIBODIES; DERMATITIS, CONTACT; DERMIS; EAR; EDEMA; EPIDERMIS; HYDROXYL RADICAL; IODINE; MALE; MICE; MICE, INBRED ICR; MUSTARD GAS; NECROSIS; NEUTROPHILS; RESPIRATORY BURST; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 27744593323     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-005-0681-5     Document Type: Article

References (42)

1. Arroyo CM, Von Tersch RL, Broomfield CA (1995) Activation of alpha-human tumour necrosis factor (TNF-alpha) by human monocytes (THP-1) exposed to 2-chloroethyl ethyl sulphide (HMG). Hum Exp Toxicol 14:547-553
2. Arroyo CM, Schafer RJ, Kurt EM, Broomfield CA, Carmichael AJ (1999) Response of normal human keratinocytes to sulfur mustard (HD): cytokine release using a non-enzymatic detachment procedure. Hum Exp Toxicol 18:1-11
3. Arroyo CM, Schafer RJ, Kurt EM, Broomfield CA, Carmichael AJ (2000) Response of normal human keratinocytes to sulfur mustard: cytokine release. J Appl Toxicol 20 (suppl 1):S63-S72
4. Blaha M et al (2000) Effects of CEES on inflammatory mediators, heat shock protein 70A, histology and ultrastructure in two skin models. J Appl Toxicol 20 (suppl 1):S101-S108
5. Chatterjee D, Mukherjee S, Smith MG, Das SK (2003) Signal transduction events in lung injury induced by 2-chloroethyl ethyl sulfide, a mustard analog. J Biochem Mol Toxicol 17:114-121
6. Coleman CA, Hull BE, McDougal JN, Rogers JV (2003) The effect of m-xylene on cytotoxicity and cellular antioxidant status in rat dermal equivalents. Toxicol Lett 142:133-142
7. Fang WH et al (2003) The mRNA expression patterns of tumor necrosis factor-alpha and TNFR-1 in some vital organs after thermal injury. World J Gastroenterol 9:1038-1044
8. IJzermans JN, Scheringa M, van der Schelling GP, Geerling RA, Marquet RL, Jeekel J (1992) Injection of recombinant tumor necrosis factor directly into liver metastases: an experimental and clinical approach. Clin Exp Metastasis 10:91-97
9. Irie K, Satonaka K, Matsuura M, Miura Y, Nakayama H (1988) A case of vulva cancer responding to the recombinant human tumor necrosis factor (PT-950) - local injection therapy. Gan No Rinsho 34:946-950
10. Lefkowitz LJ, Smith WJ (2002) Sulfur mustard-induced arachidonic acid release is mediated by phospholipase D in human keratinocytes. Biochem Biophys Res Commun 295:1062-1067
11. Machida Y et al (2003) Overexpression of tumor necrosis factor-alpha increases production of hydroxyl radical in murine myocardium. Am J Physiol Heart Circ Physiol 284:H449-H455
12. McClintock SD, Till GO, Smith MG, Ward PA (2002) Protection from half-mustard-gas-induced acute lung injury in the rat. J Appl Toxicol 22:257-262
13. Mellor SG, Rice P, Cooper GJ (1991) Vesicant burns. Br J Plast Surg 44:434-437
14. Miesel R, Murphy MP, Kroger H (1996) Enhanced mitochondrial radical production in patients which rheumatoid arthritis correlates with elevated levels of tumor necrosis factor alpha in plasma. Free Radic Res 25:161-169
15. Molloy RG, O'Riordain M, Holzheimer R, Nestor M, Collins K, Mannick JA, Rodrick ML (1993) Mechanism of increased tumor necrosis factor production after thermal injury. Altered sensitivity to PGE2 and immunomodulation with indomethacin. J Immunol 151:2142-2149
16. Nyska A, Lomnitski L, Maronpot R, Moomaw C, Brodsky B, Sintov A, Wormser U (2001) Effects of iodine on inducible nitric oxide synthase and cyclooxygenase-2 expression in sulfur mustard-induced skin. Arch Toxicol 74:768-774
17. Oberyszyn TM, Robertson FM, Tober KL, Ross MS, Parrett ML, Wilgus TA, Iyer S, Woo J, Buelow R (2001) Inhibition of cutaneous UV light-induced tumor necrosis factor-alpha protein production by allotrap 1258, a novel immunomodulatory peptide. Photochem Photobiol 73:184-190
18. Petrali JP, Oglesby-Megee S (1997) Toxicity of mustard gas skin lesions. Microsc Res Tech 37:221-228
19. Reimold AM (2003) New indications for treatment of chronic inflammation by TNF-alpha blockade. Am J Med Sci 325:75-92
20. Ricketts KM, Santai CT, France JA, Graziosi AM, Doyel TD, Gazaway MY, Casillas RP (2000) Inflammatory cytokine response in sulfur mustard-exposed mouse skin. J Appl Toxicol 20 (suppl 1):S73-S76
