Necroinflammatory liver disease in BALB/c background, TGF-β1-deficient mice requires CD4+ T cells

Journal of Immunology

Volumn 170, Issue 9, 2003, Pages 4785-4792

  Rudner, Lynnie A ^a   Lin, Jack T ^a   Park, Il Kyoo ^a   Cates, Justin M M ^a   Dyer, Darci A ^a   Franz, Douglas M ^a   French, Margaret A ^a   Duncan, Elizabeth M ^a   White, Hillary D ^a   Gorham, James D ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; FEMALE; GENE; GENE DELETION; IMMUNOREGULATION; KNOCKOUT MOUSE; LIVER DISEASE; LYMPHOCYTE DEPLETION; MACROPHAGE; MALE; MONONUCLEAR CELL; MOUSE; MOUSE STRAIN; NECROINFLAMMATORY LIVER DISEASE; NEWBORN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RECOMBINASE ACTIVATING GENE; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

EID: 0242584864     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.9.4785     Document Type: Article

References (37)

1. Krawitt, E. L. 1996. Autoimmune hepatitis. N. Engl. J. Med. 334:897.
2. Strettell, M. D., P. T. Donaldson, L. J. Thomson, P. J. Santrach, S. B. Moore, A. J. Czaja, and R. Williams. 1997. Allelic basis for HLA-encoded susceptibility to type 1 autoimmune hepatitis. Gastroenterology 112:2028.
3. Doherty, D. G., P. T. Donaldson, J. A. Underhill, J. M. Farrant, A. Duthie, G. Mieli-Vergani, I. G. McFarlane, P. J. Johnson, A. L. Eddleston, and A. P. Mowat. 1994. Allelic sequence variation in the HLA class II genes and proteins in patients with autoimmune hepatitis. Hepatology 19:609.
4. Agarwal, K., A. J. Czaja, D. E. Jones, and P. T. Donaldson. 2000. Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphisms and susceptibility to type 1 autoimmune hepatitis. Hepatology 31:49.
5. Lohr, H. F., J. F. Schlaak, G. Gerken, B. Fleischer, H. P. Dienes, and K. H. Meyer Zum Buschenfelde. 1994. Phenotypical analysis and cytokine release of liver-infiltrating and peripheral blood T lymphocytes from patients with chronic hepatitis of different etiology. Liver 14:161.
6. Hussain, M. J., A. Mustafa, H. Gallati, A. P. Mowat, G. Mieli-Vergani, and D. Vergani. 1994. Cellular expression of tumour necrosis factor-α and interferon-γ in the liver biopsies of children with chronic liver disease. J. Hepatol. 21:816.
7. Gorham, J. D., J. T. Lin, J. L. Sung, L. A. Rudner, and M. A. French. 2001. Genetic regulation of autoimmune disease: BALB/c background TGF-β1-deficient mice develop necroinflammatory IFN-γ-dependent hepatitis. J. Immunol. 166:6413.
8. Shull, M. M., I. Ormsby, A. B. Kier, S. Pawlowski, R. J. Diebold, M. Yin, R. Allen, C. Sidman, G. Proetzel, D. Calvin, et al. 1992. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature 359:693.
9. Kulkami, A. B., C. G. Huh, D. Becker, A. Geiser, M. Lyght, K. C. Flanders, A. B. Roberts, M. B. Sporn, J. M. Ward, and S. Karlsson. 1993. Transforming growth factor β1 null mutation in mice causes excessive inflammatory response and early death. Proc. Natl. Acad. Sci. USA 90:770.
10. Watanabe, H., K. Ohtsuka, M. Kimura, Y. Ikarashi, K. Ohmori, A. Kusumi, T. Ohteki, S. Seki, and T. Abo. 1992, Details of an isolation method for hepatic lymphocytes in mice. J. Immunol. Methods 146:145.
11. + CTL activity within the human female reproductive tract: influence of stage of the menstrual cycle and menopause. J. Immunol. 158:3017.
12. + T lymphocytes. J. Immunol. 152:1523.
13. Dialynas, D. P., D. B. Wilde, P. Marrack, A. Pierres, K. A. Wall, W. Havran, G. Otten, M. R. Loken, M. Pierres, and J. Kappler. 1983. Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity. Immunol. Rev. 74:29.
14. Kruisbeek, A. M. 2000. In vivo depletion of CD4- and CD8-specific T cells. In Current Protocols in Immunology. J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober, eds. John Wiley & Sons, New York, p. 4.1.1.
15. Narita, J., T. Kawamura, C. Miyaji, H. Watanabe, S. Honda, T. Koya, M. Arakawa, and T. Abo. 1999. Abundance of NKT cells in the salivary glands but absence thereof in the liver and thymus of aly/aly mice with Sjogren syndrome. Cell. Immunol. 192:149.
