TGF-β type II receptor-deficient thymocytes develop normally but demonstrate increased CD8+ proliferation in vivo

Blood

Volumn 106, Issue 13, 2005, Pages 4234-4240

  Levéen, Per ^b   Carlsén, Maria ^b   Makowska, Anna ^b   Oddsson, Saemundur ^b   Larsson, Jonas ^b   Goumans, Marie José ^b   Cilio, Corrado M ^a   Karlsson, Stefan ^b  

^a LUND UNIVERSITY   (Sweden)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CD4 ANTIGEN; CD8 ANTIGEN; GROWTH FACTOR RECEPTOR; HERMES ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE MARROW TRANSPLANTATION; CELL FUNCTION; CELL MATURATION; CELL PROLIFERATION; HEMATOPOIESIS; IMMUNOREGULATION; IN VITRO STUDY; MOUSE; NONHUMAN; ORGAN CULTURE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMOCYTE; THYMUS;

EID: 28844448286     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2005-05-1871     Document Type: Article

References (44)

1. Boyd RL, Hugo P. Towards an integrated view of thymopoiesis. Immunol Today. 1991;12:71-79.
2. Nikolic-Zugic J. Phenotypic and functional stages in the intrathymic development of alpha beta T cells. Immunol Today. 1991;12:65-70.
3. Ellingsworth LR, Nakayama D, Segarini P, Dasch J, Carrillo P, Waegell W. Transforming growth factor-betas are equipotent growth inhibitors of interleukin-1-induced thymocyte proliferation. Cell Immunol. 1988;114:41-54.
4. Chantry D, Turner M, Feldmann M. Interleukin 7 (murine pre-B cell growth factor/lymphopoietin 1) stimulates thymocyte growth: regulation by transforming growth factor beta. Eur J Immunol. 1989;19:783-786.
5. Kehrl JH, Wakefield LM, Roberts AB, et al. Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med. 1986;163:1037-1050.
6. Mossalayi MD, Mentz F, Ouaaz F, et al. Early human thymocyte proliferation is regulated by an externally controlled autocrine transforming growth factor-beta 1 mechanism. Blood. 1995;85:3594-3601.
7. Zhang X, Giangreco L, Broome HE, Dargan CM, Swain SL. Control of CD4 effector fate: transforming growth factor beta 1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion. J Exp Med. 1995;182:699-709.
8. Rich S, Van Nood N, Lee HM. Role of alpha 5 beta 1 integrin in TGF-beta 1-costimulated CD8+ T cell growth and apoptosis. J Immunol. 1996;157:2916-2923.
9. Cerwenka A, Kovar H, Majdic O, Holter W. Fasand activation-induced apoptosis are reduced in human T cells preactivated in the presence of TGF-beta 1. J Immunol. 1996;156:459-464.
10. Plum J, De Smedt M, Leclercq G, Vandekerckhove B. Influence of TGF-beta on murine thymocyte development in fetal thymus organ culture. J Immunol. 1995;154:5789-5798.
11. Sad S, Mosmann TR. Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype. J Immunol. 1994;153:3514-3522.
12. Swain SL, Huston G, Tonkonogy S, Weinberg A. Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype. J Immunol. 1991;147:2991-3000.
13. Cerwenka A, Bevec D, Majdic O, Knapp W, Holter W. TGF-beta 1 is a potent inducer of human effector T cells. J Immunol. 1994;153:4367-4377.
14. Diebold RJ, Eis MJ, Yin M, et al. Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated. Proc Natl Acad Sci U S A. 1995;92:12215-12219.
15. Letterio JJ, Geiser AG, Kulkarni AB, et al. Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression. J Clin Invest. 1996;98:2109-2119.
16. Kulkarni AB, Ward JM, Yaswen L, et al. Transforming growth factor-beta 1 null mice: an animal model for inflammatory disorders. Am J Pathol. 1995;146:264-275.
17. Shull MM, Ormsby I, Kier AB, et al. Targeted disruption of the mouse transforming growth factorbeta 1 gene results in multifocal inflammatory disease. Nature. 1992;359:693-699.
18. Chen W, Jin W, Tian H, et al. Requirement for transforming growth factor beta1 in controlling T cell apoptosis. J Exp Med. 2001;194:439-453.
19. Gorelik L, Flavell RA. Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity. 2000;12:171-181.