21. Rikimaru T, Nakamura M, Yano T, Beck G, Habicht GS, Rennie LL, Widra M, Hirshman CA, Boulay MG, Spannhake EW et al (1991) Mediators, initiating the inflammatory response, released in organ culture by full-thickness human skin explants exposed to the irritant, sulfur mustard. J Invest Dermatol 96:888-897
22. Sabourin CLK, Petrali JP, Casillas RP (2000) Alterations in inflammatory cytokine gene expression in sulfur mustard-exposed mouse skin. J Biochem Molecular Toxicol 14:291-302
23. Sabourin CL, Danne MM, Buxton KL, Casillas RP, Schlager JJ (2002) Cytokine, chemokine, and matrix metalloproteinase response after sulfur mustard injury to weanling pig skin. J Biochem Mol Toxicol 16:263-272
24. Simeonova PP, Luster MI (1995) Iron and reactive oxygen species in the asbestos-induced tumor necrosis factor-alpha response from alveolar macrophages. Am J Respir Cell Mol Biol 12:676-683
25. Smith KJ (1999) The prevention and treatment of cutaneous injury secondary to chemical warfare agents. Application of these finding to other dermatologic conditions and wound healing. Dermatol Clin 17:41-60
26. Smith WJ, Gross CL (2002) Sulfur mustard medical countermeasures in a nuclear environment. Mil Med 167:101-102
27. Smith KJ, Skelton HG, Hobson DW, Reid FM, Blank JA, Hurst CG (1996) Cutaneous histopathologic features in weanling pigs after exposure to three different doses of liquid sulfur mustard. Am J Dermatopathol 18:515-520
28. Smith KJ, Casillas R, Graham J, Skelton HG, Stemler F, Hackley B-EJ (1997) Histopathologic features seen with different animal models following cutaneous sulfur mustard exposure. J Dermatol Sci 14:126-135
29. Stone WL, Qui M, Smith M (2003) Lipopolysaccharide enhances the cytotoxicity of 2-chloroethyl ethyl sulfide. BMC Cell Biol 4:1
30. Tsuruta J, Sugisaki K, Dannenberg A-MJ, Yoshimura T, Abe Y, Mounts P (1996) The cytokines NAP-1 (IL-8), MCP-1, IL-1 beta, and GRO in rabbit inflammatory skin lesions produced by the chemical irritant sulfur mustard. Inflammation 20:293-318
31. US Department of Health and Human Services Guide for the Care and Use of Laboratory Animals (1996) In: National Academy Press, Washington, DC
32. Viviani B, Corsini E, Pesenti M, Galli CL, Marinovich M (2001) Trimethyltin-activated cyclooxygenase stimulates tumor necrosis factor-alpha release from glial cells through reactive oxygen species. Toxicol Appl Pharmacol 172:93-97
33. Vulcano M, Rosa MF, Breyer I, Isturiz MA (1998) Hydroxyl radical scavengers inhibit TNF-alpha production in mononuclear cells but not in polymorphonuclear leukocytes. Int J Immunopharmacol 20:709-722
34. Worledge KL, Godiska R, Barrett TA, Kink JA (2000) Oral administration of avian tumor necrosis factor antibodies effectively treats experimental colitis in rats. Dig Dis Sci 45:2298-2305
35. Wormser U (1991) Toxicology of mustard gas. Trends Pharmacol Sci 12:164-167
36. Wormser U (1998) Early topical treatment with povidone-iodine ointment reduces, and sometimes prevents, skin damage following heat stimulus. Burns 24:383
37. Wormser U, Brodsky B, Green BS, Arad-Yellin R, Nyska A (1997) Protective effect of povidone-iodine ointment against skin lesions induced by sulphur and nitrogen mustards and by non-mustard vesicants. Arch Toxicol 71:165-170
38. Wormser U, Sintov A, Brodsky B, Nyska A (2000) Topical iodine preparation as therapy against sulfur mustard-induced skin lesions. Toxicol Appl Pharmacol 169:33-39
39. Wormser U, Brodsky B, Reich R (2002a) Topical treatment with povidone iodine reduces nitrogen mustard-induced skin collagenolytic activity. Arch Toxicol 76:119-121
40. Wormser U, Sintov A, Brodsky B, Amitai Y, Nyska A (2002b) Protective effect of topical iodine preparations upon heat-induced and hydrofluoric acid-induced skin lesions. Toxicol Pathol 30:552-558
41. Wormser U, Sintov A, Brodsky B, Casillas R, Nyska A (2004) Protective effect of topical iodine containing anti-inflammatory drugs against sulfur mustard-induced skin lesions. Arch Toxicol 78:156-166
42. Zhang Z, Monteiro-Riviere NA (1997) Comparison of integrins in human skin, pig skin, and perfused skin: an in vitro skin toxicology model. J Appl Toxicol 17:247-253