16. + natural T cells with distinct cytotoxic activities and Th1, Th2, and Th0 cytokine secretion patterns. J. Immunol. 163:2314.
17. Norris, S., C. Collins, D. G. Doherty, F. Smith, G. McEntee, O. Traynor, N. Nolan, J. Hegarty, and C. O'Farrelly. 1998. Resident human hepatic lymphocytes are phenotypically different from circulating lymphocytes. J. Hepatol. 28:84.
18. Sentman, C. L., J. Hackett, Jr., T. A. Moore, M. M. Tutt, M. Bennett, and V. Kumar. 1989. Pan natural killer cell monoclonal antibodies and their relationship to the NK1.1 antigen. Hybridoma 8:605.
19. Mombaerts, P., J. Iacomini, R. S. Johnson, K. Herrup, S. Tonegawa, and V. E. Papaioannou. 1992. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68:869.
20. Kaneko, Y., M. Harada, T. Kawano, M. Yamashita, Y. Shibata, F. Gejyo, T. Nakayama, and M. Taniguchi. 2000. Augmentation of Vα14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis. J. Exp. Med. 191:105.
21. Hong, S., M. T. Wilson, I. Serizawa, L. Wu, N. Singh, O. V. Naidenko, T. Miura, T. Haba, D. C. Scherer, J. Wei, et al. 2001. The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat. Med. 7:1052.
22. Singh, A. K., M. T. Wilson, S. Hong, D. Olivares-Villagomez, C. Du, A. K. Stanic, S. Joyce, S. Sriram, Y. Koezuka, and L. Van Kaer. 2001. Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. J. Exp. Med. 194:1801.
23. Mars, L. T., V. Laloux, K. Goude, S. Desbois, A. Saoudi, L. Van Kaer, H. Lassmann, A. Herbelin, A. Lehuen, and R. S. Liblau. 2002. Cutting edge: Vα14-Jα281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice. J. Immunol. 168:6007.
24. + NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage. Clin. Immunol. 100:144.
25. -/- mice: role for IFN-γ in activating apoptosis of hepatocytes. J. Immunol. 159:1418.
26. Kusters, S., F. Gantner, G. Kunstle, and G. Tiegs. 1996. Interferon γ plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology 111:462.
27. Gantner, F., M. Leist, A. W. Lohse, P. G. Germann, and G. Tiegs. 1995. Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology 21:190.
28. + T cells is Fas dependent. J. Immunol. 167:6654.
29. Mehal, W. Z., F. Azzaroli, and I. N. Crispe. 2001. Antigen presentation by liver cells controls intrahepatic T cell trapping, whereas bone marrow-derived cells preferentially promote intrahepatic T cell apoptosis. J. Immunol. 167:667.
30. Bowen, D. G., A. Warren, T. Davis, M. W. Hoffmann, G. W. McCaughan, B. F. De St Groth, and P. Bertolino. 2002. Cytokine-dependent bystander hepatitis due to intrahepatic murine CD8 T-cell activation by bone marrow-derived cells. Gastroenterology 123:1252.
31. Clemmings, S. M., T. J. Alan, G. L. Bumgardner, and N. L. Ascher. 1991. Lack of class II antigen expression on hepatocytes profoundly affects CTL development in vitro and in vivo. Transplant. Proc. 23:817.
32. Bumgardner, G. L., A. J. Matas, S. Chen, D. Cahill, T. R. Cunningham, W. D. Payne, F. H. Bach, and N. L. Ascher. 1990. Comparison of in vivo and in vitro immune response to purified hepatocytes. Transplantation 49:429.
33. Geiser, A. G., J. J. Letterio, A. B. Kulkarni, S. Karlsson, A. B. Roberts, and M. B. Sporn. 1993. Transforming growth factor β1 (TGF-β1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-β1 null mouse phenotype. Proc. Natl. Acad. Sci. USA 90:9944.
34. Giacomini, P., P. B. Fisher, G. J. Duigou, R. Gambari, and P. G. Natali. 1988. Regulation of class II MHC gene expression by interferons: insights into the mechanism of action of interferon (review). Anticancer Res. 8:1153.
35. Lee, Y. J., Y. Han, H. T. Lu, V. Nguyen, H. Qin, P. H. Howe, B. A. Hocevar, J. M. Boss, R. M. Ransohoff, and E. N. Benveniste. 1997. TGF-β suppresses IFN-γ induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression. J. Immunol. 158:2065.
36. + T cells by the normal liver. J. Immunol. 163:3202.
37. Letterio, J. J., and A. B. Roberts. 1998. Regulation of immune responses by TGF-β. Annu. Rev. Immunol. 16:137.