20. Lucas PJ, Kim SJ, Melby SJ, Gress RE. Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor. J Exp Med. 2000;191:1187-1196.
21. Levéen P, Larsson J, Ehinger M, et al. Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable. Blood. 2002;100:560-568.
22. Kuhn R, Schwenk F, Aguet M, Rajewsky K. Inducible gene targeting in mice. Science. 1995;269:1427-1429.
23. Ema H, Douagi I, Cumano A, Kourilsky P. Development of T cell precursor activity in the murine fetal liver. Eur J Immunol. 1998;28:1563-1569.
24. Douagi I, Andre I, Ferraz JC, Cumano A. Characterization of T cell precursor activity in the murine fetal thymus: evidence for an input of T cell precursors between days 12 and 14 of gestation. Eur J Immunol. 2000;30:2201-2210.
25. Goumans MJ, Valdimarsdottir G, Itoh S, Rosendahl A, Sideras P, ten Dijke P. Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors. EMBO J. 2002;21:1743-1753.
26. Larsson J, Blank U, Helgadottir H, et al. TGF-beta signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro. Blood. 2003;102:3129-3135.
27. Larsson J, Blank U, Klintman J, Magnusson M, Karlsson S. Quiescence of hematopoietic stem cells and maintenance of the stem cell pool is not dependent on TGF-beta signaling in vivo. Exp Hematol. 2005;33:592-596.
28. Luo K, Lodish HF. Positive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues. EMBO J. 1997;16:1970-1981.
29. Ceredig R. Differentiation potential of 14-day fetal mouse thymocytes in organ culture: analysis of CD4/CD8-defined single-positive and doublenegative cells. J Immunol. 1988;141:355-362.
30. Godfrey DI, Kennedy J, Mombaerts P, Tonegawa S, Zlotnik A. Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation. J Immunol. 1994;152:4783-4792.
31. Crispe IN, Moore MW, Husmann LA, Smith L, Bevan MJ, Shimonkevitz RP. Differentiation potential of subsets of CD4-8- thymocytes. Nature. 1987;329:336-339.
32. Smith CA, Williams GT, Kingston R, Jenkinson EJ, Owen JJ. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature. 1989;337:181-184.
33. McConkey DJ, Hartzell P, Amador-Perez JF, Orrenius S, Jondal M. Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex. J Immunol. 1989;143:1801-1806.
34. Letterio JJ, Roberts AB. Regulation of immune responses by TGF-beta. Annu Rev Immunol. 1998;16:137-161.
35. Cerwenka A, Swain SL. TGF-beta1: immunosuppressant and viability factor for T lymphocytes. Microbes Infect. 1999;1:1291-1296.
36. Letterio JJ, Roberts AB. TGF-beta: a critical modulator of immune cell function. Clin Immunol Immunopathol. 1997;84:244-250.
37. Roberts AB. Molecular and cell biology of TGFbeta. Miner Electrolyte Metab. 1998;24:111-119.
38. Yaswen L, Kulkarni AB, Fredrickson T, et al. Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse. Blood. 1996;87:1439-1445.
39. Kulkarni AB, Karlsson S. Inflammation and TGF beta 1: lessons from the TGF beta 1 null mouse. Res Immunol. 1997;148:453-456.
40. Letterio JJ. Murine models define the role of TGF-beta as a master regulator of immune cell function. Cytokine Growth Factor Rev. 2000;11:81-87.
41. Letterio JJ, Geiser AG, Kulkarni AB, Roche NS, Sporn MB, Roberts AB. Maternal rescue of transforming growth factor-beta 1 null mice. Science. 1994;264:1936-1938.
42. Bommireddy R, Saxena V, Ormsby I, et al. TGF-beta 1 regulates lymphocyte homeostasis by preventing activation and subsequent apoptosis of peripheral lymphocytes. J Immunol. 2003;170:4612-4622.
43. Thulesen S, Nielsen M, Petersen TR, Holst Nissen M, Odum N, Ropke C. Interleukin 15 is a growth factor for human thymocytes with preferential effect on CD8(+)cells. Cytokine. 2000;12:751-755.
44. Campbell JD, Cook G, Robertson SE, et al. Suppression of IL-2-induced T cell proliferation and phosphorylation of STAT3 and STAT5 by tumorderived TGF beta is reversed by IL-15. J Immunol. 2001;167:553-561.